Detailed information for compound 790334

Basic information

Technical information
  • TDR Targets ID: 790334
  • Name: N-(3,4-dimethoxyphenyl)-1-propanoyl-2,3-dihyd roindole-5-sulfonamide
  • MW: 390.453 | Formula: C19H22N2O5S
  • H donors: 1 H acceptors: 3 LogP: 2.25 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(=O)N1CCc2c1ccc(c2)S(=O)(=O)Nc1ccc(c(c1)OC)OC
  • InChi: 1S/C19H22N2O5S/c1-4-19(22)21-10-9-13-11-15(6-7-16(13)21)27(23,24)20-14-5-8-17(25-2)18(12-14)26-3/h5-8,11-12,20H,4,9-10H2,1-3H3
  • InChiKey: JTFIUNXZSTYTHE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3,4-dimethoxyphenyl)-1-propanoyl-indoline-5-sulfonamide
  • N-(3,4-dimethoxyphenyl)-1-(1-oxopropyl)-5-indolinesulfonamide
  • N-(3,4-dimethoxyphenyl)-1-propionyl-indoline-5-sulfonamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0921 0.8634
Echinococcus granulosus cpg binding protein 0.0031 0.0343 0.0339
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0027 0.0022
Schistosoma mansoni nuclear receptor 0.0111 0.1473 0.1469
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0241 0.2227
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0234 0.3228 0.485
Schistosoma mansoni survival motor neuron protein 0.0097 0.1282 0.1278
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0234 0.3228 0.3225
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0357 0.3325
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0156 0.143
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.027 0.2496
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0748 0.0744
Onchocerca volvulus 0.0248 0.3423 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0234 0.3228 0.485
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0024 0.0241 0.0356
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Echinococcus granulosus smad 0.0008 0.0027 0.0022
Brugia malayi Pre-SET motif family protein 0.0218 0.2997 0.4503
Loa Loa (eye worm) hypothetical protein 0.0476 0.6651 1
Mycobacterium tuberculosis Conserved protein 0.0072 0.0921 0.1435
Onchocerca volvulus Protein ultraspiracle homolog 0.0234 0.3228 0.943
Loa Loa (eye worm) hypothetical protein 0.0124 0.1661 0.2493
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.6651 0.665
Schistosoma mansoni ap endonuclease 0.0018 0.0168 0.0164
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.0666 0.0662
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Brugia malayi hypothetical protein 0.0038 0.0448 0.0667
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0748 0.7003
Entamoeba histolytica hypothetical protein 0.0038 0.0448 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.032 0.0474
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0748 0.7003
Brugia malayi nuclear receptor NHR-67 0.0111 0.1473 0.221
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0168 0.1786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1899 0.1895
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Schistosoma mansoni cpg binding protein 0.0029 0.032 0.0315
Schistosoma mansoni coup transcription factor 0.0234 0.3228 0.3225
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0241 0.2227
Onchocerca volvulus 0.0111 0.1473 0.4296
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0921 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0143 0.0216
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0921 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0069 0.0065
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0332 0.0328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1899 0.1895
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0234 0.3228 0.485
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0234 0.3228 0.3225
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Entamoeba histolytica hypothetical protein 0.0038 0.0448 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0111 0.1473 0.1469
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1674 0.2512
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0448 0.0443
Brugia malayi Probable ClpP-like protease 0.0082 0.1066 0.1597
Onchocerca volvulus 0.0032 0.0357 0.1032
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1674 0.2512
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0234 0.3228 0.3225
Schistosoma mansoni hypothetical protein 0.0038 0.0448 0.0443
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0021
Brugia malayi hypothetical protein 0.0124 0.1661 0.2493
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0241 0.2227
Mycobacterium ulcerans beta-lactamase 0.0072 0.0921 0.8634
Entamoeba histolytica hypothetical protein 0.0038 0.0448 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0143 0.0216
Loa Loa (eye worm) hypothetical protein 0.0453 0.6325 0.951
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0234 0.3228 0.3225
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Loa Loa (eye worm) histone methyltransferase 0.001 0.0051 0.0069
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0241 0.5334
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0457 0.6389 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0241 0.2227
Schistosoma mansoni ap endonuclease 0.0018 0.0168 0.0164
Schistosoma mansoni thyroid hormone receptor 0.0234 0.3228 0.3225
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.1066 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0234 0.3228 0.3225
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0234 0.3228 0.3225
Brugia malayi Nuclear hormone receptor E75 0.0111 0.1473 0.221
Schistosoma mansoni nuclear hormone receptor 0.0234 0.3228 0.3225
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0228
Brugia malayi MH2 domain containing protein 0.0125 0.1674 0.2512
Brugia malayi Nuclear hormone receptor E75 0.0111 0.1473 0.221
Echinococcus multilocularis cpg binding protein 0.0031 0.0343 0.0339
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0921 0.1435
Schistosoma mansoni RAR-like nuclear receptor 0.0234 0.3228 0.3225
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0026 0.027 0.0399
Brugia malayi Pre-SET motif family protein 0.0032 0.0357 0.0531
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0234 0.3228 0.3225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.08 0.0795
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0234 0.3228 0.3225
Brugia malayi nuclear receptor NHR-88 0.0111 0.1473 0.221
Leishmania major hypothetical protein, conserved 0.0072 0.0921 1
Onchocerca volvulus 0.0072 0.0921 0.268
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0228
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0241 0.5334
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0921 0.269
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0241 0.2579
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0124 0.1661 0.1657
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0082 0.1066 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0306 0.1533
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0027 0.0033
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0168 0.0246
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0748 0.8111
Echinococcus multilocularis thyroid hormone receptor alpha 0.0234 0.3228 0.3225
Mycobacterium tuberculosis Conserved protein 0.0072 0.0921 0.1435
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Brugia malayi ecdysteroid receptor 0.0234 0.3228 0.485
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0357 0.0353
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0241 0.0356
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0124 0.1661 0.1657
Echinococcus granulosus FTZ F1 alpha 0.0234 0.3228 0.3225
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0921 0.0917
Brugia malayi nuclear hormone receptor family member nhr-6 0.0111 0.1473 0.221
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0082 0.1066 0.1062
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0921 0.1435
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.027 0.2496
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.0666 0.6236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0357 0.0353
Schistosoma mansoni hypothetical protein 0.0712 1 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0168 0.0256
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.027 0.2496
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0921 0.0917
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0241 0.2579
Toxoplasma gondii exonuclease III APE 0.0018 0.0168 0.1542
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0234 0.3228 0.485
Schistosoma mansoni cpg binding protein 0.0031 0.0343 0.0339
Onchocerca volvulus 0.0029 0.032 0.0922
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0234 0.3228 0.485
Brugia malayi nuclear receptor RXR 0.0111 0.1473 0.221
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0234 0.3228 0.485
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0049 0.0067
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0921 0.1435
Loa Loa (eye worm) hypothetical protein 0.0082 0.1066 0.1597
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0748 0.0744
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.027 0.2892
Loa Loa (eye worm) nuclear hormone receptor 0.0111 0.1473 0.221
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0921 0.8634
Onchocerca volvulus 0.0024 0.0241 0.0691
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0111 0.1473 0.1469
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0921 0.269
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0156 0.143
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0234 0.3228 0.3225
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0168 0.0164
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0168 0.5
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0921 0.1435
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.027 0.2892
Onchocerca volvulus 0.0072 0.0921 0.268
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.0666 0.1037
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0156 0.0238
Loa Loa (eye worm) hypothetical protein 0.0453 0.6325 0.951
Onchocerca volvulus Bile acid receptor homolog 0.0234 0.3228 0.943
Loa Loa (eye worm) beta-lactamase 0.0072 0.0921 0.1379
Schistosoma mansoni nuclear hormone receptor 0.0111 0.1473 0.1469
Loa Loa (eye worm) hypothetical protein 0.0124 0.1661 0.2493
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0228
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.027 0.2496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0234 0.3228 0.485
Toxoplasma gondii hypothetical protein 0.0028 0.0306 0.2839
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0234 0.3228 0.3225
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0051 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0234 0.3228 0.485
Brugia malayi hypothetical protein 0.0111 0.1473 0.221
Brugia malayi hypothetical protein 0.0017 0.0141 0.0205
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0005 0.0013
Schistosoma mansoni peptidase Clp (S14 family) 0.0082 0.1066 0.1062
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0306 0.2839
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0241 0.2227
Toxoplasma gondii ABC1 family protein 0.0072 0.0921 0.8634
Brugia malayi MH2 domain containing protein 0.0008 0.0027 0.0033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0234 0.3228 0.3225
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Echinococcus granulosus ecdysone induced protein 78C 0.0234 0.3228 0.3225
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0027 0.0022
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0168 0.1542
Echinococcus granulosus thyroid hormone receptor alpha 0.0111 0.1473 0.1469
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0306 0.2839
Mycobacterium leprae Probable lipase LipE 0.0072 0.0921 0.8634
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0234 0.3228 0.3225
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0357 0.0353
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0168 0.1542
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0234 0.3228 0.485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0234 0.3228 0.485
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0143 0.0216
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1899 0.285
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0228
Schistosoma mansoni retinoic acid receptor RXR 0.0234 0.3228 0.3225
Onchocerca volvulus 0.0234 0.3228 0.943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0234 0.3228 0.485
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0748 0.0744
Plasmodium vivax SET domain protein, putative 0.0032 0.0357 0.3325
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0241 0.0356
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.027 0.2892
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0234 0.3228 0.485
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0124 0.1661 0.1657
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Schistosoma mansoni steroid hormone receptor ad4bp 0.0234 0.3228 0.3225
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0025 0.0021
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0111 0.1473 0.221
Brugia malayi nuclear hormone receptor 0.0111 0.1473 0.221
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.0666 0.1037
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0069 0.0065
Schistosoma mansoni nuclear hormone receptor 0.0111 0.1473 0.1469
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0111 0.1473 0.4296
Echinococcus multilocularis FTZ F1 alpha 0.0234 0.3228 0.3225
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Echinococcus multilocularis nuclear receptor nhr 48 0.0111 0.1473 0.1469
Loa Loa (eye worm) steroid hormone receptor 0.0234 0.3228 0.485
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0748 0.7003
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0706 0.6607
Brugia malayi nuclear receptor NHR-88 0.0234 0.3228 0.485
Brugia malayi beta-lactamase family protein 0.0072 0.0921 0.1379
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0168 0.0491
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0027 0.0022
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0921 0.1379
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0124 0.1661 0.2493
Echinococcus granulosus nuclear receptor nhr 48 0.0111 0.1473 0.1469
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0241 0.0356
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0027 0.0022
Brugia malayi hypothetical protein 0.0124 0.1661 0.2493
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0082 0.1066 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0111 0.1473 0.221
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0748 0.0744
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1899 0.1895
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Mycobacterium ulcerans hypothetical protein 0.0072 0.0921 0.8634
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0111 0.1473 0.4296
Loa Loa (eye worm) hypothetical protein 0.0234 0.3228 0.485
Brugia malayi Nuclear hormone receptor-like 1 0.0234 0.3228 0.485
Brugia malayi steroid hormone receptor 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0024 0.0241 0.0356
Brugia malayi nuclear receptor RXR 0.0124 0.1661 0.2493
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0111 0.1473 0.1469
Brugia malayi nuclear hormone receptor 0.0234 0.3228 0.485
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0234 0.3228 0.3225
Loa Loa (eye worm) hypothetical protein 0.0024 0.0241 0.0356
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0306 0.2839
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0025 0.0021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0357 0.0353
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0143 0.0216
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0921 0.1435
Loa Loa (eye worm) nuclear receptor NHR-67 0.0111 0.1473 0.221
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0027 0.0033
Entamoeba histolytica hypothetical protein 0.0038 0.0448 1
Echinococcus granulosus Smad4 0.0008 0.0027 0.0022
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0168 0.3693
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0357 0.0353
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0748 0.7003
Schistosoma mansoni smad1 5 8 and 0.0008 0.0027 0.0022
Brugia malayi hypothetical protein 0.0476 0.6651 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0234 0.3228 0.3225
Brugia malayi ecdysone receptor 0.0111 0.1473 0.221
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Brugia malayi beta-lactamase family protein 0.0072 0.0921 0.1379
Schistosoma mansoni nuclear receptor nhr-48 0.0111 0.1473 0.1469
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0241 0.2227
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0234 0.3228 0.485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0025 0.0021
Brugia malayi hypothetical protein 0.0026 0.027 0.0399
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0111 0.1473 0.1469
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0111 0.1473 0.1469
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0234 0.3228 0.485
Echinococcus multilocularis muscleblind protein 1 0.0453 0.6325 0.6324
Schistosoma mansoni nuclear receptor 0.0111 0.1473 0.1469
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0921 0.8634
Echinococcus granulosus Nuclear hormone receptor HR96 0.0111 0.1473 0.1469
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0168 0.1786
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0241 0.037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0234 0.3228 0.943
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0168 0.1786
Loa Loa (eye worm) Smad1 0.0008 0.0027 0.0033
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0234 0.3228 0.485
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0921 0.8634
Brugia malayi orphan nuclear receptor NR2E1 0.0111 0.1473 0.221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0357 0.0353
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0234 0.3228 0.3225
Schistosoma mansoni Smad4 0.0008 0.0027 0.0022
Loa Loa (eye worm) hypothetical protein 0.0111 0.1473 0.221
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0921 0.1379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0921 0.269
Mycobacterium tuberculosis Conserved protein 0.0072 0.0921 0.1435
Echinococcus multilocularis muscleblind protein 0.0453 0.6325 0.6324
Schistosoma mansoni hypothetical protein 0.0011 0.0069 0.0065
Brugia malayi Steroid receptor seven-up type 2 0.0234 0.3228 0.485
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0168 0.0246
Echinococcus multilocularis geminin 0.0712 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0124 0.1661 0.1657
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1899 0.1895
Brugia malayi photoreceptor-specific nuclear receptor 0.0234 0.3228 0.485
Loa Loa (eye worm) hypothetical protein 0.0032 0.0357 0.0531
Schistosoma mansoni hypothetical protein 0.0097 0.1282 0.1278
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0921 0.269
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0111 0.1473 0.1469
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0921 0.0917
Echinococcus granulosus Nuclear hormone receptor HR96 0.0111 0.1473 0.1469
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0921 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1899 0.285
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1899 0.1895
Schistosoma mansoni smad 0.0008 0.0027 0.0022
Onchocerca volvulus 0.0097 0.1282 0.3737
Brugia malayi MH2 domain containing protein 0.0008 0.0027 0.0033
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0111 0.1473 0.1469
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1899 0.1895
Mycobacterium ulcerans lipase LipD 0.0072 0.0921 0.8634
Loa Loa (eye worm) DR-78 0.0111 0.1473 0.221
Schistosoma mansoni hypothetical protein 0.0712 1 1
Brugia malayi Muscleblind-like protein 0.0453 0.6325 0.951
Trichomonas vaginalis set domain proteins, putative 0.0248 0.3423 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0005 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0448 0.0443
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0168 0.1786
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.2997 0.4503
Schistosoma mansoni thyroid hormone receptor 0.0234 0.3228 0.3225
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0156 0.143
Schistosoma mansoni zinc finger protein 0.0111 0.1473 0.1469
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0234 0.3228 0.3225
Leishmania major hypothetical protein, conserved 0.0026 0.027 0.2892
Loa Loa (eye worm) hypothetical protein 0.0124 0.1661 0.2493
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0168 0.0164
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.6651 0.665
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.1282 0.1922
Brugia malayi Nuclear hormone receptor-like 1 0.0124 0.1661 0.2493
Brugia malayi nuclear hormone receptor family member odr-7 0.0111 0.1473 0.221
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0921 0.269
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0921 0.0917
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0241 0.2227
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0241 0.5334
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0921 0.1435
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0241 0.2227
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0234 0.3228 0.3225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0234 0.3228 0.3225
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0357 0.0353
Onchocerca volvulus 0.0111 0.1473 0.4296
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0241 0.037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0448 0.0443
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0082 0.1066 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0156 0.0228
Onchocerca volvulus 0.0072 0.0921 0.268
Echinococcus multilocularis Smad4 0.0008 0.0027 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0234 0.3228 0.485
Brugia malayi tailless protein 0.0111 0.1473 0.221
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1899 0.1895
Trichomonas vaginalis esterase, putative 0.0072 0.0921 0.269
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.032 0.0474
Brugia malayi Smad1 0.0008 0.0027 0.0033
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0748 0.1164
Echinococcus multilocularis ecdysone induced protein 78C 0.0234 0.3228 0.3225
Brugia malayi conserved hypotetical protein 0.0111 0.1473 0.221
Schistosoma mansoni cpg binding protein 0.0031 0.0343 0.0339
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0111 0.1473 0.1469
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0241 0.2579
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0241 0.2227
Echinococcus multilocularis smad 0.0008 0.0027 0.0022
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0921 0.1435
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0025 0.0021
Brugia malayi MH1 domain containing protein 0.0008 0.0027 0.0033
Loa Loa (eye worm) hypothetical protein 0.0124 0.1661 0.2493
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0168 0.1542
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0124 0.1661 0.2493
Brugia malayi Nuclear hormone receptor-like 1 0.0124 0.1661 0.2493
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0082 0.1066 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0111 0.1473 0.1469
Brugia malayi hypothetical protein 0.0111 0.1473 0.221
Echinococcus granulosus muscleblind protein 0.0453 0.6325 0.6324
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0241 0.2227
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0051 0.0046
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.0666 0.0662
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0921 0.1379
Brugia malayi beta-lactamase 0.0072 0.0921 0.1379
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0234 0.3228 0.3225
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0082 0.1066 0.1062
Brugia malayi MH1 domain containing protein 0.0008 0.0027 0.0033
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0168 0.0491
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0234 0.3228 0.485

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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