Detailed information for compound 794016

Basic information

Technical information
  • TDR Targets ID: 794016
  • Name: ethyl 4-[[7-[(2-chlorophenyl)methyl]-1,3-dime thyl-2,6-dioxopurin-8-yl]methyl]piperazine-1- carboxylate
  • MW: 474.941 | Formula: C22H27ClN6O4
  • H donors: 0 H acceptors: 4 LogP: 1.7 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOC(=O)N1CCN(CC1)Cc1nc2c(n1Cc1ccccc1Cl)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C22H27ClN6O4/c1-4-33-22(32)28-11-9-27(10-12-28)14-17-24-19-18(20(30)26(3)21(31)25(19)2)29(17)13-15-7-5-6-8-16(15)23/h5-8H,4,9-14H2,1-3H3
  • InChiKey: NCBAIPTUFVKRLZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl 4-[[7-[(2-chlorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-purin-8-yl]methyl]piperazine-1-carboxylate
  • 4-[[7-[(2-chlorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester
  • 4-[[7-(2-chlorobenzyl)-2,6-diketo-1,3-dimethyl-purin-8-yl]methyl]piperazine-1-carboxylic acid ethyl ester
  • STOCK5S-59150

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum importin beta, putative 0.0029 0.0125 0.7057
Mycobacterium tuberculosis Conserved protein 0.0073 0.0492 0.1311
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0052 0.0256
Schistosoma mansoni coup transcription factor 0.002 0.0052 0.0052
Mycobacterium leprae Probable lipase LipE 0.0073 0.0492 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0076 0.0512 0.1974
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0052 0.0256
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.1077
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0054
Schistosoma mansoni alpha glucosidase 0.0037 0.0196 0.0196
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0273 0.5538
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0492 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0052 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0128 0.0126
Brugia malayi nuclear receptor NHR-88 0.002 0.0052 0.0197
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0176 0.5
Echinococcus granulosus cpg binding protein 0.0093 0.0656 0.0654
Echinococcus granulosus importin subunit beta 1 0.0029 0.0125 0.0123
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0273 0.5538
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0028 0.0026
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0273 0.5538
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0006
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0052 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0424
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0203 0.4106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0184 0.1404 0.1404
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0273 0.0726
Echinococcus granulosus mixed lineage leukemia protein mll 0.0023 0.0075 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0052 0.0197
Schistosoma mansoni nuclear hormone receptor 0.002 0.0052 0.0052
Mycobacterium ulcerans bacterioferritin BfrB 0.0017 0.0027 0.0514
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0492 0.0491
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0132 0.0504
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0923 0.3564
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0492 0.2465
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0052 0.0197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0052 0.0197
Brugia malayi Importin beta-1 subunit 0.0029 0.0125 0.0476
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1424 0.1422
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.0328 0.1262
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0052 0.0051
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0052 0.0052
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0125 0.0123
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0054 0.1077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0028 0.0101
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0196 0.0977
Echinococcus granulosus snurportin 1 0.0306 0.2409 0.2408
Echinococcus multilocularis zinc finger protein 0.0026 0.0102 0.01
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0492 0.1897
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0054 0.1077
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0039 0.0037
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.0787 0.0787
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0176 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0047 0.0273 0.105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0052 0.0197
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0203 0.0201
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0023 0.0075 0.0073
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0075 0.0075
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0052 0.0052
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0095 0.074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1424 0.1422
Brugia malayi nuclear hormone receptor 0.002 0.0052 0.0197
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0196 0.2476
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0196 0.2476
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0028 0.0026
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0167 0.1313
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Echinococcus multilocularis tar DNA binding protein 0.0328 0.2588 0.2587
Loa Loa (eye worm) hypothetical protein 0.0041 0.0227 0.0871
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1274 0.1272
Trypanosoma brucei glucosidase, putative 0.0037 0.0196 0.3962
Brugia malayi RNA recognition motif domain containing protein 0.0328 0.2588 1
Echinococcus granulosus geminin 0.0339 0.2676 0.2675
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0196 0.0977
Brugia malayi hypothetical protein 0.0016 0.0022 0.0078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0273 0.5538
Loa Loa (eye worm) hypothetical protein 0.0052 0.0318 0.1222
Leishmania major importin beta-1 subunit, putative 0.0023 0.008 0.1599
Entamoeba histolytica hypothetical protein 0.0109 0.0787 1
Trichomonas vaginalis ran, putative 0.0021 0.0062 0.0305
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0203 0.1012
Leishmania major GTP-binding protein, putative 0.0021 0.0062 0.1239
Echinococcus granulosus tar DNA binding protein 0.0328 0.2588 0.2587
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0044 0.0165
Echinococcus multilocularis lysosomal alpha glucosidase 0.0168 0.1274 0.1272
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0128 0.0126
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0052 0.0256
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0273 0.346
Brugia malayi Bromodomain containing protein 0.0085 0.059 0.2276
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.0787 0.0785
Brugia malayi steroid hormone receptor 0.002 0.0052 0.0197
Echinococcus multilocularis expressed protein 0.0017 0.0027 0.0025
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0492 0.1311
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0118 0.045
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0049 0.0241
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0142 0.0141
Mycobacterium ulcerans hypothetical protein 0.0073 0.0492 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.0492 0.1897
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 0.303
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0052 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0424
Loa Loa (eye worm) CXXC zinc finger family protein 0.0086 0.0598 0.2308
Brugia malayi Glycosyl hydrolases family 31 protein 0.0168 0.1274 0.4918
Toxoplasma gondii histone lysine methyltransferase SET1 0.0167 0.1264 1
Schistosoma mansoni tar DNA-binding protein 0.0328 0.2588 0.2588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.008 0.0394
Schistosoma mansoni ferritin light chain 0.0017 0.0027 0.0027
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.3484
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0196 0.0977
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0003 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0052 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0052 0.0197
Echinococcus multilocularis geminin 0.0339 0.2676 0.2675
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0492 0.2465
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0054 0.0204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0273 0.0726
Loa Loa (eye worm) hypothetical protein 0.0047 0.0273 0.105
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0062 0.0482
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0196 0.0752
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0273 0.5538
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0028 0.0026
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0037 0.0189 0.0725
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0052 0.0051
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0047 0.0273 0.105
Plasmodium vivax SET domain protein, putative 0.0034 0.0167 0.3378
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0492 0.1311
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0052 0.0052
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0069 0.0455 0.0454
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0054 0.0673
Mycobacterium tuberculosis Conserved protein 0.0073 0.0492 0.1311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0674
Schistosoma mansoni ferritin 0.0017 0.0027 0.0027
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.1239
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0028
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0095 0.1904
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.0328 0.1262
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0027 0.0067
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0492 0.0492
Schistosoma mansoni ran 0.0021 0.0062 0.0062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.0787 0.0785
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0203 0.0203
Schistosoma mansoni ferritin 0.0017 0.0027 0.0027
Entamoeba histolytica hypothetical protein 0.0109 0.0787 1
Schistosoma mansoni ferritin 0.0017 0.0027 0.0027
Schistosoma mansoni apoferritin-2 0.0017 0.0027 0.0027
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0031
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0052 0.0197
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0052 0.0197
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0054 0.0266
Mycobacterium ulcerans beta-lactamase 0.0073 0.0492 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0196 0.154
Brugia malayi Pre-SET motif family protein 0.0034 0.0167 0.0641
Schistosoma mansoni hypothetical protein 0.0109 0.0787 0.0787
Echinococcus multilocularis dnaJ subfamily B 0.1229 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Onchocerca volvulus 0.0086 0.0598 0.2999
Schistosoma mansoni alpha-glucosidase 0.0145 0.1081 0.1081
Echinococcus multilocularis GPCR, family 2 0.0017 0.0028 0.0026
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0273 0.5538
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0196 0.0977
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0196 0.3962
Onchocerca volvulus 0.002 0.0052 0.0256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0492 0.0492
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0029 0.0125 0.0476
Loa Loa (eye worm) RNA binding protein 0.0328 0.2588 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0052 0.0197
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0128 0.0128
Brugia malayi ecdysteroid receptor 0.002 0.0052 0.0197
Echinococcus multilocularis snurportin 1 0.0306 0.2409 0.2408
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0052 0.0052
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0176 0.3556
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0054 0.0204
Brugia malayi PHD-finger family protein 0.0032 0.0149 0.0569
Schistosoma mansoni thyroid hormone receptor 0.002 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0022 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0028
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.5354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0273 0.346
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0039
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0273 0.5538
Schistosoma mansoni ferritin light chain 0.0017 0.0027 0.0027
Loa Loa (eye worm) TAR-binding protein 0.0328 0.2588 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0196 0.0977
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0054 0.1077
Onchocerca volvulus 0.0073 0.0492 0.2465
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0306 0.2409 0.9305
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0008
Mycobacterium tuberculosis Conserved protein 0.0073 0.0492 0.1311
Schistosoma mansoni ferritin 0.0017 0.0027 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0187 0.1424 0.5498
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0052 0.0052
Brugia malayi RNA, U transporter 1 0.0082 0.056 0.2158
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0203 0.0201
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0003 0.0031
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0196 0.0194
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0361
Onchocerca volvulus 0.0256 0.1992 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0054 0.0053
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.008 0.0394
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0167 0.0166
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0203 0.2565
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0187 0.1424 0.5498
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0492 0.2465
Schistosoma mansoni zinc finger protein 0.0016 0.0023 0.0023
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0003 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0203 0.0201
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0492 0.1311
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0095 0.5354
Schistosoma mansoni hypothetical protein 0.0016 0.0023 0.0023
Echinococcus granulosus FTZ F1 alpha 0.002 0.0052 0.0051
Schistosoma mansoni cpg binding protein 0.0093 0.0656 0.0656
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0492 0.0491
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0273 0.5538
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0052 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0028 0.0101
Schistosoma mansoni tar DNA-binding protein 0.0328 0.2588 0.2588
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0196 0.0752
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0492 0.1311
Leishmania major hypothetical protein, conserved 0.0073 0.0492 1
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0017 0.0027 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1424 0.1424
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0052 0.0318 0.0316
Schistosoma mansoni thyroid hormone receptor 0.002 0.0052 0.0052
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0674
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.2509
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0273 0.5538
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0001 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0118 0.0116
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0052 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0196 0.3962
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0052 0.0197
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0492 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0003 0.0008
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0235
Loa Loa (eye worm) hypothetical protein 0.0051 0.0305 0.1173
Brugia malayi TAR-binding protein 0.0328 0.2588 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0118 0.0116
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Trichomonas vaginalis esterase, putative 0.0073 0.0492 0.2465
Schistosoma mansoni hypothetical protein 0.1229 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0095 0.1904
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0196 0.0977
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0125 0.2509
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0054 0.1077
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0039 0.0039
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0049 0.0241
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0196 0.0194
Brugia malayi beta-lactamase family protein 0.0073 0.0492 0.1897
Brugia malayi Bromodomain containing protein 0.0041 0.0226 0.0869
Schistosoma mansoni tar DNA-binding protein 0.0328 0.2588 0.2588
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0008
Brugia malayi Pre-SET motif family protein 0.0225 0.1739 0.6716
Echinococcus granulosus GPCR family 2 0.0017 0.0028 0.0026
Schistosoma mansoni hypothetical protein 0.0306 0.2409 0.2409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0424
Loa Loa (eye worm) hypothetical protein 0.0044 0.0248 0.0952
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0054 1
Mycobacterium ulcerans hypothetical protein 0.0047 0.0273 0.5538
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0189 0.0725
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Schistosoma mansoni hypothetical protein 0.0339 0.2676 0.2676
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.016 0.0424
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0196 0.3962
Brugia malayi hypothetical protein 0.0109 0.0787 0.3036
Schistosoma mansoni tar DNA-binding protein 0.0328 0.2588 0.2588
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0052 0.0051
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0052 0.0051
Trichomonas vaginalis helicase, putative 0.002 0.0049 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0196 0.0977
Echinococcus multilocularis ferritin 0.0017 0.0027 0.0025
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0062 0.1239
Trichomonas vaginalis ferritin, putative 0.0017 0.0027 0.0127
Brugia malayi beta-lactamase family protein 0.0073 0.0492 0.1897
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0492 0.1311
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0492 0.1311
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0052 0.0052
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.008 0.1599
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0205 0.0204
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0003 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0273 0.346
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0492 0.2465
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0052 0.0051
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0052 0.0197
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.1239
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0187 0.1424 0.1422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.0328 0.1262
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0187 0.1424 0.1422
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0028 0.0101
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0125 0.0975
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0167 0.0167
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.1739 0.6716
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0052 0.0052
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0069 0.0455 0.0454
Echinococcus granulosus histone lysine methyltransferase setb 0.0052 0.0318 0.0316
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0318 0.0318
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0062 0.1239
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0492 1
Schistosoma mansoni bromodomain containing protein 0.0073 0.0487 0.0487
Schistosoma mansoni cpg binding protein 0.0093 0.0656 0.0656
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0023 0.0075 0.0073
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0203 0.1012
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0203 0.0779
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0203 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0196 0.0977
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0203 0.0203
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0054 0.0141
Schistosoma mansoni cpg binding protein 0.0086 0.0598 0.0598
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0203 0.4106
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0203 0.4106
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0807 0.6528 0.6527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0052 0.0318 0.0318
Toxoplasma gondii exonuclease III APE 0.002 0.0054 0.0419
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0003 0.0031
Onchocerca volvulus 0.0073 0.0492 0.2465
Trypanosoma cruzi ISWI complex protein 0.0016 0.0023 0.0447
Trichomonas vaginalis importin beta-1, putative 0.0023 0.008 0.0394
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0492 0.2465
Brugia malayi CXXC zinc finger family protein 0.0086 0.0598 0.2308
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0054 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0168 0.1274 0.4918
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0492 1
Brugia malayi hypothetical protein 0.0025 0.0095 0.0361
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.3745 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0674
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0052 0.0051
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0492 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0052 0.0051
Plasmodium vivax importin-beta 2, putative 0.0029 0.0125 0.2509
Echinococcus granulosus ferritin 0.0017 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0101
Schistosoma mansoni ran 0.0021 0.0062 0.0062
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0039 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0052 0.0051
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0923 0.3564
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0008
Schistosoma mansoni ap endonuclease 0.002 0.0054 0.0054
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0052 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1424 0.1424
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0053 0.0328 0.1262
Leishmania major hypothetical protein, conserved 0.0025 0.0095 0.1904
Leishmania major hypothetical protein, conserved 0.0016 0.0023 0.0447
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0273 0.5538
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0054 0.0266
Mycobacterium ulcerans lipase LipD 0.0073 0.0492 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0203 0.0201
Echinococcus multilocularis cpg binding protein 0.0093 0.0656 0.0654
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0052 0.0052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0203 0.4106
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0003 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0534
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0203 0.0201
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.1904
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0197
Loa Loa (eye worm) hypothetical protein 0.0073 0.0492 0.1897
Onchocerca volvulus 0.0034 0.0167 0.0833
Mycobacterium ulcerans bacterioferritin BfrA 0.0017 0.0027 0.0514
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0187 0.1424 0.1424
Echinococcus granulosus lysosomal alpha glucosidase 0.0168 0.1274 0.1272
Schistosoma mansoni zinc finger protein 0.0026 0.0102 0.0102
Onchocerca volvulus 0.0047 0.0273 0.1365
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0052 0.0051
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0095 0.1904
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0027 0.0067
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0196 0.0977
Schistosoma mansoni apoferritin-2 0.0017 0.0027 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0273 0.105
Onchocerca volvulus 0.0073 0.0492 0.2465
Toxoplasma gondii ABC1 family protein 0.0073 0.0492 0.3886
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0052 0.0197
Schistosoma mansoni hypothetical protein 0.0339 0.2676 0.2676
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0028 0.0026
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0328 0.2588 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0052 0.0197
Entamoeba histolytica hypothetical protein 0.0023 0.008 0.0999
Entamoeba histolytica hypothetical protein 0.0109 0.0787 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0273 0.5538
Brugia malayi MH2 domain containing protein 0.0126 0.0923 0.3564
Entamoeba histolytica Ran family GTPase 0.0021 0.0062 0.0774
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0205 0.0204
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0674
Brugia malayi beta-lactamase 0.0073 0.0492 0.1897
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0003 0.0008
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0203 1
Schistosoma mansoni tar DNA-binding protein 0.0328 0.2588 0.2588
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0273 0.5538
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0273 0.105
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Schistosoma mansoni importin beta-1 0.0029 0.0125 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0049 0.0241
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0062 0.0235
Trypanosoma brucei ISWI complex protein 0.0016 0.0023 0.0447
Echinococcus granulosus expressed protein 0.0017 0.0027 0.0025
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0492 0.1311
Loa Loa (eye worm) hypothetical protein 0.0035 0.0176 0.0674
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0203 0.1012
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0052 0.0051
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0054 0.1077
Trichomonas vaginalis set domain proteins, putative 0.0256 0.1992 1
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.007 0.0267
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0052 0.0052
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0203 0.0201
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0492 1
Schistosoma mansoni alpha-glucosidase 0.0145 0.1081 0.1081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0052 0.0197
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0023 0.0075 0.0073
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0003 0.0006
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0176 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0167 0.0167
Entamoeba histolytica hypothetical protein 0.0109 0.0787 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0052 0.0197
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0049 0.0241
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0273 0.105
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0492 1
Echinococcus granulosus zinc finger protein 0.0026 0.0102 0.01
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0054 0.0053
Schistosoma mansoni hypothetical protein 0.0037 0.0189 0.0189
Brugia malayi RNA binding protein 0.0328 0.2588 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0492 0.1897
Onchocerca volvulus 0.0097 0.069 0.3457
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0052 0.0051
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0176 0.3556
Schistosoma mansoni hypothetical protein 0.0017 0.0028 0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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