TDR Targets

Basic information

Technical information

TDR Targets ID: 791226
Name: 4-(2-fluorophenyl)-5,6,7-trimethoxy-3,4-dihyd ro-1H-quinolin-2-one
MW: 331.338 | Formula: C18H18FNO4
H donors: 1 H acceptors: 1 LogP: 2.53 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1c(OC)c(OC)cc2c1C(CC(=O)N2)c1ccccc1F
InChi: 1S/C18H18FNO4/c1-22-14-9-13-16(18(24-3)17(14)23-2)11(8-15(21)20-13)10-6-4-5-7-12(10)19/h4-7,9,11H,8H2,1-3H3,(H,20,21)
InChiKey: WDRFBEQFCVGFPK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-(2-fluorophenyl)-5,6,7-trimethoxy-3,4-dihydrocarbostyril
IVK/2008387

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0011	0.0469	1
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0011	0.0469	0.1215
Schistosoma mansoni	nuclear hormone receptor	0.0011	0.0469	0.1215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0011	0.0469	0.0469
Giardia lamblia	Kinase, CMGC MAPK	0.0052	0.3864	0.5
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0006	0.005	0.013
Brugia malayi	hypothetical protein	0.0006	0.005	0.005
Trypanosoma brucei	protein kinase, putative	0.0052	0.3864	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.3573	0.9246
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0052	0.3864	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0011	0.0469	0.1215
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0469	0.1215
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.3573	0.9246
Brugia malayi	MAP kinase sur-1	0.0052	0.3864	0.3864
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.3573	0.9246
Loa Loa (eye worm)	hypothetical protein	0.0006	0.005	0.005
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0469	0.0469
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0011	0.0469	0.1215
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0291	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0006	0.005	0.005
Loa Loa (eye worm)	MH1 domain-containing protein	0.0009	0.0291	0.0291
Echinococcus granulosus	mothers against decapentaplegic 5	0.0009	0.0291	0.0753
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.3573	0.9246
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0011	0.0469	0.0469
Brugia malayi	MH2 domain containing protein	0.0009	0.0291	0.0291
Onchocerca volvulus	Bile acid receptor homolog	0.0011	0.0469	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0469	0.0469
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0469	0.1215
Echinococcus multilocularis	mitogen activated protein kinase	0.0052	0.3864	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0052	0.3864	1
Schistosoma mansoni	inositol monophosphatase	0.0039	0.2804	0.7257
Brugia malayi	Inositol-1	0.0039	0.2804	0.2804
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.3864	1
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0035	0.2467	0.5
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0009	0.0291	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.3864	1
Schistosoma mansoni	Smad4	0.0009	0.0291	0.0753
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0011	0.0469	0.0469
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0469	0.1215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0011	0.0469	0.0469
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0052	0.3864	1
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0039	0.2804	0.5
Loa Loa (eye worm)	inositol-1	0.0039	0.2804	0.2804
Schistosoma mansoni	RAR-like nuclear receptor	0.0011	0.0469	0.1215
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.3573	0.9246
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0011	0.0469	0.1215
Loa Loa (eye worm)	steroid hormone receptor	0.0011	0.0469	0.0469
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0469	0.1215
Echinococcus multilocularis	ecdysone induced protein 78C	0.0011	0.0469	0.1215
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0011	0.0469	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0009	0.0291	0.0753
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0291	0.0753
Brugia malayi	MH2 domain containing protein	0.0009	0.0291	0.0291
Echinococcus multilocularis	Smad4	0.0009	0.0291	0.0753
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0006	0.005	0.013
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0011	0.0469	0.1215
Echinococcus granulosus	mitogen activated protein kinase 3	0.0052	0.3864	1
Schistosoma mansoni	smad	0.0009	0.0291	0.0753
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.3573	0.9246
Echinococcus granulosus	inositol monophosphatase 1	0.0039	0.2804	0.7257
Schistosoma mansoni	smad1 5 8 and	0.0009	0.0291	0.0753
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0011	0.0469	0.1215
Echinococcus multilocularis	inositol monophosphatase 1	0.0039	0.2804	0.7257
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.3864	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0128	1	1
Echinococcus granulosus	Smad4	0.0009	0.0291	0.0753
Echinococcus granulosus	smad	0.0009	0.0291	0.0753
Brugia malayi	photoreceptor-specific nuclear receptor	0.0011	0.0469	0.0469
Loa Loa (eye worm)	hypothetical protein	0.0006	0.005	0.005
Loa Loa (eye worm)	Smad1	0.0009	0.0291	0.0291
Echinococcus multilocularis	smad	0.0009	0.0291	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0011	0.0469	0.1215
Onchocerca volvulus		0.0011	0.0469	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0469	0.0469
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0006	0.005	0.013
Loa Loa (eye worm)	transcription factor SMAD2	0.0128	1	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0052	0.3864	1
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.3864	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0011	0.0469	0.1215
Brugia malayi	ecdysteroid receptor	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0011	0.0469	0.0469
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0052	0.3864	1
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0006	0.005	0.013
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0011	0.0469	0.0469
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0052	0.3864	1
Brugia malayi	hypothetical protein	0.0006	0.005	0.005
Echinococcus multilocularis	FTZ F1 alpha	0.0011	0.0469	0.1215
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0011	0.0469	0.1215
Loa Loa (eye worm)	hypothetical protein	0.0006	0.005	0.005
Brugia malayi	Smad1	0.0009	0.0291	0.0291
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0011	0.0469	0.0469
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0011	0.0469	0.1215
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.3573	0.3573
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.3573	0.3573
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0011	0.0469	0.1215
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0052	0.3864	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0039	0.2804	0.5
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0011	0.0469	0.1215
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0052	0.3864	1
Brugia malayi	MH1 domain containing protein	0.0009	0.0291	0.0291
Schistosoma mansoni	retinoic acid receptor RXR	0.0011	0.0469	0.1215
Echinococcus granulosus	mitogen activated protein kinase	0.0052	0.3864	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0011	0.0469	0.0469
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0009	0.0291	0.0753
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0011	0.0469	0.0469
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.3864	1
Schistosoma mansoni	thyroid hormone receptor	0.0011	0.0469	0.1215
Trichomonas vaginalis	CMGC family protein kinase	0.0052	0.3864	1
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0035	0.2467	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0011	0.0469	0.0469
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0011	0.0469	0.1215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0011	0.0469	0.0469
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0011	0.0469	0.0469
Brugia malayi	steroid hormone receptor	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.005	0.005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0011	0.0469	0.1215
Brugia malayi	MH1 domain containing protein	0.0009	0.0291	0.0291
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.3573	0.9246
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0011	0.0469	0.0469
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0052	0.3864	0.3864
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0011	0.0469	0.1215
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0011	0.0469	0.0469
Echinococcus granulosus	FTZ F1 alpha	0.0011	0.0469	0.1215
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0011	0.0469	0.1215
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0011	0.0469	0.1215
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0006	0.005	0.005
Loa Loa (eye worm)	hypothetical protein	0.0006	0.005	0.005
Brugia malayi	nuclear hormone receptor	0.0011	0.0469	0.0469
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0009	0.0291	0.0753
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0469	0.0469
Onchocerca volvulus	Protein ultraspiracle homolog	0.0011	0.0469	1
Schistosoma mansoni	coup transcription factor	0.0011	0.0469	0.1215
Brugia malayi	Steroid receptor seven-up type 2	0.0011	0.0469	0.0469
Brugia malayi	Nuclear hormone receptor-like 1	0.0006	0.005	0.005
Schistosoma mansoni	inositol monophosphatase	0.0039	0.2804	0.7257
Brugia malayi	nuclear receptor NHR-88	0.0011	0.0469	0.0469
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0011	0.0469	0.1215
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0039	0.2804	0.5
Brugia malayi	nuclear receptor RXR	0.0006	0.005	0.005
Loa Loa (eye worm)	MH2 domain-containing protein	0.0009	0.0291	0.0291

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 791226