TDR Targets

Basic information

Technical information

TDR Targets ID: 795596
Name: N-(2-methylphenyl)-3-[3-(4-methylphenyl)-1,2, 4-oxadiazol-5-yl]propanamide
MW: 321.373 | Formula: C19H19N3O2
H donors: 1 H acceptors: 3 LogP: 3.63 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1ccccc1C)CCc1onc(n1)c1ccc(cc1)C
InChi: 1S/C19H19N3O2/c1-13-7-9-15(10-8-13)19-21-18(24-22-19)12-11-17(23)20-16-6-4-3-5-14(16)2/h3-10H,11-12H2,1-2H3,(H,20,23)
InChiKey: ZMQBFGCMHBTLEU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2-methylphenyl)-3-[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]propionamide
SMR000035243
ZINC04295220
STOCK5S-22659
MLS000080570

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	penicillin-binding protein	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references
Mus musculus	RAR-related orphan receptor gamma	Starlite/ChEMBL	No references
Homo sapiens	lamin A/C	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	Intermediate filament tail domain containing protein	Get druggable targets OG5_128723	All targets in OG5_128723
Mycobacterium tuberculosis	Possible penicillin-binding protein	Get druggable targets OG5_149948	All targets in OG5_149948
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	intermediate filament proteins	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Intermediate filament protein ifa-1, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K07611 lamin, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	Lamin-C, putative	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Onchocerca volvulus		Get druggable targets OG5_128723	All targets in OG5_128723
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128723	All targets in OG5_128723
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	musashi	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	lamin dm0	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus granulosus	cytoplasmic intermediate filament protein	Get druggable targets OG5_128723	All targets in OG5_128723
Echinococcus multilocularis	lamin	Get druggable targets OG5_128723	All targets in OG5_128723
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0893	0.0893
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0118	0.2318	0.6708
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.1743	1
Brugia malayi	Nuclear hormone receptor-like 1	0.002	0.0088	0.0093
Brugia malayi	Intermediate filament tail domain containing protein	0.0033	0.0381	0.0653
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.007	0.1222	0.0811
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.002	0.0088	0.0093
Onchocerca volvulus		0.007	0.1222	0.3618
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.002	0.0088	0.0088
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0483	0.0483
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.1222	0.2189
Echinococcus multilocularis	FTZ F1 alpha	0.002	0.0088	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0088	0.0093
Brugia malayi	glutathione reductase	0.0037	0.0472	0.0828
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.007	0.1222	0.0811
Echinococcus multilocularis	lamin	0.0033	0.0381	0.0381
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.002	0.0088	0.0093
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0472	0.0896
Trichomonas vaginalis	esterase, putative	0.007	0.1222	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.002	0.0088	0.0166
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.1222	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0448	0.0448
Loa Loa (eye worm)	steroid hormone receptor	0.002	0.0088	0.0166
Mycobacterium tuberculosis	Probable lipase LipD	0.007	0.1222	0.0811
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.5272	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0893	0.1693
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0118	0.2318	0.1995
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0381	0.0722
Echinococcus granulosus	ecdysone induced protein 78C	0.002	0.0088	0.0088
Brugia malayi	Steroid receptor seven-up type 2	0.002	0.0088	0.0093
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.002	0.0088	0.0088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0893	0.1553
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.1222	0.5
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.1532	0.5954
Trypanosoma brucei	hypothetical protein, conserved	0.007	0.1222	1
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.007	0.1222	0.0811
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0893	0.0893
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.1532	0.1146
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1222	0.5
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.1532	0.1146
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0446	0.9723	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0249	0.5272	1
Brugia malayi	beta-lactamase	0.007	0.1222	0.2261
Echinococcus multilocularis	thyroid hormone receptor alpha	0.002	0.0088	0.0088
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.5272	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0088	0.0088
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.007	0.1222	0.2261
Loa Loa (eye worm)	intermediate filament protein	0.0033	0.0381	0.0722
Schistosoma mansoni	ngng-dimethylarginine dimethylaminohydrolase	0.0158	0.3224	0.6049
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0472	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Brugia malayi	RNA recognition motif domain containing protein	0.0249	0.5272	1
Mycobacterium tuberculosis	Probable lipase LipE	0.007	0.1222	0.0811
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0118	0.2318	0.2318
Echinococcus multilocularis	beta LACTamase domain containing family member	0.007	0.1222	0.1222
Leishmania major	hypothetical protein, unknown function	0.0158	0.3224	1
Leishmania major	hypothetical protein, unknown function	0.0158	0.3224	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.002	0.0088	0.0093
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.1532	0.1146
Onchocerca volvulus		0.0033	0.0381	0.0934
Echinococcus granulosus	beta LACTamase domain containing family member	0.007	0.1222	0.1222
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.002	0.0088	0.0088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0893	0.0893
Brugia malayi	photoreceptor-specific nuclear receptor	0.002	0.0088	0.0093
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.002	0.0088	0.0093
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1222	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.1532	0.1146
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.002	0.0088	0.0166
Brugia malayi	nuclear hormone receptor	0.002	0.0088	0.0093
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0893	0.1553
Mycobacterium tuberculosis	Conserved protein	0.007	0.1222	0.0811
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.002	0.0088	0.0166
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.5272	1
Brugia malayi	RNA binding protein	0.0249	0.5272	1
Loa Loa (eye worm)	hypothetical protein	0.0158	0.3224	0.6115
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.007	0.1222	0.2189
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.002	0.0088	0.0088
Mycobacterium tuberculosis	Probable reductase	0.0084	0.1532	0.1146
Onchocerca volvulus		0.007	0.1222	0.3618
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.002	0.0088	0.0093
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Echinococcus multilocularis	neuropeptide receptor A26	0.0458	1	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0088	0.0088
Entamoeba histolytica	hypothetical protein	0.0036	0.0448	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.1532	0.1146
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0483	0.0483
Schistosoma mansoni	lamin	0.0033	0.0381	0.0565
Schistosoma mansoni	lamin	0.0033	0.0381	0.0565
Brugia malayi	follicle stimulating hormone receptor	0.0226	0.4752	0.9007
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.2318	1
Echinococcus multilocularis	musashi	0.0033	0.0381	0.0381
Entamoeba histolytica	hypothetical protein	0.0036	0.0448	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0458	1	1
Brugia malayi	NG,NG-dimethylarginine dimethylaminohydrolase 1, putative	0.0158	0.3224	0.6086
Entamoeba histolytica	hypothetical protein	0.0036	0.0448	0.5
Onchocerca volvulus		0.0033	0.0381	0.0934
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.002	0.0088	0.0093
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.1743	0.1373
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.002	0.0088	0.0166
Schistosoma mansoni	intermediate filament proteins	0.0033	0.0381	0.0565
Toxoplasma gondii	aldehyde dehydrogenase	0.0118	0.2318	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.002	0.0088	0.0088
Entamoeba histolytica	hypothetical protein	0.0036	0.0448	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.002	0.0088	0.0166
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0448	0.0695
Trichomonas vaginalis	D-aminoacylase, putative	0.007	0.1222	0.5
Trichomonas vaginalis	penicillin-binding protein, putative	0.007	0.1222	0.5
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0367	0.0696
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.002	0.0088	0.0088
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.002	0.0088	0.0093
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0088	0.0093
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0472	0.0896
Schistosoma mansoni	ngng-dimethylarginine dimethylaminohydrolase	0.0158	0.3224	0.6049
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Leishmania major	hypothetical protein, conserved	0.007	0.1222	0.2726
Loa Loa (eye worm)	beta-lactamase	0.007	0.1222	0.2319
Brugia malayi	nuclear receptor NHR-88	0.002	0.0088	0.0093
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.2318	0.4302
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0448	0.0448
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0088	0.0093
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.002	0.0088	0.0088
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Loa Loa (eye worm)	TAR-binding protein	0.0249	0.5272	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.002	0.0088	0.0166
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.1743	0.1373
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.002	0.0088	0.0093
Brugia malayi	ecdysteroid receptor	0.002	0.0088	0.0093
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Echinococcus multilocularis	ecdysone induced protein 78C	0.002	0.0088	0.0088
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0033	0.0381	0.0722
Brugia malayi	steroid hormone receptor	0.002	0.0088	0.0093
Echinococcus multilocularis	neuropeptide s receptor	0.0458	1	1
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.007	0.1222	0.2319
Mycobacterium tuberculosis	Probable esterase LipL	0.007	0.1222	0.0811
Brugia malayi	Thioredoxin reductase	0.0037	0.0472	0.0828
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0893	0.1631
Toxoplasma gondii	ABC1 family protein	0.007	0.1222	0.4064
Brugia malayi	intermediate filament protein	0.0033	0.0381	0.0653
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.1743	0.1373
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.002	0.0088	0.0088
Schistosoma mansoni	tar DNA-binding protein	0.0249	0.5272	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0118	0.2318	0.2318
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0226	0.4752	0.9015
Echinococcus granulosus	tar DNA binding protein	0.0249	0.5272	0.5272
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.2318	1
Schistosoma mansoni	hypothetical protein	0.0036	0.0448	0.0695
Schistosoma mansoni	aldehyde dehydrogenase	0.0118	0.2318	0.4302
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.002	0.0088	0.0088
Echinococcus granulosus	lamin dm0	0.0033	0.0381	0.0381
Echinococcus multilocularis	lamin dm0	0.0033	0.0381	0.0381
Echinococcus granulosus	intermediate filament protein	0.0033	0.0381	0.0381
Echinococcus granulosus	lamin	0.0033	0.0381	0.0381
Onchocerca volvulus		0.007	0.1222	0.3618
Trypanosoma cruzi	hypothetical protein, conserved	0.007	0.1222	1
Loa Loa (eye worm)	hypothetical protein	0.007	0.1222	0.2319
Mycobacterium tuberculosis	Conserved protein	0.007	0.1222	0.0811
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.002	0.0088	0.0093
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0893	0.0893
Brugia malayi	hypothetical protein	0.0036	0.0448	0.0781
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0893	0.1553
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0118	0.2318	1
Loa Loa (eye worm)	hypothetical protein	0.002	0.0088	0.0166
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.002	0.0088	0.0088
Brugia malayi	beta-lactamase family protein	0.007	0.1222	0.2261
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.002	0.0088	0.0166
Plasmodium falciparum	glutathione reductase	0.0037	0.0472	0.5
Loa Loa (eye worm)	RNA binding protein	0.0249	0.5272	1
Echinococcus granulosus	ng dimethylarginine dimethylaminohydrolase	0.0158	0.3224	0.3224
Echinococcus multilocularis	ng dimethylarginine dimethylaminohydrolase	0.0158	0.3224	0.3224
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.002	0.0088	0.0088
Onchocerca volvulus		0.0158	0.3224	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.002	0.0088	0.0093
Brugia malayi	beta-lactamase family protein	0.007	0.1222	0.2261
Echinococcus multilocularis	tar DNA binding protein	0.0249	0.5272	0.5272
Plasmodium vivax	hypothetical protein, conserved	0.007	0.1222	1
Mycobacterium tuberculosis	Conserved protein	0.007	0.1222	0.0811
Mycobacterium tuberculosis	Probable hydrolase	0.007	0.1222	0.0811
Brugia malayi	TAR-binding protein	0.0249	0.5272	1
Echinococcus granulosus	FTZ F1 alpha	0.002	0.0088	0.0088
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0017	0.0039	0.0074

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 0.631 um	PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))]	ChEMBL.	No reference
Potency (functional)	= 8.9125 um	PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	56.2341 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1508135
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 795596