Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0155 | 1 | 1 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0155 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3167 | 0.365 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0155 | 1 | 1 |
Plasmodium vivax | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0127 | 0.7911 | 0.9117 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.8677 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0138 | 0.8677 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3167 | 0.365 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0155 | 1 | 1 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0155 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0155 | 1 | 1 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0155 | 1 | 1 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0155 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0155 | 1 | 0.5 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0155 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0064 | 0.3167 | 0.3167 |
Brugia malayi | TAR-binding protein | 0.0064 | 0.3167 | 0.3167 |
Giardia lamblia | Synaptic glycoprotein SC2 | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3167 | 0.365 |
Plasmodium vivax | polyprenol reductase, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3167 | 0.365 |
Schistosoma mansoni | thyroid hormone receptor | 0.0138 | 0.8677 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0127 | 0.7911 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0064 | 0.3167 | 0.3167 |
Echinococcus multilocularis | tar DNA binding protein | 0.0064 | 0.3167 | 0.365 |
Onchocerca volvulus | 0.0022 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0064 | 0.3167 | 0.365 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0064 | 0.3167 | 0.3167 |
Loa Loa (eye worm) | RNA binding protein | 0.0064 | 0.3167 | 0.3167 |
Loa Loa (eye worm) | TAR-binding protein | 0.0064 | 0.3167 | 0.3167 |
Plasmodium falciparum | polyprenol reductase, putative | 0.0022 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0064 | 0.3167 | 0.4004 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0127 | 0.7911 | 0.9117 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.