Detailed information for compound 79528

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 460.954 | Formula: C21H17ClN2O4S2
  • H donors: 1 H acceptors: 4 LogP: 4.83 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(s1)C(=O)CCc1nc(oc1C)c1ccc(cc1)Cl
  • InChi: 1S/C21H17ClN2O4S2/c1-11-15(23-20(28-11)12-2-4-13(22)5-3-12)7-8-16(25)17-9-6-14(29-17)10-18-19(26)24-21(27)30-18/h2-6,9,18H,7-8,10H2,1H3,(H,24,26,27)
  • InChiKey: APWXMEKKKMUMAR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Toxoplasma gondii ImpB/MucB/SamB family protein 0.004 0.0152 0.0546
Mycobacterium tuberculosis Probable dehydrogenase 0.0117 0.0529 0.0687
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5668
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0045 0.0173 0.0978
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0039 0.0901
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.8455
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0069 0.0388
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0117 0.0529 0.0687
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0016 0.006
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0039 0.1629
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0291 0.1643
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0007 0.0041
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0016 0.006
Plasmodium falciparum glutathione reductase 0.0018 0.0039 0.1926
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0074 0.3402
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0205 0.6797
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.029 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0054 0.2657
Plasmodium falciparum thioredoxin reductase 0.0018 0.0039 0.1926
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0094 0.2853
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Brugia malayi Protein cec-1. 0.0011 0.0007 0.0047
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Schistosoma mansoni chromobox protein 0.0011 0.0007 0.0041
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0045 0.0173 0.0978
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0069 0.0292 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0007 0.0041
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0016 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0045 0.0173 0.1118
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0069 0.0292 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5822
Echinococcus granulosus dna polymerase eta 0.0069 0.0295 0.1664
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.177 1
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine 1-carboxyvinyltransferase MurA 0.1458 0.7167 1
Schistosoma mansoni hypothetical protein 0.035 0.1683 0.9507
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0007 0.0047
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0173 0.8455
Echinococcus multilocularis Chromo domain 0.0011 0.0007 0.0041
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0039 0.0024
Leishmania major hypothetical protein, conserved 0.0025 0.0074 0.2149
Trypanosoma brucei DNA damage repair protein, putative 0.0013 0.0016 0.006
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0291 0.9954
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0007 0.0041
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.2149
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0042 0.0158 0.0894
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Schistosoma mansoni DNA polymerase eta 0.0069 0.0295 0.1664
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0007 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.4222
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0367 0.177 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0127 0.0717
Echinococcus granulosus bloom syndrome protein 0.0024 0.0069 0.0388
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0031 0.119
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Brugia malayi Heterochromatin protein 1 0.0069 0.0291 0.1878
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0173 0.1118
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0016 0.006
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0205 0.1157
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0007 0.0041
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0007 0.0026
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0323 0.1549 1
Leishmania major DNA damage repair protein, putative 0.0013 0.0016 0.006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0042 0.0158 0.0167
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0173 0.5668
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Leishmania major DNA polymerase kappa, putative 0.0013 0.0016 0.006
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.059 0.3336
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0223
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0158 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0156 0.523
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0045 0.0173 0.0978
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000069803
Brugia malayi ImpB/MucB/SamB family protein 0.0042 0.0158 0.1022
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trypanosoma cruzi DNA damage repair protein, putative 0.0013 0.0016 0.006
Leishmania major trypanothione reductase 0.0051 0.0205 0.6797
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0127 0.0717
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0007 0.0041
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0045 0.0173 0.1118
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0039 0.0901
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0038
Loa Loa (eye worm) hypothetical protein 0.0045 0.0173 0.0978
Giardia lamblia Myb 1-like protein 0.0069 0.0292 0.165
Schistosoma mansoni chromobox protein 0.0069 0.0291 0.1643
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0007 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0569
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Loa Loa (eye worm) hypothetical protein 0.0038 0.0142 0.0801
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0156 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Echinococcus granulosus chromobox protein 1 0.0069 0.0291 0.1643
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0367 0.177 1
Trypanosoma brucei hypothetical protein, conserved 0.0013 0.0016 0.006
Brugia malayi polk-prov protein 0.0013 0.0016 0.0102
Loa Loa (eye worm) hypothetical protein 0.0069 0.0295 0.1664
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trichomonas vaginalis pc-MYB2, putative 0.0068 0.029 0.9943
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0007 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0042 0.0158 0.5301
Trypanosoma brucei unspecified product 0.0029 0.0094 0.2853
Loa Loa (eye worm) helicase 0.0011 0.0007 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Loa Loa (eye worm) RecQ helicase 0.0024 0.0069 0.0388
Leishmania major hypothetical protein, conserved 0.0045 0.0173 0.5668
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.4222
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0039 0.0901
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Chlamydia trachomatis phosphoshikimate 1-carboxyl vinyltransferase 0.0573 0.2784 0.2756
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0039 0.0024
Plasmodium falciparum thioredoxin reductase 0.0051 0.0205 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0024
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Echinococcus granulosus Chromobox protein 3 0.0011 0.0007 0.0041
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0039 0.1926
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Brugia malayi chromobox protein homolog 3 0.0038 0.0142 0.0916
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0045 0.0173 0.0978
Schistosoma mansoni hypothetical protein 0.0011 0.0007 0.0041
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0069 0.2153
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0045 0.0173 0.1118
Echinococcus multilocularis chromobox protein 2 0.0011 0.0007 0.0041
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0223
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0007 0.0355
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0323 0.1549 0.875
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0042 0.0158 0.0894
Brugia malayi hypothetical protein 0.0016 0.0031 0.02
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0039 0.1629
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.029 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0117 0.0529 0.0687
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.3636
Loa Loa (eye worm) hypothetical protein 0.0025 0.0074 0.0421
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0094 0.2853
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0323 0.1549 0.875
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Brugia malayi SET domain containing protein 0.0011 0.0007 0.0047
Loa Loa (eye worm) hypothetical protein 0.0367 0.177 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Treponema pallidum UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2031 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Brugia malayi ImpB/MucB/SamB family protein 0.0069 0.0295 0.1902
Trypanosoma brucei trypanothione reductase 0.0051 0.0205 0.6797
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0007 0.0355
Trypanosoma brucei chrX additional, unordered contigs 0.0013 0.0016 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0016 0.006
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0011 0.0007 0.0041
Brugia malayi CHD4 protein 0.0011 0.0007 0.0047
Schistosoma mansoni DNA polymerase IV / kappa 0.0013 0.0016 0.009
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0367 0.177 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis C-MYB, putative 0.0068 0.029 0.9943
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.003 0.0107
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0074 0.2149
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0045 0.0173 0.5668
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0016 0.006
Trichomonas vaginalis C-MYB, putative 0.0068 0.029 0.9943
Schistosoma mansoni chromobox protein 0.0011 0.0007 0.0041
Echinococcus granulosus chromobox protein 1 0.0069 0.0291 0.1643
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0173 0.1118
Giardia lamblia DINP protein human, muc B family 0.0042 0.0158 0.0894
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.4222
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0173 0.0978
Brugia malayi MH2 domain containing protein 0.0129 0.059 0.3812
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.8455
Loa Loa (eye worm) hypothetical protein 0.0045 0.0173 0.0978
Schistosoma mansoni hypothetical protein 0.035 0.1683 0.9507
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0074 0.0267
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000070202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0007 0.0041
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0016 0.0104
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trichomonas vaginalis DNA polymerase eta, putative 0.0042 0.0158 0.5301
Plasmodium vivax phosphodiesterase gamma, putative 0.0045 0.0173 0.8398
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2031 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0901
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0039 0.0142
Echinococcus granulosus geminin 0.035 0.1683 0.9507
Trypanosoma brucei unspecified product 0.0029 0.0094 0.2853
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Leishmania major cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0044 0.0249
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.8398
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0042 0.0158 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.2776
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0173 0.5822
Loa Loa (eye worm) hypothetical protein 0.0045 0.0173 0.0978
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0117 0.0529 0.0687
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0156 0.523
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0069 0.2153
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000069803
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.013 0.0593 0.0777
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0042 0.0158 0.5139
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0173 0.0978
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0045 0.0173 0.0978
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Echinococcus granulosus Chromo domain 0.0011 0.0007 0.0041
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0016 0.0057
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0086 0.2776
Echinococcus granulosus dna polymerase kappa 0.0042 0.0158 0.0894
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Brugia malayi hypothetical protein 0.0025 0.0074 0.0481
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0045 0.0173 0.5668
Brugia malayi glutathione reductase 0.0051 0.0205 0.1322
Leishmania major DNA polymerase eta, putative 0.004 0.0152 0.4921
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0205 1
Toxoplasma gondii Myb family DNA-binding domain-containing protein 0.0069 0.0292 0.1049
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0127 0.0717
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0045 0.0173 0.8455
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.013 0.0593 0.0097
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0074 0.3636
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0039 0.0901
Mycobacterium tuberculosis Conserved hypothetical protein 0.0042 0.0158 0.0167
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Loa Loa (eye worm) hypothetical protein 0.0119 0.054 0.305
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0173 0.5822
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0117 0.0529 0.0687
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0142 0.4724
Plasmodium vivax glutathione reductase, putative 0.0051 0.0205 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0039 0.1926
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0205 0.1157
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000070202
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0045 0.0173 0.0978
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Mycobacterium ulcerans UDP-N-acetylglucosamine 1-carboxyvinyltransferase 0.2031 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0901
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0014 0.0243
Trichomonas vaginalis MYB72, putative 0.0068 0.029 0.9943
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0045 0.0173 0.0978
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0045 0.0173 0.0978
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000069803
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0045 0.0173 0.5668
Trypanosoma brucei DNA polymerase kappa, putative 0.0029 0.0094 0.2853
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0045 0.0173 0.5668
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0007 0.0355
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0039 0.0142
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0367 0.177 0.6357
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Echinococcus multilocularis chromobox protein 1 0.0069 0.0291 0.1643
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0173 0.0978
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Mycobacterium leprae probable 3-phosphoshikimate 1-carboxyvinyl transferase AroA (5-ENOLPYRUVYLSHIKIMATE-3-PHOSPHATE SYNTHASE) (EPSP SYNTHASE) (EPSPS 0.0573 0.2784 0.3398
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.029 1
Entamoeba histolytica hypothetical protein 0.0011 0.0007 0.00000000070202
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Plasmodium falciparum phosphodiesterase gamma, putative 0.0045 0.0173 0.8455
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0323 0.1549 0.875
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0173 0.5668
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.177 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.013 0.0593 0.0777
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.029 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0045 0.0173 0.0978
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5668
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0042 0.0158 0.0894
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0173 0.5668
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0173 0.5822
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0039 0.0901
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0205 0.0232
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0007 0.0026
Brugia malayi hypothetical protein 0.0035 0.0127 0.0819
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0007 0.0000000010069
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0007 0.0041
Schistosoma mansoni hypothetical protein 0.0035 0.0127 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0173 0.5668
Trichomonas vaginalis r2r3-MYB transcription factor, putative 0.0068 0.029 0.9943
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0039 0.0255
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Trichomonas vaginalis MYB3r3, putative 0.0068 0.029 0.9943
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.5822
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0205 0.1157
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0045 0.0173 0.0978
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0039 0.0223
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0045 0.0173 0.0978
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Schistosoma mansoni terminal deoxycytidyl transferase 0.0042 0.0158 0.0894
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000069803
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0013 0.0016 0.0057
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0045 0.0173 0.0978
Leishmania major DNA polymerase eta, putative 0.0069 0.0295 1
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0158 0.5139
Brugia malayi hypothetical protein 0.0011 0.0007 0.0047
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Mycobacterium tuberculosis Probable reductase 0.0117 0.0529 0.0687
Giardia lamblia Hypothetical protein 0.0045 0.0173 0.0978
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0074 0.2149
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0007 0.0047
Plasmodium falciparum glutathione reductase 0.0051 0.0205 1
Giardia lamblia DNA damage repair protein 0.0013 0.0016 0.009
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0069 0.0443
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.0158 0.5139
Mycobacterium leprae PROBABLE UDP-N-ACETYLGLUCOSAMINE 1-CARBOXYVINYLTRANSFERASE MURA 0.1458 0.7167 1
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0045 0.0173 0.1118
Toxoplasma gondii thioredoxin reductase 0.0051 0.0205 0.0735
Echinococcus multilocularis dna polymerase kappa 0.0042 0.0158 0.0894
Entamoeba histolytica myb-like DNA-binding domain containing protein 0.0068 0.029 1
Echinococcus multilocularis dna polymerase eta 0.0069 0.0295 0.1664
Plasmodium vivax DNA repair protein REV1, putative 0.0013 0.0016 0.0435
Mycobacterium ulcerans DNA polymerase IV 0.0042 0.0158 0.0143
Giardia lamblia hypothetical protein 0.0045 0.0173 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0007 0.0047
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.059 0.3336
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0007 0.0038
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Loa Loa (eye worm) hypothetical protein 0.0013 0.0016 0.009
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0039 0.0901
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0039 0.0901
Echinococcus multilocularis chromobox protein 1 0.0069 0.0291 0.1643
Entamoeba histolytica hypothetical protein 0.0035 0.0127 0.4222
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0007 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0013 0.0016 0.006
Trichomonas vaginalis MYB, putative 0.0069 0.0292 1
Plasmodium falciparum phosphodiesterase delta, putative 0.0045 0.0173 0.8455
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0045 0.0173 0.5822
Schistosoma mansoni chromobox protein 0.0069 0.0291 0.1643
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.8398
Leishmania major DNA polymerase kappa, putative 0.0042 0.0158 0.5139
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0039 0.1129
Loa Loa (eye worm) PDE1B protein 0.0045 0.0173 0.0978
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0039 0.0901
Plasmodium falciparum DNA repair protein REV1, putative 0.0013 0.0016 0.0775
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.0593 0.0777
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0142 0.9031
Loa Loa (eye worm) hypothetical protein 0.0011 0.0007 0.0041
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0291 0.9954
Echinococcus granulosus chromobox protein 2 0.0011 0.0007 0.0041
Toxoplasma gondii shikimate dehydrogenase substrate binding domain-containing protein 0.0573 0.2784 1
Trichomonas vaginalis pc-MYB2, putative 0.0068 0.029 0.9943
Leishmania major hypothetical protein, conserved 0.0045 0.0173 0.5668
Trypanosoma brucei unspecified product 0.0042 0.0158 0.5139
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0039 0.0223
Brugia malayi Thioredoxin reductase 0.0051 0.0205 0.1322
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000070202
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0045 0.0173 0.0622
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0039 0.1129
Onchocerca volvulus 0.003 0.0101 0.6276
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0045 0.0173 0.5668
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0045 0.0173 0.0978
Trypanosoma cruzi DNA polymerase eta, putative 0.0069 0.0295 1
Trypanosoma brucei DNA polymerase eta, putative 0.0069 0.0295 1
Trypanosoma cruzi DNA polymerase eta, putative 0.004 0.0152 0.4921
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0007 0.0041
Mycobacterium ulcerans 3-phosphoshikimate 1-carboxyvinyltransferase 0.0573 0.2784 0.2773
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0007 0.0026
Echinococcus multilocularis geminin 0.035 0.1683 0.9507
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0045 0.0173 0.5668
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0007 0.00000000069803
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0142 0.4724
Loa Loa (eye worm) glutathione reductase 0.0051 0.0205 0.1157
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.0007 0.00000000069803
Entamoeba histolytica deoxycytidyl transferase, putative 0.0042 0.0158 0.5331
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0014 0.0244
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0016 0.0104
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0045 0.0173 0.5822
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0045 0.0173 0.8398
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0045 0.0173 0.0978
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0367 0.177 1

Activities

Activity type Activity value Assay description Source Reference
Normalization (functional) = 51 % In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 1 mg/kg. ChEMBL. 1588563
Normalization (functional) = 51 % In vivo euglycemic activity (administered by oral gavage) in C57/6J-ob/ob mice by normalization of blood glucose levels at a dose of 1 mg/kg. ChEMBL. 1588563
Normalization (functional) = 100 % In vivo euglycemic activity of the compound(administered by oral gavage) in C57/6J-ob/ob mice is measured by normalization of blood glucose levels at a dose of 2.5(mg/kg) ChEMBL. 1588563
Normalization (functional) = 100 % In vivo euglycemic activity of the compound(administered by oral gavage) in C57/6J-ob/ob mice is measured by normalization of blood glucose levels at a dose of 2.5(mg/kg) ChEMBL. 1588563

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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