TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 275.429 | Formula: C18H29NO
H donors: 0 H acceptors: 0 LogP: 4.87 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CCCN([C@H]1Cc2cc(OC)ccc2CC1C)CCC
InChi: 1S/C18H29NO/c1-5-9-19(10-6-2)18-13-16-12-17(20-4)8-7-15(16)11-14(18)3/h7-8,12,14,18H,5-6,9-11,13H2,1-4H3/t14?,18-/m0/s1
InChiKey: QKCNEXZXPCSGSQ-IBYPIGCZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycogen phosphorylase	0.0104	0.0752	0.0752
Leishmania major	hypothetical protein, conserved	0.0063	0.0215	0.0674
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Schistosoma mansoni	unc-13 (munc13)	0.0057	0.0131	0.0145
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0071	0.0314	0.0398
Brugia malayi	RhoGAP domain containing protein	0.005	0.0041	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0585	0.0742
Brugia malayi	p70 ribosomal S6 kinase beta	0.0071	0.0314	0.0398
Entamoeba histolytica	protein kinase, putative	0.0071	0.0314	0.0866
Echinococcus multilocularis	protein kinase c iota type	0.0121	0.0972	0.0972
Plasmodium vivax	PST-A protein	0.029	0.3188	1
Loa Loa (eye worm)	amidase	0.0063	0.0215	0.0273
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Brugia malayi	RhoGEF domain containing protein	0.005	0.0041	0.0052
Treponema pallidum	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0063	0.0215	0.5
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0094	0.0619	0.0619
Toxoplasma gondii	AGC kinase	0.0071	0.0314	1
Mycobacterium tuberculosis	Possible lysophospholipase	0.029	0.3188	0.4673
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.0671	0.0851
Entamoeba histolytica	protein kinase, putative	0.0071	0.0314	0.0866
Mycobacterium tuberculosis	Probable amidase AmiC (aminohydrolase)	0.0063	0.0215	0.0315
Schistosoma mansoni	tyrosinase precursor	0.0098	0.0671	0.1009
Brugia malayi	Carboxylesterase family protein	0.0131	0.1101	0.1398
Loa Loa (eye worm)	hypothetical protein	0.031	0.3444	0.437
Brugia malayi	bZIP transcription factor family protein	0.0094	0.0619	0.0785
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.029	0.3188	1
Brugia malayi	diacylglycerol kinase	0.005	0.0041	0.0052
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0314	0.0398
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0052	0.0061	0.0061
Echinococcus granulosus	RNA directed DNA polymerase	0.0172	0.1645	0.1645
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0181	0.1755	0.2228
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0671	0.0851
Mycobacterium tuberculosis	Probable dehydrogenase	0.0107	0.079	0.1159
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0104	0.0752	0.2088
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0071	0.0314	0.0398
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.0671	0.0851
Mycobacterium tuberculosis	Probable reductase	0.0107	0.079	0.1159
Entamoeba histolytica	protein kinase, putative	0.0071	0.0314	0.0866
Schistosoma mansoni	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0063	0.0215	0.0279
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0119	0.0947	0.1389
Loa Loa (eye worm)	raf kinase	0.005	0.0041	0.0052
Trichomonas vaginalis	valacyclovir hydrolase, putative	0.029	0.3188	1
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0315	0.3522	0.447
Echinococcus granulosus	raf serine:threonine protein kinase	0.005	0.0041	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0052	0.0061	0.0077
Leishmania major	monoglyceride lipase, putative	0.029	0.3188	1
Brugia malayi	hypothetical protein	0.0121	0.0971	0.1232
Echinococcus multilocularis	serine threonine protein kinase	0.025	0.2666	0.2666
Echinococcus granulosus	protein kinase c epsilon type	0.0205	0.2077	0.2077
Echinococcus granulosus	jun protein	0.0094	0.0619	0.0619
Brugia malayi	RhoGAP domain containing protein	0.005	0.0041	0.0052
Echinococcus multilocularis	RNA directed DNA polymerase	0.0172	0.1645	0.1645
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Trichomonas vaginalis	conserved hypothetical protein	0.029	0.3188	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0119	0.0947	0.1389
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0071	0.0314	0.0314
Brugia malayi	ShTK domain containing protein	0.0098	0.0671	0.0851
Echinococcus granulosus	Glycosyl transferase family 35	0.0104	0.0752	0.0752
Echinococcus granulosus	glutamyl tRNAGln amidotransferase subunit A	0.0063	0.0215	0.0215
Brugia malayi	hypothetical protein	0.0074	0.0353	0.0448
Brugia malayi	Amidase family protein	0.0063	0.0215	0.0273
Brugia malayi	Protein kinase c protein 2	0.0231	0.2413	0.3062
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Schistosoma mansoni	jun-related protein	0.0077	0.0387	0.0555
Schistosoma mansoni	serine/threonine kinase	0.0071	0.0314	0.0437
Echinococcus granulosus	N chimaerin	0.005	0.0041	0.0041
Echinococcus granulosus	protein kinase c eta type	0.005	0.0041	0.0041
Giardia lamblia	Glycogen phosphorylase	0.0104	0.0752	0.5
Trypanosoma cruzi	amidase, putative	0.0063	0.0215	0.0674
Echinococcus granulosus	unc 13 munc13	0.0057	0.0131	0.0131
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0071	0.0314	0.0314
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0314	0.0437
Echinococcus multilocularis	raf serine:threonine protein kinase	0.005	0.0041	0.0041
Echinococcus multilocularis	Rac GTPase activating protein 1	0.005	0.0041	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.029	0.3188	1
Trypanosoma brucei	monoglyceride lipase, putative	0.029	0.3188	1
Toxoplasma gondii	diacylglycerol kinase, putative	0.005	0.0041	0.1307
Entamoeba histolytica	glycogen phosphorylase, putative	0.0104	0.0752	0.2258
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0071	0.0314	0.0314
Brugia malayi	small heat shock protein	0.0648	0.7881	1
Echinococcus multilocularis	glycogen phosphorylase	0.0104	0.0752	0.0752
Brugia malayi	protein kinase C3,putative	0.0052	0.0061	0.0077
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0205	0.2077	0.2636
Brugia malayi	Variant SH3 domain containing protein	0.005	0.0041	0.0052
Mycobacterium tuberculosis	Probable oxidoreductase	0.0567	0.6822	1
Schistosoma mansoni	protein kinase C mu	0.0052	0.0061	0.0032
Echinococcus granulosus	acetylcholinesterase	0.0131	0.1101	0.1101
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0314	0.0437
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0314	0.0437
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0104	0.0752	0.1582
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0071	0.0314	0.0398
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Brugia malayi	putative amidase	0.0063	0.0215	0.0273
Plasmodium falciparum	lysophospholipase, putative	0.029	0.3188	1
Plasmodium falciparum	lysophospholipase, putative	0.029	0.3188	1
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0079	0.0418	0.1199
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1101	0.1398
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0052	0.0061	0.0077
Echinococcus multilocularis	Diacylglycerol kinase theta	0.005	0.0041	0.0041
Schistosoma mansoni	atypical protein kinase C	0.0121	0.0972	0.1492
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.005	0.0041	0.0041
Entamoeba histolytica	glycogen phosphorylase, putative	0.0104	0.0752	0.2258
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0071	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0131	0.0167
Echinococcus granulosus	protein kinase C gamma type	0.025	0.2666	0.2666
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.029	0.3188	1
Echinococcus multilocularis	protein kinase c eta type	0.005	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0119	0.094	0.094
Brugia malayi	Carboxylesterase family protein	0.0131	0.1101	0.1398
Echinococcus multilocularis	expressed protein	0.0809	1	1
Echinococcus granulosus	Rac GTPase activating protein 1	0.005	0.0041	0.0041
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0314	0.0398
Brugia malayi	C1-like domain containing protein	0.0052	0.0061	0.0077
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0071	0.0314	0.0398
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0098	0.0671	0.0851
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0094	0.0619	0.0619
Schistosoma mansoni	tyrosinase precursor	0.0098	0.0671	0.1009
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0071	0.0314	0.0398
Schistosoma mansoni	amidase	0.0526	0.628	1
Loa Loa (eye worm)	ShTK domain-containing protein	0.0098	0.0671	0.0851
Echinococcus multilocularis	glutamyl tRNA(Gln) amidotransferase subunit A	0.0063	0.0215	0.0215
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.005	0.0041	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0526	0.628	0.7968
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0107	0.079	0.1159
Schistosoma mansoni	hypothetical protein	0.0077	0.0387	0.0555
Loa Loa (eye worm)	acetylcholinesterase 1	0.0131	0.1101	0.1398
Brugia malayi	protein kinase C II.	0.0205	0.2077	0.2636
Loa Loa (eye worm)	hypothetical protein	0.036	0.4102	0.5205
Onchocerca volvulus		0.0057	0.0131	0.0266
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0526	0.628	0.628
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0098	0.0671	0.0851
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0671	0.0851
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0131	0.1101	0.17
Trypanosoma brucei	monoglyceride lipase, putative	0.029	0.3188	1
Brugia malayi	Common central domain of tyrosinase family protein	0.0098	0.0671	0.0851
Echinococcus granulosus	NDR protein kinase	0.0071	0.0314	0.0314
Schistosoma mansoni	serine/threonine protein kinase	0.03	0.3324	0.5262
Mycobacterium tuberculosis	Probable oxidoreductase	0.0119	0.0947	0.1389
Echinococcus granulosus	Protein kinase C brain isozyme	0.03	0.3324	0.3324
Mycobacterium tuberculosis	Probable amidase AmiA2 (aminohydrolase)	0.0063	0.0215	0.0315
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.005	0.0041	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0061	0.0032
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.029	0.3188	1
Loa Loa (eye worm)	RasGEF domain-containing protein	0.005	0.0041	0.0052
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0071	0.0314	0.0314
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0172	0.1645	0.1645
Mycobacterium tuberculosis	Possible amidase (aminohydrolase)	0.0063	0.0215	0.0315
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Echinococcus granulosus	carboxylesterase 5A	0.0131	0.1101	0.1101
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0052	0.0061	0.0077
Entamoeba histolytica	protein kinase, putative	0.0071	0.0314	0.0866
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0052	0.0061	0.0077
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.03	0.3324	0.3324
Echinococcus granulosus	acetylcholinesterase	0.0131	0.1101	0.1101
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0104	0.0752	0.1582
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.029	0.3188	1
Mycobacterium tuberculosis	Probable amidase AmiB2 (aminohydrolase)	0.0063	0.0215	0.0315
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0063	0.0215	0.0215
Onchocerca volvulus		0.031	0.3444	1
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0104	0.0752	0.0752
Loa Loa (eye worm)	hypothetical protein	0.0131	0.1101	0.1398
Echinococcus multilocularis	unc 13 (munc13)	0.0057	0.0131	0.0131
Brugia malayi	diacylglycerol kinase	0.005	0.0041	0.0052
Loa Loa (eye worm)	hypothetical protein	0.031	0.3444	0.437
Schistosoma mansoni	lipoxygenase	0.0083	0.0472	0.069
Onchocerca volvulus		0.0074	0.0353	0.0917
Echinococcus granulosus	Diacylglycerol kinase theta	0.005	0.0041	0.0041
Schistosoma mansoni	protein kinase C	0.0057	0.0131	0.0145
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0057	0.0131	0.0131
Echinococcus granulosus	glycogen phosphorylase	0.0104	0.0752	0.0752
Schistosoma mansoni	serine/threonine protein kinase	0.0052	0.0061	0.0032
Loa Loa (eye worm)	ShTK domain-containing protein	0.0098	0.0671	0.0851
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0107	0.079	0.1159
Loa Loa (eye worm)	tyrosinase 1	0.0098	0.0671	0.0851
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0071	0.0314	0.0398
Chlamydia trachomatis	glycogen phosphorylase	0.0104	0.0752	1
Schistosoma mansoni	glycogen phosphorylase	0.0104	0.0752	0.1139
Mycobacterium tuberculosis	Probable amidase AmiD (acylamidase) (acylase)	0.0063	0.0215	0.0315
Schistosoma mansoni	unc-13 (munc13)	0.0057	0.0131	0.0145
Echinococcus granulosus	serine:threonine protein kinase N2	0.0071	0.0314	0.0314
Plasmodium vivax	glutamyl-tRNA(Gln) amidotransferase subunit A, putative	0.0063	0.0215	0.0674
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0526	0.628	0.628
Onchocerca volvulus		0.0098	0.0671	0.1851
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.005	0.0041	0.0052
Schistosoma mansoni	serine/threonine protein kinase	0.03	0.3324	0.5262
Echinococcus multilocularis	protein kinase c epsilon type	0.0205	0.2077	0.2077
Mycobacterium leprae	POSSIBLE LYSOPHOSPHOLIPASE	0.029	0.3188	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0526	0.628	0.628
Echinococcus granulosus	protein kinase c iota type	0.0121	0.0972	0.0972
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0071	0.0314	0.0314
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0119	0.0947	0.2464
Mycobacterium ulcerans	short chain dehydrogenase	0.0567	0.6822	1
Trypanosoma cruzi	amidase, putative	0.0063	0.0215	0.0674
Brugia malayi	Hr1 repeat family protein	0.0071	0.0314	0.0398
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.029	0.3188	1
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0057	0.0131	0.0131
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Trypanosoma cruzi	monoglyceride lipase, putative	0.029	0.3188	1
Echinococcus granulosus	myotubularin protein 13	0.005	0.0041	0.0041
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.005	0.0041	0.0041
Schistosoma mansoni	fatty-acid amide hydrolase	0.0526	0.628	1
Echinococcus multilocularis	acetylcholinesterase	0.0131	0.1101	0.1101
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.0314	0.0437
Loa Loa (eye worm)	glycogen phosphorylase	0.0104	0.0752	0.0954
Echinococcus multilocularis	myotubularin protein 13	0.005	0.0041	0.0041
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0107	0.079	0.1159
Echinococcus multilocularis	jun protein	0.0094	0.0619	0.0619
Trypanosoma brucei	fatty-acid amide hydrolase, putative	0.0063	0.0215	0.0674
Loa Loa (eye worm)	hypothetical protein	0.038	0.4375	0.5551
Onchocerca volvulus		0.0098	0.0671	0.1851
Schistosoma mansoni	glycogen phosphorylase	0.0104	0.0752	0.1139
Brugia malayi	Protein kinase domain containing protein	0.0071	0.0314	0.0398
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0071	0.0314	0.0314
Echinococcus multilocularis	carboxylesterase 5A	0.0131	0.1101	0.1101
Loa Loa (eye worm)	carboxylesterase	0.0131	0.1101	0.1398
Loa Loa (eye worm)	hypothetical protein	0.0648	0.7881	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0107	0.079	0.1936
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0107	0.079	0.1159
Onchocerca volvulus		0.0098	0.0671	0.1851
Brugia malayi	Ras association domain family 1 isoform A	0.005	0.0041	0.0052
Mycobacterium ulcerans	lysophospholipase	0.029	0.3188	0.45
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0119	0.094	0.094
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Trichomonas vaginalis	Clan SC, family S33, methylesterase-like serine peptidase	0.029	0.3188	1
Plasmodium falciparum	esterase, putative	0.029	0.3188	1
Echinococcus granulosus	fatty acid amide hydrolase 1	0.0063	0.0215	0.0215
Schistosoma mansoni	fatty-acid amide hydrolase	0.0063	0.0215	0.0279
Brugia malayi	Pleckstrin Homology Domain	0.005	0.0041	0.0052
Echinococcus multilocularis	N chimaerin	0.005	0.0041	0.0041
Plasmodium falciparum	glutamyl-tRNA(Gln) amidotransferase subunit A	0.0063	0.0215	0.0674
Echinococcus granulosus	serine:threonine protein kinase N2	0.0079	0.0418	0.0418
Brugia malayi	amidase	0.0526	0.628	0.7968
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0071	0.0314	0.0398
Plasmodium falciparum	lysophospholipase, putative	0.029	0.3188	1
Loa Loa (eye worm)	amidase	0.0063	0.0215	0.0273
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0148	0.1329	0.1329
Wolbachia endosymbiont of Brugia malayi	aspartyl/glutamyl-tRNA amidotransferase subunit A	0.0063	0.0215	0.5
Onchocerca volvulus		0.0098	0.0671	0.1851
Loa Loa (eye worm)	hypothetical protein	0.0223	0.2303	0.2922
Echinococcus multilocularis	acetylcholinesterase	0.0131	0.1101	0.1101
Brugia malayi	carbohydrate phosphorylase	0.0104	0.0752	0.0954
Brugia malayi	Amidase family protein	0.0063	0.0215	0.0273
Trichomonas vaginalis	AGC family protein kinase	0.0071	0.0314	0.0069
Loa Loa (eye worm)	hypothetical protein	0.031	0.3444	0.437
Loa Loa (eye worm)	hypothetical protein	0.005	0.0041	0.0052
Echinococcus multilocularis	fatty acid amide hydrolase 1	0.0526	0.628	0.628
Entamoeba histolytica	hydrolase, alpha/beta fold family domain containing protein	0.029	0.3188	1
Mycobacterium ulcerans	hypothetical protein	0.029	0.3188	0.45
Echinococcus granulosus	glycogen phosphorylase	0.0104	0.0752	0.0752
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0071	0.0314	0.0314
Schistosoma mansoni	lipoxygenase	0.0119	0.094	0.1441
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0071	0.0314	0.0984
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0052	0.0061	0.0061
Loa Loa (eye worm)	hypothetical protein	0.0172	0.1645	0.2087
Schistosoma mansoni	serine/threonine protein kinase	0.0205	0.2077	0.3264

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	NA 0 uM kg-1	Effect on half-maximal decrease of DOPA formation in rat limbic regions; In active (no significant effect at 1.4 pmol/kg ip)	ChEMBL.	3656358
ED50 (functional)	NA 0 uM kg-1	Effect on half-maximal decrease of DOPA formation in rat striatal regions; In active (no significant effect at 1.4 pmol/kg ip)	ChEMBL.	3656358
No. of counts (functional)	= 96 uM kg-1	Tested for locomotor activity by measuring accumulated counts/30 min in reserpine-nonpretreated rats	ChEMBL.	3656358

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL298399

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 79163