Detailed information for compound 795246

Basic information

Technical information
  • TDR Targets ID: 795246
  • Name: N-(4-bromophenyl)-4,5,6,7-tetrahydro-1,2-benz oxazole-3-carboxamide
  • MW: 321.169 | Formula: C14H13BrN2O2
  • H donors: 1 H acceptors: 2 LogP: 3.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(cc1)NC(=O)c1noc2c1CCCC2
  • InChi: 1S/C14H13BrN2O2/c15-9-5-7-10(8-6-9)16-14(18)13-11-3-1-2-4-12(11)19-17-13/h5-8H,1-4H2,(H,16,18)
  • InChiKey: YSJUVACQKBNUGZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-4,5,6,7-tetrahydroindoxazene-3-carboxamide
  • EU-0090429

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0444 0.1422
Echinococcus granulosus sodium:glucose cotransporter 2 0.004 0.0494 0.0494
Brugia malayi Sodium:solute symporter family protein 0.004 0.0494 0.0494
Plasmodium vivax amine transporter, putative 0.0022 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0038 0.0444 0.0444
Plasmodium falciparum glutathione reductase 0.0144 0.3123 0.3123
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0129 0.2742 0.2742
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0038 0.0444 0.0444
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.003 0.003
Echinococcus granulosus glutamate synthase 0.0038 0.0444 0.0444
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0022 0.003 0.003
Chlamydia trachomatis thioredoxin reductase 0.0038 0.0444 0.1337
Echinococcus multilocularis thioredoxin glutathione reductase 0.0415 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0038 0.0444 0.0444
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0144 0.3123 0.3123
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0444 0.1422
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.017 0.017
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0144 0.3123 0.3123
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0129 0.2742 0.2742
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0022 0.003 0.003
Mycobacterium tuberculosis Probable reductase 0.0038 0.0444 0.0444
Loa Loa (eye worm) intermediate filament protein 0.0027 0.017 0.017
Schistosoma mansoni lamin 0.0027 0.017 0.017
Schistosoma mansoni inositol transporter 0.004 0.0494 0.0494
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0022 0.003 0.003
Echinococcus multilocularis sodium:glucose cotransporter 2 0.004 0.0494 0.0494
Mycobacterium ulcerans hypothetical protein 0.0038 0.0444 0.1422
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0038 0.0444 0.0444
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0022 0.003 0.003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0144 0.3123 0.3123
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0144 0.3123 0.3123
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.004 0.0494 0.0494
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0038 0.0444 0.1422
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0444 0.1422
Toxoplasma gondii selenide, water dikinase 0.0038 0.0444 0.0444
Loa Loa (eye worm) norepinephrine transporter 0.0129 0.2742 0.2742
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0022 0.003 0.003
Treponema pallidum oxidoreductase 0.0038 0.0444 0.1422
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.003 0.003
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.004 0.0494 0.0494
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.003 0.003
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.003 0.003
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0038 0.0444 0.1422
Trypanosoma cruzi trypanothione reductase, putative 0.0415 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.003 0.003
Mycobacterium ulcerans glutamate synthase subunit beta 0.0038 0.0444 0.1422
Schistosoma mansoni glutamate synthase 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0444 0.0444
Schistosoma mansoni hypothetical protein 0.0038 0.0444 0.0444
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0444 0.0444
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0144 0.3123 1
Plasmodium vivax thioredoxin reductase, putative 0.0415 1 1
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0038 0.0444 0.0444
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0144 0.3123 0.3123
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0038 0.0444 0.0444
Mycobacterium tuberculosis Probable oxidoreductase 0.0144 0.3123 0.3123
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.003 0.003
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0038 0.0444 0.0444
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0038 0.0444 0.0444
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.003 0.003
Trichomonas vaginalis apoptosis inducing factor, putative 0.0038 0.0444 0.1422
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0144 0.3123 0.3123
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0038 0.0444 0.0444
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0038 0.0444 0.0444
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Mycobacterium tuberculosis Probable dehydrogenase 0.0038 0.0444 0.0444
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Echinococcus granulosus high affinity choline transporter 1 0.0364 0.8706 0.8706
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0144 0.3123 0.3123
Plasmodium falciparum thioredoxin reductase 0.0415 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Schistosoma mansoni hypothetical protein 0.0338 0.8037 0.8037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.003 0.003
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0144 0.3123 0.3123
Treponema pallidum thioredoxin reductase (trxB) 0.0038 0.0444 0.1422
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0444 0.0444
Schistosoma mansoni sodium/solute symporter 0.004 0.0494 0.0494
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0106 0.2155 0.2155
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Echinococcus granulosus serotonin transporter 0.0129 0.2742 0.2742
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0038 0.0444 0.1422
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0038 0.0444 0.1422
Giardia lamblia Glutamate synthase 0.0038 0.0444 0.1422
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Echinococcus granulosus lamin dm0 0.0027 0.017 0.017
Toxoplasma gondii NADPH-glutathione reductase 0.0144 0.3123 0.3123
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0038 0.0444 0.1422
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0038 0.0444 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0022 0.003 0.003
Mycobacterium ulcerans ferredoxin reductase 0.0038 0.0444 0.1422
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0144 0.3123 0.3123
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.017 0.017
Entamoeba histolytica disulphide oxidoreductase, putative 0.0038 0.0444 1
Echinococcus multilocularis musashi 0.0027 0.017 0.017
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0144 0.3123 0.3123
Toxoplasma gondii hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei trypanothione reductase 0.0415 1 1
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0444 0.0444
Trypanosoma cruzi trypanothione reductase, putative 0.0144 0.3123 0.3123
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0038 0.0444 0.0444
Schistosoma mansoni sodium/chloride dependent transporter 0.0129 0.2742 0.2742
Trichomonas vaginalis glutathione reductase, putative 0.0144 0.3123 1
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0038 0.0444 0.1422
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0038 0.0444 0.0444
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0038 0.0444 0.0444
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0144 0.3123 0.3123
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0038 0.0444 0.0444
Plasmodium falciparum thioredoxin reductase 0.0144 0.3123 0.3123
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0144 0.3123 0.3123
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0038 0.0444 0.1422
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0144 0.3123 0.3123
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0038 0.0444 0.0444
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0144 0.3123 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0444 0.0444
Echinococcus granulosus geminin 0.0338 0.8037 0.8037
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0038 0.0444 0.1422
Schistosoma mansoni inositol transporter 0.004 0.0494 0.0494
Onchocerca volvulus 0.0027 0.017 0.0513
Plasmodium vivax ferrodoxin reductase, putative 0.0038 0.0444 0.0444
Trypanosoma brucei NADH dehydrogenase 0.0038 0.0444 0.0444
Echinococcus granulosus sodium and chloride dependent glycine 0.0022 0.003 0.003
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0444 0.0444
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0038 0.0444 0.1422
Entamoeba histolytica thioredoxin reductase, putative 0.0038 0.0444 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0038 0.0444 0.0444
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Loa Loa (eye worm) thioredoxin reductase 0.0415 1 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0144 0.3123 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0144 0.3123 0.3123
Loa Loa (eye worm) hypothetical protein 0.004 0.0494 0.0494
Echinococcus granulosus intermediate filament protein 0.0027 0.017 0.017
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0444 0.0444
Toxoplasma gondii thioredoxin reductase 0.0415 1 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.2742 0.2742
Toxoplasma gondii hypothetical protein 0.0022 0.003 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0144 0.3123 0.3123
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0022 0.003 0.003
Brugia malayi GH02984p 0.0364 0.8706 0.8706
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.003 0.003
Echinococcus multilocularis glutamate synthase 0.0038 0.0444 0.0444
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0444 0.0444
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0038 0.0444 1
Leishmania major NADH dehydrogenase, putative 0.0038 0.0444 0.0444
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.004 0.0494 0.0494
Schistosoma mansoni glutamate synthase 0.0038 0.0444 0.0444
Schistosoma mansoni sodium/chloride dependent transporter 0.0022 0.003 0.003
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0144 0.3123 1
Echinococcus multilocularis solute carrier family 5 0.004 0.0494 0.0494
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0144 0.3123 0.3123
Plasmodium falciparum ferrodoxin reductase-like protein 0.0038 0.0444 0.0444
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0038 0.0444 0.0444
Echinococcus multilocularis sodium and chloride dependent glycine 0.0022 0.003 0.003
Brugia malayi intermediate filament protein 0.0027 0.017 0.017
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0038 0.0444 0.0444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Onchocerca volvulus 0.0027 0.017 0.0513
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Plasmodium vivax glutathione reductase, putative 0.0415 1 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.017 0.017
Plasmodium falciparum glutathione reductase 0.0415 1 1
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0038 0.0444 0.0444
Mycobacterium ulcerans dehydrogenase 0.0038 0.0444 0.1422
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0038 0.0444 0.0444
Loa Loa (eye worm) solute carrier family 6 member 4 0.0129 0.2742 0.2742
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0038 0.0444 0.0444
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0038 0.0444 0.0444
Brugia malayi Thioredoxin reductase 0.0415 1 1
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0444 0.0444
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0038 0.0444 0.1422
Echinococcus multilocularis high affinity choline transporter 1 0.0364 0.8706 0.8706
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0038 0.0444 0.0444
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0038 0.0444 0.1422
Loa Loa (eye worm) hypothetical protein 0.0129 0.2742 0.2742
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Onchocerca volvulus 0.0038 0.0444 0.1525
Loa Loa (eye worm) serotonin transporter b 0.0129 0.2742 0.2742
Schistosoma mansoni lamin 0.0027 0.017 0.017
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0022 0.003 0.003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0022 0.003 0.003
Echinococcus granulosus solute carrier family 5 0.004 0.0494 0.0494
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0144 0.3123 1
Loa Loa (eye worm) glutathione reductase 0.0415 1 1
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0038 0.0444 0.0444
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0038 0.0444 0.0444
Leishmania major trypanothione reductase 0.0415 1 1
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0444 0.0444
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0157 0.0157
Echinococcus multilocularis lamin 0.0027 0.017 0.017
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0038 0.0444 0.1422
Schistosoma mansoni sodium-dependent amino acid transporter 0.0022 0.003 0.003
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0038 0.0444 0.0444
Plasmodium vivax hypothetical protein, conserved 0.0022 0.003 0.003
Treponema pallidum sodium- and chloride- dependent transporter 0.0129 0.2742 0.8781
Trichomonas vaginalis glutamate synthase, putative 0.0038 0.0444 0.1422
Echinococcus granulosus sodium:myo inositol cotransporter 0.004 0.0494 0.0494
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0444 0.0444
Echinococcus multilocularis lamin dm0 0.0027 0.017 0.017
Echinococcus multilocularis sodium:myo inositol cotransporter 0.004 0.0494 0.0494
Mycobacterium ulcerans NADH dehydrogenase 0.0038 0.0444 0.1422
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0038 0.0444 0.0444
Onchocerca volvulus 0.0129 0.2742 1
Giardia lamblia Thioredoxin reductase 0.0038 0.0444 0.1422
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0038 0.0444 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Mycobacterium ulcerans monoxygenase 0.0038 0.0444 0.1422
Schistosoma mansoni disulfide oxidoreductase 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0129 0.2742 0.2742
Echinococcus granulosus lamin 0.0027 0.017 0.017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0038 0.0444 0.0444
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0444 0.0444
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0415 1 1
Echinococcus multilocularis serotonin transporter 0.0129 0.2742 0.2742
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0038 0.0444 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0444 0.0444
Onchocerca volvulus 0.004 0.0494 0.171
Trypanosoma cruzi NADH dehydrogenase, putative 0.0038 0.0444 0.0444
Echinococcus granulosus thioredoxin glutathione reductase 0.0415 1 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0144 0.3123 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Brugia malayi glutamate synthase 0.0038 0.0444 0.0444
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0144 0.3123 0.3123
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0444 0.0444
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0144 0.3123 0.3123
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0038 0.0444 0.0444
Echinococcus multilocularis geminin 0.0338 0.8037 0.8037
Schistosoma mansoni sulfide quinone reductase 0.0038 0.0444 0.0444
Leishmania major hypothetical protein, conserved 0.0038 0.0444 0.0444
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0144 0.3123 1
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0038 0.0444 0.0444
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0144 0.3123 1
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0038 0.0444 0.0444
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0038 0.0444 0.1422
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0364 0.8706 0.8706
Brugia malayi hypothetical protein 0.0022 0.003 0.003
Schistosoma mansoni glutamate synthase 0.0038 0.0444 0.0444
Echinococcus granulosus sodium:glucose cotransporter 0.004 0.0494 0.0494
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0038 0.0444 0.0444
Loa Loa (eye worm) hypothetical protein 0.0027 0.017 0.017
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0144 0.3123 0.3123
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0038 0.0444 0.0444
Loa Loa (eye worm) programmed cell death 8 0.0038 0.0444 0.0444
Leishmania major hypothetical protein, conserved 0.0038 0.0444 0.0444
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0038 0.0444 0.0444
Schistosoma mansoni hypothetical protein 0.0338 0.8037 0.8037
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0038 0.0444 0.0444
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0038 0.0444 0.0444
Trichomonas vaginalis mercuric reductase, putative 0.0144 0.3123 1
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0144 0.3123 0.3123
Schistosoma mansoni high-affinity choline transporter 0.0364 0.8706 0.8706
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0106 0.2155 0.2155
Loa Loa (eye worm) hypothetical protein 0.0022 0.003 0.003
Plasmodium falciparum amino acid transporter, putative 0.0022 0.003 0.003
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0038 0.0444 0.1422
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0022 0.003 0.003
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0144 0.3123 0.3123
Treponema pallidum NADH oxidase 0.0144 0.3123 1
Plasmodium falciparum transporter, putative 0.0022 0.003 0.003
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0022 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0444 0.0444

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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