Detailed information for compound 794468

Basic information

Technical information
  • TDR Targets ID: 794468
  • Name: propan-2-yl 4-(4-hydroxy-3-methoxy-5-nitrophe nyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine -5-carboxylate
  • MW: 365.338 | Formula: C16H19N3O7
  • H donors: 3 H acceptors: 5 LogP: 1.81 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1O)[N+](=O)[O-])C1NC(=O)NC(=C1C(=O)OC(C)C)C
  • InChi: 1S/C16H19N3O7/c1-7(2)26-15(21)12-8(3)17-16(22)18-13(12)9-5-10(19(23)24)14(20)11(6-9)25-4/h5-7,13,20H,1-4H3,(H2,17,18,22)
  • InChiKey: HMUVNDUXYVHYPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isopropyl 4-(4-hydroxy-3-methoxy-5-nitro-phenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  • 4-(4-hydroxy-3-methoxy-5-nitrophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylic acid isopropyl ester
  • 4-(4-hydroxy-3-methoxy-5-nitro-phenyl)-2-keto-6-methyl-3,4-dihydro-1H-pyrimidine-5-carboxylic acid isopropyl ester
  • propan-2-yl 4-(4-hydroxy-3-methoxy-5-nitro-phenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate
  • Oprea1_516903
  • A2554/0108773
  • EU-0052873

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.1059 0.415
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.2551 0.2913
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0108 0.0422
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0008 0.0136 0.0538
Schistosoma mansoni DNA ligase IV 0.001 0.0195 0.0763
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0206 0.0807
Toxoplasma gondii exonuclease III APE 0.002 0.0625 0.2317
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1059 0.415
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0108 0.0422
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0206 0.0807
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0108 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0195 0.168
Schistosoma mansoni carbonyl reductase 0.0008 0.0108 0.0422
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Echinococcus granulosus oxidoreductase 0.0008 0.0108 0.0422
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 1
Treponema pallidum DNA ligase (lig) 0.001 0.0195 0.1207
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Brugia malayi hypothetical protein 0.001 0.0195 0.0222
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0195 0.0222
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0195 0.168
Onchocerca volvulus 0.001 0.0195 0.0088
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0206 0.0235
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0108 0.0422
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0206 0.0099
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0625 0.0792
Brugia malayi steroid hormone receptor 0.001 0.0206 0.0235
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0625 1
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0195 0.0088
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0206 0.0807
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0206 0.0807
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Brugia malayi Pre-SET motif family protein 0.0207 0.8758 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0625 0.0523
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0108 0.0123
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0206 0.0807
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0625 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1059 0.415
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0195 0.168
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Brugia malayi hypothetical protein 0.0008 0.0108 0.0123
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0108 0.0422
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0206 0.0235
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0108 0.0422
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.234 0.3416
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Plasmodium vivax SET domain protein, putative 0.003 0.1059 1
Schistosoma mansoni carbonyl reductase 0.0008 0.0108 0.0422
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0625 1
Chlamydia trachomatis DNA ligase 0.001 0.0195 0.5
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Schistosoma mansoni ferritin 0.0008 0.0136 0.0531
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0206 0.0807
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.234 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Brugia malayi hypothetical protein 0.0008 0.0108 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0195 0.0763
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0206 0.0807
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0625 0.2317
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0625 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0108 0.0123
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0195 0.0088
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0206 0.0235
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0108 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0195 0.0088
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0206 0.0807
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0108 0.0422
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0108 0.0422
Echinococcus granulosus expressed protein 0.0008 0.0136 0.0531
Echinococcus granulosus hypothetical protein 0.0008 0.0108 0.0422
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0108 0.0422
Brugia malayi ecdysteroid receptor 0.001 0.0206 0.0235
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.1059 0.415
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0206 0.0235
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1745 0.6841
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0206 0.0235
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0206 0.0099
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0008 0.0136 0.0043
Brugia malayi Pre-SET motif family protein 0.003 0.1059 0.1209
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0206 0.0807
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0108 0.0422
Schistosoma mansoni coup transcription factor 0.001 0.0206 0.0807
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0625 1
Echinococcus multilocularis expressed protein 0.0008 0.0136 0.0531
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0195 0.0222
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Schistosoma mansoni ferritin 0.0008 0.0136 0.0531
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Mycobacterium ulcerans bacterioferritin BfrA 0.0008 0.0136 0.0043
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.234 0.9172
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0108 0.0123
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1745 0.1992
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0206 0.0807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0206 0.0235
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0195 0.0389
Schistosoma mansoni apoferritin-2 0.0008 0.0136 0.0531
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0108 0.0422
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0195 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0206 0.0235
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni ap endonuclease 0.002 0.0625 0.245
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0108 0.0422
Brugia malayi DKFZp564C0469 protein 0.001 0.0195 0.0222
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.1059 0.415
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 1
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0158 0.6641 1
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.2551 0.2913
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0108 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0206 0.0235
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0625 1
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0625 0.0523
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni nuclear hormone receptor 0.001 0.0206 0.0807
Schistosoma mansoni tar DNA-binding protein 0.0064 0.2551 1
Loa Loa (eye worm) hypothetical protein 0.003 0.1059 0.1209
Mycobacterium ulcerans epoxide hydrolase EphA 0.0158 0.6641 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0206 0.0807
Mycobacterium ulcerans bacterioferritin BfrB 0.0008 0.0136 0.0043
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0108 0.0422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0206 0.0807
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0625 0.245
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.1059 0.4261
Echinococcus granulosus replication factor c subunit 1 0.001 0.0195 0.0763
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0108 0.0422
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni ferritin light chain 0.0008 0.0136 0.0531
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0108 0.0422
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.1011 0.3964
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1745 0.1992
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0625 0.0792
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0206 0.0235
Brugia malayi topoisomerase 0.001 0.0195 0.0222
Schistosoma mansoni apoferritin-2 0.0008 0.0136 0.0531
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0108 0.0422
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Entamoeba histolytica hypothetical protein 0.001 0.0195 0.168
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0206 0.0235
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0206 0.0235
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0195 0.0133
Giardia lamblia Replication factor C, subunit 1 0.001 0.0195 0.168
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0008 0.0136 0.1476
Schistosoma mansoni thyroid hormone receptor 0.001 0.0206 0.0807
Loa Loa (eye worm) dehydrogenase 0.0008 0.0108 0.0123
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0108 0.0422
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1745 0.6841
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0108 0.0422
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.1059 0.415
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Brugia malayi nuclear hormone receptor 0.001 0.0206 0.0235
Onchocerca volvulus 0.003 0.1059 0.0961
Schistosoma mansoni ferritin light chain 0.0008 0.0136 0.0531
Brugia malayi nuclear receptor NHR-88 0.001 0.0206 0.0235
Loa Loa (eye worm) dehydrogenase 0.0008 0.0108 0.0123
Echinococcus granulosus tar DNA binding protein 0.0064 0.2551 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.234 0.3416
Echinococcus granulosus hypothetical protein 0.0008 0.0108 0.0422
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0625 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0108 0.0422
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0206 0.0807
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0195 0.0914
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0195 0.168
Brugia malayi RNA binding protein 0.0064 0.2551 0.2913
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0206 0.0099
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0206 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0206 0.0807
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.1059 0.415
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0108 0.0422
Loa Loa (eye worm) hypothetical protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0625 0.0714
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.234 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0108 0.0422
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0206 0.0235
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0195 0.168
Loa Loa (eye worm) RNA binding protein 0.0064 0.2551 0.2913
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0296 0.0289
Schistosoma mansoni ap endonuclease 0.002 0.0625 0.245
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0206 0.0807
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0195 0.0763
Brugia malayi oxidoreductase 0.0008 0.0108 0.0123
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0206 0.0235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1745 0.6841
Onchocerca volvulus 0.001 0.0206 0.0099
Brugia malayi hypothetical protein 0.001 0.0195 0.0222
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0108 0.0422
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.234 0.9172
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0195 0.168
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0108 0.0422
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0108 0.0422
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0625 0.0714
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0012 0.0296 0.0289
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0195 0.0088
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0195 0.0389
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0206 0.0807
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni ferritin 0.0008 0.0136 0.0531
Echinococcus multilocularis oxidoreductase 0.0008 0.0108 0.0422
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0108 0.0422
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.234 0.3416
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0206 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0195 0.0222
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0206 0.0807
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1745 0.6841
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0195 0.0088
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.234 0.9172
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0108 0.0422
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0108 0.0123
Trichomonas vaginalis set domain proteins, putative 0.0235 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0008 0.0136 0.0043
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0206 0.0807
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Echinococcus multilocularis ferritin 0.0008 0.0136 0.0531
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0206 0.0235
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0108 0.0422
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0195 0.168
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Trichomonas vaginalis ferritin, putative 0.0008 0.0136 0.0028
Schistosoma mansoni ferritin 0.0008 0.0136 0.0531
Loa Loa (eye worm) hypothetical protein 0.001 0.0206 0.0235
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0206 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0206 0.0807
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.0296 1
Loa Loa (eye worm) TAR-binding protein 0.0064 0.2551 0.2913
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0108 0.0422
Loa Loa (eye worm) oxidoreductase 0.0008 0.0108 0.0123
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0625 1
Brugia malayi TAR-binding protein 0.0064 0.2551 0.2913
Echinococcus granulosus ferritin 0.0008 0.0136 0.0531
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0108 0.0123
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0195 0.168
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Echinococcus granulosus nibrin 0.001 0.0195 0.0763
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0206 0.0235
Echinococcus multilocularis tar DNA binding protein 0.0064 0.2551 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.234 0.3416
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0108 0.0422
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.234 0.9172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0206 0.0235
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0108 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0206 0.0235
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0206 0.0235
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0206 0.0807
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0206 0.0807
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0206 0.0807
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1745 0.6841
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0108 0.0123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0206 0.0807
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0195 0.0088
Schistosoma mansoni carbonyl reductase 0.0008 0.0108 0.0422
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0195 0.0088
Echinococcus multilocularis nibrin 0.001 0.0195 0.0763
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0625 0.5438
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0206 0.0807
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0206 0.0807
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0108 0.0422
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0195 0.0088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1745 0.6841
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1745 0.6841
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0108 0.0123
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0206 0.0235
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0108 0.0422
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0206 0.0235
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0625 0.245
Schistosoma mansoni thyroid hormone receptor 0.001 0.0206 0.0807
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0195 0.4606
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0195 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0207 0.8758 1
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Echinococcus granulosus FTZ F1 alpha 0.001 0.0206 0.0807
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0108 0.0422
Schistosoma mansoni topbp1 0.001 0.0195 0.0763
Schistosoma mansoni topbp1 0.001 0.0195 0.0763
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0206 0.0235
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0206 0.0807

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.