Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0473 | 0.0569 | 0.0301 |
Mycobacterium ulcerans | FAD-dependent thymidylate synthase | 0.161 | 0.2389 | 0.2255 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0473 | 0.0569 | 0.0301 |
Echinococcus multilocularis | thymidylate synthase | 0.6116 | 0.9598 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0375 | 0.0412 | 0.0412 |
Treponema pallidum | thymidylate kinase (tmk) | 0.0298 | 0.029 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.6367 | 1 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.032 | 0.0326 | 0.0104 |
Mycobacterium tuberculosis | Hypothetical protein | 0.2909 | 0.4468 | 0.4489 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0298 | 0.029 | 0.0067 |
Brugia malayi | Dihydrofolate reductase | 0.0473 | 0.0569 | 0.0301 |
Leishmania major | thymidylate kinase-like protein | 0.0298 | 0.029 | 0.029 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0473 | 0.0569 | 0.0301 |
Mycobacterium ulcerans | thymidylate synthase | 0.6116 | 0.9598 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2909 | 0.4468 | 1 |
Trypanosoma cruzi | deoxyuridine triphosphatase, putative | 0.0375 | 0.0412 | 0.0412 |
Schistosoma mansoni | dihydrofolate reductase | 0.0473 | 0.0569 | 0.0301 |
Trypanosoma brucei | thymidylate kinase, putative | 0.0298 | 0.029 | 0.0067 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0298 | 0.029 | 0.0154 |
Wolbachia endosymbiont of Brugia malayi | thymidylate kinase | 0.0298 | 0.029 | 0.5 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase) | 0.161 | 0.2389 | 0.2255 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.6116 | 0.9598 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.6367 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.032 | 0.0326 | 0.0039 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6367 | 1 | 1 |
Trichomonas vaginalis | thymidylate kinase, putative | 0.0298 | 0.029 | 0.0154 |
Loa Loa (eye worm) | thymidylate synthase | 0.6116 | 0.9598 | 1 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyX (ts) (TSase) | 0.161 | 0.2389 | 0.2255 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0473 | 0.0569 | 1 |
Brugia malayi | thymidylate synthase | 0.6116 | 0.9598 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.0473 | 0.0569 | 0.0301 |
Entamoeba histolytica | Thymidylate kinase, putative | 0.0298 | 0.029 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0473 | 0.0569 | 0.0301 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0473 | 0.0569 | 0.0301 |
Giardia lamblia | CDC8 | 0.0298 | 0.029 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0298 | 0.029 | 0.029 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.6367 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.6116 | 0.9598 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6116 | 0.9598 | 1 |
Leishmania major | thymidine kinase, putative | 0.0257 | 0.0224 | 0.0224 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0257 | 0.0224 | 0.0224 |
Leishmania major | deoxyuridine triphosphatase, putative,dUTP diphosphatase | 0.0375 | 0.0412 | 0.0412 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.6367 | 1 | 1 |
Onchocerca volvulus | 0.6116 | 0.9598 | 1 | |
Brugia malayi | hypothetical protein | 0.2909 | 0.4468 | 0.4489 |
Trypanosoma cruzi | thymidine kinase, putative | 0.0257 | 0.0224 | 0.0224 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.6116 | 0.9598 | 1 |
Trypanosoma cruzi | thymidylate kinase, putative | 0.0298 | 0.029 | 0.029 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0473 | 0.0569 | 0.0301 |
Trypanosoma brucei | deoxyuridine triphosphatase, putative | 0.0375 | 0.0412 | 0.0193 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.2909 | 0.4468 | 0.4468 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED100 (functional) | = 160 ug | ED100 of was measured in the TPA induced mouse ear edema assay. | ChEMBL. | 2362263 |
ED100 (functional) | = 160 ug | ED100 of was measured in the TPA induced mouse ear edema assay. | ChEMBL. | 2362263 |
Potency (functional) | = 0 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 10 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 0 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 10 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 5 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 40 ugm/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 5 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 40 ugm/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 15.7 % | Atrophogenicity potency of the compound was observed in mouse at 200 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 15.7 % | Atrophogenicity potency of the compound was observed in mouse at 200 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 21 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 100 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 21 % | Systemic Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 100 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 41 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 10 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 41 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 10 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 67 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 40 ugm/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 67 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 40 ugm/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 81 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 100 ug/mouse. | ChEMBL. | 2362263 |
Potency (functional) | = 81 % | Topical Antiinflammatory activity was measured in the TPA induced mouse ear edema assay at 100 ug/mouse. | ChEMBL. | 2362263 |
Skin thickness (functional) | = 13.92 | Skin thickness of mouse was measured at 200 ug/mouse | ChEMBL. | 2362263 |
Systemic effect (functional) | = 0 % | Percentage systemic effect to assess the degree of absorption was measured 40 ugm/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 0 % | Percentage systemic effect to assess the degree of absorption was measured 40 ugm/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 2 % | Percentage systemic effect to assess the degree of absorption was measured at 10 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 2 % | Percentage systemic effect to assess the degree of absorption was measured at 10 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 4 % | Percentage systemic effect to assess the degree of absorption was measured at 10 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 4 % | Percentage systemic effect to assess the degree of absorption was measured at 10 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 5 % | Percentage systemic effect to assess the degree of absorption was measured at 100 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 5 % | Percentage systemic effect to assess the degree of absorption was measured at 100 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 13 % | Percentage systemic effect to assess the degree of absorption was measured 40 ugm/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 13 % | Percentage systemic effect to assess the degree of absorption was measured 40 ugm/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 14 % | Percentage systemic effect to assess the degree of absorption was measured at 100 ug/mouse. | ChEMBL. | 2362263 |
Systemic effect (functional) | = 14 % | Percentage systemic effect to assess the degree of absorption was measured at 100 ug/mouse. | ChEMBL. | 2362263 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.