Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Human immunodeficiency virus 1 | Aberrant vpr protein | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.1028 | 0.3213 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.1028 | 0.3213 |
Echinococcus multilocularis | geminin | 0.0168 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3199 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3199 | 0.3199 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1028 | 0.1028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3199 | 0.3199 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3199 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3199 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0108 | 0.5525 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0108 | 0.5525 | 0.5525 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.1148 | 0.3588 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3199 | 0.3199 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.1148 | 0.3588 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.1148 | 0.3588 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3199 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1028 | 0.1028 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3199 | 0.3199 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3199 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.1148 | 0.3588 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.1028 | 0.1028 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3199 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3199 | 0.242 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3199 | 0.242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.