Detailed information for compound 792738

Basic information

Technical information
  • TDR Targets ID: 792738
  • Name: 2-[2-oxo-2-(3-oxo-2,4-dihydroquinoxalin-1-yl) ethoxy]acetic acid
  • MW: 264.234 | Formula: C12H12N2O5
  • H donors: 2 H acceptors: 4 LogP: -0.26 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccccc2N(C1)C(=O)COCC(=O)O
  • InChi: 1S/C12H12N2O5/c15-10-5-14(11(16)6-19-7-12(17)18)9-4-2-1-3-8(9)13-10/h1-4H,5-7H2,(H,13,15)(H,17,18)
  • InChiKey: GCRQQWTWSHLEOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[2-keto-2-(3-keto-2,4-dihydroquinoxalin-1-yl)ethoxy]acetic acid
  • 2-[2-oxo-2-(3-oxo-2,4-dihydroquinoxalin-1-yl)ethoxy]ethanoic acid
  • BAS 14051447
  • [2-Oxo-2-(3-oxo-3,4-dihydro-2H-quinoxalin-1-yl)-ethoxy]-acetic acid
  • A3859/0163908

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tar DNA-binding protein 0.0379 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0165 0.8693
Schistosoma mansoni hypothetical protein 0.1028 1 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0465 0.1552
Loa Loa (eye worm) hypothetical protein 0.0051 0.0329 0.0409
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0409 0.2752
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Schistosoma mansoni coup transcription factor 0.003 0.0124 0.0124
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0186 0.0215
Echinococcus multilocularis thyroid hormone receptor alpha 0.003 0.0124 0.0124
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0186 0.0565
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.003 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Echinococcus multilocularis ecdysone induced protein 78C 0.003 0.0124 0.0124
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0186 0.0565
Schistosoma mansoni tar DNA-binding protein 0.0379 0.358 0.358
Echinococcus multilocularis tumor protein p63 0.0699 0.6742 0.6742
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0165 0.0491
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0901 0.0901
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0379 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.0767 0.7423 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0465 0.0465
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0329 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0054 0.0095
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1256 0.4357
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0165 0.0187
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0409 0.0409
Leishmania major pyruvate kinase 0.0034 0.0165 0.0491
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0465 0.1552
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0251 0.0794
Echinococcus multilocularis geminin 0.1028 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0186 1
Schistosoma mansoni nuclear hormone receptor 0.003 0.0124 0.0124
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0027
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0186 0.0186
Schistosoma mansoni retinoid-x-receptor (RXR) 0.003 0.0124 0.0124
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0165 0.1421
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0165 0.0187
Schistosoma mansoni hypothetical protein 0.0023 0.0052 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.003 0.0124 0.0124
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0409 0.1357
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0186 0.0215
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0246 0.2264 0.3025
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0329 0.1072
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0186 0.0758
Onchocerca volvulus Protein ultraspiracle homolog 0.003 0.0124 0.0891
Brugia malayi Muscleblind-like protein 0.0767 0.7423 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0165 0.1421
Echinococcus multilocularis G protein coupled receptor 139 0.0156 0.137 0.137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.003 0.0124 0.0131
Echinococcus granulosus FTZ F1 alpha 0.003 0.0124 0.0124
Toxoplasma gondii exonuclease III APE 0.002 0.0027 0.0654
Brugia malayi Nuclear hormone receptor family member nhr-3 0.003 0.0124 0.0131
Schistosoma mansoni hypothetical protein 0.0078 0.0597 0.0597
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0165 0.0491
Brugia malayi beta-lactamase 0.0036 0.0186 0.0215
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0186 0.0758
Leishmania major hypothetical protein, conserved 0.0051 0.0329 0.1072
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0165 0.0659
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0102 0.0838 0.1097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0379 0.358 0.4804
Echinococcus granulosus muscleblind protein 0.0767 0.7423 0.7423
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-14 0.003 0.0124 0.0131
Brugia malayi Steroid receptor seven-up type 2 0.003 0.0124 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-31 0.003 0.0124 0.0131
Schistosoma mansoni hypothetical protein 0.0109 0.0901 0.0901
Mycobacterium tuberculosis Conserved protein 0.0036 0.0186 0.0758
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0054 0.0036
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0027 0.5
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0186 0.5653
Brugia malayi hypothetical protein 0.0051 0.0329 0.0409
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0329 0.1072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1259 0.1259
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Loa Loa (eye worm) hypothetical protein 0.0168 0.1493 0.1982
Schistosoma mansoni hypothetical protein 0.0078 0.0597 0.0597
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0196 0.0196
Toxoplasma gondii ABC1 family protein 0.0036 0.0186 0.4543
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0305 0.2847 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.003 0.0124 0.0131
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0124 0.0131
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2847 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0186 1
Schistosoma mansoni hypothetical protein 0.0078 0.0597 0.0597
Schistosoma mansoni tar DNA-binding protein 0.0379 0.358 0.358
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0409 0.2752
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0251 0.0794
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0186 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0186 0.1145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0124 0.0124
Echinococcus multilocularis pyruvate kinase 0.0034 0.0165 0.0165
Mycobacterium ulcerans beta-lactamase 0.0036 0.0186 0.1145
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0329 0.1072
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0329 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0465 0.1552
Echinococcus multilocularis FTZ F1 alpha 0.003 0.0124 0.0124
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.003 0.0124 0.0891
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0165 0.5021
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0186 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-40 0.003 0.0124 0.0131
Echinococcus granulosus neuropeptide receptor 0.0156 0.137 0.137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.003 0.0124 0.0124
Onchocerca volvulus Bile acid receptor homolog 0.003 0.0124 0.0891
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0465 0.0592
Loa Loa (eye worm) hypothetical protein 0.0024 0.0063 0.0048
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0165 0.8427
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0054 0.0193
Brugia malayi ecdysteroid receptor 0.003 0.0124 0.0131
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.003 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0186 0.0186
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0409 1
Leishmania major hypothetical protein, conserved 0.0036 0.0186 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1259 0.1259
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.1417 0.6621
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0597 0.0771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1259 0.1259
Brugia malayi RNA recognition motif domain containing protein 0.0379 0.358 0.4804
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0186 0.1145
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0027 0.5
Entamoeba histolytica hypothetical protein 0.0109 0.0901 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Loa Loa (eye worm) transcription factor SMAD2 0.0238 0.2183 0.2915
Mycobacterium tuberculosis Conserved protein 0.0036 0.0186 0.0758
Echinococcus granulosus tumor protein p63 0.0699 0.6742 0.6742
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0165 0.0995
Giardia lamblia Pyruvate kinase 0.0034 0.0165 1
Schistosoma mansoni cellular tumor antigen P53 0.0102 0.0838 0.0838
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0063 0.0408
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0186 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1259 0.1259
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0165 0.1421
Brugia malayi beta-lactamase family protein 0.0036 0.0186 0.0215
Echinococcus granulosus pyruvate kinase 0.0034 0.0165 0.0165
Echinococcus granulosus nuclear receptor 2DBD gamma 0.003 0.0124 0.0124
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0787 0.7621 0.7621
Echinococcus multilocularis GPCR, family 2 0.0078 0.0597 0.0597
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0186 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0054 0.0193
Mycobacterium ulcerans hypothetical protein 0.0036 0.0186 0.1145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0027 0.0814
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2127 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0465 0.0465
Echinococcus multilocularis pyruvate kinase 0.0027 0.0094 0.0094
Brugia malayi Nuclear hormone receptor-like 1 0.003 0.0124 0.0131
Entamoeba histolytica hypothetical protein 0.0109 0.0901 1
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0165 0.0187
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0186 0.0758
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.003 0.0124 0.0124
Schistosoma mansoni pyruvate kinase 0.0034 0.0165 0.0165
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0409 0.0409
Loa Loa (eye worm) RNA binding protein 0.0379 0.358 0.4804
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0186 0.0758
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.003 0.0124 0.0124
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1256 0.4357
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.003 0.0124 0.0124
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0052 0.0052
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0305 0.2847 1
Brugia malayi hypothetical protein 0.0033 0.0151 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0329 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0027 0.0027
Mycobacterium tuberculosis Conserved protein 0.0036 0.0186 0.0758
Mycobacterium ulcerans hypothetical protein 0.0161 0.1417 1
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0165 0.4034
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0186 0.0758
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0465 0.5006
Brugia malayi photoreceptor-specific nuclear receptor 0.003 0.0124 0.0131
Echinococcus multilocularis pyruvate kinase 0.0034 0.0165 0.0165
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0054 0.0036
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0036
Brugia malayi latrophilin 2 splice variant baaae 0.0168 0.1493 0.1982
Schistosoma mansoni tar DNA-binding protein 0.0379 0.358 0.358
Loa Loa (eye worm) hypothetical protein 0.0036 0.0186 0.0215
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0054 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-49 0.003 0.0124 0.0131
Brugia malayi beta-lactamase family protein 0.0036 0.0186 0.0215
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0027 0.0814
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0165 0.0491
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.003 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-41 0.003 0.0124 0.0131
Schistosoma mansoni hypothetical protein 0.1028 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0251 0.0794
Echinococcus granulosus ecdysone induced protein 78C 0.003 0.0124 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0054 0.0128
Echinococcus granulosus retinoic acid receptor rxr beta a 0.003 0.0124 0.0124
Schistosoma mansoni ap endonuclease 0.002 0.0027 0.0027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1259 0.1259
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0186 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0052 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.003 0.0124 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0238 0.2183 0.2915
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0054 0.0193
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0901 0.0901
Trichomonas vaginalis esterase, putative 0.0036 0.0186 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0597 0.0771
Onchocerca volvulus 0.0036 0.0186 0.1687
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0054 0.0193
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.003 0.0124 0.0131
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0165 0.0491
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0054 0.0193
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.003 0.0124 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0124 0.0131
Schistosoma mansoni Tr4/Tr2 (homologue) 0.003 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0036
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0251 0.0794
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.003 0.0124 0.0124
Toxoplasma gondii hypothetical protein 0.0049 0.0313 0.7648
Echinococcus granulosus tar DNA binding protein 0.0379 0.358 0.358
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1259 0.1666
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0901 0.0901
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1259 0.1259
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0246 0.2264 0.3025
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0409 0.0409
Onchocerca volvulus 0.0102 0.0838 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0054 0.0193
Brugia malayi nuclear receptor NHR-88 0.003 0.0124 0.0131
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.003 0.0124 0.0124
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0054 0.0193
Plasmodium falciparum pyruvate kinase 0.0034 0.0165 0.5021
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0597 0.0597
Chlamydia trachomatis pyruvate kinase 0.0034 0.0165 0.5
Brugia malayi RNA binding protein 0.0379 0.358 0.4804
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0186 0.0565
Echinococcus granulosus GPCR family 2 0.0078 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.0078 0.0597 0.0771
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Loa Loa (eye worm) hypothetical protein 0.0767 0.7423 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0465 0.0465
Schistosoma mansoni retinoic acid receptor RXR 0.003 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0246 0.2264 0.3025
Onchocerca volvulus 0.003 0.0124 0.0891
Entamoeba histolytica hypothetical protein 0.0109 0.0901 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0344 0.1123
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0054 0.0095
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0597 0.0597
Schistosoma mansoni pyruvate kinase 0.0034 0.0165 0.0165
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.003 0.0124 0.0131
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1259 0.1666
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0165 0.0187
Mycobacterium ulcerans hypothetical protein 0.0023 0.0054 0.0193
Brugia malayi steroid hormone receptor 0.003 0.0124 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0124 0.0131
Brugia malayi TAR-binding protein 0.0379 0.358 0.4804
Brugia malayi MH2 domain containing protein 0.0238 0.2183 0.2915
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0186 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0465 0.1552
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0054 0.0128
Schistosoma mansoni neuropeptide receptor 0.0156 0.137 0.137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.003 0.0124 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0027 0.1621
Schistosoma mansoni hypothetical protein 0.0168 0.1493 0.1493
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0196 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-25 0.003 0.0124 0.0131
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0186 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.003 0.0124 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.003 0.0124 0.0131
Echinococcus multilocularis muscleblind protein 1 0.0767 0.7423 0.7423
Onchocerca volvulus 0.0036 0.0186 0.1687
Schistosoma mansoni thyroid hormone receptor 0.003 0.0124 0.0124
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.003 0.0124 0.0131
Loa Loa (eye worm) hypothetical protein 0.0023 0.0054 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-19 0.003 0.0124 0.0131
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0027 0.0027
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.003 0.0124 0.0124
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.003 0.0124 0.0131
Loa Loa (eye worm) hypothetical protein 0.003 0.0124 0.0131
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0329 0.8036
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1259 0.1259
Mycobacterium ulcerans lipase LipD 0.0036 0.0186 0.1145
Loa Loa (eye worm) TAR-binding protein 0.0379 0.358 0.4804
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0465 0.0592
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0054 0.0308
Leishmania major mitochondrial DNA polymerase beta 0.0305 0.2847 1
Brugia malayi hypothetical protein 0.0109 0.0901 0.1182
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0186 0.0186
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.003 0.0124 0.0131
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0597 0.0597
Schistosoma mansoni thyroid hormone receptor 0.003 0.0124 0.0124
Loa Loa (eye worm) beta-lactamase 0.0036 0.0186 0.0215
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0165 0.0187
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0409 0.1822
Entamoeba histolytica hypothetical protein 0.0109 0.0901 1
Loa Loa (eye worm) steroid hormone receptor 0.003 0.0124 0.0131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0409 0.2752
Loa Loa (eye worm) hypothetical protein 0.0034 0.0165 0.0187
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0063 0.0048
Brugia malayi nuclear hormone receptor 0.003 0.0124 0.0131
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1256 0.4357
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0409 0.0409
Mycobacterium leprae Probable lipase LipE 0.0036 0.0186 1
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0054 0.0036
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0054 0.0308
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0054 0.0308
Echinococcus multilocularis neuropeptide receptor 0.0156 0.137 0.137
Schistosoma mansoni steroid hormone receptor ad4bp 0.003 0.0124 0.0124
Echinococcus granulosus pyruvate kinase 0.0034 0.0165 0.0165
Echinococcus multilocularis muscleblind protein 0.0767 0.7423 0.7423
Onchocerca volvulus 0.0036 0.0186 0.1687
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0597 0.0597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0597 0.0771
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0165 0.8693
Brugia malayi Calcitonin receptor-like protein seb-1 0.0246 0.2264 0.3025
Echinococcus multilocularis tar DNA binding protein 0.0379 0.358 0.358
Schistosoma mansoni hypothetical protein 0.0078 0.0597 0.0597
Leishmania major pyruvate kinase 0.0034 0.0165 0.0491

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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