Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase | 0.0039 | 0.0468 | 0.0104 |
Trichomonas vaginalis | 6-phosphogluconolactonase, putative | 0.0039 | 0.0468 | 0.0096 |
Chlamydia trachomatis | glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.1354 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0096 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0039 | 0.0468 | 0.0096 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0049 | 0.0828 | 0.0471 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0828 | 0.0894 |
Plasmodium falciparum | glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.0509 |
Schistosoma mansoni | glucosamine-6-phosphate isomerase | 0.0039 | 0.0468 | 0.0104 |
Plasmodium vivax | glucose-6-phosphate 1-dehydrogenase, putative | 0.0039 | 0.0468 | 0.0104 |
Brugia malayi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0059 | 0.1161 | 0.0883 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0293 | 0.9266 | 1 |
Brugia malayi | glucose phosphate isomerase a | 0.0049 | 0.0828 | 0.0509 |
Trypanosoma cruzi | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0059 | 0.1161 | 0.0918 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0375 | 0.0405 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0154 | 0.4443 | 1 |
Loa Loa (eye worm) | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.4014 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0375 | 0.0405 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.0883 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0293 | 0.9266 | 1 |
Brugia malayi | fructose-bisphosphate aldolase 1 | 0.0293 | 0.9266 | 1 |
Plasmodium vivax | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0059 | 0.1161 | 0.0883 |
Giardia lamblia | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0059 | 0.1161 | 0.0816 |
Entamoeba histolytica | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0468 |
Brugia malayi | fructose-bisphosphate aldolase 2 | 0.0293 | 0.9266 | 1 |
Leishmania major | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0104 |
Echinococcus granulosus | glucose 6 phosphate isomerase | 0.0049 | 0.0828 | 0.0509 |
Plasmodium vivax | glucose-6-phosphate isomerase, putative | 0.0049 | 0.0828 | 0.0509 |
Leishmania major | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0059 | 0.1161 | 0.0883 |
Trichomonas vaginalis | 3-hydroxyisobutyrate dehydrogenase, putative | 0.0059 | 0.1161 | 0.0816 |
Mycobacterium ulcerans | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.8223 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0059 | 0.1161 | 0.0816 |
Mycobacterium tuberculosis | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0094 | 0.2387 | 0.4947 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0141 |
Trypanosoma brucei | fructose-bisphosphate aldolase, glycosomal, putative | 0.0293 | 0.9266 | 1 |
Giardia lamblia | Glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.0471 |
Schistosoma mansoni | glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.0509 |
Toxoplasma gondii | glucose-6-phosphate 1-dehydrogenase | 0.0039 | 0.0468 | 0.0104 |
Trypanosoma brucei | glucose-6-phosphate isomerase, glycosomal | 0.0049 | 0.0828 | 0.0509 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0375 | 0.5 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0314 | 1 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0314 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.1931 |
Toxoplasma gondii | glucose-6-phosphate isomerase GPI | 0.0049 | 0.0828 | 0.0509 |
Giardia lamblia | Glucosamine-6-phosphate deaminase | 0.0039 | 0.0468 | 0.0096 |
Plasmodium falciparum | 6-phosphogluconate dehydrogenase, decarboxylating, putative | 0.0059 | 0.1161 | 0.0883 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0154 | 0.4443 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0078 | 0.0084 |
Toxoplasma gondii | fructose-bisphosphate aldolase, putative | 0.0293 | 0.9266 | 1 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0096 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0375 | 0.5 |
Schistosoma mansoni | fructose 16-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0133 | 0.372 | 0.3785 |
Schistosoma mansoni | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.0883 |
Treponema pallidum | glucose-6-phosphate 1-dehydrogenase | 0.0133 | 0.372 | 0.3153 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.3762 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0049 | 0.0828 | 0.0545 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 2 | 0.0293 | 0.9266 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Echinococcus granulosus | 6 phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.0883 |
Plasmodium vivax | fructose 1,6-bisphosphate aldolase, putative | 0.0293 | 0.9266 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0375 | 0.0285 |
Entamoeba histolytica | glucose-6-phosphate isomerase, putative | 0.0049 | 0.0828 | 0.0828 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Schistosoma mansoni | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.3762 |
Trichomonas vaginalis | 6-phosphogluconate dehydrogenase, putative | 0.0059 | 0.1161 | 0.0816 |
Treponema pallidum | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.0362 |
Echinococcus granulosus | fructose bisphosphate aldolase class I | 0.0293 | 0.9266 | 1 |
Mycobacterium ulcerans | glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.1114 |
Echinococcus multilocularis | pyruvate kinase | 0.0036 | 0.0375 | 0.0285 |
Echinococcus multilocularis | 6 phosphogluconolactonase | 0.0133 | 0.372 | 0.394 |
Echinococcus multilocularis | fructose 1,6 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Mycobacterium ulcerans | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.1931 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0293 | 0.9266 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase Gnd1 | 0.0059 | 0.1161 | 0.1931 |
Trypanosoma cruzi | 6-phosphogluconolactonase, putative | 0.0133 | 0.372 | 0.3785 |
Loa Loa (eye worm) | phosphoglucose isomerase | 0.0049 | 0.0828 | 0.0894 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0375 | 0.0405 |
Plasmodium falciparum | fructose-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Mycobacterium tuberculosis | Probable 6-phosphogluconate dehydrogenase, decarboxylating Gnd2 | 0.0059 | 0.1161 | 0.1931 |
Echinococcus multilocularis | glucose 6 phosphate isomerase | 0.0049 | 0.0828 | 0.078 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Trypanosoma cruzi | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0141 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Mycobacterium leprae | Probable glucose-6-phosphate isomerase Pgi (phosphoglucose isomerase) (phosphohexose isomerase) (PHI) | 0.0049 | 0.0828 | 0.1114 |
Echinococcus multilocularis | fructose bisphosphate aldolase class I | 0.0293 | 0.9266 | 1 |
Leishmania major | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.3762 |
Leishmania major | glucose-6-phosphate isomerase | 0.0049 | 0.0828 | 0.0509 |
Leishmania major | fructose-1,6-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Trypanosoma brucei | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0104 |
Chlamydia trachomatis | 6-phosphogluconolactonase | 0.0133 | 0.372 | 1 |
Loa Loa (eye worm) | pgd protein | 0.0059 | 0.1161 | 0.1253 |
Trypanosoma cruzi | glucose-6-phosphate isomerase, glycosomal, putative | 0.0049 | 0.0828 | 0.0545 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0375 | 0.0038 |
Toxoplasma gondii | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.0883 |
Toxoplasma gondii | fructose-1,6-bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Trypanosoma cruzi | fructose-bisphosphate aldolase, glycosomal, putative | 0.0293 | 0.9266 | 1 |
Loa Loa (eye worm) | fructose-bisphosphate aldolase 1 | 0.0293 | 0.9266 | 1 |
Echinococcus granulosus | fructose 16 bisphosphate aldolase | 0.0293 | 0.9266 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.0036 | 0.0375 | 0.0405 |
Mycobacterium leprae | PROBABLE 6-PHOSPHOGLUCONATE DEHYDROGENASE GND1 | 0.0059 | 0.1161 | 0.1931 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.0036 | 0.0375 | 0.5 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0154 | 0.4443 | 1 |
Echinococcus multilocularis | 6 phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.1144 |
Mycobacterium tuberculosis | Probable glucose-6-phosphate isomerase Pgi (GPI) (phosphoglucose isomerase) (phosphohexose isomerase) (phi) | 0.0049 | 0.0828 | 0.1114 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Chlamydia trachomatis | 6-phosphogluconate dehydrogenase | 0.0059 | 0.1161 | 0.2348 |
Trypanosoma brucei | 6-phosphogluconolactonase | 0.0133 | 0.372 | 0.3762 |
Mycobacterium leprae | Probable 6-phosphogluconolactonase DevB (6PGL) | 0.0133 | 0.372 | 0.8223 |
Giardia lamblia | Glucose-6-phosphate 1-dehydrogenase | 0.0039 | 0.0468 | 0.0096 |
Trypanosoma brucei | 6-phosphogluconate dehydrogenase, decarboxylating | 0.0059 | 0.1161 | 0.0883 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0314 | 1 | 1 |
Trichomonas vaginalis | glucose-6-phosphate isomerase, putative | 0.0049 | 0.0828 | 0.0471 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.0036 | 0.0375 | 0.0038 |
Brugia malayi | 6-phosphogluconolactonase family protein | 0.0133 | 0.372 | 0.3762 |
Echinococcus granulosus | 6 phosphogluconolactonase | 0.0133 | 0.372 | 0.3762 |
Trichomonas vaginalis | glucosamine-6-phosphate isomerase, putative | 0.0039 | 0.0468 | 0.0096 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ID50 (functional) | = 0.007 uM | In vitro cytotoxicity against L1210 cell line as concentration of the compound required for 50% inhibition of cell growth | ChEMBL. | 6827534 |
ID50 (functional) | = 0.007 uM | In vitro cytotoxicity against L1210 cell line as concentration of the compound required for 50% inhibition of cell growth | ChEMBL. | 6827534 |
ILS (functional) | = 46 % | Antitumor activity against L1210 leukemia cells measured as percent increase in life span (% ILS) at 10 mg/kg | ChEMBL. | 6827534 |
ILS (functional) | = 46 % | Antitumor activity against L1210 leukemia cells measured as percent increase in life span (% ILS) at 10 mg/kg | ChEMBL. | 6827534 |
K (functional) | = 143 uM-1 | Cytotoxicity against L1210 tumor cell line, activity is expressed as K (inverse value of drug concentration) | ChEMBL. | 6827534 |
K (functional) | = 143 uM-1 | Cytotoxicity against L1210 tumor cell line, activity is expressed as K (inverse value of drug concentration) | ChEMBL. | 6827534 |
LD0 (ADMET) | = 10 mg kg-1 | Acute toxicity in mice (LD0) after i.p. administration (highest nontoxic dose) | ChEMBL. | 6827534 |
LD0 (ADMET) | = 10 mg kg-1 | Acute toxicity in mice (LD0) after i.p. administration (highest nontoxic dose) | ChEMBL. | 6827534 |
LD100 (ADMET) | = 20 mg kg-1 | Acute toxicity in mice (LD100) after i.p. administration | ChEMBL. | 6827534 |
LD100 (ADMET) | = 20 mg kg-1 | Acute toxicity in mice (LD100) after i.p. administration | ChEMBL. | 6827534 |
MST (functional) | = 16.8 day | Antitumor activity against L1210 leukemia cells measured as Median survival time at 10 mg/kg | ChEMBL. | 6827534 |
MST (functional) | = 16.8 day | Antitumor activity against L1210 leukemia cells measured as Median survival time at 10 mg/kg | ChEMBL. | 6827534 |
Range of death (functional) | = 20 day | Antitumor activity against L1210 leukemia cells measured as range of death at 20 mg/kg ; value may range from 16 to 20 | ChEMBL. | 6827534 |
Range of death (functional) | = 20 day | Antitumor activity against L1210 leukemia cells measured as range of death at 20 mg/kg ; value may range from 16 to 20 | ChEMBL. | 6827534 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.