Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.3057 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.3057 | 1 |
Echinococcus multilocularis | Ankyrin | 0.0016 | 0.0021 | 0.0021 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.3057 | 0.3057 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3057 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3057 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0021 | 0.5 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0079 | 1 | 1 |
Echinococcus granulosus | Ankyrin | 0.0016 | 0.0021 | 0.0021 |
Brugia malayi | hypothetical protein | 0.0035 | 0.3057 | 1 |
Schistosoma mansoni | retinoblastoma-binding protein 4 (rbbp4) | 0.0016 | 0.0021 | 0.0067 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3057 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.3057 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.3057 | 0.3057 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
PD50 (functional) | > 178 mg kg-1 | Dose that protects 50% of guinea pig from collapse was determined in guinea pig anaphylaxis assay | ChEMBL. | 2342077 |
PFA (functional) | = -91 | Percent change in volume of foot edema of test compound to that of positive control was determined at a dose of 31.6 mg/kg in rat; -91/-83 | ChEMBL. | 2342077 |
PFA (functional) | = -70 | Percent change in volume of foot edema of test compound to that of positive control was determined at a dose of 10 mg/kg in rat; -70/-88 | ChEMBL. | 2342077 |
PFA (functional) | = -42 | Oral Antiallergic activity in the passive foot anaphylaxis (PFA) assay of various amines at the dose of 3.16 mg/kg; -42/-78 | ChEMBL. | 2342077 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.