Detailed information for compound 792289

Basic information

Technical information
  • TDR Targets ID: 792289
  • Name: N-(2,4-dimethylphenyl)-[1,2,4]triazolo[3,4-c] quinoxalin-4-amine
  • MW: 289.335 | Formula: C17H15N5
  • H donors: 1 H acceptors: 3 LogP: 4.14 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)C)Nc1nc2ccccc2n2c1nnc2
  • InChi: 1S/C17H15N5/c1-11-7-8-13(12(2)9-11)19-16-17-21-18-10-22(17)15-6-4-3-5-14(15)20-16/h3-10H,1-2H3,(H,19,20)
  • InChiKey: NTCYECWYLMYKAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2,4-dimethylphenyl)-([1,2,4]triazolo[3,4-c]quinoxalin-4-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0033 0.0129 0.0218
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.144 0.2427
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0063 0.0383 0.1411
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.024
Echinococcus granulosus beta LACTamase domain containing family member 0.0188 0.144 0.2427
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0852 0.5696
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0036 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1122 0.1891
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0499 0.0841
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0305 0.1397
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0101 0.0374
Schistosoma mansoni hypothetical protein 0.0041 0.0202 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.144 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0383 0.1759
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0101 0.0374
Plasmodium vivax glutathione reductase, putative 0.0052 0.029 0.1996
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0073 0.0488
Brugia malayi glutathione reductase 0.0052 0.029 0.1069
Onchocerca volvulus 0.0188 0.144 0.6609
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0036 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.144 0.2427
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0443 0.0747
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0036 0.006
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0019 0.0008 0.0032
Loa Loa (eye worm) beta-lactamase 0.0188 0.144 0.5307
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0036 0.006
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0073 0.0488
Echinococcus granulosus lamin dm0 0.003 0.0101 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1122 0.1891
Brugia malayi intermediate filament protein 0.003 0.0101 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.144 1
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.144 0.666
Onchocerca volvulus 0.003 0.0101 0.031
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0852 0.0849
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0036 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1122 0.1891
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0033 0.0129 0.0218
Loa Loa (eye worm) RNA binding protein 0.0338 0.2713 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0142 0.024
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0583
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0036 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.015 0.1122 0.1891
Trypanosoma cruzi target of rapamycin kinase 3 0.0054 0.0305 0.21
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0164 0.0744
Mycobacterium tuberculosis Conserved protein 0.0188 0.144 0.1437
Schistosoma mansoni tar DNA-binding protein 0.0338 0.2713 0.4573
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0188 0.144 0.1437
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0276 0.1476
Trypanosoma brucei trypanothione reductase 0.0052 0.029 0.1996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0036 0.0131
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0021 0.0026 0.0157
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0073 0.1413
Brugia malayi MH2 domain containing protein 0.024 0.1885 0.6949
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0019 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Onchocerca volvulus 0.0034 0.0142 0.0502
Loa Loa (eye worm) hypothetical protein 0.0038 0.0173 0.0636
Brugia malayi beta-lactamase family protein 0.0188 0.144 0.5307
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0036 0.0131
Schistosoma mansoni lamin 0.003 0.0101 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0321 0.1185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0383 0.1759
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0338 0.2713 1
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0276 0.0465
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0852 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0164 0.0744
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.029 0.1996
Loa Loa (eye worm) hypothetical protein 0.0026 0.0073 0.027
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0964 0.6515
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0076 0.0505
Schistosoma mansoni tar DNA-binding protein 0.0338 0.2713 0.4573
Onchocerca volvulus 0.0273 0.216 1
Schistosoma mansoni hypothetical protein 0.0038 0.0173 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0036 0.0131
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0025 0.0061 0.0399
Leishmania major trypanothione reductase 0.0052 0.029 0.1996
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0321 0.1185
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.144 0.666
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0063 0.0383 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0036 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0262 0.1198
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 0.3453
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0033 0.0129 0.0876
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0036 0.0131
Loa Loa (eye worm) phosphatidylinositol 3 0.0063 0.0383 0.1411
Echinococcus granulosus intermediate filament protein 0.003 0.0101 0.0171
Entamoeba histolytica hypothetical protein 0.0041 0.0202 0.517
Schistosoma mansoni microtubule-associated protein tau 0.0718 0.5933 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0129 0.0476
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0036 0.006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0036 0.006
Loa Loa (eye worm) phosphatidylinositol 3 0.0033 0.0129 0.0476
Schistosoma mansoni thyroid hormone receptor 0.0293 0.2332 0.3931
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0063 0.0383 0.0645
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0188 0.144 0.5307
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0499 0.0841
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0443 0.0747
Trichomonas vaginalis set domain proteins, putative 0.0273 0.216 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0944
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0036 0.006
Plasmodium vivax SET domain protein, putative 0.0034 0.0142 0.0967
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0036 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0073 0.0488
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0374
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 0.3453
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Brugia malayi Thioredoxin reductase 0.0052 0.029 0.1069
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0063 0.0383 0.0645
Onchocerca volvulus 0.0188 0.144 0.6609
Mycobacterium tuberculosis Probable esterase LipL 0.0188 0.144 0.1437
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0036 0.006
Echinococcus granulosus lamin 0.003 0.0101 0.0171
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0142 0.024
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0036 0.0131
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0276 0.0273
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1885 0.6949
Schistosoma mansoni lamin 0.003 0.0101 0.0171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0499 0.3111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Mycobacterium ulcerans esterase/lipase LipP 0.0188 0.144 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.1037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.029 0.1996
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0036 0.006
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0964 0.0961
Toxoplasma gondii target of rapamycin (TOR), putative 0.0051 0.0285 0.1961
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0063 0.0383 0.2642
Echinococcus granulosus microtubule associated protein 2 0.0718 0.5933 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0036 0.006
Toxoplasma gondii thioredoxin reductase 0.0052 0.029 0.1996
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0188 0.144 0.1437
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0033 0.0129 0.0876
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.024
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0443 0.3062
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Mycobacterium ulcerans lipase LipD 0.0188 0.144 1
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0036 0.0131
Toxoplasma gondii hypothetical protein 0.0026 0.0074 0.0496
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Schistosoma mansoni hypothetical protein 0.0186 0.1424 0.24
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.015 0.1122 0.4136
Echinococcus granulosus geminin 0.0186 0.1424 0.24
Mycobacterium tuberculosis Probable hydrolase 0.0188 0.144 0.1437
Loa Loa (eye worm) hypothetical protein 0.0027 0.0076 0.0279
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0443 0.3062
Leishmania major hypothetical protein, conserved 0.0026 0.0073 0.0488
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0443 0.0747
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0063 0.0383 0.0645
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0036 0.006
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.024 0.188 0.693
Brugia malayi steroid hormone receptor 0.0022 0.0036 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0036 0.006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0964 0.0961
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0852 0.0849
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0073 0.0488
Schistosoma mansoni intermediate filament proteins 0.003 0.0101 0.0171
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.029 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0305 0.1397
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0271 0.2148 0.3621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0584
Plasmodium falciparum glutathione reductase 0.0052 0.029 0.5782
Echinococcus granulosus tar DNA binding protein 0.0338 0.2713 0.4573
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1885 0.6949
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0945
Leishmania major hypothetical protein, conserved 0.0188 0.144 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.029 0.1069
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0036 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0944
Schistosoma mansoni tar DNA-binding protein 0.0338 0.2713 0.4573
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0036 0.006
Entamoeba histolytica hypothetical protein 0.0041 0.0202 0.517
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0945
Trichomonas vaginalis PIKK family atypical protein kinase 0.0063 0.0383 0.1759
Schistosoma mansoni tar DNA-binding protein 0.0338 0.2713 0.4573
Loa Loa (eye worm) hypothetical protein 0.0034 0.0142 0.0524
Mycobacterium tuberculosis Probable lipase LipD 0.0188 0.144 0.1437
Echinococcus multilocularis geminin 0.0186 0.1424 0.24
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0036 0.006
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0443 0.0747
Trichomonas vaginalis PIKK family atypical protein kinase 0.0051 0.0285 0.1306
Mycobacterium ulcerans beta-lactamase 0.0188 0.144 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0188 0.144 0.5307
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0499 0.0841
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0142 0.024
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0443 0.3062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0142 0.024
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0852 0.0849
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0036 0.006
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0063 0.0383 0.2642
Leishmania major phosphatidylinositol 3-kinase, putative 0.0033 0.0129 0.0876
Brugia malayi Probable ClpP-like protease 0.0077 0.0499 0.184
Schistosoma mansoni fkbp-rapamycin associated protein 0.0019 0.0008 0.0013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1122 0.1891
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0073 0.1413
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0054 0.0305 0.21
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0305 0.1397
Schistosoma mansoni tar DNA-binding protein 0.0338 0.2713 0.4573
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0036 0.0131
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0964 0.0961
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0036 0.0131
Brugia malayi hypothetical protein 0.0041 0.0202 0.0743
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0276 0.0273
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0036 0.006
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0074 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0945
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0063 0.0383 0.2642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0008 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0019 0.0008 0.0022
Mycobacterium tuberculosis Conserved protein 0.0188 0.144 0.1437
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0129 0.0876
Trichomonas vaginalis esterase, putative 0.0188 0.144 0.666
Mycobacterium tuberculosis Probable lipase LipE 0.0188 0.144 0.1437
Mycobacterium tuberculosis Probable reductase 0.0118 0.0852 0.0849
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0033 0.0129 0.0876
Entamoeba histolytica hypothetical protein 0.0033 0.0129 0.3237
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0074 0.1436
Echinococcus multilocularis lamin dm0 0.003 0.0101 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0188 0.144 1
Loa Loa (eye worm) TAR-binding protein 0.0338 0.2713 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0499 0.3453
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0443 0.3062
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0036 0.006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0271 0.2148 0.3621
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0063 0.0383 0.2642
Entamoeba histolytica hypothetical protein 0.0041 0.0202 0.517
Brugia malayi RNA binding protein 0.0338 0.2713 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0036 0.006
Mycobacterium ulcerans hypothetical protein 0.0188 0.144 1
Brugia malayi beta-lactamase 0.0188 0.144 0.5307
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0036 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0036 0.0131
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Schistosoma mansoni hypothetical protein 0.0271 0.2148 0.3621
Echinococcus multilocularis serine protein kinase ATM 0.0033 0.0129 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0036 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0036 0.0131
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0033 0.0129 0.0877
Brugia malayi hypothetical protein 0.0026 0.0073 0.027
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.003 0.0104 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0305 0.1397
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0036 0.006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0164 0.0744
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0063 0.0383 0.2642
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0201 0.0919
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0227 0.1037
Mycobacterium tuberculosis Conserved protein 0.0188 0.144 0.1437
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.144 0.666
Echinococcus multilocularis thyroid hormone receptor alpha 0.0293 0.2332 0.3931
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0006
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0033 0.0129 0.0218
Schistosoma mansoni hypothetical protein 0.0186 0.1424 0.24
Loa Loa (eye worm) hypothetical protein 0.0022 0.0036 0.0131
Schistosoma mansoni coup transcription factor 0.0022 0.0036 0.006
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0003 0.0006
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0003 0.0012
Echinococcus multilocularis microtubule associated protein 2 0.0718 0.5933 1
Brugia malayi Pre-SET motif family protein 0.0034 0.0142 0.0524
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.144 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0184 0.0836
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.015 0.1122 0.1891
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0443 0.3062
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0583
Plasmodium vivax hypothetical protein, conserved 0.0188 0.144 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0499 0.184
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0036 0.0131
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0036 0.006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0443 0.044
Brugia malayi beta-lactamase family protein 0.0188 0.144 0.5307
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0036 0.0131
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0033 0.0129 0.0877
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0276 0.0465
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0188 0.144 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.029 0.0489
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0036 0.006
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0132 0.0222
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0357
Toxoplasma gondii FATC domain-containing protein 0.0033 0.0129 0.0877
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0019 0.0008 0.0013
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0056 0.0321 0.1185
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0499 0.3453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0202 0.034
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0063 0.0383 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0583
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0063 0.0383 0.2642
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0188 0.144 0.1437
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0173 0.0636
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.015 0.1122 0.1891
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0036 0.006
Onchocerca volvulus 0.0188 0.144 0.6609
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0036 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0036 0.006
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0033 0.0129 0.0218
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0852 0.0849
Leishmania major phosphatidylinositol kinase related protein, putative 0.0021 0.0026 0.0158
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0036 0.0131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Plasmodium falciparum thioredoxin reductase 0.0052 0.029 0.5782
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0074 0.1436
Brugia malayi RNA recognition motif domain containing protein 0.0338 0.2713 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0073 0.0488
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0008 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.144 0.666
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0499 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0188 0.144 0.2427
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0033 0.0129 0.0876
Brugia malayi ecdysteroid receptor 0.0022 0.0036 0.0131
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0305 0.1397
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0202 0.034
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.144 0.666
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.029 0.0489
Entamoeba histolytica hypothetical protein 0.0041 0.0202 0.517
Brugia malayi TAR-binding protein 0.0338 0.2713 1
Schistosoma mansoni thyroid hormone receptor 0.0293 0.2332 0.3931
Echinococcus multilocularis tar DNA binding protein 0.0338 0.2713 0.4573
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0142 0.024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0036 0.0131
Brugia malayi nuclear hormone receptor 0.0022 0.0036 0.0131
Loa Loa (eye worm) hypothetical protein 0.0188 0.144 0.5307
Loa Loa (eye worm) intermediate filament protein 0.003 0.0101 0.0374
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0321 0.1185
Giardia lamblia GTOR 0.0063 0.0383 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0036 0.0131
Echinococcus multilocularis musashi 0.003 0.0101 0.0171
Echinococcus multilocularis lamin 0.003 0.0101 0.0171
Onchocerca volvulus 0.003 0.0101 0.031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.029 0.0287
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0944
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0207 0.0945
Loa Loa (eye worm) hypothetical protein 0.0021 0.0026 0.0095
Toxoplasma gondii ABC1 family protein 0.0188 0.144 1
Brugia malayi Pre-SET motif family protein 0.024 0.188 0.693
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0202 0.034
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0026 0.0158
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0036 0.006
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0033 0.0129 0.0476
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0499 0.3453
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0036 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0036 0.0131
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0054 0.0305 0.21
Mycobacterium leprae Probable lipase LipE 0.0188 0.144 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0142 0.0967
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.015 0.1122 0.4136
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0026 0.0105
Echinococcus granulosus serine protein kinase ATM 0.0033 0.0129 0.0218

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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