TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 204.228 | Formula: C10H12N4O
H donors: 1 H acceptors: 4 LogP: 1.11 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ncnc2c1nc1n2CCCCC1
InChi: 1S/C10H12N4O/c15-10-8-9(11-6-12-10)14-5-3-1-2-4-7(14)13-8/h6H,1-5H2,(H,11,12,15)
InChiKey: NSRRBDQRKMIYCN-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0089	0.2855	1
Brugia malayi	jmjC domain containing protein	0.0044	0.1094	0.1278
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0089	0.2855	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1252	0.4319
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.003	0.0542	0.1807
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0083	0.2628	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0058	0.1634	0.5676
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0851	0.0994
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0702	0.082
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0037
Echinococcus granulosus	dna polymerase eta	0.0072	0.2215	0.2588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1252	0.4319
Brugia malayi	hypothetical protein	0.0017	0.0043	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.1038	0.3564
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1205	0.1407
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0071	0.2143	0.7478
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Echinococcus multilocularis	serine protein kinase ATM	0.0017	0.0033	0.0039
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.1086	0.3734
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0409	0.1453
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0555	0.1853
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0044	0.1086	0.1732
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.003	0.0542	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0046	0.1186	0.1385
Schistosoma mansoni	synaptojanin	0.0017	0.0032	0.0051
Schistosoma mansoni	hypothetical protein	0.0176	0.6271	1
Loa Loa (eye worm)	hypothetical protein	0.0072	0.2215	0.2588
Echinococcus granulosus	inositol polyphosphate 5 phosphatase OCRL 1	0.0017	0.0032	0.0037
Schistosoma mansoni	hypothetical protein	0.0045	0.112	0.1787
Schistosoma mansoni	hypothetical protein	0.0045	0.112	0.1787
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.1038	0.3564
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.002	0.0148	0.0237
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0733	0.2699
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0733	0.1168
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0089	0.2855	1
Echinococcus multilocularis	geminin	0.0176	0.6271	0.7325
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0083	0.2628	0.5
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0071	0.2146	0.7488
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0037
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0017	0.0032	0.0037
Schistosoma mansoni	jumonji domain containing protein	0.009	0.2907	0.4636
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0083	0.2628	1
Brugia malayi	beta-lactamase family protein	0.0042	0.1038	0.1213
Plasmodium vivax	hypothetical protein, conserved	0.0042	0.1038	0.3875
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0042	0.1038	0.1213
Brugia malayi	Niemann-Pick C1 protein precursor	0.0108	0.3594	0.4198
Echinococcus multilocularis	CCR4 NOT transcription complex subunit 6	0.0017	0.0032	0.0037
Schistosoma mansoni	ap endonuclease	0.0083	0.2628	0.4191
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.003	0.0542	0.0865
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.003	0.0542	0.1807
Trypanosoma brucei	unspecified product	0.003	0.0555	0.1853
Echinococcus multilocularis	protein dispatched 1	0.0053	0.1442	0.1684
Loa Loa (eye worm)	TAR-binding protein	0.0124	0.4232	0.4943
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.1205	0.1407
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.1038	0.3564
Echinococcus multilocularis	Niemann Pick C1 protein	0.0154	0.5404	0.6312
Entamoeba histolytica	protein kinase rad3, putative	0.0017	0.0033	0.0004
Mycobacterium tuberculosis	Conserved protein	0.0042	0.1038	0.1009
Giardia lamblia	PHD finger protein 15	0.0035	0.0733	0.2482
Schistosoma mansoni	hypothetical protein	0.0045	0.112	0.1787
Schistosoma mansoni	cpg binding protein	0.0036	0.0777	0.124
Onchocerca volvulus		0.0042	0.1038	0.8269
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0409	0.1336
Brugia malayi	CCR4	0.0017	0.0032	0.0037
Mycobacterium tuberculosis	Probable lipase LipE	0.0042	0.1038	0.1009
Echinococcus granulosus	neutral sphingomyelinase	0.0017	0.0032	0.0037
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.4232	0.6748
Mycobacterium tuberculosis	Probable hydrolase	0.0042	0.1038	0.1009
Loa Loa (eye worm)	RNA binding protein	0.0124	0.4232	0.4943
Loa Loa (eye worm)	CCR4-NOT transcription complex subunit 6 family protein	0.0017	0.0032	0.0037
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0409	0.1453
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0083	0.2628	0.307
Schistosoma mansoni	nocturnin	0.0017	0.0032	0.0051
Brugia malayi	exodeoxyribonuclease III family protein	0.0083	0.2628	0.307
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Loa Loa (eye worm)	phosphatidylinositol 3	0.0089	0.2855	0.3335
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0042	0.1038	0.1009
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1205	0.1921
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0044	0.1086	0.1732
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0089	0.2855	1
Loa Loa (eye worm)	hypothetical protein	0.0234	0.8562	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Brugia malayi	ImpB/MucB/SamB family protein	0.0072	0.2215	0.2588
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0042	0.1038	0.1213
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0017	0.0032	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0037
Echinococcus multilocularis	jumonji domain containing protein	0.0048	0.1264	0.1477
Brugia malayi	hypothetical protein	0.0026	0.0409	0.0478
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0017	0.0032	0.0037
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0017	0.0033	0.0053
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0042	0.1038	0.1009
Echinococcus granulosus	Niemann Pick C1 protein	0.0108	0.3594	0.4198
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0042	0.1038	0.1009
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0089	0.2855	0.7926
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.1455	0.5039
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0017	0.0033	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1703	0.1989
Echinococcus granulosus	peregrin	0.0035	0.0733	0.0856
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0019	0.0109	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0084	0.0099
Leishmania major	DNA polymerase eta, putative	0.0042	0.1035	0.3554
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0108	0.3594	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Giardia lamblia	DINP protein human, muc B family	0.0044	0.1086	0.3734
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Echinococcus granulosus	beta LACTamase domain containing family member	0.0042	0.1038	0.1213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1254	0.433
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.1205	0.1407
Mycobacterium leprae	Probable lipase LipE	0.0042	0.1038	0.5
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0089	0.2855	0.3335
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0109	0.0127
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Leishmania major	hypothetical protein, conserved	0.0042	0.1038	0.3564
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0017	0.0033	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0046	0.1186	0.1385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.1455	0.5039
Trypanosoma brucei	unspecified product	0.003	0.0555	0.1853
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0017	0.0032	0.0037
Toxoplasma gondii	FATC domain-containing protein	0.0017	0.0033	0.0006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0033	0.0005
Trypanosoma brucei	DNA polymerase eta, putative	0.0072	0.2215	0.7733
Plasmodium vivax	ataxin-2 like protein, putative	0.0026	0.0409	0.1453
Trichomonas vaginalis	ap endonuclease, putative	0.0083	0.2628	0.9196
Mycobacterium tuberculosis	Probable esterase LipL	0.0042	0.1038	0.1009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0071	0.2143	0.7478
Loa Loa (eye worm)	phosphatidylinositol 3	0.003	0.0542	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0032	0.0037
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0089	0.2855	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0542	0.1807
Toxoplasma gondii	ABC1 family protein	0.0042	0.1038	0.3875
Echinococcus granulosus	dna polymerase kappa	0.0044	0.1086	0.1269
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0083	0.2628	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0108	0.3594	0.4198
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0702	0.082
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.1086	0.0301
Schistosoma mansoni	cpg binding protein	0.0034	0.0702	0.1119
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0133	0.4589	0.5361
Echinococcus multilocularis	peregrin	0.0035	0.0733	0.0856
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0089	0.2855	1
Schistosoma mansoni	hypothetical protein	0.0048	0.1249	0.1992
Echinococcus multilocularis	protein patched	0.0046	0.1186	0.1385
Mycobacterium tuberculosis	Conserved protein	0.0042	0.1038	0.1009
Echinococcus granulosus	Niemann Pick C1 protein	0.0154	0.5404	0.6312
Echinococcus granulosus	expressed conserved protein	0.0101	0.3338	0.3899
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0044	0.1086	0.1058
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.4232	0.6748
Loa Loa (eye worm)	transcription factor SMAD2	0.0234	0.8544	0.998
Trichomonas vaginalis	penicillin-binding protein, putative	0.0042	0.1038	0.3564
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0017	0.0033	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0409	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0044	0.1086	0.3734
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0123	0.4202	0.4908
Entamoeba histolytica	hypothetical protein	0.0038	0.0851	0.23
Schistosoma mansoni	carbon catabolite repressor protein	0.0017	0.0032	0.0051
Trypanosoma brucei	unspecified product	0.0044	0.1086	0.3734
Schistosoma mansoni	hypothetical protein	0.0035	0.0733	0.1168
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0733	0.0856
Echinococcus granulosus	serine protein kinase ATM	0.0017	0.0033	0.0039
Echinococcus granulosus	sterol regulatory element binding protein	0.0046	0.1186	0.1385
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0409	0.1336
Leishmania major	DNA polymerase eta, putative	0.0072	0.2215	0.7733
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Entamoeba histolytica	hypothetical protein	0.0038	0.0851	0.23
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0089	0.2855	0.3335
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Brugia malayi	RNA binding protein	0.0124	0.4232	0.4943
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.1094	0.1744
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0017	0.0033	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.1038	0.1656
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Schistosoma mansoni	patched 1	0.0046	0.1186	0.1891
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0066	0.1964	0.7439
Trypanosoma cruzi	DNA polymerase eta, putative	0.0072	0.2215	0.7733
Entamoeba histolytica	hypothetical protein	0.0017	0.0033	0.0004
Brugia malayi	hypothetical protein	0.0038	0.0851	0.0994
Trypanosoma brucei	hypothetical protein, conserved	0.0042	0.1038	0.3564
Entamoeba histolytica	hypothetical protein	0.0038	0.0851	0.23
Loa Loa (eye worm)	hypothetical protein	0.0108	0.3594	0.4198
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1205	0.1921
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0033	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0071	0.2143	0.7478
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.003	0.0542	0.0633
Trichomonas vaginalis	esterase, putative	0.0042	0.1038	0.3564
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0113	0.3821	0.4463
Echinococcus granulosus	lysine specific demethylase 5A	0.0044	0.1094	0.1278
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0555	0.1853
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0037	0.0821	0.2793
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0083	0.2628	0.9196
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0017	0.0032	0.0037
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0044	0.1094	0.1744
Echinococcus multilocularis	sterol regulatory element binding protein	0.0046	0.1186	0.1385
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0033	0.0039
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0083	0.2628	0.9196
Echinococcus multilocularis	cpg binding protein	0.0036	0.0777	0.0908
Echinococcus multilocularis	traf and tnf receptor associated protein	0.0017	0.0032	0.0037
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0017	0.0033	0.0005
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0123	0.4202	0.4908
Schistosoma mansoni	survival motor neuron protein	0.0048	0.1249	0.1992
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.003	0.0542	0.1807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0089	0.2855	1
Echinococcus multilocularis	neutral sphingomyelinase	0.0017	0.0032	0.0037
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.8562	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.1038	0.3564
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0409	0.1336
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0072	0.2189	0.349
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Trypanosoma cruzi	hypothetical protein, conserved	0.0042	0.1038	0.3564
Loa Loa (eye worm)	jmjC domain-containing protein	0.0072	0.2178	0.2544
Echinococcus granulosus	cpg binding protein	0.0036	0.0777	0.0908
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0733	0.0856
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0071	0.2143	0.7478
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0083	0.2628	0.9196
Echinococcus multilocularis	expressed conserved protein	0.0101	0.3338	0.3899
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0089	0.2855	0.3335
Echinococcus multilocularis	lysine specific demethylase 5A	0.0042	0.1018	0.1189
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.1086	0.3734
Echinococcus granulosus	geminin	0.0176	0.6271	0.7325
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0083	0.2628	0.9196
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0076	0.2347	0.8198
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0851	0.0994
Schistosoma mansoni	neutral sphingomyelinase	0.0017	0.0032	0.0051
Schistosoma mansoni	hypothetical protein	0.0045	0.112	0.1787
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0089	0.2855	0.4553
Loa Loa (eye worm)	beta-lactamase	0.0042	0.1038	0.1213
Loa Loa (eye worm)	endonuclease/Exonuclease/phosphatase	0.0017	0.0032	0.0037
Giardia lamblia	GTOR	0.0089	0.2855	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.1434	0.4966
Onchocerca volvulus	Alhambra homolog	0.0035	0.0733	0.5758
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0017	0.0033	0.0053
Mycobacterium leprae	conserved hypothetical protein	0.0042	0.1038	0.5
Schistosoma mansoni	synaptojanin	0.0017	0.0032	0.0051
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0044	0.1086	0.1269
Echinococcus granulosus	CCR4 NOT transcription complex subunit 6	0.0017	0.0032	0.0037
Brugia malayi	PHD-finger family protein	0.0035	0.0733	0.0856
Echinococcus multilocularis	tar DNA binding protein	0.0124	0.4232	0.4943
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0042	0.1035	0.3864
Loa Loa (eye worm)	jmjC domain-containing protein	0.0044	0.1094	0.1278
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0733	0.2699
Echinococcus multilocularis	dna polymerase eta	0.0072	0.2215	0.2588
Brugia malayi	Endonuclease/Exonuclease/phosphatase family protein	0.0017	0.0032	0.0037
Echinococcus granulosus	Protein patched homolog 1	0.0046	0.1186	0.1385
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0033	0.0005
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0042	0.1038	0.1656
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.4589	0.7318
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0071	0.2146	0.7488
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1205	0.1407
Schistosoma mansoni	cript-related	0.0017	0.0032	0.0051
Brugia malayi	beta-lactamase family protein	0.0042	0.1038	0.1213
Trichomonas vaginalis	conserved hypothetical protein	0.0046	0.1186	0.4086
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0089	0.2855	0.7926
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0542	0.1807
Echinococcus multilocularis	dna polymerase kappa	0.0044	0.1086	0.1269
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0733	0.2699
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0089	0.2855	1
Brugia malayi	MH2 domain containing protein	0.0234	0.8544	0.998
Echinococcus granulosus	tar DNA binding protein	0.0124	0.4232	0.4943
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.1434	0.4966
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0851	0.1357
Trichomonas vaginalis	D-aminoacylase, putative	0.0042	0.1038	0.3564
Loa Loa (eye worm)	MH2 domain-containing protein	0.0234	0.8544	0.998
Onchocerca volvulus		0.0042	0.1038	0.8269
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0017	0.0032	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0017	0.0033	0.0005
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0124	0.4232	0.4943
Echinococcus multilocularis	inositol polyphosphate 5 phosphatase OCRL 1	0.0017	0.0032	0.0037
Onchocerca volvulus		0.0042	0.1038	0.8269
Brugia malayi	ImpB/MucB/SamB family protein	0.0044	0.1086	0.1269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0309	0.0981
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0542	0.1807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1254	0.433
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.1205	0.1407
Entamoeba histolytica	hypothetical protein	0.0038	0.0851	0.23
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.003	0.0542	0.1807
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Mycobacterium tuberculosis	Probable lipase LipD	0.0042	0.1038	0.1009
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0017	0.0033	0.0039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0542	0.1807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0053	0.1455	0.5039
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1252	0.4319
Schistosoma mansoni	hypothetical protein	0.0123	0.4202	0.67
Leishmania major	phosphatidylinositol 3-kinase, putative	0.003	0.0542	0.1807
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.4232	0.6748
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.1205	0.1921
Schistosoma mansoni	hypothetical protein	0.0017	0.0032	0.0051
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0083	0.2628	0.307
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0555	0.1853
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0083	0.2628	0.2605
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.1888	0.715
Schistosoma mansoni	hypothetical protein	0.0038	0.0851	0.1357
Leishmania major	hypothetical protein, conserved	0.0026	0.0409	0.1336
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0044	0.1086	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0057	0.1593	0.1861
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0113	0.3821	0.4463
Plasmodium falciparum	ataxin-2 like protein, putative	0.0026	0.0409	0.1453
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0733	0.0856
Brugia malayi	beta-lactamase	0.0042	0.1038	0.1213
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0044	0.1086	0.1058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	cpg binding protein	0.0036	0.0777	0.124
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.4232	0.6748
Trypanosoma cruzi	target of rapamycin kinase 3	0.0071	0.2146	0.7488
Trypanosoma brucei	DNA polymerase IV, putative	0.0044	0.1086	0.3734
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0017	0.0033	0.0005
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	ap endonuclease	0.0083	0.2628	0.4191
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0044	0.1086	0.2959
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1254	0.433
Brugia malayi	hypothetical protein	0.0234	0.8562	1
Echinococcus multilocularis	synaptojanin 1	0.0017	0.0032	0.0037
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.0542	0.0633
Mycobacterium ulcerans	DNA polymerase IV	0.0044	0.1086	0.0301
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Onchocerca volvulus		0.0048	0.1249	1
Onchocerca volvulus		0.0034	0.0702	0.5503
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0083	0.2628	1
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0083	0.2628	0.307
Toxoplasma gondii	PHD-finger domain-containing protein	0.0035	0.0733	0.2699
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0083	0.2628	0.9196
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.003	0.0542	0.1807
Brugia malayi	RNA recognition motif domain containing protein	0.0124	0.4232	0.4943
Echinococcus granulosus	traf and tnf receptor associated protein	0.0017	0.0032	0.0037
Echinococcus granulosus	jumonji domain containing protein	0.0048	0.1264	0.1477
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.1254	0.433
Brugia malayi	jmjC domain containing protein	0.0113	0.3821	0.4463
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.1249	0.1459
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0109	0.3659	0.5835
Mycobacterium tuberculosis	Conserved protein	0.0042	0.1038	0.1009
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0066	0.1964	0.6841
Trypanosoma cruzi	DNA polymerase eta, putative	0.0042	0.1035	0.3554
Schistosoma mansoni	ocrl type II inositol 5-phosphatase	0.0017	0.0032	0.0051
Trichomonas vaginalis	ap endonuclease, putative	0.0083	0.2628	0.9196
Echinococcus granulosus	synaptojanin 1	0.0017	0.0032	0.0037
Brugia malayi	Bromodomain containing protein	0.0035	0.0733	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0733	0.0856
Brugia malayi	CHE-14 protein	0.0046	0.1186	0.1385
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0044	0.1086	0.1269
Trichomonas vaginalis	PIKK family atypical protein kinase	0.006	0.171	0.5942
Schistosoma mansoni	DNA polymerase eta	0.0072	0.2215	0.3532
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0071	0.2143	0.7478
Echinococcus multilocularis	deoxyribonuclease 1 2	0.0017	0.0032	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0542	0.1807
Schistosoma mansoni	thyroid hormone receptor	0.0133	0.4589	0.7318
Trichomonas vaginalis	conserved hypothetical protein	0.0019	0.0109	0.0271
Brugia malayi	F/Y-rich N-terminus family protein	0.0022	0.0224	0.0262
Leishmania major	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.1205	0.1407
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.8562	1
Toxoplasma gondii	exonuclease III APE	0.0083	0.2628	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0042	0.1021	0.3503
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0042	0.1038	0.1213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0089	0.2855	1
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	tar DNA-binding protein	0.0124	0.4232	0.6748
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1038	0.1213
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0083	0.2628	0.7289
Trypanosoma brucei	DNA polymerase kappa, putative	0.0044	0.1086	0.3734
Trichomonas vaginalis	DNA polymerase eta, putative	0.0044	0.1086	0.3734
Schistosoma mansoni	hypothetical protein	0.0176	0.6271	1
Brugia malayi	TAR-binding protein	0.0124	0.4232	0.4943

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 789569