Detailed information for compound 789533

Basic information

Technical information
  • TDR Targets ID: 789533
  • Name: ethyl 5-amino-4-cyano-2-methylfuran-3-carboxy late
  • MW: 194.187 | Formula: C9H10N2O3
  • H donors: 1 H acceptors: 2 LogP: 1.53 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)c1c(C)oc(c1C#N)N
  • InChi: 1S/C9H10N2O3/c1-3-13-9(12)7-5(2)14-8(11)6(7)4-10/h3,11H2,1-2H3
  • InChiKey: VMLFLMJTRHHRBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • ethyl 5-amino-4-cyano-2-methyl-furan-3-carboxylate
  • 5-amino-4-cyano-2-methyl-3-furancarboxylic acid ethyl ester
  • 5-amino-4-cyano-2-methyl-furan-3-carboxylic acid ethyl ester
  • 14476-67-6
  • IFLab1_000861
  • SBB015811
  • ZINC00065016

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.241 0.241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0895 0.0895
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0742 0.0742
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Echinococcus multilocularis expressed conserved protein 0.0102 0.2817 0.342
Echinococcus granulosus peregrin 0.0035 0.0385 0.0217
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0221 0.0156
Echinococcus multilocularis protein patched 0.0047 0.0807 0.0772
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0673 0.0673
Schistosoma mansoni thyroid hormone receptor 0.0147 0.4476 0.8136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.1736 0.1736
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.089 0.0829
Plasmodium vivax SET domain protein, putative 0.0035 0.0374 0.2392
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.3683 0.4562
Loa Loa (eye worm) hypothetical protein 0.0035 0.0374 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Schistosoma mansoni DNA polymerase eta 0.0074 0.1815 0.3047
Schistosoma mansoni survival motor neuron protein 0.0049 0.089 0.1279
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0091 0.241 0.7501
Brugia malayi RNA binding protein 0.0125 0.3642 0.36
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0374 0.0294
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.1739 0.7137
Loa Loa (eye worm) hypothetical protein 0.0074 0.1815 0.176
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0374 0.0294
Echinococcus granulosus dna polymerase eta 0.0074 0.1815 0.21
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0652 0.0825
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0673 0.259
Loa Loa (eye worm) RNA binding protein 0.0125 0.3642 0.36
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0221 0.0221
Echinococcus granulosus geminin 0.0174 0.5451 0.6891
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0062 0.1356 0.5504
Onchocerca volvulus Alhambra homolog 0.0035 0.0385 0.0013
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Trypanosoma brucei unspecified product 0.0031 0.0237 0.0732
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.1153
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0742 0.0742
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.3642 0.36
Treponema pallidum exodeoxyribonuclease (exoA) 0.0062 0.1356 0.5
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0385 0.0315
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0673 0.259
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.3642 0.36
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0824 0.0795
Brugia malayi PHD-finger family protein 0.0035 0.0385 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.1928 0.1928
Onchocerca volvulus 0.0275 0.9099 1
Giardia lamblia GTOR 0.0091 0.241 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0045 0.0742 0.2884
Schistosoma mansoni hypothetical protein 0.0045 0.0746 0.1004
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.3055 0.3735
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0114 0.3273 0.4021
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0385 0.2132
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0221 0.0221
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0824 0.0763
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0895 0.0895
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3642 0.6542
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0742 0.1047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1084 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.1736 0.1736
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.7811 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0471 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0895 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0237 0.0732
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.1815 0.7461
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0824 0.0763
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0742 0.0996
Trypanosoma brucei unspecified product 0.0045 0.0742 0.2884
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.6642 0.6642
Loa Loa (eye worm) hypothetical protein 0.006 0.1292 0.1235
Schistosoma mansoni hypothetical protein 0.0174 0.5451 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0062 0.1356 0.4794
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0221 0.0221
Echinococcus multilocularis inositol monophosphatase 1 0.0043 0.0673 0.0596
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0471 0.033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0374 0.0202
Echinococcus multilocularis protein dispatched 1 0.0053 0.1046 0.1087
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0221 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.1254 0.1254
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0742 0.1009
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.1566 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0374 0.0294
Trichomonas vaginalis glucosylceramidase, putative 0.0207 0.6642 0.6642
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0742 0.0996
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.03 1 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0385 0.0217
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.1356 1
Schistosoma mansoni hypothetical protein 0.0037 0.0471 0.0479
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0742 0.1009
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0385 0.0322
Onchocerca volvulus Glucosylceramidase homolog 0.0197 0.6257 0.6743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Loa Loa (eye worm) hypothetical protein 0.0035 0.0385 0.0322
Schistosoma mansoni inositol monophosphatase 0.0043 0.0673 0.0864
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0742 0.2884
Echinococcus multilocularis Niemann Pick C1 protein 0.0155 0.4746 0.5962
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.1356 0.1356
Echinococcus granulosus sterol regulatory element binding protein 0.0047 0.0807 0.0772
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0374 0.0202
Schistosoma mansoni ap endonuclease 0.0062 0.1356 0.217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0091 0.241 1
Echinococcus granulosus expressed conserved protein 0.0102 0.2817 0.342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1084 0.1084
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0237 0.0732
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0091 0.241 0.2884
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.0484 0.1786
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0694 0.4186
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0062 0.1356 0.1496
Echinococcus granulosus Niemann Pick C1 protein 0.0155 0.4746 0.5962
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0062 0.1356 1
Schistosoma mansoni thyroid hormone receptor 0.0147 0.4476 0.8136
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0062 0.1356 0.5504
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0062 0.1356 1
Schistosoma mansoni hypothetical protein 0.0174 0.5451 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0091 0.241 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0328 0.0141
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0091 0.241 1
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.3055 0.3735
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0062 0.1356 0.5504
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0221 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0742 0.2742
Schistosoma mansoni patched 1 0.0047 0.0807 0.112
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0221 0.0662
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.1326 0.1326
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0824 0.0795
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0045 0.0742 0.2742
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0091 0.241 0.7501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.1736 0.1736
Brugia malayi Pre-SET motif family protein 0.0241 0.7887 0.7873
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0091 0.241 1
Brugia malayi CHE-14 protein 0.0047 0.0807 0.0746
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0824 0.0795
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0673 0.259
Schistosoma mansoni hypothetical protein 0.0045 0.0746 0.1004
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3642 0.6542
Schistosoma mansoni hypothetical protein 0.0049 0.089 0.1279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Echinococcus granulosus inositol monophosphatase 1 0.0043 0.0673 0.0596
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Schistosoma mansoni jumonji domain containing protein 0.0091 0.2419 0.4202
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0742 0.0686
Brugia malayi MH2 domain containing protein 0.0239 0.7802 0.7787
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0221 0.0221
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.1739 0.7137
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0062 0.1356 0.1299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.1736 0.1736
Plasmodium falciparum phd finger protein, putative 0.0035 0.0385 0.2478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0892 0.0892
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0824 0.0795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0694 0.2679
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1065 0.1065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0674 0.2595
Schistosoma mansoni ap endonuclease 0.0062 0.1356 0.217
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.1815 0.7461
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.003 0.0221 0.0662
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0385 0.2132
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0062 0.1356 0.1496
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0221 0.0662
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.241 0.241
Brugia malayi exodeoxyribonuclease III family protein 0.0062 0.1356 0.1299
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.3116 0.5537
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3642 0.6542
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0043 0.0673 0.4048
Echinococcus multilocularis peregrin 0.0035 0.0385 0.0217
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0043 0.0673 0.259
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0091 0.241 0.4186
Echinococcus multilocularis tar DNA binding protein 0.0125 0.3642 0.4508
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.241 0.241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.1736 0.1736
Brugia malayi TAR-binding protein 0.0125 0.3642 0.36
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0241 0.7887 0.7873
Trypanosoma brucei unspecified product 0.0031 0.0237 0.0732
Brugia malayi Bromodomain containing protein 0.0035 0.0385 0.0322
Schistosoma mansoni hypothetical protein 0.0045 0.0746 0.1004
Onchocerca volvulus 0.0049 0.089 0.0591
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.1153
Trichomonas vaginalis set domain proteins, putative 0.0275 0.9099 0.9099
Loa Loa (eye worm) jmjC domain-containing protein 0.0072 0.1737 0.1682
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0221 0.0156
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0895 0.0895
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Brugia malayi jmjC domain containing protein 0.0042 0.0652 0.0591
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0043 0.0673 0.078
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0043 0.0673 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0237 0.0732
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0374 0.0202
Loa Loa (eye worm) hypothetical protein 0.0047 0.0807 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1065 0.1065
Loa Loa (eye worm) transcription factor SMAD2 0.0239 0.7802 0.7787
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0742 0.0681
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0062 0.1356 0.5504
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Loa Loa (eye worm) phosphatidylinositol 3 0.0091 0.241 0.236
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.3683 0.4562
Leishmania major DNA polymerase eta, putative 0.0074 0.1815 0.7461
Schistosoma mansoni hypothetical protein 0.0045 0.0746 0.1004
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.3055 0.301
Schistosoma mansoni inositol monophosphatase 0.0043 0.0673 0.0864
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0883 0.0872
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0742 0.0686
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0742 0.0686
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0091 0.241 0.2884
Echinococcus granulosus tar DNA binding protein 0.0125 0.3642 0.4508
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0091 0.241 1
Brugia malayi hypothetical protein 0.0239 0.7811 0.7796
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.051 0.5
Schistosoma mansoni hypothetical protein 0.0126 0.3683 0.6621
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Echinococcus granulosus Protein patched homolog 1 0.0047 0.0807 0.0772
Brugia malayi Inositol-1 0.0043 0.0673 0.0611
Brugia malayi Pre-SET motif family protein 0.0035 0.0374 0.0311
Trichomonas vaginalis ap endonuclease, putative 0.0062 0.1356 0.1356
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0062 0.1356 0.3423
Trichomonas vaginalis inositol monophosphatase, putative 0.0043 0.0673 0.0673
Loa Loa (eye worm) TAR-binding protein 0.0125 0.3642 0.36
Echinococcus multilocularis thyroid hormone receptor alpha 0.0147 0.4476 0.5606
Echinococcus multilocularis lysine specific demethylase 5A 0.0042 0.0652 0.0569
Toxoplasma gondii exonuclease III APE 0.0062 0.1356 0.8601
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0652 0.0591
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.1739 0.7137
Echinococcus multilocularis dna polymerase eta 0.0074 0.1815 0.21
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0091 0.241 0.236
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0892 0.0892
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0062 0.1356 1
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0742 0.2884
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0652 0.0825
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.3055 1
Giardia lamblia DINP protein human, muc B family 0.0045 0.0742 0.176
Loa Loa (eye worm) hypothetical protein 0.0057 0.1187 0.1129
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0471 0.0479
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.1084 0.1084
Loa Loa (eye worm) inositol-1 0.0043 0.0673 0.0611
Echinococcus granulosus dna polymerase kappa 0.0045 0.0742 0.0686
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0239 0.7811 0.7796
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0742 0.2884
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3642 0.6542
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.7811 1
Trichomonas vaginalis glucosylceramidase, putative 0.03 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0892 0.0892
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0062 0.1356 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.3055 0.301
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0374 0.0294
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0047 0.0807 0.0746
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0221 0.0662
Loa Loa (eye worm) MH2 domain-containing protein 0.0239 0.7802 0.7787
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0221 0.0662
Schistosoma mansoni tar DNA-binding protein 0.0125 0.3642 0.6542
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0091 0.241 1
Brugia malayi hypothetical protein 0.0037 0.0471 0.0408
Echinococcus multilocularis sterol regulatory element binding protein 0.0047 0.0807 0.0772
Brugia malayi jmjC domain containing protein 0.0114 0.3273 0.3228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.1566 0.1566
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0652 0.0569
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0742 0.2884
Trichomonas vaginalis glucosylceramidase, putative 0.0197 0.6257 0.6257
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0114 0.3273 0.4021
Leishmania major DNA polymerase eta, putative 0.0043 0.0694 0.2679
Schistosoma mansoni hypothetical protein 0.0035 0.0385 0.0315
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.1815 0.176
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0883 0.0872
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0385 0.2478
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0385 0.0217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0824 0.1153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0374 0.2058
Echinococcus multilocularis geminin 0.0174 0.5451 0.6891
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0742 0.0681
Leishmania major DNA polymerase kappa, putative 0.0045 0.0742 0.2884

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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