Detailed information for compound 791797

Basic information

Technical information
  • TDR Targets ID: 791797
  • Name: 1-[(2,4-dimethylphenyl)methyl]-3-(4-methylphe nyl)thieno[2,3-e]pyrimidine-2,4-dione
  • MW: 376.471 | Formula: C22H20N2O2S
  • H donors: 0 H acceptors: 2 LogP: 4.97 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)n1c(=O)n(Cc2ccc(cc2C)C)c2c(c1=O)scc2
  • InChi: 1S/C22H20N2O2S/c1-14-5-8-18(9-6-14)24-21(25)20-19(10-11-27-20)23(22(24)26)13-17-7-4-15(2)12-16(17)3/h4-12H,13H2,1-3H3
  • InChiKey: CQBNPKCKNGMBKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,4-dimethylbenzyl)-3-(4-methylphenyl)thieno[2,3-e]pyrimidine-2,4-quinone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.193 0.2921
Schistosoma mansoni ets-related 0.0222 0.5903 1
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0305 0.0409
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0038 0.0305 0.0378
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0305 0.0074
Loa Loa (eye worm) hypothetical protein 0.0097 0.2091 0.2946
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.013 0.3086 0.948
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0097 0.2091 0.3183
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0135 0.324 0.5064
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0038 0.0305 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1323 0.2221
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0262 0.0192
Mycobacterium tuberculosis Probable reductase 0.0121 0.283 0.4392
Brugia malayi hypothetical protein 0.0036 0.0255 0.0338
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.013 0.3086 0.4811
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0262 0.0192
Echinococcus multilocularis thioredoxin glutathione reductase 0.0053 0.0763 0.0748
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.1374 0.1361
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0016 0.0022
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0097 0.2091 0.6476
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1402 1
Onchocerca volvulus 0.0038 0.0305 0.0474
Loa Loa (eye worm) hypothetical protein 0.013 0.3086 0.4348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0029 0.0022
Echinococcus granulosus tar DNA binding protein 0.0072 0.1323 0.1309
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0305 0.0409
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1323 0.2221
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Loa Loa (eye worm) hypothetical protein 0.0103 0.2282 0.3216
Mycobacterium ulcerans fatty-acid-CoA ligase 0.013 0.3086 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.007 0.1272 0.3576
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0029 0.0013
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0038 0.0305 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0029 0.0022
Onchocerca volvulus 0.0037 0.0262 0.0404
Echinococcus granulosus geminin 0.0171 0.4355 0.4346
Onchocerca volvulus 0.023 0.6123 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0029 0.0022
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0212
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0262 0.0419
Echinococcus multilocularis transcription factor Dp 1 0.0043 0.0454 0.0438
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0029 0.0013
Echinococcus multilocularis GPCR, family 2 0.0033 0.0141 0.0125
Loa Loa (eye worm) hypothetical protein 0.0033 0.0141 0.0199
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0038 0.0305 0.0263
Onchocerca volvulus 0.0047 0.0576 0.0917
Brugia malayi Ets-domain containing protein 0.0073 0.1374 0.1919
Brugia malayi AMP-binding enzyme family protein 0.013 0.3086 0.4336
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0053 0.0763 0.1011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.013 0.3086 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0262 0.0348
Mycobacterium tuberculosis Conserved protein 0.0037 0.0262 0.0192
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0305 0.0263
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0074 0.1402 0.4052
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0212
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0121 0.283 0.4392
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Loa Loa (eye worm) hypothetical protein 0.0153 0.3792 0.5343
Brugia malayi AMP-binding enzyme family protein 0.013 0.3086 0.4336
Leishmania major 4-coumarate:coa ligase-like protein 0.013 0.3086 1
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0262 0.0192
Schistosoma mansoni gabp alpha 0.0073 0.1374 0.2307
Brugia malayi Fli-1 protein 0.0222 0.5903 0.8315
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0255 0.024
Loa Loa (eye worm) RNA binding protein 0.0072 0.1323 0.1865
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.2282 0.3216
Onchocerca volvulus 0.0153 0.3792 0.6182
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0305 0.0409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.193 0.2921
Loa Loa (eye worm) thioredoxin reductase 0.0053 0.0763 0.1075
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0038 0.0305 0.3769
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.193 0.2921
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0016 0.0022
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0074 0.1402 0.1388
Entamoeba histolytica acyl-coA synthetase, putative 0.013 0.3086 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.2091 0.2946
Loa Loa (eye worm) TAR-binding protein 0.0072 0.1323 0.1865
Loa Loa (eye worm) hypothetical protein 0.013 0.3086 0.4348
Loa Loa (eye worm) hypothetical protein 0.0097 0.2091 0.2946
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0141 0.0125
Onchocerca volvulus 0.0029 0.0029 0.0021
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0255 0.024
Loa Loa (eye worm) beta-lactamase 0.0037 0.0262 0.037
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0141 0.0177
Schistosoma mansoni hypothetical protein 0.0126 0.2971 0.502
Echinococcus multilocularis geminin 0.0171 0.4355 0.4346
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.1272 0.1258
Mycobacterium tuberculosis Conserved protein 0.0037 0.0262 0.0192
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1001 0.1411
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0121 0.283 0.4392
Entamoeba histolytica acyl-CoA synthetase, putative 0.013 0.3086 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0038 0.0305 0.0263
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0092 0.193 0.2921
Loa Loa (eye worm) hypothetical protein 0.0052 0.0738 0.104
Brugia malayi AMP-binding enzyme family protein 0.0038 0.0305 0.0409
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0262 0.0192
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0262 0.0192
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.007 0.1272 0.2133
Brugia malayi Pre-SET motif family protein 0.0029 0.0029 0.0018
Echinococcus multilocularis tumor protein p63 0.0357 1 1
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0738 0.1227
Brugia malayi beta-lactamase family protein 0.0037 0.0262 0.0348
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0121 0.283 0.8621
Mycobacterium ulcerans hypothetical protein 0.013 0.3086 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0074 0.1402 0.2354
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0038 0.0305 0.0153
Mycobacterium tuberculosis Conserved protein 0.0037 0.0262 0.0192
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0038 0.0305 0.0409
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0305 0.0263
Echinococcus granulosus GPCR family 2 0.0033 0.0141 0.0125
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0305 0.0378
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0038 0.0305 0.3769
Toxoplasma gondii thioredoxin reductase 0.0053 0.0763 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0146 0.3589 0.3578
Mycobacterium tuberculosis Probable dehydrogenase 0.0121 0.283 0.4392
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0262 0.0192
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0038 0.0305 0.0263
Brugia malayi beta-lactamase 0.0037 0.0262 0.0348
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0072 0.1323 0.1865
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0305 0.043
Trichomonas vaginalis antibiotic synthetase, putative 0.0038 0.0305 0.0074
Loa Loa (eye worm) hypothetical protein 0.0038 0.0305 0.043
Mycobacterium ulcerans acyl-CoA synthetase 0.013 0.3086 1
Brugia malayi AMP-binding enzyme family protein 0.013 0.3086 0.4336
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0141 0.0125
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0038 0.0305 0.0145
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.2282 0.3201
Onchocerca volvulus 0.0038 0.0305 0.0474
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0074 0.1402 0.1958
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1323 0.2221
Schistosoma mansoni thyroid hormone receptor 0.0146 0.3589 0.6068
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0038 0.0305 0.029
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0262 0.037
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.6258 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0038 0.0305 0.0263
Plasmodium falciparum acyl-CoA synthetase 0.0097 0.2091 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0038 0.0305 0.029
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0262 0.0247
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0038 0.0305 0.0145
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0038 0.0305 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.013 0.3086 1
Trypanosoma cruzi trypanothione reductase, putative 0.0053 0.0763 0.4394
Loa Loa (eye worm) glutathione reductase 0.0053 0.0763 0.1075
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0038 0.0305 0.043
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.5277 0.7436
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0038 0.0305 0.0409
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.013 0.3086 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Loa Loa (eye worm) hypothetical protein 0.0097 0.2091 0.2946
Mycobacterium ulcerans acyl-CoA synthetase 0.013 0.3086 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0097 0.2091 0.5
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0038 0.0305 0.0153
Loa Loa (eye worm) hypothetical protein 0.0038 0.0305 0.043
Leishmania major 4-coumarate:coa ligase-like protein 0.013 0.3086 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.013 0.3086 1
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0074 0.1402 0.1388
Echinococcus granulosus thioredoxin glutathione reductase 0.0053 0.0763 0.0748
Plasmodium vivax thioredoxin reductase, putative 0.0053 0.0763 0.3562
Brugia malayi TAR-binding protein 0.0072 0.1323 0.1846
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0135 0.324 0.5064
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0126 0.2971 0.296
Toxoplasma gondii propionate-CoA ligase 0.0038 0.0305 0.3769
Echinococcus granulosus transcription factor Dp 1 0.0043 0.0454 0.0438
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0029 0.0013
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0141 0.0125
Brugia malayi beta-lactamase family protein 0.0037 0.0262 0.0348
Onchocerca volvulus 0.0037 0.0262 0.0404
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0074 0.1402 0.4037
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.007 0.1272 0.1844
Leishmania major trypanothione reductase 0.0053 0.0763 0.1773
Loa Loa (eye worm) hypothetical protein 0.0071 0.1291 0.1819
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0038 0.0305 0.0178
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.013 0.3086 0.4811
Mycobacterium ulcerans acetyl-CoA synthetase 0.0038 0.0305 0.0153
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0141 0.0199
Brugia malayi Ets-domain containing protein 0.0073 0.1374 0.1919
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Onchocerca volvulus 0.0037 0.0262 0.0404
Schistosoma mansoni thyroid hormone receptor 0.0146 0.3589 0.6068
Brugia malayi RNA recognition motif domain containing protein 0.0072 0.1323 0.1846
Onchocerca volvulus 0.0052 0.0738 0.1182
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1402 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0038 0.0305 0.0145
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.007 0.1272 0.1258
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0038 0.0305 0.0153
Loa Loa (eye worm) hypothetical protein 0.0029 0.0016 0.0022
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0038 0.0305 0.0263
Loa Loa (eye worm) hypothetical protein 0.013 0.3086 0.4348
Plasmodium falciparum glutathione reductase 0.0053 0.0763 0.2563
Plasmodium vivax acyl-CoA synthetase, putative 0.0097 0.2091 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Mycobacterium ulcerans acyl-CoA synthetase 0.013 0.3086 1
Brugia malayi glutathione reductase 0.0053 0.0763 0.1055
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0126 0.2971 0.296
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0141 0.0177
Entamoeba histolytica acyl-CoA synthetase, putative 0.013 0.3086 1
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0212
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0305 0.0263
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0121 0.283 0.4392
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0305 0.0378
Schistosoma mansoni hypothetical protein 0.0036 0.0255 0.0406
Schistosoma mansoni hypothetical protein 0.0071 0.1291 0.2166
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.1272 0.3576
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.007 0.1272 0.1774
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Plasmodium vivax glutathione reductase, putative 0.0053 0.0763 0.3562
Plasmodium vivax acetyl-CoA synthetase, putative 0.0038 0.0305 0.1342
Brugia malayi Pre-SET motif family protein 0.0202 0.5277 0.743
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0262 0.0192
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0141 0.0125
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0038 0.0305 0.0378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Loa Loa (eye worm) hypothetical protein 0.0097 0.2091 0.2946
Brugia malayi hypothetical protein 0.0153 0.3792 0.5333
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0038 0.0305 0.0263
Trichomonas vaginalis set domain proteins, putative 0.023 0.6123 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0038 0.0305 0.0153
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.007 0.1272 0.3576
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0038 0.0305 0.0263
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0262 0.1133
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0074 0.1402 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Onchocerca volvulus 0.013 0.3086 0.5026
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0305 0.0153
Schistosoma mansoni acetyl-CoA synthetase 0.0038 0.0305 0.0492
Loa Loa (eye worm) hypothetical protein 0.0029 0.0029 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0255 0.0406
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1323 0.2221
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0038 0.0305 0.0153
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.013 0.3086 0.948
Loa Loa (eye worm) oxidoreductase 0.0038 0.0305 0.043
Schistosoma mansoni hypothetical protein 0.0033 0.0141 0.0212
Schistosoma mansoni tar DNA-binding protein 0.0072 0.1323 0.2221
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.0305 0.0263
Trypanosoma brucei trypanothione reductase 0.0053 0.0763 0.4394
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.1374 0.1937
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0305 0.0378
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0262 0.7096 1
Loa Loa (eye worm) hypothetical protein 0.0063 0.1052 0.1482
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0029 0.0022
Loa Loa (eye worm) fli-1 protein 0.0222 0.5903 0.8319
Schistosoma mansoni hypothetical protein 0.0171 0.4355 0.737
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0074 0.1402 0.1976
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.2282 0.3201
Plasmodium falciparum thioredoxin reductase 0.0053 0.0763 0.2563
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0121 0.283 0.4392
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1291 0.1801
Onchocerca volvulus 0.0038 0.0305 0.0474
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0305 0.0153
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0262 0.0419
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0038 0.0305 0.0378
Schistosoma mansoni hypothetical protein 0.0171 0.4355 0.737
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0135 0.324 1
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.1374 0.1361
Brugia malayi RNA binding protein 0.0072 0.1323 0.1846
Brugia malayi follicle stimulating hormone receptor 0.0262 0.7096 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0038 0.0305 0.0153
Mycobacterium tuberculosis Probable oxidoreductase 0.0135 0.324 0.5064
Loa Loa (eye worm) hypothetical protein 0.0037 0.0262 0.037
Toxoplasma gondii ABC1 family protein 0.0037 0.0262 0.3182
Leishmania major acetyl-CoA synthetase, putative 0.0038 0.0305 0.0153
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0262 0.0247
Brugia malayi Thioredoxin reductase 0.0053 0.0763 0.1055
Echinococcus multilocularis tar DNA binding protein 0.0072 0.1323 0.1309

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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