Detailed information for compound 793071

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 486.581 | Formula: C25H30N2O6S
  • H donors: 1 H acceptors: 2 LogP: 3.54 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(CNC(=O)c1ccc2c(c1)n(C)c(=O)c(=Cc1ccc(c(c1)OC)OC)s2)OCC
  • InChi: 1S/C25H30N2O6S/c1-6-32-23(33-7-2)15-26-24(28)17-9-11-21-18(14-17)27(3)25(29)22(34-21)13-16-8-10-19(30-4)20(12-16)31-5/h8-14,23H,6-7,15H2,1-5H3,(H,26,28)/b22-13-
  • InChiKey: CVJNTNKCVAESSM-XKZIYDEJSA-N  


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Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0298 0.6793 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0307 0.0307
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.2082 0.3151
Schistosoma mansoni tyrosine kinase 0.0017 0.0008 0.0008
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0372 0.0372
Treponema pallidum NADH oxidase 0.0047 0.0725 0.5
Echinococcus granulosus expressed protein 0.0036 0.0453 0.0455
Brugia malayi glutathione reductase 0.0135 0.2854 0.4325
Brugia malayi hypothetical protein 0.0161 0.3474 0.5266
Echinococcus granulosus tyrosine protein kinase ABL1 0.0423 0.98 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.003 0.0322 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.3058 0.4583
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0372 0.045
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Trypanosoma brucei trypanothione reductase 0.0135 0.2854 0.4142
Trypanosoma brucei polo-like protein kinase 0.029 0.659 0.9698
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0044
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0051 0.0032
Brugia malayi protein-tyrosine kinase 0.0074 0.1392 0.2103
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.007 0.007
Echinococcus multilocularis GPCR, family 2 0.0048 0.0747 0.0754
Entamoeba histolytica serine/threonine protein kinase, putative 0.029 0.659 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0725 0.5
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0034 0.0425 0.0634
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0308 0.7028 0.8941
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0307 0.0307
Plasmodium falciparum glutathione reductase 0.0047 0.0725 0.2406
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.0201
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.0461
Echinococcus multilocularis tyrosine protein kinase shark 0.0017 0.0008 0.00000003043
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0372 0.0372
Brugia malayi serine/threonine-protein kinase plk-2 0.029 0.659 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0307 0.0306
Mycobacterium ulcerans DNA polymerase IV 0.002 0.007 0.0057
Brugia malayi hypothetical protein 0.0036 0.0453 0.0677
Echinococcus multilocularis expressed protein 0.0036 0.0453 0.0455
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.007 0.0063
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Plasmodium falciparum thioredoxin reductase 0.0047 0.0725 0.2406
Giardia lamblia NADH oxidase lateral transfer candidate 0.0047 0.0725 0.1005
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0342 0.7858 1
Brugia malayi SRC-1 0.0087 0.1706 0.258
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0372 0.045
Mycobacterium ulcerans hypothetical protein 0.0025 0.0204 0.0461
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0299
Echinococcus multilocularis tyrosine protein kinase Abl 0.0185 0.4065 0.4144
Mycobacterium tuberculosis Probable reductase 0.0308 0.7028 0.8941
Brugia malayi Tyrosine-protein kinase abl-1 0.0185 0.4065 0.6165
Echinococcus multilocularis c src tyrosine kinase 0.003 0.0322 0.032
Toxoplasma gondii thioredoxin reductase 0.0135 0.2854 1
Plasmodium falciparum glutathione reductase 0.0135 0.2854 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0087 0.1706 0.1734
Brugia malayi Pre-SET motif family protein 0.0029 0.0307 0.0455
Echinococcus multilocularis growth factor receptor bound protein 2 0.0026 0.0231 0.0228
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0608 0.0801
Trichomonas vaginalis CAMK family protein kinase 0.0143 0.3058 0.4583
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.3233 0.3293
Echinococcus multilocularis dna polymerase kappa 0.002 0.007 0.0063
Schistosoma mansoni hypothetical protein 0.0103 0.2082 0.2082
Schistosoma mansoni hypothetical protein 0.0048 0.0747 0.0747
Echinococcus granulosus NCK adaptor protein 0.0026 0.0231 0.0228
Echinococcus granulosus tyrosine protein kinase HCK 0.0061 0.1071 0.1085
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0087 0.1706 0.1734
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.007 0.0094
Echinococcus multilocularis tyrosine protein kinase Blk 0.0074 0.1392 0.1414
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0372 0.045
Loa Loa (eye worm) hypothetical protein 0.0048 0.0747 0.0754
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0372 0.0372
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0074 0.1392 0.1414
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0047 0.0725 0.164
Entamoeba histolytica hypothetical protein 0.0036 0.0453 0.0677
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0035 0.0433 0.054
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0231 0.0228
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0204 0.0299
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0204 0.0299
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0047 0.0725 0.0975
Schistosoma mansoni tyrosine kinase 0.0017 0.0008 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Loa Loa (eye worm) hypothetical protein 0.0151 0.3233 0.3293
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0372 0.0553
Echinococcus granulosus tyrosine protein kinase Src64B 0.0087 0.1706 0.1734
Brugia malayi Sex muscle abnormal protein 5 0.0026 0.0231 0.0339
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0433 0.054
Echinococcus multilocularis tyrosine protein kinase Srms 0.0074 0.1392 0.1414
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0307 0.0307
Schistosoma mansoni kinase 0.0147 0.315 0.315
Echinococcus granulosus tyrosine protein kinase Blk 0.0074 0.1392 0.1414
Plasmodium falciparum thioredoxin reductase 0.0135 0.2854 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0044
Echinococcus granulosus growth factor receptor bound protein 2 0.0026 0.0231 0.0228
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0047 0.0725 0.109
Trichomonas vaginalis set domain proteins, putative 0.0234 0.5241 0.7931
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0047 0.0725 0.2406
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.0461
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.6793 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.007 0.0056
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3002 0.4362
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0747 0.1122
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0047 0.0725 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0372 0.0372
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0035 0.0433 0.054
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0047 0.0725 0.2406
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0308 0.7028 0.8941
Brugia malayi Pre-SET motif family protein 0.0205 0.4555 0.6909
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0342 0.7858 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0298 0.6793 1
Brugia malayi isocitrate dehydrogenase 0.0032 0.0372 0.0553
Echinococcus granulosus tyrosine protein kinase shark 0.0017 0.0008 0.00000003043
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0231 0.0339
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0047 0.0725 0.2022
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0141 0.3002 0.4362
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0372 0.045
Loa Loa (eye worm) hypothetical protein 0.0029 0.0307 0.0306
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0829 0.113
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0035 0.0433 0.054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0044
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0087 0.1706 0.1734
Trypanosoma cruzi trypanothione reductase, putative 0.0135 0.2854 0.4142
Mycobacterium ulcerans DNA polymerase IV 0.002 0.007 0.0057
Onchocerca volvulus 0.0029 0.0307 0.0455
Loa Loa (eye worm) SRC-1 0.0087 0.1706 0.1734
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0747 0.0754
Onchocerca volvulus Serine\/threonine kinase homolog 0.029 0.659 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0307 0.0306
Schistosoma mansoni hypothetical protein 0.0048 0.0747 0.0747
Plasmodium vivax SET domain protein, putative 0.0029 0.0307 0.0916
Loa Loa (eye worm) hypothetical protein 0.0161 0.3474 0.354
Loa Loa (eye worm) TK protein kinase 0.0061 0.1071 0.1085
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0453 0.0588
Brugia malayi Tyrosine-protein kinase abl-1 0.0251 0.5644 0.8563
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Schistosoma mansoni tyrosine kinase 0.003 0.0322 0.0322
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0047 0.0725 0.0975
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0372 0.0442
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0204 0.0461
Schistosoma mansoni tyrosine kinase 0.0087 0.1706 0.1706
Echinococcus multilocularis NCK adaptor protein 0.0026 0.0231 0.0228
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0047 0.0725 0.2022
Mycobacterium tuberculosis Probable dehydrogenase 0.0308 0.7028 0.8941
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0087 0.1706 0.1734
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0036 0.0453 0.0676
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0372 0.0372
Echinococcus granulosus dna polymerase kappa 0.002 0.007 0.0063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0725 0.0975
Trichomonas vaginalis mercuric reductase, putative 0.0047 0.0725 0.1005
Loa Loa (eye worm) hypothetical protein 0.0159 0.343 0.3495
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.3233 0.4899
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0204 0.0461
Mycobacterium tuberculosis Probable oxidoreductase 0.0342 0.7858 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.029 0.659 0.9698
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0372 0.0372
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0141 0.3002 0.4362
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0308 0.7028 0.8916
Loa Loa (eye worm) glutathione reductase 0.0135 0.2854 0.2907
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0453 0.0455
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0026 0.0231 0.0231
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0725 0.0975
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0372 0.0372
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.3233 0.4899
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0372 0.045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0747 0.0754
Onchocerca volvulus 0.0161 0.3474 0.5266
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.0201
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0047 0.0725 0.0975
Trypanosoma cruzi polo-like protein kinase, putative 0.029 0.659 0.9698
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0204 0.0461
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.02
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0747 0.0754
Mycobacterium tuberculosis Conserved hypothetical protein 0.0157 0.3387 0.4291
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.007 0.0056
Echinococcus granulosus tyrosine protein kinase Src42A 0.0087 0.1706 0.1734
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0307 0.0307
Schistosoma mansoni tyrosine kinase 0.0409 0.9478 0.9478
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0372 0.0254
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0204 0.0461
Plasmodium vivax thioredoxin reductase, putative 0.0135 0.2854 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.4555 0.4644
Loa Loa (eye worm) hypothetical protein 0.0025 0.0204 0.0201
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0087 0.1706 0.1734
Echinococcus granulosus tyrosine kinase 0.0074 0.1392 0.1414
Trichomonas vaginalis glutathione reductase, putative 0.0047 0.0725 0.1005
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0231 0.0339
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0034 0.0425 0.0634
Toxoplasma gondii NADPH-glutathione reductase 0.0047 0.0725 0.164
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0231 0.0231
Onchocerca volvulus 0.0234 0.5241 0.795
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.003 0.0322 0.032
Echinococcus granulosus serine:threonine protein kinase PLK1 0.029 0.659 0.6722
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0087 0.1706 0.1734
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.0063
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0204 0.0228
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0047 0.0725 0.0893
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.007 0.007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0608 0.0801
Echinococcus multilocularis thioredoxin glutathione reductase 0.0136 0.2867 0.292
Entamoeba histolytica hypothetical protein 0.0036 0.0453 0.0677
Loa Loa (eye worm) hypothetical protein 0.0103 0.2082 0.2118
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0047 0.0725 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0204 0.0299
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0725 0.0975
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0047 0.0725 0.0975
Schistosoma mansoni tyrosine kinase 0.0087 0.1706 0.1706
Echinococcus multilocularis tyrosine protein kinase HCK 0.0061 0.1071 0.1085
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Schistosoma mansoni DNA polymerase eta 0.002 0.007 0.007
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0453 0.0455
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0308 0.7028 0.8941
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0372 0.0372
Mycobacterium ulcerans hypothetical protein 0.0157 0.3387 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Toxoplasma gondii peptidylprolyl isomerase 0.0035 0.0433 0.0493
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0135 0.2854 0.3611
Schistosoma mansoni tyrosine kinase 0.003 0.0322 0.0322
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0342 0.7858 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.029 0.659 0.6722
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0047 0.0725 0.2406
Echinococcus granulosus tyrosine protein kinase Btk29A 0.003 0.0322 0.032
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0308 0.7028 0.8941
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.029 0.659 0.6722
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0035 0.0433 0.0646
Loa Loa (eye worm) thioredoxin reductase 0.0135 0.2854 0.2907
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0047 0.0725 0.0975
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0087 0.1706 0.1734
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0423 0.98 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0608 0.0801
Schistosoma mansoni hypothetical protein 0.0048 0.0747 0.0747
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0047 0.0725 0.0732
Plasmodium vivax glutathione reductase, putative 0.0135 0.2854 1
Entamoeba histolytica hypothetical protein 0.0036 0.0453 0.0677
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0036 0.0453 0.0455
Entamoeba histolytica hypothetical protein 0.0036 0.0453 0.0677
Echinococcus multilocularis dna polymerase eta 0.002 0.007 0.0063
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0047 0.0725 0.0725
Trichomonas vaginalis rotamase, putative 0.0036 0.0453 0.0588
Echinococcus granulosus tyrosine protein kinase Fyn 0.0087 0.1706 0.1734
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0087 0.1706 0.1734
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0204 0.0461
Echinococcus granulosus thioredoxin glutathione reductase 0.0136 0.2867 0.292
Toxoplasma gondii hypothetical protein 0.0048 0.0757 0.1765
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0204 0.0299
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0747 0.0754
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0747 0.1122
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0044
Trypanosoma cruzi polo-like protein kinase, putative 0.029 0.659 0.9698
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0307 0.0306
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0372 0.0254
Echinococcus granulosus tyrosine protein kinase Src42A 0.0071 0.1302 0.1321
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Schistosoma mansoni hypothetical protein 0.0048 0.0747 0.0747
Schistosoma mansoni serine/threonine protein kinase 0.029 0.659 0.659
Onchocerca volvulus 0.0025 0.0204 0.0299
Echinococcus granulosus tyrosine protein kinase Lyn 0.0088 0.1729 0.1757
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0047 0.0725 0.2022
Leishmania major trypanothione reductase 0.0135 0.2854 0.4142
Brugia malayi Thioredoxin reductase 0.0135 0.2854 0.4325
Echinococcus granulosus dna polymerase eta 0.002 0.007 0.0063
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0026 0.0231 0.0228
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0071 0.1302 0.1321
Loa Loa (eye worm) hypothetical protein 0.0019 0.0051 0.0044
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0047 0.0725 0.2406
Entamoeba histolytica protein kinase, putative 0.0061 0.1071 0.1614
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0608 0.0801
Giardia lamblia Kinase, PLK 0.029 0.659 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0204 0.0228
Echinococcus granulosus c src tyrosine kinase 0.003 0.0322 0.032
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Schistosoma mansoni hypothetical protein 0.0036 0.0453 0.0453
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0204 0.02
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0453 0.0453
Loa Loa (eye worm) TK/ABL protein kinase 0.0423 0.98 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0231 0.0228
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0372 0.1146
Echinococcus granulosus GPCR family 2 0.0048 0.0747 0.0754
Schistosoma mansoni nck2/grb4 0.0026 0.0231 0.0231
Schistosoma mansoni adapter molecule crk 0.0026 0.0231 0.0231
Leishmania major mitochondrial DNA polymerase beta 0.0298 0.6793 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.007 0.0063
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0047 0.0725 0.0975
Schistosoma mansoni rotamase 0.0036 0.0453 0.0453
Loa Loa (eye worm) TK protein kinase 0.0074 0.1392 0.1414
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0231 0.0231
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.007 0.0094
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0047 0.0725 0.0975
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0372 0.1146
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0281 0.0279
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.007 0.0063
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0047 0.0725 0.0732
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0074 0.1392 0.1414
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0747 0.0754
Trichomonas vaginalis CAMK family protein kinase 0.029 0.659 1
Trichomonas vaginalis rotamase, putative 0.0035 0.0433 0.0557
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.007 0.0094

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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