Detailed information for compound 795776

Basic information

Technical information
  • TDR Targets ID: 795776
  • Name: 2-amino-6-(3,3-dimethyl-2-oxobutyl)sulfanyl-4 -thiophen-2-ylpyridine-3,5-dicarbonitrile
  • MW: 356.465 | Formula: C17H16N4OS2
  • H donors: 1 H acceptors: 4 LogP: 3.83 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1c(SCC(=O)C(C)(C)C)nc(c(c1c1cccs1)C#N)N
  • InChi: 1S/C17H16N4OS2/c1-17(2,3)13(22)9-24-16-11(8-19)14(12-5-4-6-23-12)10(7-18)15(20)21-16/h4-6H,9H2,1-3H3,(H2,20,21)
  • InChiKey: UXLZGMYVRQZAOI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-6-(3,3-dimethyl-2-oxo-butyl)sulfanyl-4-(2-thienyl)pyridine-3,5-dicarbonitrile
  • 2-amino-6-[(3,3-dimethyl-2-oxobutyl)thio]-4-(2-thienyl)pyridine-3,5-dicarbonitrile
  • 2-amino-6-[(2-keto-3,3-dimethyl-butyl)thio]-4-(2-thienyl)dinicotinonitrile
  • 2-amino-6-(3,3-dimethyl-2-oxo-butyl)sulfanyl-4-thiophen-2-yl-pyridine-3,5-dicarbonitrile
  • A0529/0024517
  • BAS 01107931
  • TimTec1_002327

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0038 0.0038
Schistosoma mansoni coup transcription factor 0.0041 0.0286 0.0344
Leishmania major hypothetical protein, conserved 0.0227 0.2033 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0192
Schistosoma mansoni cpg binding protein 0.0066 0.0526 0.0632
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0436 0.2145
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.1517 0.1825
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0286 0.0527
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0009 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0009 0.0044
Brugia malayi F/Y-rich N-terminus family protein 0.0022 0.0104 0.0192
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0121 0.0224
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0237 0.1157
Schistosoma mansoni hypothetical protein 0.0049 0.0363 0.0437
Entamoeba histolytica phosphoinositide kinase, putative 0.0015 0.0038 0.0671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0286 0.0527
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0286 0.0344
Loa Loa (eye worm) hypothetical protein 0.0181 0.1604 0.2957
Leishmania major endonuclease/exonuclease protein-like protein 0.0011 0.0009 0.0044
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0363 0.0363
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0172 0.1517 0.7465
Echinococcus multilocularis dnaJ subfamily B 0.0895 0.8317 0.8317
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0286 0.0527
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0009 0.0017
Brugia malayi beta-lactamase 0.0036 0.0237 0.0436
Brugia malayi Muscleblind-like protein 0.0168 0.1476 0.2721
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0237 0.1157
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0462 0.3045
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Schistosoma mansoni synaptojanin 0.0011 0.0009 0.0011
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0237 0.1164
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0011 0.0009 0.0044
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0237 0.1157
Echinococcus multilocularis muscleblind protein 1 0.0168 0.1476 0.1476
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0104 0.0192
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0178 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0237 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0286 0.0527
Schistosoma mansoni cpg binding protein 0.0066 0.0526 0.0632
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0121 0.0146
Brugia malayi ecdysteroid receptor 0.0041 0.0286 0.0527
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0083 0.0155
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0104 0.0126
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0147 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0462 0.0556
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0015 0.0038 0.0185
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0462 0.2273
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0436 0.4281
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0147 0.1456
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0237 0.1164
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0011 0.0009 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0286 0.0286
Trypanosoma brucei protein kinase, putative 0.0172 0.1517 0.7465
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0066 0.0526 0.3465
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0083 0.0099
Onchocerca volvulus 0.0063 0.0492 0.1014
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0288 0.1419
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0104 0.0104
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0038 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0286 0.0527
Loa Loa (eye worm) hypothetical protein 0.0168 0.1476 0.2721
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0286 0.0344
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0436 0.2145
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0286 0.0344
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0011 0.0009 0.0017
Brugia malayi nuclear receptor NHR-67 0.0019 0.0083 0.0152
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0083 0.0155
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0011 0.0009 0.0009
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.2033 1
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0288 0.0288
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0121 0.0121
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0286 0.0527
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0436 0.0897
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0237 0.1164
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Onchocerca volvulus 0.0066 0.0526 0.1086
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0237 0.0436
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0015 0.0038 0.0185
Schistosoma mansoni zinc finger protein 0.0019 0.0083 0.0099
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0462 0.459
Trichomonas vaginalis set domain proteins, putative 0.0518 0.4769 1
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0147 0.1456
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0015 0.0038 0.007
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1517 0.3169
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0104 0.0126
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0286 0.0286
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0172 0.1517 0.7465
Toxoplasma gondii leucyl aminopeptidase LAP 0.0118 0.1007 0.6634
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.075 0.075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0286 0.0286
Onchocerca volvulus 0.0041 0.0286 0.0582
Onchocerca volvulus 0.0036 0.0237 0.0478
Onchocerca volvulus 0.0036 0.0237 0.0478
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0172 0.1517 0.7465
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0121 0.0121
Toxoplasma gondii exonuclease III APE 0.0057 0.0436 0.2874
Schistosoma mansoni ap endonuclease 0.0057 0.0436 0.0524
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0011 0.0009 0.0044
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0638 0.5899 0.5899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.075 0.0902
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0015 0.0038 0.0185
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0147 0.0717
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0083 0.0083
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0237 0.235
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0288 0.0288
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0436 0.0804
Onchocerca volvulus 0.0019 0.0083 0.0155
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Echinococcus granulosus histone lysine methyltransferase setb 0.0066 0.0526 0.0526
Mycobacterium ulcerans hypothetical protein 0.0026 0.0147 0.1456
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0462 0.459
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0018 0.007 0.0085
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0192
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0083 0.0083
Trichomonas vaginalis helicase, putative 0.0014 0.0035 0.0054
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0011 0.0009 0.0044
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0009 0.0044
Echinococcus granulosus mixed lineage leukemia protein mll 0.0018 0.007 0.007
Echinococcus granulosus muscleblind protein 0.0168 0.1476 0.1476
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0286 0.0527
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.1604 0.1928
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0286 0.0286
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0027 0.0153 0.0281
Brugia malayi nuclear receptor NHR-88 0.0019 0.0083 0.0152
Mycobacterium tuberculosis Conserved protein 0.0026 0.0147 0.0717
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0286 0.0344
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0436 0.0436
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0286 0.0527
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0147 0.0147
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.075 0.0902
Echinococcus granulosus cpg binding protein 0.0066 0.0526 0.0526
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0237 0.0237
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0015 0.0038 0.0185
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.0038 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0286 0.0527
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0436 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0041 0.0288 0.0532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0526 0.0632
Onchocerca volvulus 0.0181 0.1604 0.335
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0063 0.049 0.049
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0172 0.1517 0.7465
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0121 0.0121
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0237 0.0478
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0118 0.1007 1
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0237 0.1157
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0064 0.0506 0.0932
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0462 0.0556
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.1604 0.1604
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0237 0.228
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0121 0.0121
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0286 0.0527
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0049 0.0363 0.0437
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0015 0.0038 0.0038
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.0038 0.0248
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0465 0.0857
Brugia malayi hypothetical protein 0.0019 0.0083 0.0152
Loa Loa (eye worm) hypothetical protein 0.0137 0.1193 0.2199
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0286 0.0527
Mycobacterium ulcerans beta-lactamase 0.0036 0.0237 0.235
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0009 0.0044
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0286 0.0286
Loa Loa (eye worm) FYVE zinc finger family protein 0.0015 0.0038 0.007
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0015 0.0038 0.0185
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0286 0.0527
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0237 0.0478
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0363 0.0669
Trypanosoma brucei RNA editing exonuclease 2 0.0011 0.0009 0.0044
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0015 0.0038 0.0287
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0011 0.0009 0.0044
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.1361 0.2509
Brugia malayi beta-lactamase family protein 0.0036 0.0237 0.0436
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0009 0.0017
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0462 0.226
Leishmania major hypothetical protein, conserved 0.0011 0.0009 0.0044
Echinococcus multilocularis traf and tnf receptor associated protein 0.0011 0.0009 0.0009
Echinococcus granulosus geminin 0.0392 0.359 0.359
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0286 0.0344
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0287
Schistosoma mansoni nuclear receptor 0.0019 0.0083 0.0099
Brugia malayi conserved hypotetical protein 0.0019 0.0083 0.0152
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0671
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0286 0.0286
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0237 0.0478
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0015 0.0038 0.0045
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0462 0.0462
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0066 0.0526 0.0526
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0038 0.0287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0083 0.0083
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0008 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0286 0.0527
Echinococcus multilocularis geminin 0.0392 0.359 0.359
Leishmania major pantothenate kinase subunit, putative 0.0011 0.0009 0.0044
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1517 0.3169
Brugia malayi CCR4 0.0011 0.0009 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0083 0.0152
Echinococcus granulosus synaptojanin 1 0.0011 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Schistosoma mansoni hypothetical protein 0.0392 0.359 0.4316
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0286 0.0527
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0436 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0363 0.0669
Brugia malayi nuclear receptor RXR 0.0019 0.0083 0.0152
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0011 0.0009 0.0009
Echinococcus multilocularis neutral sphingomyelinase 0.0011 0.0009 0.0009
Echinococcus multilocularis GPCR, family 2 0.0049 0.0363 0.0363
Schistosoma mansoni cript-related 0.0011 0.0009 0.0011
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0011 0.0009 0.0044
Brugia malayi hypothetical protein 0.0022 0.0104 0.0192
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0237 0.1157
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0192
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0172 0.1517 0.7465
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0121 0.0121
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0286 0.0582
Leishmania major hypothetical protein, conserved 0.0011 0.0009 0.0044
Brugia malayi tailless protein 0.0019 0.0083 0.0152
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0083 0.0083
Echinococcus multilocularis muscleblind protein 0.0168 0.1476 0.1476
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0638 0.5899 0.5899
Leishmania major RNA-editing complex protein MP100, putative 0.0011 0.0009 0.0044
Onchocerca volvulus 0.0019 0.0083 0.0155
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0017
Echinococcus granulosus dnaJ subfamily B 0.0895 0.8317 0.8317
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0181 0.1604 0.1604
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0083 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1517 0.3169
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0185
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0237 0.0478
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0011 0.0009 0.0011
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0288 0.0587
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0017
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0436 0.0897
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0049 0.0363 0.0437
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0363 0.0669
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0015 0.0038 0.0248
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0038 0.0185
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0083 0.0083
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0436 0.2145
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0288 0.1419
Echinococcus multilocularis mitogen activated protein kinase 0.0172 0.1517 0.1517
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0172 0.1517 0.7465
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0009 0.0017
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0066 0.0526 0.0526
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0121 0.0224
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0083 0.0099
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0035 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0286 0.0527
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.007 0.007
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0147 0.0721
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0041 0.0288 0.1419
Mycobacterium ulcerans hypothetical protein 0.0036 0.0237 0.235
Loa Loa (eye worm) histone methyltransferase 0.0022 0.0106 0.0196
Mycobacterium ulcerans leucyl aminopeptidase 0.0118 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0286 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0286 0.0527
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0011 0.0009 0.0009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0237 0.0237
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0192
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0011 0.0009 0.0044
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0286 0.0344
Onchocerca volvulus 0.0518 0.4769 1
Schistosoma mansoni hypothetical protein 0.0392 0.359 0.4316
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0011 0.0009 0.0044
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0015 0.0038 0.0045
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0436 0.2133
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0015 0.0038 0.0185
Echinococcus multilocularis mitogen activated protein kinase 3 0.0172 0.1517 0.1517
Brugia malayi hypothetical protein 0.0019 0.0083 0.0152
Schistosoma mansoni neutral sphingomyelinase 0.0011 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0049 0.0363 0.0437
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0455 0.418 0.7705
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Brugia malayi Pre-SET motif family protein 0.0066 0.0526 0.0969
Echinococcus granulosus neutral sphingomyelinase 0.0011 0.0009 0.0009
Onchocerca volvulus Huntingtin homolog 0.0137 0.1193 0.2487
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0286 0.0527
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0436 0.2831
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0899 0.1658
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0136 0.1177 0.1415
Schistosoma mansoni synaptojanin 0.0011 0.0009 0.0011
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0121 0.0146
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0017
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0015 0.0038 0.0185
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0104 0.0192
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0237 0.0436
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0011 0.0009 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0436 0.0436
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0506 0.5025
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0286 0.0344
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0015 0.0038 0.007
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0083 0.0099
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0041 0.0288 0.0288
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0011 0.0009 0.0044
Loa Loa (eye worm) hypothetical protein 0.0168 0.1476 0.2721
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0288 0.0587
Trypanosoma cruzi mitochondrial protein 99, putative 0.0011 0.0009 0.0044
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0286 0.0286
Echinococcus granulosus mitogen activated protein kinase 0.0172 0.1517 0.1517
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0147 0.0721
Leishmania major hypothetical protein, conserved 0.0011 0.0009 0.0044
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0014 0.0035 0.0054
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0064 0.0506 0.5025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Brugia malayi beta-lactamase family protein 0.0036 0.0237 0.0436
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0172 0.1517 0.7465
Loa Loa (eye worm) hypothetical protein 0.0022 0.0104 0.0192
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0121 0.0597
Echinococcus multilocularis deoxyribonuclease 1 2 0.0011 0.0009 0.0009
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0009 0.0017
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0083 0.0152
Schistosoma mansoni nocturnin 0.0011 0.0009 0.0011
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.019
Brugia malayi hypothetical protein 0.0022 0.0104 0.0192
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.007 0.007
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0083 0.0099
Echinococcus granulosus neuropeptide receptor A26 0.1075 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0286 0.0286
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.075 0.1382
Onchocerca volvulus Huntingtin homolog 0.0137 0.1193 0.2487
Loa Loa (eye worm) DR-78 0.0019 0.0083 0.0152
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0172 0.1517 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0104 0.0104
Brugia malayi Pre-SET motif family protein 0.0455 0.418 0.7705
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0118 0.1007 0.4952
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0104 0.0192
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0011 0.0009 0.0009
Echinococcus granulosus traf and tnf receptor associated protein 0.0011 0.0009 0.0009
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Brugia malayi ecdysone receptor 0.0019 0.0083 0.0152
Brugia malayi nuclear receptor RXR 0.0022 0.0104 0.0192
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0083 0.0152
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0011
Brugia malayi nuclear hormone receptor 0.0041 0.0286 0.0527
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0083 0.0152
Trichomonas vaginalis esterase, putative 0.0036 0.0237 0.0478
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0064 0.0506 0.0608
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.2045 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0286 0.0344
Brugia malayi hypothetical protein 0.0137 0.1193 0.2199
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0083 0.0099
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0022 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0137 0.1193 0.2199
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0083 0.0083
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0083 0.0083
Brugia malayi photoreceptor-specific nuclear receptor 0.0588 0.5425 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Loa Loa (eye worm) pip kinase 1 0.0015 0.0038 0.007
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0286 0.0344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0237 0.0284
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.0038 0.0045
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0041 0.0288 0.0288
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0237 0.1157
Echinococcus multilocularis cpg binding protein 0.0066 0.0526 0.0526
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0041 0.0288 0.6543
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0064 0.0506 0.2474
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0286 0.0286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0526 0.0632
Loa Loa (eye worm) hypothetical protein 0.0106 0.0899 0.1658
Mycobacterium tuberculosis Conserved protein 0.0036 0.0237 0.1157
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0018 0.007 0.007
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0185
Mycobacterium ulcerans lipase LipD 0.0036 0.0237 0.235
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Echinococcus multilocularis leucine aminopeptidase protein 0.0118 0.1007 0.1007
Mycobacterium tuberculosis Probable exported protein 0.0011 0.0009 0.0044
Schistosoma mansoni cpg binding protein 0.0063 0.0492 0.0591
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0041 0.0288 0.0587
Giardia lamblia Kinase, CMGC MAPK 0.0172 0.1517 1
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Trypanosoma cruzi hypothetical protein, conserved 0.0227 0.2033 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0436 0.4332
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Loa Loa (eye worm) hypothetical protein 0.0588 0.5425 1
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0038 0.0038
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0118 0.1007 0.4952
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0363 0.0363
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0286 0.0527
Brugia malayi follicle stimulating hormone receptor 0.0512 0.4716 0.8693
Echinococcus granulosus mitogen activated protein kinase 3 0.0172 0.1517 0.1517
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0895 0.8317 1
Chlamydia trachomatis cytosol aminopeptidase 0.0118 0.1007 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.075 0.075
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0015 0.0038 0.0045
Echinococcus granulosus GPCR family 2 0.0049 0.0363 0.0363
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0286 0.0286
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0118 0.1007 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.1361 0.2509
Echinococcus granulosus leucine aminopeptidase protein 0.0118 0.1007 0.1007
Leishmania major hypothetical protein, conserved 0.0036 0.0237 0.1164
Loa Loa (eye worm) CXXC zinc finger family protein 0.0063 0.0492 0.0907
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0011 0.0009 0.0009
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.075 0.1382
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0083 0.0083
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0363 0.0363
Echinococcus multilocularis neuropeptide receptor A26 0.1075 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0121 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0049 0.0363 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Mycobacterium tuberculosis Conserved protein 0.0036 0.0237 0.1157
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0041 0.0288 0.1419
Brugia malayi Pip kinase protein 2 0.0181 0.1604 0.2957
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Brugia malayi steroid hormone receptor 0.0041 0.0286 0.0527
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0035 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0286 0.0344
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0526 0.0632
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0286 0.0344
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0015 0.0038 0.0185
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0181 0.1604 0.1928
Loa Loa (eye worm) hypothetical protein 0.0066 0.0526 0.0969
Brugia malayi Pip kinase protein 1 0.0015 0.0038 0.007
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0462 0.0462
Toxoplasma gondii histone lysine methyltransferase SET1 0.0122 0.1043 0.6874
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0083 0.0152
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0185
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0185
Loa Loa (eye worm) pip kinase 2 0.0181 0.1604 0.2957
Plasmodium vivax SET domain protein, putative 0.0066 0.0526 0.518
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0506 0.0506
Loa Loa (eye worm) hypothetical protein 0.0036 0.0237 0.0436
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0286 0.0286
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0121 0.0224
Mycobacterium leprae Probable lipase LipE 0.0036 0.0237 0.235
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0041 0.0288 0.0347
Brugia malayi Cytochrome P450 family protein 0.0029 0.0178 0.0328
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0286 0.0527
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0237 0.235
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0436 0.2145
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0083 0.0152
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0286 0.0344
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0064 0.0506 0.0506
Echinococcus multilocularis neuropeptide s receptor 0.1075 1 1
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0121 0.0224
Echinococcus multilocularis ubiquitin specific protease 41 0.0041 0.0288 0.0288
Echinococcus multilocularis synaptojanin 1 0.0011 0.0009 0.0009
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0147 0.0289
Echinococcus granulosus ubiquitin specific protease 41 0.0041 0.0288 0.0288
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0237 0.0478
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0804 0.7461 0.7461
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0015 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.0041 0.0288 0.0532
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0237 0.235
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0363 0.0363
Schistosoma mansoni ap endonuclease 0.0057 0.0436 0.0524
Trichomonas vaginalis CMGC family protein kinase 0.0172 0.1517 0.3169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0014 0.0035 0.0054
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0462 0.459
Giardia lamblia Hypothetical protein 0.0015 0.0038 0.019
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0066 0.0526 0.0632
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0512 0.4716 0.8693
Loa Loa (eye worm) hypothetical protein 0.0041 0.0286 0.0527
Onchocerca volvulus 0.0036 0.0237 0.0478
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0015 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.075 0.0902
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0121 0.0121
Trypanosoma brucei hypothetical protein, conserved 0.0227 0.2033 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0286 0.0286
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0015 0.0038 0.0185
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0286 0.0286
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0064 0.0506 0.2488
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0172 0.1517 0.2797
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0286 0.0527
Brugia malayi cytosol aminopeptidase 0.0023 0.0121 0.0224
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0118 0.1007 0.4952
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0436 0.4281
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0011 0.0009 0.0044
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0041 0.0288 0.0347
Brugia malayi nuclear hormone receptor 0.0019 0.0083 0.0152
Plasmodium falciparum M17 leucyl aminopeptidase 0.0118 0.1007 1
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0011 0.0009 0.0044
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0286 0.0286
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0118 0.1007 0.4924
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0286 0.0527
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.1361 0.2509
Brugia malayi MAP kinase sur-1 0.0172 0.1517 0.2797
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0083 0.0152
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0237 0.1157
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.075 0.075
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0083 0.0083
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0083 0.0152
Schistosoma mansoni hypothetical protein 0.0106 0.0899 0.1081
Toxoplasma gondii ABC1 family protein 0.0036 0.0237 0.1559
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0286 0.0527
Brugia malayi nuclear receptor NHR-88 0.0041 0.0286 0.0527
Brugia malayi CXXC zinc finger family protein 0.0063 0.0492 0.0907
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0022 0.0106 0.0106
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0147 0.0721
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0147 0.1456
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0083 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0286 0.0527
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0015 0.0038 0.0185
Schistosoma mansoni carbon catabolite repressor protein 0.0011 0.0009 0.0011
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0118 0.1007 1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0011 0.0009 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0083 0.0152
Mycobacterium tuberculosis Conserved protein 0.0036 0.0237 0.1157
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.1361 0.2509
Mycobacterium ulcerans hypothetical protein 0.0026 0.0147 0.1456
Schistosoma mansoni nuclear receptor 0.0019 0.0083 0.0099
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0286 0.0582
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0011 0.0009 0.0017
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.075 0.075
Loa Loa (eye worm) beta-lactamase 0.0036 0.0237 0.0436
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0011 0.0009 0.006
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0118 0.1007 0.4952
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0436 0.0804
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0041 0.0288 0.1852

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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