Detailed information for compound 793957

Basic information

Technical information
  • TDR Targets ID: 793957
  • Name: N-(4-ethylphenyl)-3-[(1-propanoyl-2,3-dihydro indol-5-yl)sulfonylamino]propanamide
  • MW: 429.532 | Formula: C22H27N3O4S
  • H donors: 2 H acceptors: 4 LogP: 2.35 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1ccc(cc1)NC(=O)CCNS(=O)(=O)c1ccc2c(c1)CCN2C(=O)CC
  • InChi: 1S/C22H27N3O4S/c1-3-16-5-7-18(8-6-16)24-21(26)11-13-23-30(28,29)19-9-10-20-17(15-19)12-14-25(20)22(27)4-2/h5-10,15,23H,3-4,11-14H2,1-2H3,(H,24,26)
  • InChiKey: VKPLRGWWBUMMNK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethylphenyl)-3-[(1-propanoylindolin-5-yl)sulfonylamino]propanamide
  • N-(4-ethylphenyl)-3-[[1-(1-oxopropyl)-5-indolinyl]sulfonylamino]propanamide
  • N-(4-ethylphenyl)-3-[(1-propionylindolin-5-yl)sulfonylamino]propionamide
  • C464-1320
  • NCGC00108755-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0026 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0051 0.1148 0.1148
Brugia malayi SET domain containing protein 0.0013 0.0003 0.0003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Loa Loa (eye worm) hypothetical protein 0.0042 0.0872 0.0872
Giardia lamblia Kinase, PLK 0.0197 0.5493 1
Brugia malayi Zinc finger, C2H2 type family protein 0.0065 0.156 0.156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0984 0.0958
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0596 0.0569
Echinococcus granulosus zinc finger protein 0.0021 0.0263 0.0235
Brugia malayi Heterochromatin protein 1 0.0069 0.1693 0.1693
Mycobacterium tuberculosis Probable dehydrogenase 0.0108 0.2823 0.6075
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0359 0.0331
Brugia malayi Pre-SET motif family protein 0.0227 0.6367 0.6367
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Echinococcus multilocularis peregrin 0.0034 0.065 0.0623
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0195 0.0149
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0238 0.0172
Plasmodium vivax glutathione reductase, putative 0.0047 0.103 0.2052
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.103 0.1003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.012 0.318 0.6874
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0401 0.0401
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0172 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1693 0.2197
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.1019 0.2029
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0596 0.1079
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.2721 0.2699
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0197 0.5493 0.548
Loa Loa (eye worm) hypothetical protein 0.0077 0.1919 0.1919
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0874 0.1057
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.1019 0.1682
Schistosoma mansoni hypothetical protein 0.0017 0.0125 0.0096
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0141 0.0049
Schistosoma mansoni hypothetical protein 0.0022 0.0298 0.0269
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0141 0.0049
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0108 0.2823 0.6075
Loa Loa (eye worm) hypothetical protein 0.0032 0.0573 0.0573
Brugia malayi Pre-SET motif family protein 0.0033 0.0596 0.0596
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0061 0.1451 0.1426
Schistosoma mansoni dihydroorotate dehydrogenase 0.0166 0.4573 0.4557
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0397 0.0525
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0141 0.0141
Echinococcus granulosus geminin 0.0185 0.5115 0.5101
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Brugia malayi isocitrate dehydrogenase 0.0017 0.0141 0.0141
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0195 0.0149
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.012 0.318 0.6663
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0238 0.023
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0401 0.0532
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0069 0.1689 0.276
Echinococcus granulosus flap endonuclease 1 0.0026 0.0401 0.0373
Echinococcus granulosus dna polymerase eta 0.0089 0.2275 0.2253
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0166 0.4573 0.4573
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0401 0.0641
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.1578 0.1578
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0069 0.1689 0.2191
Plasmodium falciparum DNA repair protein REV1, putative 0.0019 0.0195 0.0179
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0397 0.0633
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0349 1 1
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0573 0.1029
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0029 0.0029
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0401 0.0641
Echinococcus multilocularis dedicator of cytokinesis protein 0.0057 0.133 0.1305
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0166 0.4573 0.8289
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0573 0.0546
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0166 0.4573 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0238 0.021
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0068 0.165 0.1625
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0069 0.1689 0.1664
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.1562 0.1538
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0203
Brugia malayi glutathione reductase 0.0047 0.103 0.103
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0397 0.0633
Loa Loa (eye worm) hypothetical protein 0.0039 0.0786 0.0786
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0984 0.0958
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.1693 0.1693
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.1148 0.1122
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0401 0.0309
Plasmodium falciparum thioredoxin reductase 0.0047 0.103 0.2052
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0238 0.0277
Loa Loa (eye worm) hypothetical protein 0.0046 0.101 0.101
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.2537 0.3372
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0195 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0195 0.0149
Echinococcus granulosus chromobox protein 1 0.0069 0.1693 0.1668
Echinococcus multilocularis dna polymerase kappa 0.0061 0.1451 0.1426
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.1562 0.1538
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0238 0.0277
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0397 0.0633
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.103 0.103
Leishmania major trypanothione reductase 0.0047 0.103 0.1701
Onchocerca volvulus 0.0031 0.0536 0.0202
Leishmania major DNA polymerase eta, putative 0.0047 0.1019 0.1682
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.5493 1
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Schistosoma mansoni hypothetical protein 0.0185 0.5115 0.5101
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0069 0.1689 0.1664
Brugia malayi jmjC domain containing protein 0.0041 0.0834 0.0834
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.103 0.2052
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0182 0.0153
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0874 0.1057
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.5493 0.548
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0195 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0793 0.0766
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0108 0.2823 0.6075
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0834 0.0807
Trypanosoma brucei unspecified product 0.0061 0.1451 0.2483
Schistosoma mansoni hypothetical protein 0.0032 0.0573 0.0546
Brugia malayi Bromodomain containing protein 0.0082 0.2057 0.2057
Trichomonas vaginalis set domain proteins, putative 0.0258 0.7298 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0885 0.1433
Onchocerca volvulus 0.0044 0.0934 0.0777
Schistosoma mansoni ap endonuclease 0.002 0.0238 0.021
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0934 0.0907
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.103 0.2052
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0068 0.165 0.1625
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0984 0.0958
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0349 1 1
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0203 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0115 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0984 0.0958
Leishmania major DNA polymerase eta, putative 0.0089 0.2275 0.4017
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0943 0.0917
Loa Loa (eye worm) hypothetical protein 0.0026 0.0397 0.0397
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1451 0.2996
Plasmodium falciparum phd finger protein, putative 0.0032 0.0573 0.1029
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0166 0.4573 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0061 0.1451 0.1426
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0166 0.4573 1
Schistosoma mansoni zinc finger protein 0.0017 0.0125 0.0096
Echinococcus multilocularis zinc finger protein 0.0021 0.0263 0.0235
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0172 0.0128
Trichomonas vaginalis chromobox protein, putative 0.0069 0.1693 0.2197
Echinococcus multilocularis chromobox protein 1 0.0069 0.1693 0.1668
Echinococcus granulosus chromobox protein 1 0.0069 0.1693 0.1668
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.2537 0.3372
Schistosoma mansoni flap endonuclease-1 0.0023 0.0327 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0238 0.0277
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Entamoeba histolytica deoxycytidyl transferase, putative 0.0061 0.1451 0.2307
Schistosoma mansoni hypothetical protein 0.0185 0.5115 0.5101
Leishmania major DNA polymerase kappa, putative 0.0019 0.0195 0.0149
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0141 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0397 0.0302
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0061 0.1451 0.2483
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0203 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0984 0.0958
Echinococcus granulosus dna polymerase kappa 0.0061 0.1451 0.1426
Schistosoma mansoni jumonji domain containing protein 0.0083 0.2085 0.2062
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0089 0.2275 0.2275
Schistosoma mansoni ap endonuclease 0.002 0.0238 0.021
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0397 0.0525
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0573 0.0546
Schistosoma mansoni DNA polymerase IV / kappa 0.0019 0.0195 0.0166
Trypanosoma brucei unspecified product 0.0042 0.0885 0.1433
Trypanosoma cruzi polo-like protein kinase, putative 0.0197 0.5493 1
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0401 0.0373
Loa Loa (eye worm) hypothetical protein 0.0044 0.0948 0.0948
Mycobacterium tuberculosis Conserved hypothetical protein 0.0061 0.1451 0.2996
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0984 0.0958
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0166 0.4573 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0238 0.0172
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0885 0.1433
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0061 0.1451 0.186
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0397 0.0397
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0238 0.021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0061 0.1451 0.1451
Brugia malayi CHD4 protein 0.0013 0.0029 0.0029
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0349 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0793 0.0766
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0397 0.0633
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0195 0.0149
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0397 0.0633
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0203
Onchocerca volvulus Serine\/threonine kinase homolog 0.0197 0.5493 0.7385
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Echinococcus multilocularis geminin 0.0185 0.5115 0.5101
Giardia lamblia DINP protein human, muc B family 0.0061 0.1451 0.2483
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1451 0.2483
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0834 0.0834
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0238 0.0238
Onchocerca volvulus Alhambra homolog 0.0032 0.0573 0.0255
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0397 0.0397
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0141 0.0059
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0238 0.023
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0772 0.0745
Loa Loa (eye worm) hypothetical protein 0.0054 0.1248 0.1248
Trypanosoma brucei unspecified product 0.0042 0.0885 0.1433
Schistosoma mansoni DNA polymerase eta 0.0089 0.2275 0.2253
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.012 0.318 0.6874
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0115 0.0115
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0397 0.0633
Echinococcus multilocularis chromobox protein 1 0.0069 0.1693 0.1668
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0141 0.0059
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0195 0.0179
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0115 0.0086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0115 0.0086
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.2721 0.2699
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0349 1 1
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0573 0.0573
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0069 0.1689 0.1664
Echinococcus granulosus peregrin 0.0034 0.065 0.0623
Leishmania major DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Toxoplasma gondii exonuclease III APE 0.002 0.0238 0.0277
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0197 0.5493 0.5493
Trichomonas vaginalis DNA polymerase eta, putative 0.0061 0.1451 0.186
Brugia malayi chromobox protein homolog 3 0.0039 0.0786 0.0786
Entamoeba histolytica serine/threonine protein kinase, putative 0.0197 0.5493 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0203 0.0203
Echinococcus multilocularis dna polymerase eta 0.0089 0.2275 0.2253
Leishmania major dihydroorotate dehydrogenase 0.0166 0.4573 0.8289
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0195 0.0149
Plasmodium vivax DNA repair protein REV1, putative 0.0019 0.0195 0.0179
Trypanosoma cruzi ISWI complex protein 0.0017 0.0125 0.0019
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Loa Loa (eye worm) hypothetical protein 0.0026 0.0397 0.0397
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0141 0.0059
Brugia malayi polk-prov protein 0.0019 0.0195 0.0195
Loa Loa (eye worm) hypothetical protein 0.0031 0.0536 0.0536
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0298 0.0298
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0397 0.0302
Loa Loa (eye worm) glutathione reductase 0.0047 0.103 0.103
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0182 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0596 0.0569
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0203 0.0198
Brugia malayi Thioredoxin reductase 0.0047 0.103 0.103
Trypanosoma brucei trypanothione reductase 0.0047 0.103 0.1701
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0227 0.6367 0.6367
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0141 0.0059
Schistosoma mansoni dock 0.0068 0.165 0.1625
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0195 0.0149
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0786 0.0564
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0238 1
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0203 0.0198
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0885 0.1433
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0874 0.0691
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0238 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1148 0.1122
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0141 0.0049
Trypanosoma brucei ISWI complex protein 0.0017 0.0125 0.0019
Giardia lamblia PHD finger protein 15 0.0032 0.0573 0.0853
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0166 0.4573 0.8289
Brugia malayi ImpB/MucB/SamB family protein 0.0089 0.2275 0.2275
Schistosoma mansoni chromobox protein 0.0069 0.1693 0.1668
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0065 0.156 0.2012
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0448 0.0464
Brugia malayi Flap endonuclease-1 0.0026 0.0401 0.0401
Schistosoma mansoni zinc finger protein 0.0021 0.0263 0.0235
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0359 0.0331
Plasmodium falciparum dihydroorotate dehydrogenase 0.0166 0.4573 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0197 0.5493 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0238 0.023
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0069 0.1689 0.2191
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0984 0.0984
Mycobacterium tuberculosis Probable reductase 0.0108 0.2823 0.6075
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0108 0.2823 0.6075
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0065 0.156 0.2012
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0573 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0573 0.1029
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0065 0.156 0.2012
Mycobacterium ulcerans hypothetical protein 0.0019 0.0195 0.0179
Trypanosoma cruzi DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Plasmodium falciparum flap endonuclease 1 0.0026 0.0401 0.0641
Schistosoma mansoni terminal deoxycytidyl transferase 0.0061 0.1451 0.1426
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0141 0.0049
Schistosoma mansoni bromodomain containing protein 0.0069 0.1678 0.1654
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0238 0.023
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0141 0.0112
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0397 0.0302
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0397 0.0525
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0401 0.0398
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0984 0.0958
Brugia malayi Bromodomain containing protein 0.0042 0.0869 0.0869
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0834 0.0807
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0141 0.0112
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0166 0.4573 0.8289
Trichomonas vaginalis CAMK family protein kinase 0.0197 0.5493 0.7488
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0786 0.0934
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0141 0.0059
Trypanosoma cruzi DNA damage repair protein, putative 0.0019 0.0195 0.0149
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0401 0.0532
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0061 0.1451 0.1426
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0182 0.0153
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.103 0.1003
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0141 0.0112
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0108 0.2823 0.581
Brugia malayi PHD-finger family protein 0.0032 0.0573 0.0573
Schistosoma mansoni chromobox protein 0.0069 0.1693 0.1668
Trypanosoma cruzi ISWI complex protein 0.0017 0.0125 0.0019
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0401 0.0532
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0166 0.4573 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0984 0.0984
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0238 0.023
Trypanosoma brucei polo-like protein kinase 0.0197 0.5493 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0238 0.0238
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0108 0.2823 0.6075
Leishmania major hypothetical protein, conserved 0.0017 0.0125 0.0019
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0065 0.156 0.2687
Trypanosoma brucei DNA polymerase eta, putative 0.0089 0.2275 0.4017
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0019 0.0195 0.0179
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0397 0.0633
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.103 0.1701
Brugia malayi Bromodomain containing protein 0.0034 0.065 0.065
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0786 0.0934
Plasmodium falciparum glutathione reductase 0.0047 0.103 0.2052
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0197 0.5493 0.548
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0166 0.4573 0.4573
Brugia malayi serine/threonine-protein kinase plk-2 0.0197 0.5493 0.5493
Onchocerca volvulus 0.0258 0.7298 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0573 0.0546
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0141 0.0112
Trypanosoma brucei DNA damage repair protein, putative 0.0019 0.0195 0.0149
Brugia malayi jmjC domain containing protein 0.0104 0.2721 0.2721
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0401 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.1148 0.1122
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Mycobacterium ulcerans hypothetical protein 0.0026 0.0397 0.0633
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0141 0.0141
Trypanosoma brucei chrX additional, unordered contigs 0.0019 0.0195 0.0149
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.1148 0.1122
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0061 0.1451 0.2996
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0834 0.0807
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0397 0.0633
Brugia malayi ImpB/MucB/SamB family protein 0.0061 0.1451 0.1451
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1451 0.2483
Schistosoma mansoni kinase 0.01 0.2614 0.2593
Plasmodium vivax SET domain protein, putative 0.0033 0.0596 0.1079
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0069 0.1689 0.1664
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0203 0.0198
Trypanosoma cruzi DNA polymerase eta, putative 0.0089 0.2275 0.4017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0172 0.0128
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0238 0.0277
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0397 0.0633
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0065 0.156 0.2012
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0141 0.0112
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0172 0.0128
Leishmania major DNA damage repair protein, putative 0.0019 0.0195 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.0061 0.1451 0.2483
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0448 0.0464
Mycobacterium tuberculosis Probable oxidoreductase 0.012 0.318 0.6874
Mycobacterium ulcerans DNA polymerase IV 0.0061 0.1451 0.2996
Loa Loa (eye worm) hypothetical protein 0.0019 0.0195 0.0195
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0182 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0061 0.1451 0.2483
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0166 0.4573 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0141 0.0112
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0141 0.0049
Brugia malayi PHD-finger family protein 0.0027 0.0436 0.0436
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0943 0.0917
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0166 0.4573 0.8289
Toxoplasma gondii thioredoxin reductase 0.0047 0.103 0.2052
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0202 0.0202
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.056 0.0533
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0359 0.0331
Giardia lamblia DNA damage repair protein 0.0019 0.0195 0.0149

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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