Detailed information for compound 792754

Basic information

Technical information
  • TDR Targets ID: 792754
  • Name: 1,3-dimethyl-5-(3-nitrophenyl)-6,8-dihydro-5H -pyrido[5,6-e]pyrimidine-2,4,7-trione
  • MW: 330.295 | Formula: C15H14N4O5
  • H donors: 1 H acceptors: 5 LogP: 0.04 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CC(c2cccc(c2)[N+](=O)[O-])c2c(N1)n(C)c(=O)n(c2=O)C
  • InChi: 1S/C15H14N4O5/c1-17-13-12(14(21)18(2)15(17)22)10(7-11(20)16-13)8-4-3-5-9(6-8)19(23)24/h3-6,10H,7H2,1-2H3,(H,16,20)
  • InChiKey: OKOZCONOOMJAQR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A3883/0165067

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0277 0.0108
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.1153 0.1375
Schistosoma mansoni hypothetical protein 0.0183 0.7115 1
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.2558 0.2689
Plasmodium vivax SET domain protein, putative 0.0033 0.1153 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0277 0.0108
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.1153 0.1375
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.1153 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Brugia malayi CXXC zinc finger family protein 0.0031 0.1078 0.0948
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.1153 0.1533
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.2223 1
Trichomonas vaginalis set domain proteins, putative 0.0256 1 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0129 0.0129
Schistosoma mansoni hypothetical protein 0.0183 0.7115 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Echinococcus multilocularis cpg binding protein 0.0033 0.1148 0.1368
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Echinococcus multilocularis tar DNA binding protein 0.0068 0.2558 0.3407
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2558 0.3528
Brugia malayi RNA binding protein 0.0068 0.2558 0.2689
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.2501 0.3447
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.1153 0.1533
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.2558 0.2685
Echinococcus granulosus cpg binding protein 0.0033 0.1148 0.1368
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0203 0.0183
Brugia malayi TAR-binding protein 0.0068 0.2558 0.2689
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2558 0.3528
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Echinococcus multilocularis geminin 0.0183 0.7115 1
Schistosoma mansoni cpg binding protein 0.0033 0.1148 0.1526
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.108 0.1269
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.1153 0.1375
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2558 0.3528
Schistosoma mansoni cpg binding protein 0.0031 0.1078 0.1426
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0129 0.0129
Echinococcus granulosus geminin 0.0183 0.7115 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.1153 0.1533
Loa Loa (eye worm) hypothetical protein 0.0033 0.1153 0.1031
Brugia malayi Pre-SET motif family protein 0.0033 0.1153 0.1036
Brugia malayi Pre-SET motif family protein 0.0225 0.8771 1
Onchocerca volvulus 0.0033 0.1153 0.0084
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.8771 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2558 0.3528
Loa Loa (eye worm) TAR-binding protein 0.0068 0.2558 0.2685
Schistosoma mansoni tar DNA-binding protein 0.0068 0.2558 0.3528
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129
Schistosoma mansoni cpg binding protein 0.0033 0.1148 0.1526
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0129 0.0129
Loa Loa (eye worm) RNA binding protein 0.0068 0.2558 0.2685
Trichomonas vaginalis helicase, putative 0.0007 0.0129 0.0129
Echinococcus granulosus tar DNA binding protein 0.0068 0.2558 0.3407
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.1078 0.0943
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0129 0.0129

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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