Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Echinococcus granulosus | glucose 6 phosphate isomerase | 0.0048 | 0.0643 | 0.0302 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0169 | 0.4443 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0346 | 1 | 1 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0346 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Chlamydia trachomatis | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0998 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0101 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.0375 | 0.0109 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.0375 | 0.0285 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.0375 | 0.0109 |
Entamoeba histolytica | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0643 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.0375 | 0.0101 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Leishmania major | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0048 | 0.0643 | 0.0408 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0089 | 0.1922 | 0.3803 |
Toxoplasma gondii | glucose-6-phosphate isomerase GPI | 0.0048 | 0.0643 | 0.0408 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trypanosoma brucei | glucose-6-phosphate isomerase, glycosomal | 0.0048 | 0.0643 | 0.0408 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0323 | 0.9266 | 1 |
Brugia malayi | glucose phosphate isomerase a | 0.0048 | 0.0643 | 0.0302 |
Plasmodium falciparum | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.0375 | 0.0285 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0125 | 0.3064 | 0.31 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0323 | 0.9266 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0169 | 0.4443 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Leishmania major | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Entamoeba histolytica | glucosamine-6-phosphate isomerase, putative | 0.0036 | 0.0277 | 0.0277 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.0375 | 0.0109 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0101 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.0375 | 0.0109 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0375 | 0.0405 |
Leishmania major | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0048 | 0.0643 | 0.0408 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 1 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.3306 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0169 | 0.4443 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0659 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.0375 | 0.0109 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0377 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0125 | 0.3064 | 0.661 |
Plasmodium vivax | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0408 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0323 | 0.9266 | 1 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0323 | 0.9266 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0323 | 0.9266 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0346 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0125 | 0.3064 | 0.2587 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0643 | 0.0694 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Loa Loa (eye worm) | phosphoglucose isomerase | 0.0048 | 0.0643 | 0.0694 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0323 | 0.9266 | 1 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.0375 | 0.5 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0048 | 0.0643 | 0.0377 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0125 | 0.3064 | 0.31 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.0125 | 0.3064 | 0.3024 |
Schistosoma mansoni | glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0408 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) | 0.0048 | 0.0643 | 0.0659 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.0375 | 0.0405 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0323 | 0.9266 | 1 |
Mycobacterium leprae | Probable glucose-6-phosphate isomerase Pgi (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) | 0.0048 | 0.0643 | 0.0659 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.0375 | 0.0109 |
Echinococcus multilocularis | glucose 6 phosphate isomerase | 0.0048 | 0.0643 | 0.0579 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.0125 | 0.3064 | 0.3024 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Giardia lamblia | Glucose-6-phosphate isomerase | 0.0048 | 0.0643 | 0.0377 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.661 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.0375 | 0.0109 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.0125 | 0.3064 | 0.3223 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0323 | 0.9266 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0323 | 0.9266 | 1 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0125 | 0.3064 | 0.31 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0323 | 0.9266 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Degree of resistance (binding) | 0.6 | Degree of resistance is the ratio between inhibition of Bacillus subtilis DNA Polymerase III azp-12 and WT. | ChEMBL. | 6767030 |
Degree of resistance (binding) | 0.6 | Degree of resistance is the ratio between inhibition of Bacillus subtilis DNA Polymerase III azp-12 and WT. | ChEMBL. | 6767030 |
Ki (binding) | = 2.495 | Inhibition constant against Bacillus subtilis DNA topoisomerase III (wild type). | ChEMBL. | 6420570 |
Ki (binding) | = 2.71 | Inhibition constant against Bacillus subtilis azp-12 DNA topoisomerase III (mutant enzyme). | ChEMBL. | 6420570 |
Ki (binding) | = 1950 uM | In vitro inhibition of Bacillus subtilis DNA Polymerase III/azp-12(mutant). | ChEMBL. | 6767030 |
Ki (binding) | = 1950 uM | In vitro inhibition of Bacillus subtilis DNA Polymerase III/azp-12(mutant). | ChEMBL. | 6767030 |
Ki (binding) | = 3200 uM | Inhibition against Bacillus subtilis DNA topoisomerase III (wild type) | ChEMBL. | 6767030 |
Ki (binding) | = 3200 uM | Inhibition against Bacillus subtilis DNA topoisomerase III (wild type) | ChEMBL. | 6767030 |
Log 1/Ki (binding) | = 2.495 | Inhibition constant against Bacillus subtilis DNA topoisomerase III (wild type). | ChEMBL. | 6420570 |
Log 1/Ki (binding) | = 2.71 | Inhibition constant against Bacillus subtilis azp-12 DNA topoisomerase III (mutant enzyme). | ChEMBL. | 6420570 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.