Detailed information for compound 789177

Basic information

Technical information
  • TDR Targets ID: 789177
  • Name: 2-[1-[(4-methylphenyl)methyl]pyrrol-2-yl]-4-( 2-methylpropyl)-4,5-dihydro-1,3-oxazole
  • MW: 296.407 | Formula: C19H24N2O
  • H donors: 0 H acceptors: 0 LogP: 4.21 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CC1COC(=N1)c1cccn1Cc1ccc(cc1)C)C
  • InChi: 1S/C19H24N2O/c1-14(2)11-17-13-22-19(20-17)18-5-4-10-21(18)12-16-8-6-15(3)7-9-16/h4-10,14,17H,11-13H2,1-3H3
  • InChiKey: JRZPCWGXXFRHSK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-isobutyl-2-[1-[(4-methylphenyl)methyl]pyrrol-2-yl]-4,5-dihydrooxazole
  • 4-isobutyl-2-[1-[(4-methylphenyl)methyl]-2-pyrrolyl]-4,5-dihydrooxazole
  • 4-isobutyl-2-[1-(4-methylbenzyl)pyrrol-2-yl]-4,5-dihydrooxazole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0102 0.1116 0.2403
Mycobacterium ulcerans beta-lactamase 0.0035 0.0141 0.0241
Echinococcus multilocularis protein patched 0.0041 0.0228 0.0194
Entamoeba histolytica hypothetical protein 0.0453 0.6228 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.3718 0.3696
Loa Loa (eye worm) hypothetical protein 0.0047 0.0319 0.0603
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.395 0.4511
Mycobacterium tuberculosis Conserved protein 0.0035 0.0141 0.0241
Mycobacterium ulcerans hypothetical protein 0.0035 0.0141 0.0241
Toxoplasma gondii exonuclease III APE 0.0058 0.0471 0.4085
Brugia malayi beta-lactamase family protein 0.0035 0.0141 0.0172
Loa Loa (eye worm) MH2 domain-containing protein 0.0124 0.1444 0.3142
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0626 0.8757 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Mycobacterium tuberculosis Probable reductase 0.0182 0.2285 0.5111
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0453 0.6228 0.6215
Onchocerca volvulus 0.0035 0.0141 0.043
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0088 0.0915 0.1045
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0071 0.0668 0.1439
Loa Loa (eye worm) glutathione reductase 0.008 0.0795 0.1678
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0035 0.004
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0319 0.0459
Loa Loa (eye worm) hypothetical protein 0.0041 0.0228 0.0398
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.1021 0.1639
Treponema pallidum exodeoxyribonuclease (exoA) 0.0058 0.0471 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.3718 0.3696
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Schistosoma mansoni importin beta-1 0.0031 0.0086 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.008 0.0795 0.1726
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.028 0.3718 0.8276
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0499 0.1009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0058 0.0471 0.0947
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0058 0.0471 0.0991
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.1021 0.099
Loa Loa (eye worm) hypothetical protein 0.0095 0.1021 0.2188
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0228 0.0398
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0141 0.0122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0141 0.0107
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0141 0.0107
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0216 0.0182
Onchocerca volvulus 0.0035 0.0141 0.043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0149 0.1804 0.2856
Schistosoma mansoni hypothetical protein 0.0039 0.0206 0.0172
Schistosoma mansoni hypothetical protein 0.0712 1 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0058 0.0471 0.0757
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0088 0.0915 0.1009
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.014 0.0106
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.3718 0.3696
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0141 0.0202
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Loa Loa (eye worm) beta-lactamase 0.0035 0.0141 0.0202
Schistosoma mansoni hypothetical protein 0.0039 0.0206 0.0172
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.028 0.3718 0.3696
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0668 0.1439
Echinococcus granulosus jumonji domain containing protein 0.004 0.0216 0.0182
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0724 0.0692
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0028 0.0035 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Brugia malayi MH2 domain containing protein 0.0124 0.1444 0.2275
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0058 0.0471 0.0538
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0333 0.4482 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0141 0.0241
Plasmodium vivax thioredoxin reductase, putative 0.008 0.0795 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0071 0.0668 0.0763
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.028 0.3718 0.3696
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0058 0.0471 0.0538
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0141 0.0409
Plasmodium falciparum phd finger protein, putative 0.0029 0.0052 0.0221
Schistosoma mansoni ap endonuclease 0.0058 0.0471 0.0438
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0052 0.0017
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0141 0.0107
Loa Loa (eye worm) thioredoxin reductase 0.008 0.0795 0.1678
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0058 0.0471 0.0438
Schistosoma mansoni hypothetical protein 0.0333 0.4482 0.4463
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0052 0.0221
Trichomonas vaginalis glutathione reductase, putative 0.0028 0.0035 0.0101
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0668 0.0636
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0141 0.0241
Schistosoma mansoni hypothetical protein 0.0712 1 1
Brugia malayi Bromodomain containing protein 0.0029 0.0052 0.0027
Leishmania major mitochondrial DNA polymerase beta 0.0626 0.8757 1
Mycobacterium ulcerans hypothetical protein 0.033 0.4438 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.227 0.6585
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0319 0.0459
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0182 0.2285 0.5111
Brugia malayi CHE-14 protein 0.0041 0.0228 0.0312
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0141 0.0241
Brugia malayi Thioredoxin reductase 0.008 0.0795 0.1228
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0453 0.6228 0.6215
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0058 0.0471 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0319 0.0285
Brugia malayi PHD-finger family protein 0.0029 0.0052 0.0027
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0915 0.1045
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0141 0.0409
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0228 0.0194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.3718 0.3696
Schistosoma mansoni patched 1 0.0041 0.0228 0.0194
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0202 0.2582 0.5784
Schistosoma mansoni aldehyde dehydrogenase 0.0071 0.0668 0.0636
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0141 0.0241
Brugia malayi beta-lactamase 0.0035 0.0141 0.0172
Mycobacterium tuberculosis Probable dehydrogenase 0.0182 0.2285 0.5111
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0319 0.0285
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.1021 0.099
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0052 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0141 0.0161
Schistosoma mansoni transcription factor LCR-F1 0.0453 0.6228 0.6215
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0107 0.1195 0.1365
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0141 0.1398
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Echinococcus multilocularis thioredoxin glutathione reductase 0.0081 0.0811 0.0778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0149 0.1804 0.2856
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.2886 0.6476
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.1021 0.1593
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0028 0.0035 0.004
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0626 0.8757 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0141 0.0241
Echinococcus granulosus expressed conserved protein 0.009 0.0937 0.0905
Plasmodium falciparum importin beta, putative 0.0031 0.0086 0.0674
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0182 0.2285 0.5111
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.028 0.3718 0.3696
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0471 0.1367
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Loa Loa (eye worm) hypothetical protein 0.0049 0.0352 0.0677
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.1116 0.1747
Mycobacterium tuberculosis Conserved protein 0.0035 0.0141 0.0241
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Schistosoma mansoni hypothetical protein 0.0039 0.0206 0.0172
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0228 0.0194
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0028 0.0035 0.004
Echinococcus granulosus thioredoxin glutathione reductase 0.0081 0.0811 0.0778
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0058 0.0471 0.0991
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0052 0.0017
Trichomonas vaginalis mercuric reductase, putative 0.0028 0.0035 0.0101
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.014 0.0106
Schistosoma mansoni hypothetical protein 0.0047 0.0319 0.0285
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.1007 0.0976
Trypanosoma brucei trypanothione reductase 0.008 0.0795 0.0872
Plasmodium falciparum thioredoxin reductase 0.008 0.0795 1
Brugia malayi Importin beta-1 subunit 0.0031 0.0086 0.0083
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0296 0.395 0.4489
Mycobacterium ulcerans lipase LipD 0.0035 0.0141 0.0241
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.1007 0.0976
Schistosoma mansoni hypothetical protein 0.0029 0.0052 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0182 0.2285 0.5111
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0141 0.0172
Schistosoma mansoni hypothetical protein 0.0047 0.0319 0.0285
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0228 0.0194
Trypanosoma cruzi trypanothione reductase, putative 0.0028 0.0035 0.004
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0028 0.0035 0.004
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.028 0.3718 0.5948
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0141 0.0161
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.014 0.0106
Brugia malayi jmjC domain containing protein 0.0035 0.014 0.017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0319 0.0285
Entamoeba histolytica hypothetical protein 0.0453 0.6228 1
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0141 0.0241
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0626 0.8757 1
Echinococcus granulosus snurportin 1 0.0333 0.4482 0.4463
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0141 0.0409
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0058 0.0471 1
Echinococcus multilocularis protein dispatched 1 0.0047 0.0312 0.0278
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0228 0.0661
Brugia malayi hypothetical protein 0.0453 0.6228 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.3447 0.5511
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0052 0.0157
Echinococcus multilocularis GPCR, family 2 0.0047 0.0319 0.0285
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.1617 0.1588
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.227 0.6585
Plasmodium falciparum glutathione reductase 0.008 0.0795 1
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0086 0.0479
Leishmania major trypanothione reductase 0.008 0.0795 0.0908
Echinococcus multilocularis expressed conserved protein 0.009 0.0937 0.0905
Loa Loa (eye worm) transcription factor SMAD2 0.0124 0.1444 0.3142
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0141 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0319 0.0285
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0668 0.1439
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0086 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0141 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0471 0.5742
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0052 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0058 0.0471 0.0538
Trichomonas vaginalis esterase, putative 0.0035 0.0141 0.0409
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Echinococcus granulosus GPCR family 2 0.0047 0.0319 0.0285
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0071 0.0668 0.0636
Plasmodium vivax importin-beta 2, putative 0.0031 0.0086 0.0674
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0182 0.2285 0.8787
Mycobacterium ulcerans aldehyde dehydrogenase 0.0071 0.0668 0.1439
Loa Loa (eye worm) hypothetical protein 0.0031 0.0086 0.0078
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.3447 0.7665
Schistosoma mansoni ap endonuclease 0.0058 0.0471 0.0438
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0141 0.0241
Brugia malayi RNA, U transporter 1 0.0089 0.0924 0.1435
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.2135 1
Echinococcus multilocularis geminin 0.0712 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.014 0.0199
Loa Loa (eye worm) hypothetical protein 0.0149 0.1804 0.3955
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0202 0.2582 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0058 0.0471 0.05
Brugia malayi beta-lactamase family protein 0.0035 0.0141 0.0172
Leishmania major hypothetical protein, conserved 0.0035 0.0141 0.0161
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.1042 0.1011
Echinococcus multilocularis peregrin 0.0029 0.0052 0.0017
Echinococcus multilocularis snurportin 1 0.0333 0.4482 0.4463
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0086 0.0059
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0296 0.395 0.4511
Toxoplasma gondii ABC1 family protein 0.0035 0.0141 0.0995
Echinococcus granulosus importin subunit beta 1 0.0031 0.0086 0.0051
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0028 0.0035 0.004
Schistosoma mansoni hypothetical protein 0.0047 0.0319 0.0285
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0058 0.0471 0.5742
Entamoeba histolytica hypothetical protein 0.0453 0.6228 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.014 0.0106
Toxoplasma gondii aldehyde dehydrogenase 0.0071 0.0668 0.5929
Mycobacterium tuberculosis Conserved hypothetical protein 0.033 0.4438 1
Brugia malayi glutathione reductase 0.008 0.0795 0.1228
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.3447 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.1617 0.1588
Giardia lamblia PHD finger protein 15 0.0029 0.0052 0.0385
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0086 0.0051
Schistosoma mansoni hypothetical protein 0.0102 0.1116 0.1085
Plasmodium vivax glutathione reductase, putative 0.008 0.0795 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0149 0.1804 0.3955
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0141 0.0241
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0202 0.2582 0.5784
Mycobacterium tuberculosis Probable oxidoreductase 0.0202 0.2582 0.5784
Entamoeba histolytica hypothetical protein 0.0453 0.6228 1
Mycobacterium tuberculosis Conserved protein 0.0035 0.0141 0.0241
Schistosoma mansoni hypothetical protein 0.0453 0.6228 0.6215
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0088 0.0915 0.1045
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0319 0.0603
Schistosoma mansoni hypothetical protein 0.0047 0.0319 0.0285
Onchocerca volvulus 0.0035 0.0141 0.043
Loa Loa (eye worm) hypothetical protein 0.005 0.0362 0.0701
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0141 0.0107
Brugia malayi exodeoxyribonuclease III family protein 0.0058 0.0471 0.0705
Toxoplasma gondii thioredoxin reductase 0.008 0.0795 0.7114
Loa Loa (eye worm) hypothetical protein 0.0035 0.0141 0.0202
Trichomonas vaginalis ap endonuclease, putative 0.0058 0.0471 0.1367
Trypanosoma cruzi trypanothione reductase, putative 0.008 0.0795 0.0908
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0141 0.0409
Brugia malayi jmjC domain containing protein 0.0094 0.1007 0.157
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0071 0.0668 0.0636
Echinococcus granulosus peregrin 0.0029 0.0052 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0058 0.0471 0.0438
Toxoplasma gondii hypothetical protein 0.0101 0.1103 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0182 0.2285 0.5111
Schistosoma mansoni hypothetical protein 0.0039 0.0206 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.2135 0.6194

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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