Detailed information for compound 791071

Basic information

Technical information
  • TDR Targets ID: 791071
  • Name: 8-(3-chloro-5-ethoxy-4-hydroxyphenyl)-7,8-dih ydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
  • MW: 361.776 | Formula: C18H16ClNO5
  • H donors: 2 H acceptors: 2 LogP: 2.94 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(cc(c1O)Cl)C1CC(=O)Nc2c1cc1OCOc1c2
  • InChi: 1S/C18H16ClNO5/c1-2-23-16-4-9(3-12(19)18(16)22)10-6-17(21)20-13-7-15-14(5-11(10)13)24-8-25-15/h3-5,7,10,22H,2,6,8H2,1H3,(H,20,21)
  • InChiKey: ISRVSNHKHFDJGQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 8-(3-chloro-5-ethoxy-4-hydroxy-phenyl)-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]quinolin-6-one
  • IVK/2008411

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei polo-like protein kinase 0.0105 0.2071 0.2342
Brugia malayi RNA binding protein 0.0132 0.2738 0.3155
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0256 0.0339
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0426 0.0335
Loa Loa (eye worm) hypothetical protein 0.021 0.4604 0.5433
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0426 0.0349
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0152 0.0539
Entamoeba histolytica hypothetical protein 0.0075 0.1345 0.62
Schistosoma mansoni hypothetical protein 0.0066 0.1149 0.1149
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0464 0.0615
Echinococcus granulosus geminin 0.0175 0.3774 0.5009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.023 0.0305
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.1149 0.1525
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0684 0.065
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.06 0.0797
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.1149 0.1525
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0426 0.1511
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0684 0.3305
Plasmodium falciparum glutathione reductase 0.0047 0.0684 0.2424
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0684 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.2738 0.3155
Loa Loa (eye worm) glutathione reductase 0.0136 0.2823 0.326
Brugia malayi TAR-binding protein 0.0132 0.2738 0.3155
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0305 0.0405
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2937 0.2937
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0426 0.0335
Schistosoma mansoni hypothetical protein 0.0175 0.3774 0.3774
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0684 0.0546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Echinococcus multilocularis GPCR, family 2 0.0066 0.1149 0.1525
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.1149 0.1217
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0256 0.0256
Loa Loa (eye worm) transcription factor SMAD2 0.0253 0.5646 0.6705
Loa Loa (eye worm) hypothetical protein 0.0036 0.0426 0.0335
Plasmodium falciparum phd finger protein, putative 0.0031 0.0305 0.108
Loa Loa (eye worm) hypothetical protein 0.0025 0.0161 0.0011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.1149 0.1217
Plasmodium falciparum thioredoxin reductase 0.0047 0.0684 0.2424
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0426 0.0335
Brugia malayi Pre-SET motif family protein 0.0029 0.0256 0.0126
Echinococcus granulosus GPCR family 2 0.0066 0.1149 0.1525
Plasmodium falciparum thioredoxin reductase 0.0136 0.2823 1
Schistosoma mansoni hypothetical protein 0.0066 0.1149 0.1149
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.0684 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.1149 0.1525
Schistosoma mansoni kinase 0.0053 0.0831 0.0831
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.8346 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0426 0.0566
Schistosoma mansoni hypothetical protein 0.0143 0.3005 0.3005
Loa Loa (eye worm) MH2 domain-containing protein 0.0253 0.5646 0.6705
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0256 0.0256
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0426 0.0335
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.4604 0.5433
Onchocerca volvulus 0.0232 0.5147 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0684 0.065
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0256 0.0256
Echinococcus multilocularis tumor protein p63 0.0332 0.7534 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.4468 0.5267
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2071 0.2342
Plasmodium falciparum pyruvate kinase 0.0036 0.0426 0.1511
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0684 0.065
Schistosoma mansoni hypothetical protein 0.0075 0.1345 0.1345
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0152 0.0539
Leishmania major pyruvate kinase 0.0036 0.0426 0.0335
Mycobacterium tuberculosis Putative ferredoxin reductase 0.031 0.7016 0.8878
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0684 0.2424
Loa Loa (eye worm) thioredoxin reductase 0.0136 0.2823 0.326
Schistosoma mansoni pyruvate kinase 0.0036 0.0426 0.0426
Schistosoma mansoni hypothetical protein 0.0031 0.0305 0.0305
Echinococcus multilocularis thioredoxin glutathione reductase 0.0136 0.2835 0.3763
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0684 0.0908
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0426 0.0349
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Mycobacterium tuberculosis Probable oxidoreductase 0.0345 0.7849 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0256 0.0339
Echinococcus multilocularis tar DNA binding protein 0.0132 0.2738 0.3633
Schistosoma mansoni hypothetical protein 0.0066 0.1149 0.1149
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0105 0.2071 0.2342
Schistosoma mansoni jumonji domain containing protein 0.0082 0.1514 0.1514
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0684 0.065
Echinococcus multilocularis pyruvate kinase 0.0036 0.0426 0.0566
Leishmania major pyruvate kinase 0.0036 0.0426 0.0335
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0684 0.2424
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0684 0.0347
Schistosoma mansoni hypothetical protein 0.0175 0.3774 0.3774
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0152 0.0539
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0305 0.108
Echinococcus granulosus peregrin 0.0031 0.0305 0.0405
Loa Loa (eye worm) hypothetical protein 0.0066 0.1149 0.1217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2937 0.2937
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.031 0.7016 0.8878
Echinococcus multilocularis geminin 0.0175 0.3774 0.5009
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0684 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0798 0.0787
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0426 0.0335
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.8346 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.3005 0.3482
Mycobacterium tuberculosis Probable dehydrogenase 0.031 0.7016 0.8878
Giardia lamblia PHD finger protein 15 0.0031 0.0305 0.1472
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Schistosoma mansoni serine/threonine protein kinase 0.0105 0.2071 0.2071
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0105 0.2071 0.2749
Schistosoma mansoni tar DNA-binding protein 0.0132 0.2738 0.2738
Trypanosoma cruzi trypanothione reductase, putative 0.0136 0.2823 0.326
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0719 0.0719
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.1108 0.1167
Onchocerca volvulus 0.0049 0.0719 0.0947
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0684 0.5
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0684 0.0908
Brugia malayi Pre-SET motif family protein 0.0204 0.4468 0.5267
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2937 0.3898
Echinococcus granulosus pyruvate kinase 0.0036 0.0426 0.0566
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0426 0.0349
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0684 0.0684
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.031 0.7016 0.8878
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Schistosoma mansoni pyruvate kinase 0.0036 0.0426 0.0426
Plasmodium vivax thioredoxin reductase, putative 0.0136 0.2823 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.2022 0.2684
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1345 0.1786
Treponema pallidum NADH oxidase 0.0047 0.0684 0.5
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.8346 1
Brugia malayi jmjC domain containing protein 0.0038 0.0464 0.038
Schistosoma mansoni tar DNA-binding protein 0.0132 0.2738 0.2738
Echinococcus granulosus jumonji domain containing protein 0.0044 0.06 0.0797
Schistosoma mansoni tar DNA-binding protein 0.0132 0.2738 0.2738
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0464 0.0464
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0684 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2937 0.3898
Loa Loa (eye worm) TAR-binding protein 0.0132 0.2738 0.3155
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0256 0.0256
Entamoeba histolytica serine/threonine protein kinase, putative 0.0105 0.2071 1
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1345 0.1345
Echinococcus granulosus tar DNA binding protein 0.0132 0.2738 0.3633
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.2937 0.3898
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0256 0.0905
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.2022 0.2684
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0152 0.0539
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.2937 0.3398
Loa Loa (eye worm) hypothetical protein 0.0365 0.8346 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0305 0.0186
Echinococcus granulosus tumor protein p63 0.0332 0.7534 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.4046 0.4752
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0684 0.2424
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0684 0.065
Trichomonas vaginalis CAMK family protein kinase 0.0052 0.0798 0.0787
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0345 0.7849 1
Giardia lamblia Kinase, PLK 0.0105 0.2071 1
Brugia malayi glutathione reductase 0.0136 0.2823 0.326
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0035 0.0383 0.0282
Giardia lamblia Pyruvate kinase 0.0036 0.0426 0.2059
Echinococcus granulosus pyruvate kinase 0.0036 0.0426 0.0566
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Entamoeba histolytica hypothetical protein 0.0075 0.1345 0.62
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0054 0.0844 0.0844
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0464 0.0464
Brugia malayi PHD-finger family protein 0.0031 0.0305 0.0186
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1345 0.1786
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0684 1
Brugia malayi Latrophilin receptor protein 2 0.0066 0.1149 0.1217
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0464 0.0615
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Schistosoma mansoni tar DNA-binding protein 0.0132 0.2738 0.2738
Onchocerca volvulus Serine\/threonine kinase homolog 0.0105 0.2071 0.3711
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.2937 0.3898
Loa Loa (eye worm) hypothetical protein 0.0049 0.0719 0.0692
Echinococcus multilocularis pyruvate kinase 0.0029 0.0242 0.0321
Brugia malayi latrophilin 2 splice variant baaae 0.0143 0.3005 0.3482
Brugia malayi jmjC domain containing protein 0.0103 0.2022 0.2282
Entamoeba histolytica hypothetical protein 0.0075 0.1345 0.62
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0105 0.2071 0.2342
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0684 0.2424
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0464 0.038
Plasmodium falciparum glutathione reductase 0.0136 0.2823 1
Trypanosoma brucei trypanothione reductase 0.0136 0.2823 0.326
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0426 0.1511
Brugia malayi Thioredoxin reductase 0.0136 0.2823 0.326
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0345 0.7849 1
Brugia malayi MH2 domain containing protein 0.0253 0.5646 0.6705
Onchocerca volvulus Alhambra homolog 0.0031 0.0305 0.0101
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.8346 1
Plasmodium vivax glutathione reductase, putative 0.0136 0.2823 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0256 0.0339
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0684 0.2424
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0684 0.2424
Toxoplasma gondii thioredoxin reductase 0.0136 0.2823 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0305 0.0405
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0105 0.2071 0.2749
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0035 0.0383 0.0282
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0426 0.0335
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0684 0.5
Schistosoma mansoni tar DNA-binding protein 0.0132 0.2738 0.2738
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0136 0.2823 0.3229
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0684 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.031 0.7016 0.8878
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0426 0.0335
Entamoeba histolytica hypothetical protein 0.0075 0.1345 0.62
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0684 0.065
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0305 0.0186
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.031 0.7016 0.8878
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0161 0.0011
Trichomonas vaginalis CAMK family protein kinase 0.0105 0.2071 0.3484
Brugia malayi serine/threonine-protein kinase plk-2 0.0105 0.2071 0.2342
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0684 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.4604 0.5433
Loa Loa (eye worm) hypothetical protein 0.0029 0.0256 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.4604 0.5433
Plasmodium vivax SET domain protein, putative 0.0029 0.0256 0.0905
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0305 0.108
Leishmania major trypanothione reductase 0.0136 0.2823 0.326
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0684 0.065
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0305 0.108
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.1149 0.1525
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.2937 0.2937
Echinococcus multilocularis peregrin 0.0031 0.0305 0.0405
Brugia malayi hypothetical protein 0.0075 0.1345 0.1456
Schistosoma mansoni hypothetical protein 0.0066 0.1149 0.1149
Trypanosoma cruzi polo-like protein kinase, putative 0.0105 0.2071 0.2342
Trichomonas vaginalis set domain proteins, putative 0.0232 0.5147 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0684 0.065
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0684 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0426 0.0335
Mycobacterium tuberculosis Probable reductase 0.031 0.7016 0.8878
Brugia malayi Bromodomain containing protein 0.0031 0.0305 0.0186
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.2738 0.3155
Echinococcus granulosus thioredoxin glutathione reductase 0.0136 0.2835 0.3763
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.2937 0.3398
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0345 0.7849 1
Loa Loa (eye worm) RNA binding protein 0.0132 0.2738 0.3155
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0426 0.0335

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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