Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium activated potassium channel variant | 0.0043 | 0.5565 | 0.5565 |
Plasmodium falciparum | histone deacetylase 1 | 0.0062 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0062 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0043 | 0.5565 | 0.5565 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 1 | 1 |
Brugia malayi | Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog | 0.003 | 0.2834 | 0.2834 |
Loa Loa (eye worm) | large conductance calcium-activated potassium channel alpha subunit ai | 0.0043 | 0.5565 | 0.5565 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.4904 | 0.4904 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | calcium activated potassium channel | 0.0046 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.2834 | 0.2834 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0062 | 1 | 1 |
Trypanosoma brucei | histone deacetylase 1 | 0.0062 | 1 | 1 |
Echinococcus granulosus | histone deacetylase 1 | 0.0062 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0046 | 0.6285 | 0.6285 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.4904 | 0.4904 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0046 | 0.6285 | 0.6285 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Echinococcus granulosus | calcium activated potassium channel variant | 0.0043 | 0.5565 | 0.5565 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0062 | 1 | 1 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0062 | 1 | 1 |
Leishmania major | histone deacetylase, putative | 0.0062 | 1 | 1 |
Schistosoma mansoni | histone deacetylase | 0.0062 | 1 | 1 |
Echinococcus multilocularis | potassium large conductance calcium activated | 0.0046 | 0.6285 | 0.6285 |
Loa Loa (eye worm) | MaxiK calcium-activated potassium channel | 0.003 | 0.2834 | 0.2834 |
Echinococcus granulosus | histone deacetylase 3 | 0.0062 | 1 | 1 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0062 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 1 | 0.5 |
Schistosoma mansoni | histone deacetylase | 0.0062 | 1 | 1 |
Entamoeba histolytica | histone deacetylase, putative | 0.0062 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0062 | 1 | 0.5 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.4904 | 0.4904 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0062 | 1 | 1 |
Echinococcus granulosus | potassium large conductance calcium activated | 0.0046 | 0.6285 | 0.6285 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0062 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.4904 | 0.4904 |
Brugia malayi | Histone deacetylase 1 | 0.0062 | 1 | 1 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0062 | 1 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0062 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.004 | 0.4904 | 0.4904 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0062 | 1 | 1 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0062 | 1 | 1 |
Giardia lamblia | Histone deacetylase | 0.0062 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.