Detailed information for compound 794958

Basic information

Technical information
  • TDR Targets ID: 794958
  • Name: 2-amino-4-(3-fluorophenyl)-5-oxo-7-phenyl-4,6 ,7,8-tetrahydrochromene-3-carbonitrile
  • MW: 360.381 | Formula: C22H17FN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.49 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)OC2=C(C1c1cccc(c1)F)C(=O)CC(C2)c1ccccc1
  • InChi: 1S/C22H17FN2O2/c23-16-8-4-7-14(9-16)20-17(12-24)22(25)27-19-11-15(10-18(26)21(19)20)13-5-2-1-3-6-13/h1-9,15,20H,10-11,25H2
  • InChiKey: DFLZIQUVHBAGSM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-amino-4-(3-fluorophenyl)-5-keto-7-phenyl-4,6,7,8-tetrahydrochromene-3-carbonitrile
  • BAS 00667178
  • A1283/0058575

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium vivax SET domain protein, putative 0.003 0.0471 0.34
Brugia malayi Pre-SET motif family protein 0.003 0.0471 0.1033
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3124 0.3124
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0265 0.0265
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0599 0.1183
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Mycobacterium ulcerans hypothetical protein 0.0041 0.0725 0.5313
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.006
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0265 0.0265
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0831 0.1641
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0093 0.1889 0.1889
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3425 0.3425
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0431 0.0431
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0265 0.0565
Leishmania major hypothetical protein, conserved 0.0041 0.0725 0.3517
Entamoeba histolytica serine/threonine protein kinase, putative 0.0093 0.1889 1
Schistosoma mansoni inositol monophosphatase 0.0042 0.0727 0.0727
Loa Loa (eye worm) histone methyltransferase 0.0011 0.004 0.0054
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0265 0.0265
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0599 0.0599
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Brugia malayi RNA binding protein 0.0137 0.2862 0.6455
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0094 0.0185
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0599 0.2817
Brugia malayi hypothetical protein 0.0016 0.0147 0.0297
Loa Loa (eye worm) hypothetical protein 0.0166 0.3521 0.7949
Onchocerca volvulus 0.0093 0.1894 0.372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0265 0.0265
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0725 1
Brugia malayi beta-lactamase family protein 0.0041 0.0725 0.1608
Echinococcus granulosus tar DNA binding protein 0.0137 0.2862 0.2862
Brugia malayi hypothetical protein 0.0174 0.3703 0.8361
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0341 0.1376
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0599 0.1183
Trichomonas vaginalis set domain proteins, putative 0.0235 0.5063 1
Echinococcus multilocularis muscleblind protein 1 0.0166 0.3521 0.3521
Brugia malayi hypothetical protein 0.0024 0.0341 0.0736
Brugia malayi nuclear receptor RXR 0.0011 0.0043 0.006
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0265 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0265 0.0565
Mycobacterium ulcerans lipase LipD 0.0041 0.0725 0.5313
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0725 0.1608
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0265 0.0565
Onchocerca volvulus Serine\/threonine kinase homolog 0.0093 0.1889 0.371
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0016 0.0016
Brugia malayi nuclear receptor NHR-88 0.0021 0.0265 0.0565
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0471 0.0471
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0725 0.0725
Onchocerca volvulus 0.0041 0.0725 0.1405
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0043 0.006
Schistosoma mansoni inositol monophosphatase 0.0042 0.0727 0.0727
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0093 0.1889 0.1889
Schistosoma mansoni hypothetical protein 0.0011 0.0039 0.0039
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0265 0.0565
Loa Loa (eye worm) inositol-1 0.0042 0.0727 0.1613
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0043 0.0043
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0725 0.1262
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0043 0.006
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0265 0.0265
Brugia malayi RNA recognition motif domain containing protein 0.0137 0.2862 0.6455
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0265 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2862 0.2862
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0725 0.1432
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Mycobacterium tuberculosis Conserved protein 0.0041 0.0725 0.1262
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0265 0.0265
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0016 0.0016
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0016 0.0016
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0265 0.0265
Loa Loa (eye worm) TAR-binding protein 0.0137 0.2862 0.6455
Schistosoma mansoni cpg binding protein 0.0032 0.051 0.051
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0599 0.2817
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0265 0.0265
Echinococcus granulosus muscleblind protein 0.0166 0.3521 0.3521
Brugia malayi hypothetical protein 0.0011 0.0043 0.006
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.1364 0.2375
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2862 0.2862
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0341 0.1376
Toxoplasma gondii ABC1 family protein 0.0041 0.0725 0.3754
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0471 0.0471
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0265 0.0565
Echinococcus multilocularis dnaJ subfamily B 0.0454 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0093 0.1889 0.4247
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0727 0.3777
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Loa Loa (eye worm) RNA binding protein 0.0137 0.2862 0.6455
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0016 0.0016
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1889 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0039 0.0039
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0725 0.3517
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.3425 0.3425
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0725 0.1262
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0725 0.1608
Loa Loa (eye worm) hypothetical protein 0.0174 0.3703 0.8361
Leishmania major hypothetical protein, conserved 0.0024 0.0341 0.1376
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0265 0.0565
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0016 0.0016
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0265 0.0265
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0629 0.1096
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0265 0.0265
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0265 0.0565
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.006
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0265 0.0265
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.3425 0.3425
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.051 0.1121
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0043 0.006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.004 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0471 0.0471
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0013 0.0094 0.0154
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Schistosoma mansoni hypothetical protein 0.0175 0.3719 0.3719
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0727 0.353
Schistosoma mansoni nuclear hormone receptor 0.001 0.0016 0.0016
Trichomonas vaginalis esterase, putative 0.0041 0.0725 0.1432
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0629 0.8683
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0341 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0265 0.0265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0265 0.0565
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0137 0.2862 0.6455
Schistosoma mansoni hypothetical protein 0.0175 0.3719 0.3719
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1364 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0727 0.353
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0265 0.0265
Trypanosoma cruzi polo-like protein kinase, putative 0.0093 0.1889 1
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2862 0.2862
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0265 0.0265
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0265 0.0265
Giardia lamblia Kinase, PLK 0.0093 0.1889 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0599 0.2817
Trypanosoma brucei polo-like protein kinase 0.0093 0.1889 1
Mycobacterium tuberculosis Conserved protein 0.0041 0.0725 0.1262
Brugia malayi Glycosyl hydrolases family 31 protein 0.0013 0.0094 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1364 1
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0725 0.1262
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0265 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0094 0.0185
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0831 0.1641
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0727 0.353
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0727 0.0727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0265 0.0565
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0016 0.0016
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0265 0.0265
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0599 0.1183
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0725 0.0725
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0725 0.3517
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0727 0.1436
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0727 0.1436
Schistosoma mansoni zinc finger protein 0.001 0.0016 0.0016
Trichomonas vaginalis maltase-glucoamylase, putative 0.0013 0.0094 0.0185
Onchocerca volvulus 0.0174 0.3703 0.7304
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0016 0.0016
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0471 0.0471
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0725 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0471 0.0471
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.4425 1
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.1364 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0265 0.0565
Loa Loa (eye worm) hypothetical protein 0.0024 0.0341 0.0736
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.2773 0.6252
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0599 0.2817
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.3425 0.773
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0265 0.0265
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.1364 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0471 0.0471
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0599 0.2526
Echinococcus granulosus geminin 0.0175 0.3719 0.3719
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3124 0.3124
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0727 0.5331
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0599 0.0599
Schistosoma mansoni cpg binding protein 0.0034 0.0551 0.0551
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0599 0.1183
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0265 0.5744 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Schistosoma mansoni nuclear receptor 0.001 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.003 0.0471 0.1033
Echinococcus multilocularis cpg binding protein 0.0034 0.0551 0.0551
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0094 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0599 0.1183
Echinococcus granulosus cpg binding protein 0.0034 0.0551 0.0551
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0725 0.1262
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0265 0.0265
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.1364 0.1364
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1364 0.1364
Brugia malayi serine/threonine-protein kinase plk-2 0.0093 0.1889 0.4247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0265 0.0565
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0043 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.3124 0.3124
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0725 0.1432
Mycobacterium ulcerans beta-lactamase 0.0041 0.0725 0.5313
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.3124 0.3124
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0725 0.1432
Schistosoma mansoni alpha-glucosidase 0.0139 0.2919 0.2919
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0265 0.0565
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0725 0.1262
Onchocerca volvulus 0.0021 0.0265 0.0494
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.1364 0.1364
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0265 0.0565
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0725 0.5313
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0043 0.0043
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0093 0.1889 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0725 0.1432
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0265 0.0265
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0037 0.0047
Schistosoma mansoni alpha glucosidase 0.0036 0.0599 0.0599
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0725 0.1262
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0599 0.1323
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.3124 0.3124
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0039 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0265 0.0565
Brugia malayi nuclear hormone receptor 0.0021 0.0265 0.0565
Schistosoma mansoni cpg binding protein 0.0034 0.0551 0.0551
Onchocerca volvulus 0.003 0.0471 0.0902
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.3124 0.7048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0265 0.0265
Schistosoma mansoni hypothetical protein 0.0454 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0341 0.1376
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0725 0.3517
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0016 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0265 0.0565
Echinococcus multilocularis muscleblind protein 0.0166 0.3521 0.3521
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0265 0.0265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0016 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0471 0.0471
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0016 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0725 0.1432
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0725 0.0725
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0094 0.0185
Brugia malayi beta-lactamase family protein 0.0041 0.0725 0.1608
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Brugia malayi hypothetical protein 0.0011 0.0043 0.006
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0265 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0265 0.0565
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0013 0.0094 0.0185
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0725 0.1262
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0725 0.0725
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0725 0.5313
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.3124 0.3124
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.004 0.004
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0471 0.1276
Loa Loa (eye worm) hypothetical protein 0.0166 0.3521 0.7949
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0599 0.1323
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0265 0.0565
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0265 0.0265
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0727 0.1436
Brugia malayi beta-lactamase 0.0041 0.0725 0.1608
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0265 0.0565
Brugia malayi Muscleblind-like protein 0.0166 0.3521 0.7949
Brugia malayi CXXC zinc finger family protein 0.0032 0.051 0.1121
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0727 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Onchocerca volvulus 0.0041 0.0725 0.1405
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2862 0.2862
Loa Loa (eye worm) hypothetical protein 0.0013 0.0094 0.0176
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0599 0.1183
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0265 0.0265
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.1889 0.1889
Brugia malayi Pre-SET motif family protein 0.0206 0.4425 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.3425 0.773
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0265 0.0565
Onchocerca volvulus 0.0032 0.051 0.0979
Echinococcus multilocularis geminin 0.0175 0.3719 0.3719
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.1364 0.1364
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1338 0.1338
Loa Loa (eye worm) hypothetical protein 0.0021 0.0265 0.0565
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0599 0.1183
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.2773 0.6252
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0265 0.0494
Onchocerca volvulus 0.0041 0.0725 0.1405
Echinococcus multilocularis tar DNA binding protein 0.0137 0.2862 0.2862
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0265 0.0265
Brugia malayi ecdysteroid receptor 0.0021 0.0265 0.0565
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0599 0.1183
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.3124 0.7048
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0265 0.0265
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0265 0.0265
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.3124 0.3124
Mycobacterium tuberculosis Conserved protein 0.0041 0.0725 0.1262
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0094 0.0185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0016 0.0016
Brugia malayi MH2 domain containing protein 0.0133 0.2773 0.6252
Onchocerca volvulus 0.0235 0.5063 1
Brugia malayi steroid hormone receptor 0.0021 0.0265 0.0565
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0727 0.353
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0265 0.0565
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.1176 0.8156
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0265 0.0265
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0265 0.0565
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0727 0.0727
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Brugia malayi TAR-binding protein 0.0137 0.2862 0.6455
Loa Loa (eye worm) beta-lactamase 0.0041 0.0725 0.1608
Schistosoma mansoni kinase 0.0047 0.0858 0.0858
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0727 0.353
Schistosoma mansoni nuclear receptor 0.001 0.0016 0.0016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0265 0.0265
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0341 0.5
Schistosoma mansoni tar DNA-binding protein 0.0137 0.2862 0.2862
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0265 0.0565
Mycobacterium leprae Probable lipase LipE 0.0041 0.0725 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0043 0.006
Brugia malayi Inositol-1 0.0042 0.0727 0.1613
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0265 0.0565
Schistosoma mansoni alpha-glucosidase 0.0139 0.2919 0.2919
Trichomonas vaginalis alpha-glucosidase, putative 0.0013 0.0094 0.0185
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0599 0.1183
Schistosoma mansoni coup transcription factor 0.0021 0.0265 0.0265
Trichomonas vaginalis CAMK family protein kinase 0.0093 0.1889 0.373
Schistosoma mansoni nuclear hormone receptor 0.001 0.0016 0.0016
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0599 0.2817
Trypanosoma brucei glucosidase, putative 0.0036 0.0599 0.2817
Loa Loa (eye worm) hypothetical protein 0.0041 0.0725 0.1608
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.1364 0.7079

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.