Detailed information for compound 789334

Basic information

Technical information
  • TDR Targets ID: 789334
  • Name: N-(3-ethoxypropyl)-2-(4-fluorophenyl)sulfanyl quinoline-4-carboxamide
  • MW: 384.467 | Formula: C21H21FN2O2S
  • H donors: 1 H acceptors: 2 LogP: 4.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCCCNC(=O)c1cc(Sc2ccc(cc2)F)nc2c1cccc2
  • InChi: 1S/C21H21FN2O2S/c1-2-26-13-5-12-23-21(25)18-14-20(24-19-7-4-3-6-17(18)19)27-16-10-8-15(22)9-11-16/h3-4,6-11,14H,2,5,12-13H2,1H3,(H,23,25)
  • InChiKey: KMCXMAYWDIQULN-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(3-ethoxypropyl)-2-(4-fluorophenyl)sulfanyl-quinoline-4-carboxamide
  • N-(3-ethoxypropyl)-2-[(4-fluorophenyl)thio]-4-quinolinecarboxamide
  • N-(3-ethoxypropyl)-2-[(4-fluorophenyl)thio]cinchoninamide
  • MLS000586263
  • N-(3-ethoxypropyl)-2-[(4-fluorophenyl)thio]quinoline-4-carboxamide
  • SMR000204626

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Aberrant vpr protein Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0053
Echinococcus multilocularis neutral alpha glucosidase AB 0.0182 0.1729 0.1729
Trypanosoma cruzi metacaspase 5, putative 0.0222 0.2143 1
Toxoplasma gondii oxidoreductase, putative 0.0023 0.008 0.0132
Echinococcus granulosus dna polymerase eta 0.0064 0.0496 0.0593
Brugia malayi hypothetical protein 0.0037 0.0216 0.0258
Brugia malayi beta-lactamase 0.0074 0.0607 0.0725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0607 0.2791
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0607 0.1254
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0023 0.008 0.0132
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0044 0.0062
Mycobacterium ulcerans short-chain dehydrogenase 0.0023 0.008 0.0295
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0209
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0622 0.2863
Echinococcus multilocularis caspase 2 0.0429 0.4291 0.4291
Schistosoma mansoni caspase-3 (C14 family) 0.0588 0.5935 0.8271
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0448 0.2045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0053
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1118 0.2331
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0189 0.0226
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0518 0.2377
Loa Loa (eye worm) fibroinase 0.0017 0.0016 0.0019
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0044
Onchocerca volvulus 0.0023 0.008 0.0136
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Loa Loa (eye worm) hypothetical protein 0.0602 0.608 0.727
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0209
Schistosoma mansoni cpg binding protein 0.0029 0.0137 0.0191
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0053
Leishmania major pteridine reductase 1 0.0023 0.008 0.0295
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0023 0.008 0.0295
Mycobacterium ulcerans dehydrogenase/reductase 0.0023 0.008 0.0295
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0238 0.1062
Toxoplasma gondii cathepsin CPL 0.0017 0.0016 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0053
Trichomonas vaginalis alpha-glucosidase, putative 0.0182 0.1729 0.5051
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0175 0.0209
Brugia malayi jmjC domain containing protein 0.0057 0.0432 0.0516
Brugia malayi Importin beta-1 subunit 0.0059 0.0448 0.0535
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0474 0.4756 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.024 0.2328 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0189 0.0226
Echinococcus multilocularis lysine specific demethylase 5A 0.0215 0.2068 0.2068
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0044 0.0061
Schistosoma mansoni apoferritin-2 0.0017 0.0017 0.0023
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0441
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0023 0.008 0.0376
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.0332 0.1503
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0505 0.0505
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Plasmodium vivax hypothetical protein, conserved 0.0222 0.2143 1
Leishmania major trypanothione reductase 0.0049 0.0342 0.1425
Brugia malayi hypothetical protein 0.002 0.0045 0.0053
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0044 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.108 0.108
Brugia malayi Muscleblind-like protein 0.0602 0.608 0.727
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0771 0.0771
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.009 0.0771 0.1464
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0588 0.5935 0.7097
Loa Loa (eye worm) hypothetical protein 0.0429 0.4291 0.5131
Echinococcus multilocularis retinol dehydrogenase 11 0.0023 0.008 0.008
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.008 0.032
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0023 0.008 0.0376
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0394 0.1791
Schistosoma mansoni ferritin 0.0017 0.0017 0.0023
Echinococcus granulosus caspase 2 0.0429 0.4291 0.5131
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0353 0.0422
Onchocerca volvulus Sepiapterin reductase homolog 0.0023 0.008 0.0136
Loa Loa (eye worm) hypothetical protein 0.0126 0.1146 0.137
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0622 0.2863
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Entamoeba histolytica hypothetical protein 0.0037 0.0216 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0505 0.0604
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0068 0.0541 0.2485
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0023 0.008 0.0144
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0111 0.0989 0.6772
Loa Loa (eye worm) hypothetical protein 0.0064 0.0496 0.0593
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.03 0.0418
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0238 0.0977
Leishmania major alpha glucosidase II subunit, putative 0.0182 0.1729 0.7412
Plasmodium vivax glutathione reductase, putative 0.0049 0.0342 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0053
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0771 0.0922
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.1751 0.244
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0045 0.0154
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0057 0.0432 0.081
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0505 0.0703
Mycobacterium ulcerans ketoacyl reductase 0.0023 0.008 0.0295
Echinococcus multilocularis cysteine protease 0.0017 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0148 0.0148
Onchocerca volvulus 0.002 0.0045 0.0061
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0238 0.0666
Entamoeba histolytica hypothetical protein 0.0037 0.0216 0.117
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0182 0.1729 0.5051
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis retinol dehydrogenase 11 0.0023 0.008 0.008
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.108 0.1291
Echinococcus multilocularis peregrin 0.0034 0.0186 0.0186
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0628 0.6358 0.7603
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.008 0.0376
Echinococcus granulosus lysosomal alpha glucosidase 0.0821 0.8363 1
Leishmania major cathepsin L-like protease 0.0066 0.0518 0.2187
Plasmodium falciparum ataxin-2 like protein, putative 0.0076 0.0622 0.2863
Brugia malayi hypothetical protein 0.002 0.0045 0.0053
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus granulosus oxidoreductase 0.0023 0.008 0.0096
Plasmodium vivax hypothetical protein, conserved 0.003 0.0148 0.064
Toxoplasma gondii aldehyde dehydrogenase 0.0184 0.1751 0.3354
Schistosoma mansoni cpg binding protein 0.0031 0.0154 0.0214
Onchocerca volvulus Cell death protein 3 homolog 0.0429 0.4291 0.8996
Leishmania major DNA polymerase kappa, putative 0.0039 0.0238 0.0977
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0023 0.008 0.0096
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0607 0.1254
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.4109 0.4109
Brugia malayi Retinol dehydrogenase 12 0.0023 0.008 0.0096
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0175 0.0209
Brugia malayi beta-lactamase family protein 0.0074 0.0607 0.0725
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0053
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0342 0.0696
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.03 0.0418
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0045 0.0053
Echinococcus granulosus RUN 0.002 0.0045 0.0053
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0023 0.008 0.0295
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0132
Schistosoma mansoni jumonji/arid domain-containing protein 0.0217 0.2085 0.2906
Loa Loa (eye worm) MH2 domain-containing protein 0.0139 0.1275 0.1524
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0238 0.0238
Schistosoma mansoni hypothetical protein 0.0207 0.1985 0.2766
Mycobacterium tuberculosis Probable dehydrogenase 0.0023 0.008 0.0144
Leishmania major short chain dehydrogenase-like protein 0.0023 0.008 0.0295
Echinococcus multilocularis transient receptor potential cation channel 0.0023 0.008 0.008
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0505 0.0703
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0102 0.0896 0.6123
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0344 0.3411 0.4754
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0182 0.1729 0.2067
Trypanosoma brucei oxidoreductase-like protein 0.0023 0.008 0.032
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0023 0.008 0.008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0044 0.0053
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0148 0.0177
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0216 0.0301
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0023 0.008 0.0132
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Trypanosoma cruzi major cysteine proteinase, putative 0.0052 0.0373 0.1692
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0332 0.0942
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0607 0.4108
Trypanosoma brucei Metacaspase-4 0.0222 0.2143 1
Schistosoma mansoni ferritin 0.0017 0.0017 0.0023
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0044 0.0062
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0295
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0023 0.008 0.0112
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0222 0.2143 0.411
Echinococcus granulosus histone acetyltransferase KAT2B 0.0143 0.1322 0.158
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0023 0.008 0.032
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0295
Schistosoma mansoni lipoxygenase 0.0084 0.0706 0.0984
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0023 0.008 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Brugia malayi dehydrogenases, short chain protein 2 0.0023 0.008 0.0096
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0023 0.008 0.0441
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0023 0.008 0.0441
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0607 0.175
Schistosoma mansoni protein phosphatase 2C 0.0057 0.0432 0.0602
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0023 0.008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0076 0.0622 0.0744
Echinococcus multilocularis cpg binding protein 0.0031 0.0154 0.0154
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0023 0.008 0.0295
Brugia malayi Dehydrogenases, short chain protein 30 0.0023 0.008 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0114 0.0478
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0505 0.0703
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0209
Giardia lamblia DINP protein human, muc B family 0.0039 0.0238 0.2982
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0079 0.0657 0.0786
Plasmodium falciparum JmjC domain-containing protein, putative 0.0057 0.0432 0.197
Echinococcus granulosus apoptotic protease activating factor 1 0.0207 0.1985 0.2373
Onchocerca volvulus 0.0023 0.008 0.0136
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0496 0.0593
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.008 0.0144
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0016 0.0018
Brugia malayi oxidoreductase 0.0023 0.008 0.0096
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.0448 0.084
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0044 0.0053
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0023 0.008 0.032
Echinococcus multilocularis oxidoreductase 0.0023 0.008 0.008
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Trypanosoma brucei unspecified product 0.0039 0.0238 0.1062
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0496 0.2272
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0023 0.008 0.0144
Mycobacterium ulcerans lipase LipD 0.0074 0.0607 0.2568
Brugia malayi Cell death protein 3 precursor 0.0429 0.4291 0.5131
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.008 0.008
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0588 0.5935 0.5935
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0053
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0132
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0079 0.0657 0.0657
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0023 0.008 0.0112
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0056 0.0056
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0541 0.1558
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2801 0.3349
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0044 0.0062
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0132
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0068 0.0541 0.3069
Plasmodium vivax hypothetical protein, conserved 0.0023 0.008 0.032
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2801 0.2801
Loa Loa (eye worm) hypothetical protein 0.0068 0.0541 0.0647
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Loa Loa (eye worm) hypothetical protein 0.0033 0.0175 0.0209
Trypanosoma brucei metacaspase 5, putative 0.0222 0.2143 1
Onchocerca volvulus 0.002 0.0045 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Toxoplasma gondii ABC1 family protein 0.0074 0.0607 0.1147
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0023 0.008 0.0295
Brugia malayi beta-lactamase family protein 0.0074 0.0607 0.0725
Echinococcus multilocularis jumonji domain containing 1A 0.0057 0.0432 0.0432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Leishmania major hypothetical protein, conserved 0.0076 0.0622 0.2634
Trichomonas vaginalis steroid dehydrogenase, putative 0.0023 0.008 0.0201
Loa Loa (eye worm) hypothetical protein 0.0057 0.0432 0.0516
Entamoeba histolytica hypothetical protein 0.0037 0.0216 0.117
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0057 0.0432 0.197
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0216 0.0258
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Entamoeba histolytica hypothetical protein 0.0048 0.0332 0.1847
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0044 0.0053
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0023 0.008 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0053
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 0.622
Schistosoma mansoni ferritin 0.0017 0.0017 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0222 0.2143 0.2563
Mycobacterium ulcerans ketoacyl reductase 0.0023 0.008 0.0295
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0016 0.0019
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0023 0.008 0.032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0044 0.0062
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0059 0.0449 0.0537
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0079 0.0657 0.0786
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.024 0.2328 0.2328
Echinococcus granulosus lysine specific demethylase 5A 0.0217 0.2085 0.2493
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Echinococcus multilocularis apoptotic protease activating factor 1 0.0207 0.1985 0.1985
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1118 0.7668
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0238 0.1062
Loa Loa (eye worm) jmjC domain-containing protein 0.0217 0.2085 0.2493
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Schistosoma mansoni jumonji domain containing protein 0.0257 0.2502 0.3486
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0607 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0473 0.0659
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0017
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0068 0.0541 0.1558
Brugia malayi jmjC domain containing protein 0.0217 0.2085 0.2493
Trichomonas vaginalis ferritin, putative 0.0017 0.0017 0.0014
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Brugia malayi RNA, U transporter 1 0.0167 0.1574 0.1882
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Mycobacterium ulcerans short-chain dehydrogenase 0.0023 0.008 0.0295
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Leishmania major cathepsin L-like protease 0.0066 0.0518 0.2187
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0217 0.2085 0.2493
Leishmania major short chain dehydrogenase, putative 0.0023 0.008 0.0295
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0607 0.0725
Echinococcus granulosus dnaJ subfamily B 0.0412 0.4109 0.4913
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0023 0.008 0.0441
Onchocerca volvulus 0.0023 0.008 0.0136
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Giardia lamblia Reductase, putative 0.0023 0.008 0.0899
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0014
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.008 0.0376
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0016 0.0016
Loa Loa (eye worm) doublecortin family protein 0.002 0.0045 0.0053
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Echinococcus multilocularis caspase 0.0588 0.5935 0.5935
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0607 0.175
Toxoplasma gondii carbonyl reductase 1, putative 0.0023 0.008 0.0132
Echinococcus granulosus hypothetical protein 0.0023 0.008 0.0096
Schistosoma mansoni lamin 0.0033 0.0175 0.0244
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 0.6761
Echinococcus granulosus tar DNA binding protein 0.0064 0.0505 0.0604
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.1751 0.7509
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Loa Loa (eye worm) ctsf protein 0.0017 0.0016 0.0019
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0516 0.5197 0.7243
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Echinococcus granulosus peptidase Clp S14 family 0.0102 0.0896 0.1071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis expressed protein 0.0017 0.0017 0.0017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0238 0.0238
Trypanosoma brucei metacaspase MCA2 0.0222 0.2143 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0865 0.1035
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0238 0.0332
Echinococcus granulosus snurportin 1 0.0628 0.6358 0.7603
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0295
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0263
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0238 0.0285
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0607 0.175
Trichomonas vaginalis alpha-glucosidase, putative 0.0182 0.1729 0.5051
Echinococcus multilocularis importin subunit beta 1 0.0059 0.0448 0.0448
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0073 0.0595 0.083
Onchocerca volvulus 0.0023 0.008 0.0136
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0057 0.0432 0.197
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0057 0.0432 0.0602
Schistosoma mansoni ferritin 0.0017 0.0017 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0602 0.608 0.727
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0219 0.0973
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0607 0.2568
Echinococcus granulosus FTZ F1 alpha 0.002 0.0044 0.0053
Schistosoma mansoni DNA polymerase eta 0.0064 0.0496 0.0691
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0054 0.0394 0.2649
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0541 0.1558
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0238 0.0977
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0222 0.2143 0.411
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0056 0.0209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0607 0.0846
Loa Loa (eye worm) beta-lactamase 0.0074 0.0607 0.0725
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0516 0.5197 0.6214
Brugia malayi hypothetical protein 0.0076 0.0622 0.0744
Brugia malayi dehydrogenases, short chain protein 9 0.0023 0.008 0.0096
Schistosoma mansoni rab6-interacting 0.002 0.0045 0.0062
Echinococcus multilocularis lamin dm0 0.0033 0.0175 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0044 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Toxoplasma gondii LsmAD domain-containing protein 0.0076 0.0622 0.1177
Mycobacterium ulcerans hypothetical protein 0.0074 0.0607 0.2568
Plasmodium falciparum metacaspase-like protein 0.0222 0.2143 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.0102 0.0896 0.0896
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0016 0.0019
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Schistosoma mansoni hypothetical protein 0.0681 0.6902 0.9618
Onchocerca volvulus 0.0023 0.008 0.0136
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0044 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0238 0.0285
Onchocerca volvulus Alhambra homolog 0.003 0.0148 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0053
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0441
Echinococcus multilocularis ferritin 0.0017 0.0017 0.0017
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 1
Toxoplasma gondii hypothetical protein 0.0054 0.0394 0.0736
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0012 0.0014
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0017 0.0016 0.0019
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.024 0.2328 0.2784
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0342 0.0409
Echinococcus multilocularis caspase 8 0.0222 0.2143 0.2143
Leishmania major glycosyl hydrolase-like protein 0.0068 0.0541 0.2286
Echinococcus granulosus retinol dehydrogenase 11 0.0023 0.008 0.0096
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0607 0.0607
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0054 0.0394 0.2624
Echinococcus granulosus expressed protein 0.0017 0.0017 0.002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0286 0.1286
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0184 0.1751 0.2094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0044 0.0053
Brugia malayi nuclear receptor NHR-88 0.002 0.0044 0.0053
Brugia malayi nuclear hormone receptor 0.002 0.0044 0.0053
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0342 0.0409
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0249 0.3118
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0017 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0432 0.0516
Echinococcus granulosus lamin dm0 0.0033 0.0175 0.0209
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0238 0.1062
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0023 0.008 0.032
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0673 0.3835
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0053
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Echinococcus granulosus lysine specific demethylase 6a 0.0057 0.0432 0.0516
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Loa Loa (eye worm) dehydrogenase 0.0023 0.008 0.0096
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0017 0.0021
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0216 0.0216
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0023 0.008 0.0136
Echinococcus multilocularis dna polymerase eta 0.0064 0.0496 0.0496
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0023 0.008 0.032
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0023 0.008 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0044 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0607 0.2791
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0607 0.0725
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0249 0.136
Brugia malayi Glycosyl hydrolases family 31 protein 0.0821 0.8363 1
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0148 0.0177
Leishmania major metacaspase, putative 0.0222 0.2143 0.9201
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0023 0.008 0.0201
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0114 0.0478
Onchocerca volvulus 0.0074 0.0607 0.1244
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0607 0.2568
Loa Loa (eye worm) hypothetical protein 0.0057 0.0432 0.0516
Loa Loa (eye worm) hypothetical protein 0.0081 0.0673 0.0804
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Trichomonas vaginalis ran, putative 0.0021 0.0056 0.0131
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0012
Brugia malayi jmjC domain containing protein 0.0057 0.0432 0.0516
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0441 0.0528
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0044 0.0053
Plasmodium vivax vivapain-2 0.0017 0.0016 0.0018
Leishmania major short chain dehydrogenase, putative 0.0023 0.008 0.0295
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0286 0.0807
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Echinococcus granulosus neutral alpha glucosidase AB 0.0182 0.1729 0.2067
Brugia malayi hypothetical protein 0.0126 0.1146 0.137
Schistosoma mansoni rab6-interacting 0.002 0.0045 0.0062
Trypanosoma brucei metacaspase 0.0222 0.2143 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0023 0.008 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Echinococcus multilocularis muscleblind protein 1 0.0602 0.608 0.608
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0607 0.2791
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0044 0.0053
Echinococcus granulosus retinol dehydrogenase 11 0.0023 0.008 0.0096
Schistosoma mansoni alpha-glucosidase 0.0707 0.7175 1
Echinococcus granulosus cpg binding protein 0.0031 0.0154 0.0184
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0062
Mycobacterium tuberculosis Conserved protein 0.0074 0.0607 0.1254
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Schistosoma mansoni survival motor neuron protein 0.0058 0.0441 0.0615
Plasmodium falciparum importin beta, putative 0.0059 0.0448 0.2045
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.009 0.0771 0.0922
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0238 0.0666
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0607 0.1254
Loa Loa (eye worm) hypothetical protein 0.0032 0.0169 0.0202
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0342 0.1549
Brugia malayi hypothetical protein 0.0049 0.0344 0.0411
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0607 0.1254
Toxoplasma gondii Alpha-galactosidase 0.0073 0.0595 0.1126
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0541 0.1558
Echinococcus granulosus importin subunit beta 1 0.0059 0.0448 0.0535
Onchocerca volvulus 0.0058 0.0441 0.0896
Brugia malayi hypothetical protein 0.0023 0.008 0.0096
Schistosoma mansoni polycystin 1-related 0.002 0.0045 0.0062
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0045 0.0154
Schistosoma mansoni cpg binding protein 0.0031 0.0154 0.0214
Schistosoma mansoni ran 0.0021 0.0056 0.0079
Echinococcus granulosus carbonyl reductase 1 0.0023 0.008 0.0096
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Plasmodium vivax JmjC domain containing protein 0.0057 0.0432 0.197
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.008 0.008
Leishmania major importin beta-1 subunit, putative 0.0048 0.0332 0.1383
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0023 0.008 0.0144
Trypanosoma cruzi metacaspase 5, putative 0.0222 0.2143 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.03 0.0418
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0821 0.8363 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0607 0.175
Mycobacterium ulcerans oxidoreductase 0.0023 0.008 0.0295
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.024 0.2328 0.2784
Trypanosoma brucei PAB1-binding protein , putative 0.0076 0.0622 0.2863
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0023 0.008 0.008
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0518 0.2377
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Echinococcus granulosus caspase 3 0.0365 0.3628 0.4339
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus granulosus caspase 0.0588 0.5935 0.7097
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0249 0.1111
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0023 0.008 0.032
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0184 0.1751 0.1751
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Mycobacterium tuberculosis Conserved protein 0.0074 0.0607 0.1254
Trypanosoma brucei metacaspase MCA3 0.0222 0.2143 1
Brugia malayi Doublecortin family protein 0.002 0.0045 0.0053
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0111 0.0989 0.206
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0607 0.1254
Trypanosoma cruzi short chain dehydrogenase, putative 0.0023 0.008 0.032
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.008 0.0376
Brugia malayi Melibiase family protein 0.0344 0.3411 0.4079
Onchocerca volvulus 0.0023 0.008 0.0136
Brugia malayi PHD-finger family protein 0.003 0.0148 0.0177
Echinococcus multilocularis phd:f box containing protein 0.0057 0.0432 0.0432
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0045 0.0053
Schistosoma mansoni peptidase Clp (S14 family) 0.0156 0.1453 0.2025
Leishmania major 3-keto-dihydrosphingosine reductase 0.0023 0.008 0.0295
Giardia lamblia Short-chain dehydrogenase, putative 0.0023 0.008 0.0899
Trichomonas vaginalis conserved hypothetical protein 0.0222 0.2143 0.627
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0238 0.0977
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.024 0.2328 1
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0023 0.008 0.032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Schistosoma mansoni jumonji/arid domain-containing protein 0.0217 0.2085 0.2906
Brugia malayi MH2 domain containing protein 0.0139 0.1275 0.1524
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0044 0.0044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0111 0.0989 0.206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Mycobacterium ulcerans oxidoreductase 0.0023 0.008 0.0295
Onchocerca volvulus 0.0023 0.008 0.0136
Schistosoma mansoni thyroid hormone receptor 0.002 0.0044 0.0062
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0023 0.008 0.0474
Echinococcus multilocularis lysosomal alpha glucosidase 0.0821 0.8363 0.8363
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Loa Loa (eye worm) RNA binding protein 0.0064 0.0505 0.0604
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Leishmania major DNA polymerase eta, putative 0.0064 0.0496 0.209
Schistosoma mansoni phosphatidylserine receptor 0.0057 0.0432 0.0602
Toxoplasma gondii thioredoxin reductase 0.0049 0.0342 0.0637
Echinococcus granulosus intermediate filament protein 0.0033 0.0175 0.0209
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0017
Plasmodium vivax ataxin-2 like protein, putative 0.0076 0.0622 0.2863
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0023 0.008 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0053
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0505 0.0703
Echinococcus multilocularis RUN 0.002 0.0045 0.0045
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0016 0.0018
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0175 0.0209
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.1729 0.8056
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0102 0.0896 0.1864
Echinococcus multilocularis lysine specific demethylase 6a 0.0057 0.0432 0.0432
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0496 0.2272
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Echinococcus multilocularis steroid dehydrogenase 0.0023 0.008 0.008
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0277 0.2711 0.2711
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.006 0.0459 0.2099
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0023 0.008 0.0201
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0023 0.008 0.0136
Schistosoma mansoni retinal dehydrogenase 0.0023 0.008 0.0112
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0102 0.0896 0.1864
Schistosoma mansoni carbonyl reductase 0.0023 0.008 0.0112
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0023 0.008 0.032
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0045 0.0045
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.027 0.027
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0182 0.1729 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.03 0.0358
Echinococcus multilocularis steroid dehydrogenase 0.0023 0.008 0.008
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0432 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0067
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0044 0.0044
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0156 0.1453 1
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.0376
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0023 0.008 0.0144
Trypanosoma cruzi metacaspase, putative 0.0222 0.2143 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0505 0.0604
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0132
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 1
Entamoeba histolytica Ran family GTPase 0.0021 0.0056 0.0237
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.1453 0.2779
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.1751 0.7509
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0023 0.008 0.032
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0056 0.0067
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0023 0.008 0.0144
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0344 0.3411 0.4079
Trypanosoma cruzi short chain dehydrogenase, putative 0.0023 0.008 0.032
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0057 0.0432 0.081
Schistosoma mansoni lamin 0.0033 0.0175 0.0244
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Onchocerca volvulus 0.0207 0.1985 0.4143
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0044 0.0062
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0156 0.1453 0.2779
Echinococcus multilocularis muscleblind protein 0.0602 0.608 0.608
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Trypanosoma cruzi metacaspase, putative 0.0222 0.2143 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0023 0.008 0.0096
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0182 0.1729 0.5051
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.024 0.2328 0.3245
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Loa Loa (eye worm) hypothetical protein 0.009 0.0771 0.0922
Plasmodium vivax vivapain-2 0.0017 0.0016 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0044 0.0053
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Echinococcus granulosus jumonji domain containing protein 0.0042 0.027 0.0323
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0222 0.2143 0.411
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans short-chain dehydrogenase 0.0023 0.008 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Onchocerca volvulus 0.0074 0.0607 0.1244
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0023 0.008 0.0144
Schistosoma mansoni carbonyl reductase 0.0023 0.008 0.0112
Schistosoma mansoni ran 0.0021 0.0056 0.0079
Mycobacterium ulcerans carveol-like dehydrogenase 0.0023 0.008 0.0295
Mycobacterium ulcerans beta-lactamase 0.0074 0.0607 0.2568
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0068 0.0541 0.2485
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.0332 0.0942
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0156 0.1453 0.1737
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Schistosoma mansoni alpha glucosidase 0.0182 0.1729 0.2409
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0148 0.0263
Trichomonas vaginalis esterase, putative 0.0074 0.0607 0.175
Echinococcus granulosus dna polymerase kappa 0.0039 0.0238 0.0285
Onchocerca volvulus 0.0023 0.008 0.0136
Brugia malayi hypothetical protein 0.0207 0.1985 0.2373
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0023 0.008 0.008
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.008 0.032
Plasmodium falciparum glutathione reductase 0.0049 0.0342 0.1549
Leishmania major DNA polymerase eta, putative 0.0037 0.0219 0.0895
Brugia malayi RNA binding protein 0.0064 0.0505 0.0604
Schistosoma mansoni apoferritin-2 0.0017 0.0017 0.0023
Giardia lamblia PHD finger protein 15 0.003 0.0148 0.1797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.003 0.0148 0.0177
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0607 0.1254
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0541 0.1558
Echinococcus multilocularis JmjC domain containing protein 4 0.0057 0.0432 0.0432
Brugia malayi jmjC domain containing protein 0.0057 0.0432 0.0516
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.048 0.0574
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0044 0.0061
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0607 0.175
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0044 0.0062
Echinococcus granulosus carbonyl reductase 1 0.0023 0.008 0.0096
Loa Loa (eye worm) cysteine protease 0.0017 0.0016 0.0019
Onchocerca volvulus 0.0074 0.0607 0.1244
Echinococcus granulosus jumonji domain containing 1A 0.0057 0.0432 0.0516
Schistosoma mansoni hypothetical protein 0.0058 0.0441 0.0615
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0044 0.0062
Trypanosoma cruzi cysteine peptidase, putative 0.0066 0.0518 0.2377
Trichomonas vaginalis alpha-glucosidase, putative 0.0182 0.1729 0.5051
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0342 0.0342
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0607 0.2791
Loa Loa (eye worm) hypothetical protein 0.005 0.0353 0.0422
Loa Loa (eye worm) transcription factor SMAD2 0.0139 0.1275 0.1524
Entamoeba histolytica short chain dehydrogenase family protein 0.0023 0.008 0.0376
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0148 0.0263
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.03 0.0358
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Loa Loa (eye worm) hypothetical protein 0.0059 0.0448 0.0535
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Leishmania major cathepsin L-like protease 0.0017 0.0016 0.0017
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0207 0.1985 0.2373
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0238 0.0332
Onchocerca volvulus 0.0033 0.0175 0.0335
Onchocerca volvulus 0.0023 0.008 0.0136
Schistosoma mansoni nuclear hormone receptor 0.002 0.0044 0.0062
Loa Loa (eye worm) hypothetical protein 0.0126 0.1146 0.137
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0342 0.1549
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0238 0.0477
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Onchocerca volvulus 0.0023 0.008 0.0136
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0023 0.008 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0016 0.0011
Trypanosoma brucei short-chain dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0044
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0516 0.5197 0.7243
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0023 0.008 0.0144
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0079 0.0657 0.0786
Brugia malayi CXXC zinc finger family protein 0.0029 0.0137 0.0164
Trichomonas vaginalis maltase-glucoamylase, putative 0.0182 0.1729 0.5051
Onchocerca volvulus 0.0029 0.0137 0.0255
Echinococcus multilocularis snurportin 1 0.0628 0.6358 0.6358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.03 0.0358
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.003 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0505 0.0703
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0044 0.0053
Trypanosoma cruzi metacaspase, putative 0.0222 0.2143 1
Schistosoma mansoni hypothetical protein 0.0412 0.4109 0.5726
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0189 0.0226
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0016 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Echinococcus granulosus hypothetical protein 0.0023 0.008 0.0096
Schistosoma mansoni alpha-glucosidase 0.0707 0.7175 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0016 0.0016
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Schistosoma mansoni phd/f-box containing protein 0.0057 0.0432 0.0602
Mycobacterium ulcerans short-chain dehydrogenase 0.0023 0.008 0.0295
Schistosoma mansoni hypothetical protein 0.0037 0.0216 0.0301
Loa Loa (eye worm) glutathione reductase 0.0049 0.0342 0.0409
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0023 0.008 0.0136
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0068 0.0541 0.1106
Schistosoma mansoni caspase-7 (C14 family) 0.0588 0.5935 0.8271
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus multilocularis lamin 0.0033 0.0175 0.0175
Mycobacterium tuberculosis Conserved protein 0.0074 0.0607 0.1254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.024 0.2328 0.4883
Loa Loa (eye worm) oxidoreductase 0.0023 0.008 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0044 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0066 0.0518 0.2377
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0182 0.1729 0.5051
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0023 0.008 0.0144
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0023 0.008 0.032
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0023 0.008 0.0899
Leishmania major hypothetical protein, conserved 0.0023 0.008 0.0295
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Schistosoma mansoni loxhd1 0.002 0.0045 0.0062
Trichomonas vaginalis maltase-glucoamylase, putative 0.0068 0.0541 0.1558
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0068 0.0541 0.1558
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Leishmania major hypothetical protein, conserved 0.0074 0.0607 0.2568
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0607 0.0846
Brugia malayi intermediate filament protein 0.0033 0.0175 0.0209
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0023 0.008 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.03 0.03
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0016 0.0019
Toxoplasma gondii oxidoreductase, putative 0.0023 0.008 0.0132
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1364 0.1901
Echinococcus multilocularis lysosomal alpha glucosidase 0.0821 0.8363 0.8363
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0238 0.0285
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0184 0.1751 0.7509
Schistosoma mansoni importin beta-1 0.0059 0.0448 0.0624
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0023 0.008 0.032
Leishmania major hypothetical protein, conserved 0.0057 0.0432 0.1813
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0044 0.0062
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0056 0.0209
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Trypanosoma brucei glucosidase, putative 0.0182 0.1729 0.8056
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0607 0.1254
Onchocerca volvulus Huntingtin homolog 0.0126 0.1146 0.2378
Mycobacterium ulcerans ketoacyl reductase 0.0023 0.008 0.0295
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0111 0.0989 0.206
Mycobacterium leprae Probable oxidoreductase 0.0023 0.008 0.0441
Mycobacterium tuberculosis Possible oxidoreductase 0.0023 0.008 0.0144
Trypanosoma brucei trypanothione reductase 0.0049 0.0342 0.1549
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0286 0.0529
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0017 0.0017 0.0034
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0023 0.008 0.0144
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0148 0.0207
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Plasmodium falciparum metacaspase 1 0.0222 0.2143 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0023 0.008 0.0376
Brugia malayi TAR-binding protein 0.0064 0.0505 0.0604
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0286 0.0529
Plasmodium falciparum phd finger protein, putative 0.003 0.0148 0.064
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0016 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0182 0.1729 0.2067
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.0432 0.0516
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0023 0.008 0.032
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0156 0.1453 0.1453
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0045 0.0053
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0044 0.0062
Schistosoma mansoni ferritin light chain 0.0017 0.0017 0.0023
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0222 0.2143 0.2987
Loa Loa (eye worm) hypothetical protein 0.002 0.0044 0.0053
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0023 0.008 0.0096
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0054 0.0394 0.1791
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0516 0.5197 0.7243
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0023 0.008 0.0096
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.024 0.2328 1
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0016 0.0022
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0023 0.008 0.0295
Schistosoma mansoni intermediate filament proteins 0.0033 0.0175 0.0244
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0023 0.008 0.032
Brugia malayi jmjC domain containing protein 0.0057 0.0432 0.0516
Trypanosoma cruzi metacaspase, putative 0.0222 0.2143 1
Brugia malayi hypothetical protein 0.0023 0.008 0.0096
Echinococcus granulosus cathepsin l1 0.0017 0.0016 0.0019
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Brugia malayi Cathepsin L-like precursor 0.0017 0.0016 0.0019
Loa Loa (eye worm) dehydrogenase 0.0023 0.008 0.0096
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0238 0.1299
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Schistosoma mansoni coup transcription factor 0.002 0.0044 0.0062
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0044 0.0044
Schistosoma mansoni hypothetical protein 0.003 0.0148 0.0207
Echinococcus granulosus steroid dehydrogenase 0.0023 0.008 0.0096
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Echinococcus multilocularis retinol dehydrogenase 13 0.0023 0.008 0.008
Onchocerca volvulus 0.002 0.0044 0.0061
Plasmodium falciparum thioredoxin reductase 0.0049 0.0342 0.1549
Trichomonas vaginalis alpha-glucosidase, putative 0.0068 0.0541 0.1558
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0017
Echinococcus multilocularis caspase 3 0.0365 0.3628 0.3628
Trypanosoma brucei unspecified product 0.0027 0.0114 0.0478
Mycobacterium ulcerans dehydrogenase 0.0023 0.008 0.0295
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0353 0.0422
Loa Loa (eye worm) acetyltransferase 0.0147 0.1364 0.1632
Echinococcus granulosus phd:f box containing protein 0.0057 0.0432 0.0516
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0016 0.0017
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0353 0.0422
Schistosoma mansoni caspase-7 (C14 family) 0.0429 0.4291 0.598
Giardia lamblia Hypothetical protein 0.0023 0.008 0.0899
Schistosoma mansoni aldehyde dehydrogenase 0.0184 0.1751 0.244
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Loa Loa (eye worm) hypothetical protein 0.0156 0.1453 0.1737
Schistosoma mansoni hypothetical protein 0.0034 0.0189 0.0264
Plasmodium vivax metacaspase 1, putative 0.0222 0.2143 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0044 0.0053
Brugia malayi Dehydrogenases, short chain protein 2 0.0023 0.008 0.0096
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1118 0.2331
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0238 0.0477
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0057 0.0432 0.197
Echinococcus multilocularis musashi 0.0033 0.0175 0.0175
Brugia malayi jmjC domain containing protein 0.0277 0.2711 0.3242
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1364 0.1632
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0044 0.0053
Entamoeba histolytica hypothetical protein, conserved 0.0023 0.008 0.0376
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0017 0.0021
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Echinococcus granulosus muscleblind protein 0.0602 0.608 0.727
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0182 0.1729 0.3311
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Mycobacterium tuberculosis Probable reductase 0.0111 0.0989 0.206
Echinococcus granulosus carbonyl reductase 1 0.0023 0.008 0.0096
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0505 0.0604
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0344 0.3411 0.4754
Trypanosoma brucei glycosyl hydrolase-like protein 0.0068 0.0541 0.2485
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0114 0.0478
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0044 0.0053
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0277 0.2711 0.3242
Schistosoma mansoni lipoxygenase 0.012 0.108 0.1505
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0016 0.0022
Leishmania major short chain dehydrogenase/reductase, putative 0.0023 0.008 0.0295
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.03 0.0358
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0023 0.008 0.0201
Echinococcus granulosus carbonyl reductase 1 0.0023 0.008 0.0096
Trichomonas vaginalis sucrase-isomaltase, putative 0.0182 0.1729 0.5051
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0023 0.008 0.032
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0182 0.1729 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0286 0.0807
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0023 0.008 0.0376
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0017 0.001
Plasmodium vivax steroid dehydrogenase, putative 0.0023 0.008 0.032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0044 0.0053
Echinococcus granulosus peregrin 0.0034 0.0186 0.0222
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0222 0.2143 0.627
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0081 0.0673 0.3835
Schistosoma mansoni hypothetical protein 0.0628 0.6358 0.886
Brugia malayi ecdysteroid receptor 0.002 0.0044 0.0053
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0044 0.0061
Loa Loa (eye worm) hypothetical protein 0.0286 0.2801 0.3349
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0516 0.5197 0.5197
Leishmania major oxidoreductase-like protein 0.0023 0.008 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.0182 0.1729 0.8056
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0044 0.0044
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0013 0.0018
Leishmania major quinonoid dihydropteridine reductase 0.0023 0.008 0.0295
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0156 0.1453 0.622
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0023 0.008 0.032
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0023 0.008 0.032
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0023 0.008 0.032
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Trypanosoma cruzi cruzipain precursor, putative 0.0066 0.0518 0.2377
Echinococcus multilocularis conserved hypothetical protein 0.0023 0.008 0.008
Plasmodium falciparum steroid dehydrogenase, putative 0.0023 0.008 0.032
Echinococcus granulosus caspase 8 0.0222 0.2143 0.2563
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0219 0.04
Onchocerca volvulus 0.0023 0.008 0.0136
Trichomonas vaginalis alpha-glucosidase, putative 0.0182 0.1729 0.5051
Onchocerca volvulus Huntingtin homolog 0.0126 0.1146 0.2378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0044 0.0053
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0016 0.0018
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Schistosoma mansoni steroid dehydrogenase 0.0023 0.008 0.0112
Brugia malayi hypothetical protein 0.0286 0.2801 0.3349
Toxoplasma gondii melibiase subfamily protein 0.0516 0.5197 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0056 0.0086
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0286 0.0342
Echinococcus granulosus geminin 0.0681 0.6902 0.8253
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Entamoeba histolytica hypothetical protein 0.0037 0.0216 0.117
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.009 0.0771 0.0771
Brugia malayi Probable ClpP-like protease 0.0156 0.1453 0.1737
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0184 0.1751 0.3667
Onchocerca volvulus 0.0033 0.0175 0.0335
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0016 0.0018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0044 0.0053
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0516 0.5197 0.5197
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.0448 0.2045
Mycobacterium tuberculosis Probable oxidoreductase 0.0023 0.008 0.0144
Trichomonas vaginalis importin beta-1, putative 0.0048 0.0332 0.0942
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0023 0.008 0.0144
Onchocerca volvulus 0.0023 0.008 0.0136
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0222 0.2143 0.2563
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0067
Leishmania major cathepsin L-like protease 0.0066 0.0518 0.2187
Brugia malayi Thioredoxin reductase 0.0049 0.0342 0.0409
Schistosoma mansoni short chain dehydrogenase 0.0023 0.008 0.0112
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Schistosoma mansoni ferritin light chain 0.0017 0.0017 0.0023
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0137 0.0164
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.008 0.0096
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0023 0.008 0.0132
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0045 0.0045
Brugia malayi steroid hormone receptor 0.002 0.0044 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.008 0.032
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0045 0.0045
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1364 0.1364
Schistosoma mansoni carbonyl reductase 0.0023 0.008 0.0112
Trypanosoma cruzi PAB1-binding protein , putative 0.0076 0.0622 0.2863
Mycobacterium ulcerans aldehyde dehydrogenase 0.0184 0.1751 0.7509
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0044 0.0053
Leishmania major short chain dehydrogenase/reductase, putative 0.0023 0.008 0.0295
Schistosoma mansoni jumonji domain containing protein 0.0057 0.0432 0.0602
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0056 0.0586
Leishmania major GTP-binding protein, putative 0.0021 0.0056 0.0192
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0023 0.008 0.032
Mycobacterium leprae Probable lipase LipE 0.0074 0.0607 0.4108
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0023 0.008 0.0201
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0016 0.0011
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.009 0.0771 0.1075
Brugia malayi Glycosyl hydrolases family 31 protein 0.0068 0.0541 0.0647
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0111 0.0989 0.206
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.009 0.0771 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0607 0.0725
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0023 0.008 0.0144
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0018 0.0021
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1118 0.2331
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0023 0.008 0.008
Leishmania major dehydrogenase-like protein 0.0023 0.008 0.0295
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0238 0.1062
Mycobacterium ulcerans short-chain type oxidoreductase 0.0023 0.008 0.0295
Brugia malayi Bromodomain containing protein 0.0034 0.0186 0.0222
Echinococcus granulosus JmjC domain containing protein 4 0.0057 0.0432 0.0516
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0017 0.0034
Echinococcus multilocularis carbonyl reductase 1 0.0023 0.008 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0044 0.0053
Mycobacterium ulcerans short chain dehydrogenase 0.0023 0.008 0.0295
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0443 0.0831
Mycobacterium tuberculosis Probable dehydrogenase 0.0111 0.0989 0.206
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0016 0.0011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0189 0.0189
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0016 0.0019
Trypanosoma brucei unspecified product 0.0027 0.0114 0.0478
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0516 0.5197 0.7243
Onchocerca volvulus 0.0023 0.008 0.0136
Schistosoma mansoni hypothetical protein 0.0681 0.6902 0.9618
Brugia malayi glutathione reductase 0.0049 0.0342 0.0409
Echinococcus multilocularis cysteine protease 0.0017 0.0016 0.0016
Echinococcus granulosus ferritin 0.0017 0.0017 0.002
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0156 0.1453 0.6761
Echinococcus granulosus WW domain containing oxidoreductase 0.0023 0.008 0.0096
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0344 0.3411 1
Onchocerca volvulus 0.0475 0.4768 1
Schistosoma mansoni hypothetical protein 0.002 0.0045 0.0062
Plasmodium vivax importin-beta 2, putative 0.0059 0.0448 0.2045
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0059 0.0449 0.0449
Echinococcus granulosus lamin 0.0033 0.0175 0.0209
Echinococcus multilocularis geminin 0.0681 0.6902 0.6902

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.8913 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: Inhibitors of TCP-1 ring complex (TRiC) of Methanococcus maripaludis (MmCpn): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488991] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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