Detailed information for compound 793324

Basic information

Technical information
  • TDR Targets ID: 793324
  • Name: N,2-bis(4-methylphenyl)imidazo[3,2-a]pyrazin- 3-amine
  • MW: 314.384 | Formula: C20H18N4
  • H donors: 1 H acceptors: 2 LogP: 4.96 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)Nc1c(nc2n1ccnc2)c1ccc(cc1)C
  • InChi: 1S/C20H18N4/c1-14-3-7-16(8-4-14)19-20(22-17-9-5-15(2)6-10-17)24-12-11-21-13-18(24)23-19/h3-13,22H,1-2H3
  • InChiKey: XICDIBBCVLLYIT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N,2-bis(4-methylphenyl)-3-imidazo[3,2-a]pyrazinamine
  • (4-methylphenyl)-[2-(4-methylphenyl)imidazo[3,2-a]pyrazin-3-yl]amine
  • ZINC03896522
  • C169-0248
  • NCGC00104567-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.004 0.0168
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0085
Brugia malayi beta-lactamase family protein 0.0075 0.0054 0.0054
Echinococcus multilocularis potassium large conductance calcium activated 0.0097 0.0076 0.0318
Giardia lamblia Replication factor C, subunit 1 0.003 0.001 1
Echinococcus multilocularis lamin 0.0033 0.0013 0.0053
Schistosoma mansoni P2X receptor subunit 0.0469 0.0444 0.2109
Brugia malayi DKFZp564C0469 protein 0.003 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0048 0.0229
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Brugia malayi glutaminase DH11.1 0.033 0.0307 0.0307
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0039 0.0019 0.0019
Brugia malayi follicle stimulating hormone receptor 0.0234 0.0212 0.0211
Brugia malayi Steroid receptor seven-up type 2 0.0039 0.0019 0.0019
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0123 0.0299
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0281 0.0703
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0095 0.0074 0.1558
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0029 0.001 0.004
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0074 0.0054 0.9858
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Echinococcus multilocularis p2X purinoceptor 4 0.0469 0.0444 0.1861
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Brugia malayi Glycosyl hydrolases family 31 protein 0.0074 0.0054 0.0054
Brugia malayi topoisomerase 0.003 0.001 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0054 0.0054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0016 0.0068
Schistosoma mansoni tyrosine kinase 0.0029 0.001 0.0045
Onchocerca volvulus 0.0028 0.0008 0.0455
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0008 0.0065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0089 0.0088
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0028 0.0008 0.0085
Schistosoma mansoni polycystin 1-related 0.002 0 0.0001
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0043 0.7628
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0054 0.1121
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0054 0.1592
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0054 0.7031
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0028 0.0008 0.0085
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0019 0.0092
Loa Loa (eye worm) beta-lactamase 0.0075 0.0054 0.0054
Echinococcus multilocularis GA binding protein alpha chain 0.0071 0.0051 0.0214
Echinococcus granulosus replication factor c subunit 1 0.003 0.001 0.0046
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0054 0.0122
Echinococcus multilocularis Niemann Pick C1 protein 0.0423 0.0398 0.1668
Echinococcus multilocularis Niemann Pick C1 protein 0.0296 0.0273 0.1142
Echinococcus multilocularis protein patched 0.0127 0.0106 0.0443
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0021 0.3828
Loa Loa (eye worm) hypothetical protein 0.0033 0.0013 0.0013
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.007 0.0163
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0071 0.005 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.003 0.001 0.0048
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0015 0.0015
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0008 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0039 0.0019 0.0019
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0023 0.0043
Echinococcus multilocularis lamin dm0 0.0033 0.0013 0.0053
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0166
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0028 0.0008 0.0304
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0001 0.0004
Plasmodium falciparum acyl-CoA synthetase 0.0071 0.005 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0028 0.0008 0.0038
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0039 0.0019 0.1122
Echinococcus granulosus calcium activated potassium channel 0.0097 0.0076 0.0362
Schistosoma mansoni hypothetical protein 0.0122 0.0101 0.0481
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0028 0.0008 0.0085
Echinococcus multilocularis GPCR, family 2 0.0035 0.0015 0.0062
Schistosoma mansoni ets-related 0.0217 0.0195 0.0926
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.0123 0.0299
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0119 0.0098 0.0411
Schistosoma mansoni ran 0.0026 0.0006 0.0028
Schistosoma mansoni hypothetical protein 0.0122 0.0101 0.0481
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 1.0136 1 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0013 0.0013
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.009 0.007 0.0069
Onchocerca volvulus 0.0099 0.0078 0.4552
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0048 0.0048
Brugia malayi nuclear hormone receptor 0.0039 0.0019 0.0019
Brugia malayi Cytochrome P450 family protein 0.0051 0.0031 0.003
Loa Loa (eye worm) hypothetical protein 0.0099 0.0078 0.0078
Brugia malayi Importin beta-1 subunit 0.0035 0.0015 0.0015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0089 0.0088
Toxoplasma gondii HEAT repeat-containing protein 0.0035 0.0015 0.187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0035 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0028 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0095 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0477 0.0452 0.0451
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0021 0.0021
Mycobacterium tuberculosis Conserved protein 0.0075 0.0054 0.1121
Brugia malayi hypothetical protein 0.0021 0.0001 0.0001
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0028 0.0008 0.1552
Onchocerca volvulus 0.0033 0.0013 0.0731
Brugia malayi intermediate filament protein 0.0033 0.0013 0.0013
Schistosoma mansoni retinoic acid receptor RXR 0.0039 0.0019 0.0092
Loa Loa (eye worm) steroid hormone receptor 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0019 0.0019
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0026 0.0006 0.0024
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0054 0.1592
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0166
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0054 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0054 0.0124
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0039 0.0019 0.0092
Mycobacterium tuberculosis Conserved protein 0.0075 0.0054 0.1121
Brugia malayi beta-lactamase family protein 0.0075 0.0054 0.0054
Echinococcus multilocularis NCK adaptor protein 0.0026 0.0006 0.0025
Echinococcus granulosus growth factor receptor bound protein 2 0.0026 0.0006 0.0028
Brugia malayi hypothetical protein 0.0037 0.0017 0.0017
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0077 0.0076
Schistosoma mansoni tyrosine kinase 0.0029 0.001 0.0045
Schistosoma mansoni hypothetical protein 0.0097 0.0077 0.0363
Plasmodium vivax replication factor C subunit 1, putative 0.003 0.001 0.1761
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0078 0.0371
Schistosoma mansoni serine/threonine protein kinase 0.009 0.007 0.033
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0015 0.0062
Brugia malayi RNA, U transporter 1 0.0099 0.0078 0.0078
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0029 0.001 0.0045
Schistosoma mansoni topbp1 0.003 0.001 0.0046
Echinococcus granulosus tumor protein p63 0.0675 0.0647 0.3072
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0019 0.0019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0043 0.0095
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0054 0.1967
Leishmania major malonyl-coa decarboxylase-like protein 0.3983 0.3917 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0008 0.0071
Trypanosoma brucei glucosidase, putative 0.0074 0.0054 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0074 0.0074
Schistosoma mansoni hypothetical protein 0.0122 0.0101 0.0481
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0043 0.0203
Schistosoma mansoni rab6-interacting 0.002 0 0.0001
Leishmania major importin beta-1 subunit, putative 0.0028 0.0008 0.0007
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0016 0.0077
Loa Loa (eye worm) hypothetical protein 0.0095 0.0074 0.0074
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0039 0.0019 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0074 0.2211
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.007
Schistosoma mansoni alpha glucosidase 0.0074 0.0054 0.0255
Schistosoma mansoni steroid hormone receptor ad4bp 0.0039 0.0019 0.0092
Echinococcus granulosus p2X purinoceptor 4 0.0469 0.0444 0.2109
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0028 0.0008 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0039 0.0019 0.0019
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0054 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0054 0.1121
Brugia malayi Bromodomain containing protein 0.0039 0.0019 0.0019
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0054 0.1592
Echinococcus granulosus neutral alpha glucosidase AB 0.0074 0.0054 0.0255
Onchocerca volvulus 0.0193 0.0171 1
Brugia malayi Nuclear hormone receptor-like 1 0.0039 0.0019 0.0019
Echinococcus granulosus GTP binding nuclear protein Ran 0.0026 0.0006 0.0028
Echinococcus multilocularis lysosomal alpha glucosidase 0.0334 0.0311 0.1301
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0026 0.0006 0.0028
Echinococcus multilocularis calcium activated potassium channel variant 0.009 0.0069 0.029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0039 0.0019 0.0092
Echinococcus granulosus sterol regulatory element binding protein 0.0127 0.0106 0.0503
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0005
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.003 0.001 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0039 0.0019 0.0019
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0023 0.0043
Leishmania major glycosyl hydrolase-like protein 0.0028 0.0008 0.0005
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.003 0.001 0.0801
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0166
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0372 0.0348 0.0348
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0155 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0041 0.0021 0.0099
Schistosoma mansoni patched 1 0.0127 0.0106 0.0503
Entamoeba histolytica hypothetical protein 0.0108 0.0087 0.3198
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.009 0.007 0.0163
Brugia malayi hypothetical protein 0.0037 0.0017 0.0017
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0015 0.007
Brugia malayi Ets-domain containing protein 0.0071 0.0051 0.0051
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0023 0.0043
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0064 0.0044 0.0044
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.072 0.0692 0.2898
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.009 0.0069 0.0069
Brugia malayi AMP-binding enzyme family protein 0.0095 0.0074 0.0074
Echinococcus multilocularis dual specificity 0.009 0.007 0.0291
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0074 0.2712
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0023 0.0043
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0054 0.0054
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0001 0.0005
Plasmodium vivax acetyl-CoA synthetase, putative 0.0028 0.0008 0.1437
Loa Loa (eye worm) hypothetical protein 0.0032 0.0012 0.0012
Brugia malayi Bromodomain containing protein 0.0076 0.0055 0.0055
Schistosoma mansoni tyrosine kinase 0.0029 0.001 0.0045
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0048 0.0048
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.001 0.0129
Brugia malayi RNA binding protein 0.0069 0.0048 0.0048
Entamoeba histolytica hypothetical protein 0.0108 0.0087 0.3198
Echinococcus granulosus tar DNA binding protein 0.0069 0.0048 0.0229
Loa Loa (eye worm) glutaminase 0.033 0.0307 0.0307
Trichomonas vaginalis maltase-glucoamylase, putative 0.0074 0.0054 0.1592
Brugia malayi hypothetical protein 0.003 0.001 0.001
Entamoeba histolytica protein kinase domain containing protein 0.009 0.007 0.2547
Schistosoma mansoni transcription factor LCR-F1 0.0108 0.0087 0.0414
Echinococcus granulosus Niemann Pick C1 protein 0.0296 0.0273 0.1294
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0054 0.1592
Brugia malayi Protein kinase domain containing protein 0.009 0.007 0.0069
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3983 0.3917 1
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3983 0.3917 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0019 0.0092
Schistosoma mansoni glutaminase 0.033 0.0307 0.1456
Toxoplasma gondii propionate-CoA ligase 0.0028 0.0008 0.0439
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.001 0.0045
Entamoeba histolytica acyl-coA synthetase, putative 0.0095 0.0074 0.2712
Echinococcus multilocularis RUN 0.002 0 0.0001
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.0026 0.0006 0.0000071138
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0006 0.0006
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.0139 0.3
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0039 0.0019 0.0092
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0028 0.0008 0.0288
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0008 0.0065
Echinococcus granulosus ecdysone induced protein 78C 0.0039 0.0019 0.0092
Schistosoma mansoni RAR-like nuclear receptor 0.0039 0.0019 0.0092
Plasmodium falciparum importin beta, putative 0.0035 0.0015 0.2936
Echinococcus granulosus calcium activated potassium channel variant 0.009 0.0069 0.0328
Mycobacterium ulcerans beta-lactamase 0.0075 0.0054 0.1555
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0054 0.1615
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.0106 0.3325
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0008 0.0086
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0119 0.0098 0.0466
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0095 0.0074 0.2211
Schistosoma mansoni hypothetical protein 0.0122 0.0101 0.0481
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0015 0.0023
Brugia malayi hypothetical protein 0.0108 0.0087 0.0087
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0039 0.0019 0.0081
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0028 0.0008 0.0439
Echinococcus granulosus tyrosine protein kinase Src64B 0.0029 0.001 0.0045
Echinococcus granulosus nibrin 0.003 0.001 0.0046
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0043 0.0864
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0048 0.0229
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.007
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0008 0.0005
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0074 0.0054 0.1592
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0015 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0074 0.0174
Loa Loa (eye worm) hypothetical protein 0.0095 0.0074 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0147
Brugia malayi Sex muscle abnormal protein 5 0.0026 0.0006 0.0006
Echinococcus multilocularis FTZ F1 alpha 0.0039 0.0019 0.0081
Onchocerca volvulus 0.0033 0.0013 0.0731
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0074 1
Onchocerca volvulus 0.003 0.001 0.0558
Brugia malayi steroid hormone receptor 0.0039 0.0019 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0095 0.0074 0.2712
Brugia malayi nuclear receptor RXR 0.0021 0.0001 0.0001
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0089 0.0088
Loa Loa (eye worm) hypothetical protein 0.0071 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0071 0.005 0.005
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0031 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0035 0.0166
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0047 0.0946
Entamoeba histolytica Ran family GTPase 0.0026 0.0006 0.021
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0 0.0001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0029 0.001 0.004
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0095 0.0074 0.2211
Echinococcus granulosus RUN 0.002 0 0.0001
Brugia malayi hypothetical protein 0.0021 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.0051 0.0051
Schistosoma mansoni bromodomain containing protein 0.0064 0.0044 0.0207
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0108 0.0087 0.0365
Schistosoma mansoni topbp1 0.003 0.001 0.0046
Brugia malayi Pax transcription activation domain interacting protein 0.003 0.001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0048 0.0229
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0334 0.0311 0.031
Loa Loa (eye worm) hypothetical protein 0.0064 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0129
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0028 0.0008 0.0085
Loa Loa (eye worm) hypothetical protein 0.009 0.0069 0.0069
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0074 0.2211
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0035 0.0147
Schistosoma mansoni importin beta-1 0.0035 0.0015 0.0071
Trichomonas vaginalis glutaminase, putative 0.033 0.0307 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0028 0.0008 0.0033
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0029 0.001 0.0045
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0008 0.0065
Trichomonas vaginalis importin beta-1, putative 0.0028 0.0008 0.0086
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0029 0.001 0.004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0039 0.0019 0.0092
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0015 0.007
Trichomonas vaginalis sucrase-isomaltase, putative 0.0074 0.0054 0.1592
Echinococcus multilocularis expressed conserved protein 0.0278 0.0255 0.1068
Echinococcus granulosus GPCR family 2 0.0035 0.0015 0.007
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0 0.0001
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0029 0.001 0.004
Echinococcus granulosus survival motor neuron protein 1 0.0477 0.0452 0.2143
Loa Loa (eye worm) fli-1 protein 0.0217 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0015
Mycobacterium tuberculosis Conserved protein 0.0075 0.0054 0.1121
Echinococcus granulosus Polycystic kidney disease protein 0.002 0 0.0001
Loa Loa (eye worm) hypothetical protein 0.0071 0.005 0.005
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0039 0.0019 0.0092
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0039 0.0019 0.0092
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0127 0.0106 0.0106
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.001 0.004
Loa Loa (eye worm) glutaminase 2 0.033 0.0307 0.0307
Echinococcus multilocularis growth factor receptor bound protein 2 0.0026 0.0006 0.0025
Schistosoma mansoni P2X receptor subunit 0.0469 0.0444 0.2109
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0028 0.0008 0.0005
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.001 0.0129
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Schistosoma mansoni calcium-activated potassium channel 0.009 0.0069 0.0328
Trichomonas vaginalis esterase, putative 0.0075 0.0054 0.1615
Schistosoma mansoni hypothetical protein 0.0075 0.0054 0.0258
Schistosoma mansoni survival motor neuron protein 0.0097 0.0077 0.0363
Onchocerca volvulus 0.0028 0.0008 0.0455
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0054 0.1121
Leishmania major hypothetical protein, conserved 0.0075 0.0054 0.0124
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0048 0.0202
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0013 0.0013
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0028 0.0008 0.0281
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2435 0.2387 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0001 0.0001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0026 0.0006 0.0006
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0085
Brugia malayi Glycosyl hydrolases family 31 protein 0.0028 0.0008 0.0008
Trichomonas vaginalis replication factor C large subunit, putative 0.003 0.001 0.0129
Echinococcus granulosus microtubule associated protein 2 0.2151 0.2107 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0001 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0054 0.0124
Entamoeba histolytica hypothetical protein 0.0108 0.0087 0.3198
Trypanosoma cruzi FHA domain containing protein, putative 0.003 0.001 0.001
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0006 0.0006
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0026 0.0006 0.0000071138
Brugia malayi hypothetical protein 0.0477 0.0452 0.0451
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0039 0.0019 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0039 0.0019 0.0019
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0039 0.0019 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0001 0.0001
Schistosoma mansoni niemann-pick C1 (NPC1) 0.03 0.0277 0.1316
Treponema pallidum DNA ligase (lig) 0.003 0.001 0.5
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Echinococcus granulosus expressed conserved protein 0.0278 0.0255 0.121
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0029 0.001 0.004
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0047 0.0946
Echinococcus multilocularis p2X purinoceptor 4 0.0469 0.0444 0.1861
Echinococcus granulosus Protein patched homolog 1 0.0127 0.0106 0.0503
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.009 0.007 0.0163
Entamoeba histolytica protein kinase, putative 0.009 0.007 0.2547
Echinococcus granulosus Niemann Pick C1 protein 0.0423 0.0398 0.189
Echinococcus multilocularis thyroid hormone receptor alpha 0.0039 0.0019 0.0081
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.3983 0.3917 1
Entamoeba histolytica hypothetical protein 0.003 0.001 0.0352
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0006 0.0028
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0043 0.018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0028 0.0008 0.0086
Trichomonas vaginalis antibiotic synthetase, putative 0.0028 0.0008 0.0071
Schistosoma mansoni P2X receptor subunit 0.0469 0.0444 0.2109
Schistosoma mansoni tyrosine kinase 0.0707 0.0679 0.3224
Brugia malayi CHE-14 protein 0.0127 0.0106 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0039 0.0019 0.0019
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0129
Echinococcus multilocularis lysosomal alpha glucosidase 0.0334 0.0311 0.1301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0039 0.0019 0.0019
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0029 0.001 0.004
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0005
Schistosoma mansoni lipoxygenase 0.0083 0.0063 0.0298
Entamoeba histolytica hypothetical protein 0.0108 0.0087 0.3198
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0095 0.0074 0.2211
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0054 0.0258
Echinococcus multilocularis tumor protein p63 0.0675 0.0647 0.2711
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0026 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0129
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0021 0.0088
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0095 0.0074 0.1558
Echinococcus granulosus lamin dm0 0.0033 0.0013 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0039 0.0019 0.0092
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0008 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0028 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0021 0.0001 0.0005
Echinococcus granulosus GA binding protein alpha chain 0.0071 0.0051 0.0243
Echinococcus multilocularis microtubule associated protein 2 0.2151 0.2107 0.8825
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0129
Echinococcus granulosus lamin 0.0033 0.0013 0.006
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0085
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0008 0.0065
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0123 0.0123
Loa Loa (eye worm) oxidoreductase 0.0028 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0019 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0039 0.0019 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0026 0.0006 0.1127
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0043 0.1169
Onchocerca volvulus 0.0028 0.0008 0.0455
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0028 0.0008 0.0008
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0041 0.0021 0.3109
Schistosoma mansoni tyrosine kinase 0.0029 0.001 0.0045
Echinococcus multilocularis survival motor neuron protein 1 0.0477 0.0452 0.1892
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0054 0.1615
Schistosoma mansoni intermediate filament proteins 0.0033 0.0013 0.006
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0054 0.0228
Toxoplasma gondii ATPase, AAA family protein 0.003 0.001 0.0801
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.003 0.001 0.0129
Echinococcus granulosus tyrosine protein kinase Fyn 0.0029 0.001 0.0045
Echinococcus multilocularis protein dispatched 1 0.0145 0.0124 0.0518
Echinococcus granulosus p2X purinoceptor 4 0.0469 0.0444 0.2109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0047 0.0946
Echinococcus multilocularis p2X purinoceptor 4 0.0469 0.0444 0.1861
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Brugia malayi TAR-binding protein 0.0069 0.0048 0.0048
Schistosoma mansoni rab6-interacting 0.002 0 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0039 0.0019 0.0019
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0071 0.005 0.142
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0095 0.0074 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.0212 0.0211
Schistosoma mansoni vav2 0.002 0 0.0002
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.003 0.001 0.0129
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0054 0.0054
Echinococcus granulosus potassium large conductance calcium activated 0.0097 0.0076 0.036
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0028 0.0008 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.003 0.001 0.0129
Loa Loa (eye worm) hypothetical protein 0.0109 0.0089 0.0088
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0021 0.0021
Echinococcus multilocularis c src tyrosine kinase 0.0029 0.001 0.004
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0028 0.0008 0.0008
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.0026 0.0006 0.0000071138
Brugia malayi photoreceptor-specific nuclear receptor 0.0039 0.0019 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0019 0.0092
Schistosoma mansoni lamin 0.0033 0.0013 0.006
Brugia malayi PHD-finger family protein 0.0025 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0075 0.0054 0.1555
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0019 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0039 0.0019 0.0019
Echinococcus granulosus tyrosine protein kinase Btk29A 0.072 0.0692 0.3283
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0028 0.0008 0.0085
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0054 0.1555
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0006 0.0028
Schistosoma mansoni lipoxygenase 0.0119 0.0098 0.0466
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.004 0.019
Echinococcus multilocularis replication factor c subunit 1 0.003 0.001 0.0041
Loa Loa (eye worm) hypothetical protein 0.0296 0.0273 0.0273
Leishmania major hypothetical protein, conserved 0.0026 0.0006 0.0000071138
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.0123 0.0299
Schistosoma mansoni microtubule-associated protein tau 0.2151 0.2107 1
Schistosoma mansoni calcium-activated potassium channel 0.0026 0.0006 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0039 0.0019 0.0019
Brugia malayi Fli-1 protein 0.0217 0.0195 0.0195
Brugia malayi Glycosyl hydrolases family 31 protein 0.0334 0.0311 0.031
Schistosoma mansoni adapter molecule crk 0.0026 0.0006 0.0028
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0001 0.0005
Loa Loa (eye worm) MaxiK calcium-activated potassium channel 0.0064 0.0044 0.0044
Echinococcus granulosus p2X purinoceptor 4 0.0469 0.0444 0.2109
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0003 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0054 0.1121
Trichomonas vaginalis maltase-glucoamylase, putative 0.0028 0.0008 0.0065
Plasmodium vivax potassium channel, putative 0.0026 0.0006 0.1048
Echinococcus multilocularis calcium activated potassium channel 0.0097 0.0076 0.032
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0039 0.0019 0.0092
Leishmania major alpha glucosidase II subunit, putative 0.0074 0.0054 0.0122
Brugia malayi Tyrosine-protein kinase abl-1 0.0029 0.001 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0039 0.0019 0.1122
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0054 0.1592
Schistosoma mansoni hypothetical protein 0.002 0 0.0001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0043 0.1169
Loa Loa (eye worm) hypothetical protein 0.0127 0.0106 0.0106
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0054 0.1555
Schistosoma mansoni DNA ligase IV 0.003 0.001 0.0046
Toxoplasma gondii ion channel protein 0.0026 0.0006 0.0006
Echinococcus granulosus c src tyrosine kinase 0.0029 0.001 0.0045
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Plasmodium falciparum replication factor C subunit 1, putative 0.003 0.001 0.1902
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0074 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0054 0.0258
Schistosoma mansoni alpha-glucosidase 0.0287 0.0265 0.1256
Loa Loa (eye worm) hypothetical protein 0.003 0.001 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0015 0.0015
Onchocerca volvulus 0.0028 0.0008 0.0455
Schistosoma mansoni acetyl-CoA synthetase 0.0028 0.0008 0.0038
Loa Loa (eye worm) RNA binding protein 0.0069 0.0048 0.0048
Echinococcus multilocularis nibrin 0.003 0.001 0.0041
Echinococcus multilocularis musashi 0.0033 0.0013 0.0053
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Trichomonas vaginalis alpha-glucosidase, putative 0.0028 0.0008 0.0065
Loa Loa (eye worm) hypothetical protein 1.0136 1 1
Echinococcus granulosus importin subunit beta 1 0.0035 0.0015 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.001 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0047 0.0946
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.009 0.007 0.2547
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Schistosoma mansoni gabp alpha 0.0071 0.0051 0.0243
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0008
Mycobacterium ulcerans lipase LipD 0.0075 0.0054 0.1555
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.0281 0.0703
Loa Loa (eye worm) hypothetical protein 0.0035 0.0015 0.0015
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0043 0.1169
Echinococcus multilocularis tyrosine protein kinase Abl 0.0029 0.001 0.004
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.003 0.001 0.0352
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0071 0.0051 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0035 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0074 0.0054 0.1967
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0003 0.0014
Echinococcus granulosus NCK adaptor protein 0.0026 0.0006 0.0028
Leishmania major calcium/potassium channel (CAKC), putative 0.0026 0.0006 0.0000071138
Onchocerca volvulus 0.0097 0.0077 0.4464
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0043 0.0203
Leishmania major acetyl-CoA synthetase, putative 0.0028 0.0008 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0074 0.0174
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0 0.0001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.001 0.004
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0003 0.0014
Echinococcus multilocularis ecdysone induced protein 78C 0.0039 0.0019 0.0081
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0041 0.0021 0.4135
Trypanosoma brucei glycosyl hydrolase-like protein 0.0028 0.0008 0.0005
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.003 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0061 0.0041 0.0041
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0039 0.0019 0.0019
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0054 0.0124
Schistosoma mansoni chromosome transmission fidelity factor 0.003 0.001 0.0046
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0054 0.1121
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0039 0.0019 0.0081
Echinococcus granulosus snurportin 1 0.0372 0.0348 0.1651
Echinococcus granulosus tyrosine protein kinase Src42A 0.0029 0.001 0.0045
Brugia malayi SRC-1 0.0029 0.001 0.0009
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0026 0.0006 0.1043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0015 0.0015
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0028 0.0008 0.0085
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.001 0.001
Mycobacterium ulcerans hypothetical protein 0.016 0.0139 0.4376
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0028 0.0008 0.0444
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0026 0.0006 0.0006
Echinococcus granulosus FTZ F1 alpha 0.0039 0.0019 0.0092
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0048 0.0229
Brugia malayi hypothetical protein 0.003 0.001 0.001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0019 0.0081
Echinococcus granulosus intermediate filament protein 0.0033 0.0013 0.006
Echinococcus granulosus lysosomal alpha glucosidase 0.0334 0.0311 0.1474
Onchocerca volvulus 0.0075 0.0054 0.3169
Trichomonas vaginalis alpha-glucosidase, putative 0.0074 0.0054 0.1592
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0108 0.0087 0.0414
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0001 0.0001
Onchocerca volvulus 0.0075 0.0054 0.3169
Schistosoma mansoni loxhd1 0.002 0 0.0001
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.003 0.001 0.001
Toxoplasma gondii ABC1 family protein 0.0075 0.0054 1
Toxoplasma gondii hypothetical protein 0.0049 0.0029 0.4758
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0054 0.1615
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0035 0.0166
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0026 0.0006 0.0006
Schistosoma mansoni lamin 0.0033 0.0013 0.006
Onchocerca volvulus 0.0039 0.0019 0.1122
Loa Loa (eye worm) hypothetical protein 0.0021 0.0001 0.0001
Onchocerca volvulus 0.0095 0.0074 0.4314
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.0281 0.0703
Plasmodium vivax importin-beta 2, putative 0.0035 0.0015 0.2718
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0296 0.0273 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0032 0.0067
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0039 0.0019 0.0081
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0048 0.0229
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0029 0.001 0.0045
Leishmania major 4-coumarate:coa ligase-like protein 0.0095 0.0074 0.0174
Onchocerca volvulus Bile acid receptor homolog 0.0039 0.0019 0.1122
Loa Loa (eye worm) hypothetical protein 0.0071 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0372 0.0348 0.1651
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0478 0.0453 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0021 0.0021
Mycobacterium ulcerans glutaminase 0.033 0.0307 1
Brugia malayi MH2 domain containing protein 0.0144 0.0123 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0054 0.0122
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.0281 0.0703
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0028 0.0008 0.0005
Onchocerca volvulus 0.0075 0.0054 0.3169
Schistosoma mansoni hypothetical protein 0.0108 0.0087 0.0414
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0054 0.1121
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.003 0.001 0.0059
Schistosoma mansoni alpha-glucosidase 0.0287 0.0265 0.1256
Echinococcus multilocularis neutral alpha glucosidase AB 0.0074 0.0054 0.0225
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.009 0.007 0.0163
Echinococcus multilocularis sterol regulatory element binding protein 0.0127 0.0106 0.0443
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0029 0.001 0.004
Echinococcus multilocularis snurportin 1 0.0372 0.0348 0.1457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0035 0.0015 0.007
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0071 0.005 0.1031
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0013 0.0013
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0028 0.0008 0.0085
Echinococcus granulosus dual specificity 0.009 0.007 0.033
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0039 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0039 0.0019 0.0019
Brugia malayi beta-lactamase 0.0075 0.0054 0.0054
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0028 0.0008 0.0005
Plasmodium falciparum potassium channel 0.0026 0.0006 0.1133
Mycobacterium leprae Probable lipase LipE 0.0075 0.0054 0.7031
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Toxoplasma gondii ion channel protein 0.0026 0.0006 0.0006
Schistosoma mansoni thyroid hormone receptor 0.0039 0.0019 0.0092
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0123 0.0123
Brugia malayi AMP-binding enzyme family protein 0.0028 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0054 0.1615
Brugia malayi Ets-domain containing protein 0.0071 0.0051 0.0051
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0054 0.1121
Echinococcus multilocularis importin subunit beta 1 0.0035 0.0015 0.0062
Loa Loa (eye worm) SRC-1 0.0029 0.001 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0039 0.0019 0.0019
Schistosoma mansoni coup transcription factor 0.0039 0.0019 0.0092
Loa Loa (eye worm) hypothetical protein 0.0075 0.0054 0.0054
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.009 0.0069 0.0069
Schistosoma mansoni ran 0.0026 0.0006 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0095 0.0074 0.2211
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0041 0.0021 0.0021
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0039 0.0019 0.0092
Loa Loa (eye worm) hypothetical protein 0.0028 0.0008 0.0008
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0054 0.1615
Entamoeba histolytica protein kinase, putative 0.009 0.007 0.2547
Trypanosoma brucei importin beta-1 subunit, putative 0.0035 0.0015 0.0023
Plasmodium vivax acyl-CoA synthetase, putative 0.0071 0.005 0.9257
Brugia malayi nuclear receptor NHR-88 0.0039 0.0019 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0001 0.0001
Brugia malayi Niemann-Pick C1 protein precursor 0.0296 0.0273 0.0273
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0039 0.0019 0.0092
Schistosoma mansoni calcium-activated potassium channel 0.0097 0.0076 0.036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0095 0.0074 0.2211
Mycobacterium ulcerans hypothetical protein 0.0095 0.0074 0.2211
Brugia malayi ecdysteroid receptor 0.0039 0.0019 0.0019
Schistosoma mansoni nck2/grb4 0.0026 0.0006 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0039 0.0019 0.0019
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0028 0.0008 0.0439
Schistosoma mansoni P2X receptor subunit 0.0469 0.0444 0.2109
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0043 0.0203

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen. (Class of assay: confirmatory) [Related pubchem assays: 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 12.5893 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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