Detailed information for compound 795307

Basic information

Technical information
  • TDR Targets ID: 795307
  • Name: 5-propyl-N-[4-(trifluoromethoxy)phenyl]-1,2-o xazole-3-carboxamide
  • MW: 314.26 | Formula: C14H13F3N2O3
  • H donors: 1 H acceptors: 2 LogP: 3.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCc1onc(c1)C(=O)Nc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C14H13F3N2O3/c1-2-3-11-8-12(19-22-11)13(20)18-9-4-6-10(7-5-9)21-14(15,16)17/h4-8H,2-3H2,1H3,(H,18,20)
  • InChiKey: OQYIUVMQGCAHAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-propyl-N-[4-(trifluoromethoxy)phenyl]isoxazole-3-carboxamide
  • 5-propyl-N-[4-(trifluoromethoxy)phenyl]-3-isoxazolecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.001 0.0061 0.0036
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0012 0.0101 0.0115
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0061 0.0061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0061 0.0061
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0069 0.0069
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0012 0.0101 0.0075
Leishmania major hypothetical protein, conserved 0.0012 0.0101 0.0075
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0061 0.0061
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0101 0.0106
Trypanosoma cruzi NADH dehydrogenase, putative 0.0012 0.0101 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0328 0.0507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0328 0.0328
Echinococcus granulosus aldehyde dehydrogenase family 3 member B1 0.0011 0.0069 0.0069
Toxoplasma gondii aldehyde dehydrogenase 0.0194 0.4301 1
Giardia lamblia Glutamate synthase 0.0012 0.0101 0.0398
Loa Loa (eye worm) RNA binding protein 0.0066 0.1348 0.2308
Trypanosoma brucei trypanothione reductase 0.0131 0.2849 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0871 0.2886
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1348 0.2308
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0406 0.1211
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Trichomonas vaginalis chaperonin, putative 0.0025 0.0406 0.4197
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0046 0.0871 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1348 0.1348
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0328 0.0508
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0046 0.0871 0.2886
Trypanosoma cruzi NADH dehydrogenase, putative 0.0012 0.0101 0.0115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0328 0.0328
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0406 0.0406
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0328 0.0328
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0328 0.0507
Mycobacterium tuberculosis Probable reductase 0.03 0.6725 0.8963
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0131 0.2849 0.3743
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0061 0.0061
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0101 0.0948
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0052 0.1023 0.1023
Echinococcus multilocularis Fatty aldehyde dehydrogenase 0.0011 0.0069 0.0069
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0012 0.0101 0.0101
Loa Loa (eye worm) thioredoxin reductase 0.0131 0.2849 0.4956
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0012 0.0101 0.0043
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0406 0.0644
Schistosoma mansoni hypothetical protein 0.0012 0.0101 0.0101
Schistosoma mansoni nuclear hormone receptor 0.001 0.0061 0.0061
Echinococcus granulosus geminin 0.0364 0.8203 0.8203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0328 0.0508
Treponema pallidum NADH oxidase 0.0046 0.0871 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0328 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0328 0.0507
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0012 0.0101 0.0075
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0101 0.0115
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.4301 1
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0101 0.0101
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.4301 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0406 0.1211
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0046 0.0871 0.1896
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0328 0.0328
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0406 0.4197
Plasmodium vivax thioredoxin reductase, putative 0.0131 0.2849 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1348 0.2308
Brugia malayi nuclear receptor NHR-67 0.001 0.0061 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0328 0.0507
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0406 0.0406
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0328 0.2779
Schistosoma mansoni hypothetical protein 0.0011 0.0069 0.0069
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0012 0.0101 0.0043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0328 0.0508
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0046 0.0871 0.2803
Loa Loa (eye worm) hypothetical protein 0.0255 0.5706 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0328 0.0328
Plasmodium falciparum thioredoxin reductase 0.0046 0.0871 0.2803
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0061 0.0061
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0328 0.0328
Plasmodium falciparum glutathione reductase 0.0131 0.2849 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0328 0.0328
Leishmania major NADH dehydrogenase, putative 0.0012 0.0101 0.0075
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0871 0.2886
Brugia malayi glutamate synthase 0.0012 0.0101 0.0106
Loa Loa (eye worm) hypothetical protein 0.0012 0.0101 0.0106
Echinococcus multilocularis cpg binding protein 0.0033 0.0578 0.0578
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0406 1
Schistosoma mansoni nuclear receptor 0.001 0.0061 0.0061
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0033 0.0593 0.0974
Trichomonas vaginalis apoptosis inducing factor, putative 0.0012 0.0101 0.0398
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0046 0.0871 0.2886
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0012 0.0101 0.0398
Giardia lamblia Thioredoxin reductase 0.0012 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0012 0.0101 0.0075
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0046 0.0871 0.2886
Brugia malayi tailless protein 0.001 0.0061 0.0036
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.4301 0.4301
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0012 0.0101 0.0075
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0061 0.0061
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0328 0.0328
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.009 0.009
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0101 0.0075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0328 0.0507
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Mycobacterium ulcerans ferredoxin reductase 0.0012 0.0101 0.0075
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Echinococcus granulosus succinate semialdehyde dehydrogenase 0.0011 0.0069 0.0069
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0012 0.0101 0.0106
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0012 0.0101 0.0043
Loa Loa (eye worm) hypothetical protein 0.0012 0.009 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Leishmania major trypanothione reductase 0.0131 0.2849 0.6569
Mycobacterium ulcerans hypothetical protein 0.0012 0.0101 0.0075
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0364 0.8203 0.8203
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0328 0.0328
Brugia malayi CXXC zinc finger family protein 0.0031 0.0537 0.0876
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0214 0.052
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0061 0.0061
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0333 0.7496 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0101 0.0101
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0012 0.0101 0.0075
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0017 0.0214 0.0342
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0012 0.0101 0.0043
Loa Loa (eye worm) histone methyltransferase 0.001 0.0044 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0328 0.0507
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0214 0.052
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0046 0.0871 0.2803
Mycobacterium tuberculosis Probable dehydrogenase 0.03 0.6725 0.8963
Brugia malayi Aldehyde dehydrogenase protein 4 0.0011 0.0069 0.005
Onchocerca volvulus 0.0031 0.0537 0.495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0328 0.0508
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0406 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0328 0.0507
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0033 0.0593 0.0974
Echinococcus multilocularis betaine aldehyde dehydrogenase 0.0011 0.0069 0.0069
Brugia malayi Nuclear hormone receptor E75 0.001 0.0061 0.0036
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0537 0.0876
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0328 0.0508
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1348 0.1348
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.009 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0012 0.0101 0.0115
Brugia malayi nuclear hormone receptor 0.001 0.0061 0.0036
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0012 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.009 0.0087
Brugia malayi ecdysone receptor 0.001 0.0061 0.0036
Brugia malayi Cytochrome P450 family protein 0.0017 0.0214 0.0305
Loa Loa (eye worm) programmed cell death 8 0.0012 0.0101 0.0106
Onchocerca volvulus 0.0022 0.0328 0.2779
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0214 0.0305
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0328 0.0328
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0046 0.0871 0.1896
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0069 0.0069
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0046 0.0871 0.108
Echinococcus granulosus cpg binding protein 0.0033 0.0578 0.0578
Echinococcus multilocularis dnaJ subfamily B 0.0442 1 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0328 0.0328
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0194 0.4301 1
Mycobacterium ulcerans monoxygenase 0.0012 0.0101 0.0075
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.005
Mycobacterium tuberculosis Putative ferredoxin reductase 0.03 0.6725 0.8963
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0194 0.4301 0.4301
Schistosoma mansoni zinc finger protein 0.001 0.0061 0.0061
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0328 0.0328
Brugia malayi Cytochrome P450 family protein 0.0017 0.0214 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0328 0.0507
Leishmania major cytochrome p450-like protein 0.0017 0.0214 0.0342
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.1338 0.1338
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0012 0.0101 0.0948
Brugia malayi conserved hypotetical protein 0.001 0.0061 0.0036
Entamoeba histolytica thioredoxin reductase, putative 0.0012 0.0101 0.0948
Schistosoma mansoni cpg binding protein 0.0033 0.0578 0.0578
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0101 0.0398
Leishmania major hypothetical protein, conserved 0.0012 0.0101 0.0075
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0333 0.7496 1
Brugia malayi Nuclear hormone receptor E75 0.001 0.0061 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.03 0.6725 0.8963
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0871 0.2886
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0012 0.0101 0.0398
Schistosoma mansoni survival motor neuron protein 0.0052 0.1023 0.1023
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0406 0.4197
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0061 0.0036
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0406 0.0406
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0328 0.0507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0406 0.0796
Echinococcus multilocularis geminin 0.0364 0.8203 0.8203
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0328 0.0328
Schistosoma mansoni nuclear receptor 0.001 0.0061 0.0061
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.03 0.6725 0.8963
Loa Loa (eye worm) aldehyde dehydrogenase 4 0.0011 0.0069 0.005
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1348 0.1348
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0537
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0061 0.0036
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0012 0.0101 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0328 0.0328
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0012 0.0101 0.0043
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0012 0.0101 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.009 0.0087
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0101 0.0115
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.1896
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0101 0.0115
Brugia malayi nuclear hormone receptor 0.0022 0.0328 0.0507
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0046 0.0871 0.0871
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0328 0.0328
Brugia malayi hypothetical protein 0.001 0.0061 0.0036
Onchocerca volvulus 0.0052 0.1023 1
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0069 0.0069
Brugia malayi Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor 0.0011 0.0069 0.005
Mycobacterium ulcerans glutamate synthase subunit beta 0.0012 0.0101 0.0075
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0406 0.1109
Mycobacterium ulcerans NADH dehydrogenase 0.0012 0.0101 0.0075
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0046 0.0871 0.1896
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0046 0.0871 0.2803
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0101 0.0115
Trichomonas vaginalis glutathione reductase, putative 0.0046 0.0871 1
Schistosoma mansoni aldehyde dehydrogenase 0.0194 0.4301 0.4301
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0061 0.0061
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0012 0.0101 0.0101
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0012 0.0101 0.0043
Trypanosoma cruzi trypanothione reductase, putative 0.0131 0.2849 1
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0012 0.0101 0.0101
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0061 0.0036
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0061 0.0061
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0328 0.0508
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0046 0.0871 0.1896
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0012 0.0101 0.0101
Trichomonas vaginalis glutamate synthase, putative 0.0012 0.0101 0.0398
Brugia malayi RNA binding protein 0.0066 0.1348 0.2308
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0061 0.0036
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0012 0.0101 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0328 0.0507
Trichomonas vaginalis mercuric reductase, putative 0.0046 0.0871 1
Schistosoma mansoni succinate semialdehyde dehydrogenase 0.0011 0.0069 0.0069
Echinococcus granulosus thioredoxin glutathione reductase 0.0132 0.2873 0.2873
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0328 0.0328
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0046 0.0871 0.0871
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Loa Loa (eye worm) delta-1-pyrroline-5-carboxylate dehydrogenase 0.0011 0.0069 0.005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0194 0.4301 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0046 0.0871 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0333 0.7496 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0328 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0328 0.0508
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0871 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1023 0.1733
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0012 0.0101 0.0106
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0194 0.4301 0.5698
Brugia malayi nuclear receptor RXR 0.001 0.0061 0.0036
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0214 0.0305
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0046 0.0871 0.1896
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0333 0.7496 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.009 0.0087
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.03 0.6725 0.8963
Brugia malayi glutathione reductase 0.0131 0.2849 0.4956
Loa Loa (eye worm) hypothetical protein 0.0012 0.009 0.0087
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0046 0.0871 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0061 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0328 0.0328
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0101 0.0101
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0012 0.0101 0.0101
Echinococcus multilocularis glutamate synthase 0.0012 0.0101 0.0101
Echinococcus granulosus glutamate synthase 0.0012 0.0101 0.0101
Echinococcus multilocularis aldehyde dehydrogenase family 3 member B1 0.0011 0.0069 0.0069
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0101 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0328 0.0328
Echinococcus granulosus tar DNA binding protein 0.0066 0.1348 0.1348
Plasmodium falciparum thioredoxin reductase 0.0131 0.2849 1
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0012 0.0101 0.0043
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0406 0.1109
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0214 0.0305
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0328 0.0328
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0046 0.0871 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0061 0.0061
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0012 0.0101 0.0101
Loa Loa (eye worm) glutathione reductase 0.0131 0.2849 0.4956
Mycobacterium ulcerans dehydrogenase 0.0012 0.0101 0.0075
Schistosoma mansoni glutamate synthase 0.0012 0.0101 0.0101
Leishmania major hypothetical protein, conserved 0.0012 0.0101 0.0075
Loa Loa (eye worm) DR-78 0.001 0.0061 0.0036
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0012 0.0101 0.0075
Schistosoma mansoni delta 1-pyrroline-5-carboxylate synthetase 0.0011 0.0069 0.0069
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0328 0.0508
Schistosoma mansoni hypothetical protein 0.0364 0.8203 0.8203
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0012 0.0101 0.0043
Onchocerca volvulus 0.0012 0.0101 0.0413
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0214 0.052
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0069 0.0069
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0328 0.0328
Echinococcus multilocularis succinate semialdehyde dehydrogenase 0.0011 0.0069 0.0069
Treponema pallidum oxidoreductase 0.0012 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0328 0.0328
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.009 0.009
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0101 0.0115
Brugia malayi nuclear receptor NHR-88 0.001 0.0061 0.0036
Entamoeba histolytica disulphide oxidoreductase, putative 0.0012 0.0101 0.0948
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1348 0.1348
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0101 0.0075
Brugia malayi Thioredoxin reductase 0.0131 0.2849 0.4956
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0328 0.0328
Plasmodium falciparum glutathione reductase 0.0046 0.0871 0.2803
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0061 0.0061
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0328 0.0328
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.005
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1348 0.2308
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.03 0.6725 0.8963
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0406 0.0796
Schistosoma mansoni nuclear hormone receptor 0.001 0.0061 0.0061
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0406 0.0406
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0012 0.0101 0.0075
Loa Loa (eye worm) aldehyde dehydrogenase 0.0011 0.0069 0.005
Brugia malayi hypothetical protein 0.0012 0.009 0.0086
Brugia malayi aldehyde dehydrogenase 0.0011 0.0069 0.005
Schistosoma mansoni glutamate synthase 0.0012 0.0101 0.0101
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.009 0.0086
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0012 0.0101 0.0043
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0061 0.0036
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0012 0.0101 0.0101
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0012 0.0101 0.0398
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0012 0.0101 0.0948
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0069 0.0069
Echinococcus multilocularis thioredoxin glutathione reductase 0.0132 0.2873 0.2873
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0046 0.0871 0.0871
Brugia malayi Succinate semialdehyde dehydrogenase, mitochondrial precursor 0.0011 0.0069 0.005
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.1896
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1348 0.1348
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0046 0.0871 0.1896
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0012 0.0101 0.0115
Schistosoma mansoni aldehyde dehydrogenase 0.0011 0.0069 0.0069
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0044 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0046 0.0871 0.1896
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.5706 0.5706
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0046 0.0871 0.1466
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0328 0.0328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0061 0.0061
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.009 0.009
Schistosoma mansoni sulfide quinone reductase 0.0012 0.0101 0.0101
Brugia malayi steroid hormone receptor 0.0022 0.0328 0.0507
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0046 0.0871 0.2886
Schistosoma mansoni glutamate synthase 0.0012 0.0101 0.0101
Brugia malayi hypothetical protein 0.0255 0.5706 1
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0012 0.0101 0.0106
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0328 0.0328
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0012 0.0101 0.0101
Brugia malayi ecdysteroid receptor 0.0022 0.0328 0.0507
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0061 0.0061
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0061 0.0061
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.1176 0.2617
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0012 0.0101 0.0115
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0328 0.2779
Schistosoma mansoni cpg binding protein 0.0033 0.0578 0.0578
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.009 0.009
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0328 0.0507
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0328 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0328 0.0328
Plasmodium vivax glutathione reductase, putative 0.0131 0.2849 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0012 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0194 0.4301 0.4301
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0012 0.0101 0.0398
Schistosoma mansoni coup transcription factor 0.0022 0.0328 0.0328
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0012 0.0101 0.0398
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1348 0.1348
Echinococcus granulosus Fatty aldehyde dehydrogenase 0.0011 0.0069 0.0069
Brugia malayi hypothetical protein 0.0012 0.009 0.0086
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0012 0.0101 0.0948
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0061 0.0036
Trypanosoma brucei NADH dehydrogenase 0.0012 0.0101 0.0115
Treponema pallidum thioredoxin reductase (trxB) 0.0012 0.0101 0.0398
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0328 0.2779
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0328 0.0507
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0012 0.0101 0.0075
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0406 0.0644
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0328 0.0507
Echinococcus granulosus betaine aldehyde dehydrogenase 0.0011 0.0069 0.0069
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0061 0.0036
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.5706 0.5706
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0012 0.0101 0.0101
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0012 0.0101 0.0115
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0012 0.0101 0.0075
Toxoplasma gondii thioredoxin reductase 0.0131 0.2849 0.6569
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0046 0.0871 0.2886
Loa Loa (eye worm) hypothetical protein 0.0022 0.0328 0.0508
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0328 0.0507
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0012 0.0101 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0061 0.0036
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0012 0.0101 0.0948
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0328 0.0328
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0012 0.0101 0.0398
Brugia malayi nuclear receptor RXR 0.0012 0.009 0.0086
Schistosoma mansoni disulfide oxidoreductase 0.0012 0.0101 0.0101
Onchocerca volvulus Aldehyde dehydrogenase homolog 0.0011 0.0069 0.0081
Brugia malayi TAR-binding protein 0.0066 0.1348 0.2308
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.009 0.0087
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0406 0.0644
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0012 0.0101 0.0043
Toxoplasma gondii selenide, water dikinase 0.0012 0.0101 0.0075
Schistosoma mansoni hypothetical protein 0.0442 1 1
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0012 0.0101 0.0075

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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