Detailed information for compound 792218

Basic information

Technical information
  • TDR Targets ID: 792218
  • Name: N-(2,5-dimethylphenyl)tetrazolo[5,1-c]quinoxa lin-4-amine
  • MW: 290.323 | Formula: C16H14N6
  • H donors: 1 H acceptors: 4 LogP: 3.27 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)Nc1nc2ccccc2n2c1nnn2)C
  • InChi: 1S/C16H14N6/c1-10-7-8-11(2)13(9-10)18-15-16-19-20-21-22(16)14-6-4-3-5-12(14)17-15/h3-9H,1-2H3,(H,17,18)
  • InChiKey: MFFDDXPMGVGQDF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethylphenyl)-4-tetrazolo[5,1-c]quinoxalinamine
  • (2,5-dimethylphenyl)-(tetrazolo[5,1-c]quinoxalin-4-yl)amine
  • N-(2,5-dimethylphenyl)-[1,2,3,4]tetrazolo[5,1-c]quinoxalin-4-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Echinococcus multilocularis smad 0.0024 0.0061 0.0096
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0124 0.0194
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0139 0.0419
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0155 0.1071
Loa Loa (eye worm) RNA binding protein 0.0389 0.328 1
Brugia malayi hypothetical protein 0.005 0.0291 0.0884
Plasmodium vivax hypothetical protein, conserved 0.018 0.1437 1
Loa Loa (eye worm) TAR-binding protein 0.0389 0.328 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0355 0.2978 0.9062
Brugia malayi MAP kinase sur-1 0.0055 0.0334 0.1015
Plasmodium vivax thioredoxin reductase, putative 0.005 0.029 0.2012
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1437 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0124 0.0194
Brugia malayi glutathione reductase 0.005 0.029 0.0881
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0124 0.0194
Brugia malayi RNA recognition motif domain containing protein 0.0389 0.328 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0124 0.0194
Mycobacterium tuberculosis Conserved protein 0.018 0.1437 0.1437
Leishmania major hypothetical protein, conserved 0.018 0.1437 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0124 0.0194
Loa Loa (eye worm) hypothetical protein 0.0031 0.0122 0.0188
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.029 0.029
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1437 0.7111
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0008 0.0048
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0857 0.0857
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0378
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0857 0.0857
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0124 0.0375
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0254 0.2088 0.3247
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0155 0.1071
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1437 0.7111
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0216
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1096 0.1704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0124 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0122 0.019
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.029 0.0452
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0122 0.019
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0124 0.0194
Loa Loa (eye worm) thioredoxin reductase 0.005 0.029 0.0711
Brugia malayi MH2 domain containing protein 0.0024 0.0061 0.0183
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0124 0.0196
Echinococcus granulosus geminin 0.0183 0.1464 0.2277
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0191 0.0298
Brugia malayi hypothetical protein 0.0039 0.0191 0.0579
Schistosoma mansoni hypothetical protein 0.0023 0.0047 0.0073
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0234 0.0364
Mycobacterium leprae conserved hypothetical protein 0.018 0.1437 1
Leishmania major hypothetical protein, conserved 0.005 0.0291 0.2019
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0105 0.0317
Onchocerca volvulus 0.0031 0.0124 0.0099
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0124 0.0194
Schistosoma mansoni lamin 0.0029 0.0105 0.0164
Schistosoma mansoni hypothetical protein 0.0071 0.0476 0.0741
Brugia malayi Smad1 0.0024 0.0061 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0405 0.282
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0124 0.0196
Onchocerca volvulus 0.018 0.1437 0.6952
Brugia malayi beta-lactamase family protein 0.018 0.1437 0.438
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0001 0.0007
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0061 0.0096
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0124 0.0375
Echinococcus multilocularis musashi 0.0029 0.0105 0.0164
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0405 0.2812
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0122 0.019
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0857 0.0857
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1096 0.1704
Echinococcus granulosus lamin dm0 0.0029 0.0105 0.0164
Echinococcus granulosus beta LACTamase domain containing family member 0.018 0.1437 0.2235
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0278
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0124 0.0194
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.029 0.0452
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0405 0.063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0155 0.0767
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0047 0.0073
Schistosoma mansoni intermediate filament proteins 0.0029 0.0105 0.0164
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.1437 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0334 0.052
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Trypanosoma brucei protein kinase, putative 0.0055 0.0334 0.2318
Schistosoma mansoni hypothetical protein 0.0254 0.2088 0.3247
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0124 0.0375
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0279
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0096
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0112 0.0174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0124 0.0375
Echinococcus granulosus Smad4 0.0024 0.0061 0.0096
Plasmodium falciparum thioredoxin reductase 0.005 0.029 0.9967
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0124 0.0375
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0122 0.019
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0334 0.2318
Schistosoma mansoni tar DNA-binding protein 0.0389 0.328 0.5101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0155 0.0767
Mycobacterium tuberculosis Probable reductase 0.0114 0.0857 0.0857
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0405 0.063
Onchocerca volvulus 0.0031 0.0122 0.0087
Echinococcus multilocularis thyroid hormone receptor alpha 0.0285 0.2364 0.3676
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0122 0.019
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0124 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0076 0.0378
Mycobacterium tuberculosis Conserved protein 0.018 0.1437 0.1437
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.018 0.1437 0.438
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0001 0.001
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1096 0.1704
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Brugia malayi beta-lactamase family protein 0.018 0.1437 0.438
Loa Loa (eye worm) hypothetical protein 0.0033 0.0139 0.0241
Echinococcus granulosus microtubule associated protein 2 0.0746 0.6429 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0334 0.0847
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0139 0.0419
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0234 0.1618
Mycobacterium ulcerans lipase LipD 0.018 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.018 0.1437 0.1437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0278
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0124 0.0194
Loa Loa (eye worm) transcription factor SMAD2 0.0355 0.2978 0.9062
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0001 0.5
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0124 0.0375
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0857 0.5961
Echinococcus granulosus GPCR family 2 0.0033 0.0139 0.0216
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0105 0.0137
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0334 0.2318
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0857 0.0857
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0135 0.093
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0405 0.2812
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0031 0.0203
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0141 0.1096 0.3213
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0124 0.0194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0124 0.0196
Loa Loa (eye worm) hypothetical protein 0.0071 0.0476 0.1289
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0124 0.0375
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0334 0.2318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0234 0.1157
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.1437 0.7111
Mycobacterium tuberculosis Probable hydrolase 0.018 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0001 0.0001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0001 1
Trypanosoma brucei hypothetical protein, conserved 0.018 0.1437 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.1437 0.7111
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.018 0.1437 0.4275
Loa Loa (eye worm) hypothetical protein 0.0116 0.0873 0.2521
Mycobacterium ulcerans esterase/lipase LipP 0.018 0.1437 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0389 0.328 1
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0124 0.0194
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0124 0.0194
Echinococcus granulosus intermediate filament protein 0.0029 0.0105 0.0164
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0216
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0061 0.0096
Toxoplasma gondii thioredoxin reductase 0.005 0.029 0.2012
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0291 0.2019
Schistosoma mansoni tar DNA-binding protein 0.0389 0.328 0.5101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0279
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0969 0.0969
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0191 0.0298
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0124 0.0194
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0334 0.2318
Brugia malayi steroid hormone receptor 0.0031 0.0124 0.0375
Echinococcus multilocularis lamin dm0 0.0029 0.0105 0.0164
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0234 0.1618
Schistosoma mansoni smad1 5 8 and 0.0024 0.0061 0.0096
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0124 0.0194
Onchocerca volvulus 0.018 0.1437 0.6952
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0061 0.0096
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0124 0.0196
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0216
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0767 0.2335
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0334 0.2318
Echinococcus multilocularis geminin 0.0183 0.1464 0.2277
Onchocerca volvulus 0.018 0.1437 0.6952
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0405 0.0405
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0334 0.052
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.1757 0.527
Plasmodium vivax SET domain protein, putative 0.0031 0.0122 0.084
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0061 0.0096
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0141 0.1096 0.1704
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.018 0.1437 0.1437
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.1437 0.2235
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0124 0.0194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0124 0.0194
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0334 0.1654
Giardia lamblia GTOR 0.0044 0.0234 0.6983
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0124 0.0375
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0234 0.1618
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0291 1
Schistosoma mansoni hypothetical protein 0.0039 0.0191 0.0298
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.6429 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0334 0.2318
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0234 0.1157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0079 0.0389
Treponema pallidum NADH oxidase 0.0017 0.0001 1
Brugia malayi Thioredoxin reductase 0.005 0.029 0.0881
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0234 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.018 0.1437 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0969 0.0969
Brugia malayi TAR-binding protein 0.0389 0.328 1
Brugia malayi Pre-SET motif family protein 0.0217 0.1757 0.5356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0155 0.0767
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.1437 0.7111
Plasmodium falciparum glutathione reductase 0.005 0.029 0.9967
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0124 0.0196
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0254 0.2088 0.3247
Loa Loa (eye worm) hypothetical protein 0.005 0.0291 0.0714
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0155 0.0767
Mycobacterium tuberculosis Probable lipase LipD 0.018 0.1437 0.1437
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0177 0.0878
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0334 0.1654
Echinococcus multilocularis tar DNA binding protein 0.0389 0.328 0.5101
Brugia malayi hypothetical protein 0.0032 0.0134 0.0405
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Loa Loa (eye worm) hypothetical protein 0.0029 0.0101 0.0122
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0191 0.0298
Schistosoma mansoni lamin 0.0029 0.0105 0.0164
Schistosoma mansoni tar DNA-binding protein 0.0389 0.328 0.5101
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0124 0.0375
Brugia malayi intermediate filament protein 0.0029 0.0105 0.0317
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0969 0.0969
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0476 0.1449
Echinococcus multilocularis transcription factor eb 0.0117 0.0878 0.1365
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0124 0.0194
Loa Loa (eye worm) glutathione reductase 0.005 0.029 0.0711
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0291 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0155 0.0767
Schistosoma mansoni thyroid hormone receptor 0.0285 0.2364 0.3676
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0124 0.0375
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0334 0.052
Schistosoma mansoni hypothetical protein 0.0183 0.1464 0.2277
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0767 0.2192
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0405 0.282
Schistosoma mansoni Smad4 0.0024 0.0061 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0122 0.019
Echinococcus multilocularis GPCR, family 2 0.0033 0.0139 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0124 0.0375
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Brugia malayi Pre-SET motif family protein 0.0031 0.0122 0.0368
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0334 0.1654
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0124 0.0194
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0334 0.2318
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0234 0.1618
Loa Loa (eye worm) hypothetical protein 0.0104 0.0767 0.2192
Echinococcus granulosus lamin 0.0029 0.0105 0.0164
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0105 0.0137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0124 0.0196
Brugia malayi MH2 domain containing protein 0.0355 0.2978 0.9079
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0001 0.0002
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0405 0.282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0124 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.6429 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0124 0.0194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0079 0.0389
Onchocerca volvulus 0.0246 0.2021 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0234 0.1618
Loa Loa (eye worm) hypothetical protein 0.0031 0.0124 0.0196
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0234 0.0364
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0124 0.0194
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0139 0.0216
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0107 0.0529
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0234 0.0364
Mycobacterium ulcerans hypothetical protein 0.018 0.1437 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0405 0.063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0122 0.084
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0234 0.0536
Brugia malayi nuclear hormone receptor 0.0031 0.0124 0.0375
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0767 0.2335
Brugia malayi beta-lactamase 0.018 0.1437 0.438
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0001 0.0002
Mycobacterium tuberculosis Probable conserved lipoprotein 0.018 0.1437 0.1437
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0124 0.0375
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0334 0.1654
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0056 0.0279
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0124 0.0194
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2021 1
Trypanosoma brucei trypanothione reductase 0.005 0.029 0.2012
Brugia malayi MH1 domain containing protein 0.0024 0.0061 0.0183
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0216
Mycobacterium tuberculosis Probable esterase LipL 0.018 0.1437 0.1437
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0405 0.063
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0124 0.0194
Echinococcus multilocularis Smad4 0.0024 0.0061 0.0096
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0047 0.0073
Loa Loa (eye worm) beta-lactamase 0.018 0.1437 0.4275
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0216
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0291 0.2019
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0124 0.0099
Schistosoma mansoni smad 0.0024 0.0061 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0141 0.1096 0.3337
Schistosoma mansoni tar DNA-binding protein 0.0389 0.328 0.5101
Mycobacterium tuberculosis Probable lipase LipE 0.018 0.1437 0.1437
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0234 0.1618
Schistosoma mansoni hypothetical protein 0.0033 0.0139 0.0216
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Schistosoma mansoni tar DNA-binding protein 0.0389 0.328 0.5101
Schistosoma mansoni thyroid hormone receptor 0.0285 0.2364 0.3676
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0124 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0124 0.0375
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0291 0.2019
Leishmania major trypanothione reductase 0.005 0.029 0.2012
Toxoplasma gondii ABC1 family protein 0.018 0.1437 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0061 0.0096
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0334 0.2318
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0234 0.0709
Echinococcus granulosus tar DNA binding protein 0.0389 0.328 0.5101
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0116 0.0873 0.2521
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0001 0.001
Brugia malayi ecdysteroid receptor 0.0031 0.0124 0.0375
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0001 0.0002
Plasmodium vivax glutathione reductase, putative 0.005 0.029 0.2012
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0122 0.019
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0969 0.6744
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.029 0.2012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0135 0.0668
Mycobacterium ulcerans beta-lactamase 0.018 0.1437 1
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0334 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0234 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0234 0.1157
Echinococcus multilocularis beta LACTamase domain containing family member 0.018 0.1437 0.2235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0099 0.0488
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0124 0.0375
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0291 0.2019
Schistosoma mansoni coup transcription factor 0.0031 0.0124 0.0194
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0139 0.0216
Mycobacterium leprae Probable lipase LipE 0.018 0.1437 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0117 0.0878 0.2673
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0124 0.0194
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0001 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.1437 0.2235
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0334 0.052
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0124 0.0099
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0124 0.0099
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0155 0.1071
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0857 0.0857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1096 0.1704
Echinococcus granulosus smad 0.0024 0.0061 0.0096
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0291 0.2019
Mycobacterium tuberculosis Conserved protein 0.018 0.1437 0.1437
Loa Loa (eye worm) hypothetical protein 0.018 0.1437 0.4275
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0124 0.0194
Echinococcus granulosus transcription factor eb 0.0117 0.0878 0.1365
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0141 0.1096 0.1704
Brugia malayi nuclear receptor NHR-88 0.0031 0.0124 0.0375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0141 0.1096 0.1704
Echinococcus multilocularis lamin 0.0029 0.0105 0.0164
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0124 0.0196
Brugia malayi RNA binding protein 0.0389 0.328 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0139 0.0241
Loa Loa (eye worm) hypothetical protein 0.0029 0.0105 0.0137
Trichomonas vaginalis esterase, putative 0.018 0.1437 0.7111
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0124 0.0194
Schistosoma mansoni hypothetical protein 0.0183 0.1464 0.2277
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0334 0.052
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0001 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0079 0.0389
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0124 0.0375

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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