TDR Targets

Basic information

Technical information

TDR Targets ID: 793817
Name: 7-[(4-chlorophenyl)methyl]-8-[(2-ethylpiperid in-1-yl)methyl]-1,3-dimethylpurine-2,6-dione
MW: 429.943 | Formula: C22H28ClN5O2
H donors: 0 H acceptors: 3 LogP: 3.47 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCC1CCCCN1Cc1nc2c(n1Cc1ccc(cc1)Cl)c(=O)n(c(=O)n2C)C
InChi: 1S/C22H28ClN5O2/c1-4-17-7-5-6-12-27(17)14-18-24-20-19(21(29)26(3)22(30)25(20)2)28(18)13-15-8-10-16(23)11-9-15/h8-11,17H,4-7,12-14H2,1-3H3
InChiKey: FCIYPIXHLMWPSM-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

7-[(4-chlorophenyl)methyl]-8-[(2-ethyl-1-piperidyl)methyl]-1,3-dimethyl-purine-2,6-dione
7-[(4-chlorophenyl)methyl]-8-[(2-ethyl-1-piperidinyl)methyl]-1,3-dimethylpurine-2,6-dione
7-(4-chlorobenzyl)-8-[(2-ethyl-1-piperidyl)methyl]-1,3-dimethyl-xanthine
7-[(4-chlorophenyl)methyl]-8-[(2-ethylpiperidin-1-yl)methyl]-1,3-dimethyl-purine-2,6-dione

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	chromatin regulatory protein sir2	0.0931	1	1
Loa Loa (eye worm)	hypothetical protein	0.0581	0.6117	0.6106
Giardia lamblia	NADH oxidase lateral transfer candidate	0.005	0.0246	0.022
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0291	0.291	0.2825
Schistosoma mansoni	chromobox protein	0.0071	0.0471	0.0446
Trypanosoma cruzi	hypothetical protein, conserved	0.0655	0.6941	0.6864
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0128	0.0101
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0075	0.0525	0.0495
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.005	0.0246	0.5
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0385	0.3952	0.38
Plasmodium falciparum	thioredoxin reductase	0.005	0.0246	0.0559
Onchocerca volvulus		0.009	0.0689	0.2296
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0931	1	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0291	0.291	0.2731
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0128	0.0101
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.0266	0.024
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0931	1	1
Echinococcus multilocularis	lysine specific demethylase 5A	0.0037	0.0098	0.0071
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0145	0.1295	0.1272
Entamoeba histolytica	hypothetical protein, conserved	0.0239	0.2341	0.225
Echinococcus granulosus	NAD dependent deacetylase sirtuin 7	0.0239	0.2341	0.2321
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Echinococcus granulosus	citrate lyase subunit beta protein	0.0075	0.0525	0.0499
Echinococcus granulosus	chromobox protein 1	0.0071	0.0471	0.0446
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0117	0.0091
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0117	0.0091
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0128	0.0128
Plasmodium vivax	glutathione reductase, putative	0.0145	0.1295	0.3232
Echinococcus granulosus	NAD dependent deacetylase sirtuin 1	0.0581	0.6117	0.6106
Trichomonas vaginalis	CAMK family protein kinase	0.0144	0.1284	0.1284
Loa Loa (eye worm)	glutaminase	0.0559	0.5879	0.5868
Plasmodium falciparum	thioredoxin reductase	0.0145	0.1295	0.3232
Loa Loa (eye worm)	hypothetical protein	0.009	0.0689	0.0664
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0581	0.6117	0.6117
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0117	0.0091
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0331	0.3352	0.8381
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0117	0.0091
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.01	0.0793	0.0769
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0406	0.0381
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0406	0.0381
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0471	0.0446
Brugia malayi	jmjC domain containing protein	0.0037	0.0098	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0266	0.024
Schistosoma mansoni	tyrosinase precursor	0.009	0.0689	0.0664
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0406	0.0381
Giardia lamblia	Hypothetical protein	0.0931	1	1
Schistosoma mansoni	chromobox protein	0.0071	0.0471	0.0446
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0406	0.0381
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0291	0.291	0.2891
Plasmodium falciparum	transcriptional regulatory protein sir2b	0.0239	0.2341	0.5896
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Brugia malayi	NAD-dependent deacetylase SIRT1	0.0581	0.6117	0.6106
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0267	0.0241
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0406	0.0381
Loa Loa (eye worm)	PXA domain-containing protein	0.0039	0.0117	0.0091
Brugia malayi	chromobox protein homolog 3	0.004	0.0128	0.0101
Brugia malayi	RNA binding protein	0.0065	0.0406	0.0381
Schistosoma mansoni	glutaminase	0.0559	0.5879	0.5868
Leishmania major	trypanothione reductase	0.0145	0.1295	0.1076
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0406	0.0381
Echinococcus multilocularis	regulator of G protein signaling	0.0039	0.0117	0.0091
Loa Loa (eye worm)	thioredoxin reductase	0.0145	0.1295	0.1272
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0291	0.291	0.2731
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0331	0.3352	0.8381
Brugia malayi	ShTK domain containing protein	0.009	0.0689	0.0664
Trypanosoma brucei	hypothetical protein, conserved	0.0655	0.6941	0.6864
Plasmodium falciparum	glutathione reductase	0.005	0.0246	0.0559
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0581	0.6117	0.6117
Loa Loa (eye worm)	ShTK domain-containing protein	0.009	0.0689	0.0664
Schistosoma mansoni	kinase	0.0148	0.1326	0.1303
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0145	0.1295	0.2831
Loa Loa (eye worm)	jmjC domain-containing protein	0.0037	0.0098	0.0071
Loa Loa (eye worm)	hypothetical protein	0.004	0.0128	0.0101
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0117	0.0091
Brugia malayi	PXA domain containing protein	0.0039	0.0117	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0033	0.0007
Onchocerca volvulus		0.009	0.0689	0.2296
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0084	0.0057
Loa Loa (eye worm)	ShTK domain-containing protein	0.009	0.0689	0.0664
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.0266	0.024
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0239	0.2341	0.2341
Brugia malayi	hypothetical protein	0.0039	0.0117	0.0091
Echinococcus multilocularis	expressed protein	0.0752	0.8014	0.8009
Schistosoma mansoni	chromatin regulatory protein sir2	0.0931	1	1
Brugia malayi	regulator of G-protein signaling rgs-7	0.0039	0.0117	0.0091
Trypanosoma cruzi	trypanothione reductase, putative	0.0145	0.1295	0.1076
Trichomonas vaginalis	glutathione reductase, putative	0.005	0.0246	0.0246
Brugia malayi	A-kinase anchor protein 10, precursor	0.0039	0.0117	0.0091
Trypanosoma brucei	Silent information regulator 2 related protein 1	0.0931	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0655	0.6941	0.6864
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0368	0.3761	1
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0117	0.0091
Echinococcus granulosus	lysine specific demethylase 5A	0.0037	0.0098	0.0071
Echinococcus granulosus	chromobox protein 1	0.0071	0.0471	0.0446
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0075	0.0525	0.0525
Plasmodium falciparum	transcriptional regulatory protein sir2a	0.0385	0.3952	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.005	0.0246	0.0559
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.0689	0.0664
Schistosoma mansoni	chromatin regulatory protein sir2	0.0239	0.2341	0.2321
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0931	1	1
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0406	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Schistosoma mansoni	jumonji domain containing protein	0.0079	0.0567	0.0541
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0039	0.0117	0.0091
Trypanosoma brucei	SIR2-like protein 4, putative	0.0239	0.2341	0.2148
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0471	0.0471
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0161	0.0161
Echinococcus granulosus	Regulator of G protein signaling 20	0.0039	0.0117	0.0091
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0581	0.6117	0.6117
Brugia malayi	Heterochromatin protein 1	0.0071	0.0471	0.0446
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.005	0.0246	0.0559
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0385	0.3952	0.388
Plasmodium vivax	thioredoxin reductase, putative	0.0145	0.1295	0.3232
Loa Loa (eye worm)	RGS-3 protein	0.0039	0.0117	0.0091
Trypanosoma brucei	Silent information regulator 2 related protein 3	0.0385	0.3952	0.38
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.004	0.0128	0.0101
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0075	0.0525	0.0499
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0117	0.0091
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Echinococcus granulosus	chromatin regulatory protein sir2	0.0931	1	1
Brugia malayi	serine/threonine-protein kinase plk-2	0.0291	0.291	0.2891
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0386	0.036
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0161	0.0161
Mycobacterium tuberculosis	Probable reductase	0.0331	0.3352	0.8381
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0331	0.3352	0.8339
Giardia lamblia	Transcriptional regulator, Sir2 family	0.0385	0.3952	0.3936
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Loa Loa (eye worm)	transcriptional regulator	0.0239	0.2341	0.2321
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Giardia lamblia	Sirtuin type 2	0.0239	0.2341	0.2321
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0117	0.0091
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 3	0.0931	1	1
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0128	0.0351
Mycobacterium tuberculosis	Transcriptional regulatory protein	0.0385	0.3952	1
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0037	0.0099	0.0072
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0581	0.6117	0.6117
Trichomonas vaginalis	CAMK family protein kinase	0.0144	0.1284	0.1284
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0291	0.291	0.2891
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.0689	0.0664
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0406	0.0381
Brugia malayi	TAR-binding protein	0.0065	0.0406	0.0381
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0331	0.3352	0.8381
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0471	0.0446
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0037	0.0099	0.0072
Schistosoma mansoni	serine/threonine protein kinase	0.004	0.0128	0.0101
Loa Loa (eye worm)	glutaminase 2	0.0559	0.5879	0.5868
Schistosoma mansoni	chromatin regulatory protein sir2	0.0239	0.2341	0.2321
Plasmodium vivax	NAD-dependent deacetylase, putative	0.0385	0.3952	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0039	0.0117	0.0091
Onchocerca volvulus		0.009	0.0689	0.2296
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0117	0.0091
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.005	0.0246	0.022
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0239	0.2341	0.2321
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0291	0.291	1
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0075	0.0525	0.0286
Loa Loa (eye worm)	transcriptional regulator	0.0239	0.2341	0.2321
Schistosoma mansoni	axis inhibition protein axin	0.0039	0.0117	0.0091
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.005	0.0246	0.0559
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 1	0.0581	0.6117	0.6106
Leishmania major	NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe	0.0385	0.3952	0.38
Echinococcus multilocularis	beta adrenergic receptor kinase	0.004	0.0128	0.0101
Brugia malayi	transcriptional regulator, Sir2 family protein	0.0239	0.2341	0.2321
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0039	0.0117	0.0091
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0075	0.0525	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0471	0.0471
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0039	0.0117	0.0091
Giardia lamblia	NAD-dependent histone deacetylase Sir2	0.0581	0.6117	0.6106
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.005	0.0246	0.022
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.005	0.0246	0.0559
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.004	0.0128	0.0101
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.005	0.0246	0.0559
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.005	0.0246	0.022
Echinococcus multilocularis	chromatin regulatory protein sir2	0.0931	1	1
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0075	0.0525	0.0495
Schistosoma mansoni	chromatin regulatory protein sir2	0.0385	0.3952	0.3936
Echinococcus granulosus	expressed protein	0.0752	0.8014	0.8009
Schistosoma mansoni	chromatin regulatory protein sir2	0.0931	1	1
Brugia malayi	jmjC domain containing protein	0.01	0.0793	0.0769
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.009	0.0689	0.0664
Loa Loa (eye worm)	hypothetical protein	0.0341	0.3466	0.3448
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0039	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0471	0.0446
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0931	1	1
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0117	0.0091
Toxoplasma gondii	histone deacetylase SIR2	0.0385	0.3952	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0291	0.291	0.2891
Brugia malayi	hypothetical protein	0.0039	0.0117	0.0091
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0525	0.0495
Mycobacterium tuberculosis	Probable oxidoreductase	0.0368	0.3761	0.9484
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 6	0.0239	0.2341	0.2321
Brugia malayi	latrophilin 2 splice variant baaae	0.0036	0.0084	0.0057
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0117	0.0091
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0239	0.2341	0.2341
Leishmania major	sir2-family protein-like protein	0.0239	0.2341	0.2148
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0075	0.0525	0.0286
Toxoplasma gondii	thioredoxin reductase	0.0145	0.1295	0.3232
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.005	0.0246	0.5
Echinococcus multilocularis	axis inhibition protein axin	0.0039	0.0117	0.0091
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0331	0.3352	0.8381
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0161	0.0466
Brugia malayi	PXA domain containing protein	0.0039	0.0117	0.0091
Loa Loa (eye worm)	hypothetical protein	0.009	0.0689	0.0664
Onchocerca volvulus		0.009	0.0689	0.2296
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0406	0.0381
Mycobacterium ulcerans	glutaminase	0.0559	0.5879	1
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0075	0.0525	0.0495
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0039	0.0117	0.0091
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0117	0.0091
Echinococcus granulosus	thioredoxin glutathione reductase	0.0145	0.1295	0.1272
Trypanosoma brucei	trypanothione reductase	0.0145	0.1295	0.1076
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0039	0.0117	0.0091
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0385	0.3952	0.3952
Brugia malayi	glutaminase DH11.1	0.0559	0.5879	0.5868
Echinococcus granulosus	regulator of G protein signaling 7	0.0039	0.0117	0.0091
Loa Loa (eye worm)	glutathione reductase	0.0145	0.1295	0.1272
Entamoeba histolytica	NAD-dependent deacetylase 1, putative	0.0239	0.2341	0.225
Toxoplasma gondii	NADPH-glutathione reductase	0.005	0.0246	0.0559
Leishmania major	silent information regulator 2, putative	0.0931	1	1
Echinococcus granulosus	beta-adrenergic receptor kinase	0.004	0.0128	0.0101
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0368	0.3761	0.9484
Trichomonas vaginalis	mercuric reductase, putative	0.005	0.0246	0.0246
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.009	0.0689	0.0664
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.0266	0.024
Mycobacterium tuberculosis	Probable dehydrogenase	0.0331	0.3352	0.8381
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0385	0.3952	0.3952
Trichomonas vaginalis	CAMK family protein kinase	0.0291	0.291	0.291
Trypanosoma cruzi	Silent information regulator 2 related protein 1	0.0931	1	1
Schistosoma mansoni	regulator of G protein signaling	0.0039	0.0117	0.0091
Schistosoma mansoni	chromatin regulatory protein sir2	0.0581	0.6117	0.6106
Echinococcus multilocularis	regulator of G protein signaling 7	0.0039	0.0117	0.0091
Echinococcus multilocularis	jumonji domain containing protein	0.0042	0.0159	0.0132
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0117	0.0091
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0075	0.0525	0.0752
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0117	0.0117
Echinococcus granulosus	axis inhibition protein axin	0.0039	0.0117	0.0091
Brugia malayi	Common central domain of tyrosinase family protein	0.009	0.0689	0.0664
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.005	0.0246	0.022
Loa Loa (eye worm)	transcriptional regulator	0.0931	1	1
Toxoplasma gondii	histone deacetylase SIR2-like	0.0239	0.2341	0.5896
Brugia malayi	glutathione reductase	0.0145	0.1295	0.1272
Onchocerca volvulus		0.0031	0.0033	0.0023
Leishmania major	hypothetical protein, conserved	0.0655	0.6941	0.6864
Trypanosoma brucei	polo-like protein kinase	0.0291	0.291	0.2731
Trichomonas vaginalis	glutaminase, putative	0.0559	0.5879	0.5879
Echinococcus multilocularis	regulator of G protein signaling 3	0.0039	0.0117	0.0091
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0117	0.0091
Mycobacterium ulcerans	NAD-dependent deacetylase	0.0385	0.3952	0.6579
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.004	0.0128	0.0101
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0291	0.291	0.2891
Trypanosoma cruzi	polo-like protein kinase, putative	0.0291	0.291	0.2731
Echinococcus granulosus	NAD dependent deacetylase sirtuin 6	0.0239	0.2341	0.2321
Trichomonas vaginalis	chromatin regulatory protein sir2, putative	0.0385	0.3952	0.3952
Echinococcus granulosus	NAD dependent deacetylase sirtuin 3	0.0931	1	1
Echinococcus granulosus	regulator of G protein signaling 3	0.0039	0.0117	0.0091
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0039	0.0117	0.0091
Treponema pallidum	NADH oxidase	0.005	0.0246	0.5
Mycobacterium ulcerans	hypothetical protein	0.0075	0.0525	0.0495
Mycobacterium tuberculosis	Conserved protein	0.0075	0.0525	0.0752
Entamoeba histolytica	Sir2 family transcriptional regulator, putative	0.0931	1	1
Mycobacterium ulcerans	Sir2-like regulatory protein	0.0239	0.2341	0.3719
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0098	0.0071
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.005	0.0246	0.5
Loa Loa (eye worm)	tyrosinase 1	0.009	0.0689	0.0664
Schistosoma mansoni	hypothetical protein	0.0036	0.0084	0.0057
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0406	0.0381
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0128	0.0128
Plasmodium vivax	hypothetical protein, conserved	0.0239	0.2341	0.5896
Schistosoma mansoni	tyrosinase precursor	0.009	0.0689	0.0664
Echinococcus multilocularis	NAD dependent deacetylase sirtuin 7	0.0239	0.2341	0.2321
Echinococcus granulosus	jumonji domain containing protein	0.0042	0.0159	0.0132
Brugia malayi	Thioredoxin reductase	0.0145	0.1295	0.1272
Loa Loa (eye worm)	sirtuin 4	0.0239	0.2341	0.2321
Schistosoma mansoni	z-protein (S1r protein)	0.0039	0.0117	0.0091
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0039	0.0117	0.0091
Plasmodium falciparum	glutathione reductase	0.0145	0.1295	0.3232
Giardia lamblia	Kinase, PLK	0.0291	0.291	0.2891
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0037	0.0098	0.0071
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.01	0.0793	0.0769
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0406	0.0381
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0368	0.3761	0.9484
Trypanosoma cruzi	Silent information regulator 2 related protein 3	0.0385	0.3952	0.38

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

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Bibliographic References

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Detailed information for compound 793817