Detailed information for compound 795769

Basic information

Technical information
  • TDR Targets ID: 795769
  • Name: N-(4-dimethylaminophenyl)-N'-(furan-2-ylmethy l)oxamide
  • MW: 287.314 | Formula: C15H17N3O3
  • H donors: 2 H acceptors: 2 LogP: 1.53 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(=O)Nc1ccc(cc1)N(C)C)NCc1ccco1
  • InChi: 1S/C15H17N3O3/c1-18(2)12-7-5-11(6-8-12)17-15(20)14(19)16-10-13-4-3-9-21-13/h3-9H,10H2,1-2H3,(H,16,19)(H,17,20)
  • InChiKey: MYRLIQOAWSUTIX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-dimethylaminophenyl)-N'-(2-furylmethyl)oxamide
  • N-(4-dimethylaminophenyl)-N'-(furan-2-ylmethyl)ethanediamide
  • ZINC03081939
  • BAS 03818919
  • N-(4-Dimethylamino-phenyl)-N'-furan-2-ylmethyl-oxalamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Inositol-1 0.0037 0.0654 0.0779
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0712 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0237 0.0081
Onchocerca volvulus 0.024 0.7441 1
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0654 0.0654
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0536 0.0408
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3853 0.3853
Echinococcus multilocularis importin subunit beta 1 0.003 0.0424 0.0424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.1173 0.1601
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0443 0.0443
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.3719 0.3719
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0654 0.0537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0443 0.0443
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0237 0.1351
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.3719 0.3719
Echinococcus multilocularis snurportin 1 0.0317 1 1
Echinococcus multilocularis geminin 0.0172 0.5162 0.5162
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.3719 0.3719
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0712 0.0558
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3853 0.3853
Loa Loa (eye worm) hypothetical protein 0.0126 0.364 0.3534
Schistosoma mansoni ap endonuclease 0.0038 0.0712 0.0712
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.9313 1
Giardia lamblia Pyruvate kinase 0.0033 0.0536 0.0576
Loa Loa (eye worm) hypothetical protein 0.003 0.0443 0.0285
Schistosoma mansoni hypothetical protein 0.0172 0.5162 0.5162
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0536 0.038
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0712 0.06
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0623 0.0729
Loa Loa (eye worm) RNA binding protein 0.0133 0.3853 0.3751
Loa Loa (eye worm) hypothetical protein 0.0033 0.0536 0.038
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0424 0.4762
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.3719 0.3719
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.426 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.426 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0237 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0424 0.4762
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.3719 1
Loa Loa (eye worm) inositol-1 0.0037 0.0654 0.05
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0443 0.0443
Schistosoma mansoni pyruvate kinase 0.0033 0.0536 0.0536
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0443 0.1192
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.411 0.6259
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.3853 0.3751
Treponema pallidum fructose-bisphosphate aldolase 0.0296 0.9313 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0654 0.0537
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.1382
Echinococcus multilocularis tar DNA binding protein 0.0133 0.3853 0.3853
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.1173 0.1601
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0654 0.0317
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0712 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0712 0.0471
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.1173 0.1026
Brugia malayi RNA binding protein 0.0133 0.3853 0.5851
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3719 0.8547
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3719 0.8547
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0163 0.0163
Echinococcus granulosus importin subunit beta 1 0.003 0.0424 0.0424
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0712 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.8957
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0654 0.0537
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.411 0.411
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.3853 0.5851
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0536 0.6804
Plasmodium vivax importin-beta 2, putative 0.003 0.0424 0.5961
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0712 0.0496
Onchocerca volvulus Huntingtin homolog 0.0126 0.364 0.4568
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0712 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0163 0.2289
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0536 0.6804
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0237 0.0081
Plasmodium falciparum importin beta, putative 0.003 0.0424 0.5961
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0443 0.0443
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0712 0.087
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0654 0.0654
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0163 0.0163
Plasmodium falciparum pyruvate kinase 0.0033 0.0536 0.7536
Schistosoma mansoni inositol monophosphatase 0.0037 0.0654 0.0654
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.411 0.411
Leishmania major importin beta-1 subunit, putative 0.0024 0.0237 0.0208
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0443 0.0443
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0203 0.0044
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0654 0.176
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0536 0.0133
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0654 0.0537
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0712 0.06
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0712 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Plasmodium vivax SET domain protein, putative 0.003 0.0443 0.6232
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.3719 0.8551
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.3719 0.8547
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0424 0.0266
Echinococcus multilocularis pyruvate kinase 0.0026 0.0304 0.0304
Loa Loa (eye worm) hypothetical protein 0.0036 0.0623 0.0467
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0712 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.411 0.4012
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0296 0.9313 1
Brugia malayi Pre-SET motif family protein 0.003 0.0443 0.0445
Echinococcus granulosus geminin 0.0172 0.5162 0.5162
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.426 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0163 0.0175
Loa Loa (eye worm) hypothetical protein 0.0052 0.1173 0.1026
Schistosoma mansoni importin beta-1 0.003 0.0424 0.0424
Loa Loa (eye worm) hypothetical protein 0.0023 0.0203 0.0041
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0712 0.0712
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0536 0.6804
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0163 0.0438
Schistosoma mansoni hypothetical protein 0.0317 1 1
Schistosoma mansoni inositol monophosphatase 0.0037 0.0654 0.0654
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.8957
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.3719 1
Entamoeba histolytica hypothetical protein 0.0024 0.0237 0.0081
Trichomonas vaginalis set domain proteins, putative 0.024 0.7441 0.7954
Schistosoma mansoni ran 0.0022 0.0163 0.0163
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0203 0.0041
Brugia malayi TAR-binding protein 0.0133 0.3853 0.5851
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.411 0.411
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0536 0.0592
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0536 0.0592
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0424 0.1141
Chlamydia trachomatis pyruvate kinase 0.0033 0.0536 0.5
Onchocerca volvulus Huntingtin homolog 0.0126 0.364 0.4568
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0536 0.7536
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0712 0.1543
Brugia malayi hypothetical protein 0.0126 0.364 0.5513
Toxoplasma gondii exonuclease III APE 0.0038 0.0712 0.1913
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0712 0.0764
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.6469 0.641
Giardia lamblia Fructose-bisphosphate aldolase 0.0296 0.9313 1
Loa Loa (eye worm) TAR-binding protein 0.0133 0.3853 0.3751
Echinococcus granulosus tar DNA binding protein 0.0133 0.3853 0.3853
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0296 0.9313 1
Schistosoma mansoni pyruvate kinase 0.0033 0.0536 0.0536
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0406 0.0406
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.411 0.411
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0536 0.0408
Brugia malayi RNA, U transporter 1 0.0084 0.2249 0.3308
Loa Loa (eye worm) hypothetical protein 0.0126 0.364 0.3534
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0712 0.0712
Echinococcus granulosus pyruvate kinase 0.0033 0.0536 0.0536
Echinococcus granulosus pyruvate kinase 0.0033 0.0536 0.0536
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0536 0.1442
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0163 0.2289
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0536 0.0026
Brugia malayi Importin beta-1 subunit 0.003 0.0424 0.0414
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0536 0.0133
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.411 0.411
Schistosoma mansoni ran 0.0022 0.0163 0.0163
Echinococcus multilocularis pyruvate kinase 0.0033 0.0536 0.0536
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0654 0.8957
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.411 0.411
Schistosoma mansoni ap endonuclease 0.0038 0.0712 0.0712
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0712 0.06
Brugia malayi Pre-SET motif family protein 0.0211 0.6469 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3853 0.3853
Echinococcus multilocularis pyruvate kinase 0.0033 0.0536 0.0536
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 1 1
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0536 0.6804
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0443 0.0443
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0536 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3853 0.3853
Schistosoma mansoni hypothetical protein 0.0036 0.0623 0.0623
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0536 0.038
Leishmania major pyruvate kinase 0.0033 0.0536 0.105
Schistosoma mansoni hypothetical protein 0.0172 0.5162 0.5162
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0536 0.038
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0536 0.0133
Leishmania major pyruvate kinase 0.0033 0.0536 0.105
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0443 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.411 0.411
Schistosoma mansoni tar DNA-binding protein 0.0133 0.3853 0.3853

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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