Detailed information for compound 796172

Basic information

Technical information
  • TDR Targets ID: 796172
  • Name: 3-[4-[(4-chlorophenyl)methyl]piperazin-1-yl]- 1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5 -dione
  • MW: 467.869 | Formula: C22H21ClF3N3O3
  • H donors: 0 H acceptors: 2 LogP: 3.99 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)CN1CCN(CC1)C1CC(=O)N(C1=O)c1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C22H21ClF3N3O3/c23-16-3-1-15(2-4-16)14-27-9-11-28(12-10-27)19-13-20(30)29(21(19)31)17-5-7-18(8-6-17)32-22(24,25)26/h1-8,19H,9-14H2
  • InChiKey: YZOKDNPLBRUGAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[4-[(4-chlorophenyl)methyl]-1-piperazinyl]-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5-dione
  • 3-[4-(4-chlorobenzyl)piperazin-1-yl]-1-[4-(trifluoromethoxy)phenyl]pyrrolidine-2,5-quinone
  • A2376/0100471
  • EU-0052590

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0782 0.6148
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0074 0.0189
Leishmania major hypothetical protein, conserved 0.0025 0.0139 0.0402
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.004
Echinococcus multilocularis tumor protein p63 0.0343 0.3091 0.4113
Mycobacterium leprae PROBABLE NADPH:ADRENODOXIN OXIDOREDUCTASE FPRB (ADRENODOXIN REDUCTASE) (AR) (FERREDOXIN-NADP(+) REDUCTASE) 0.0031 0.0195 0.0204
Loa Loa (eye worm) MH2 domain-containing protein 0.0049 0.0358 0.0532
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0339 0.0768
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0279 0.0412
Brugia malayi MH2 domain containing protein 0.0049 0.0358 0.0534
Schistosoma mansoni glutamate synthase 0.0031 0.0195 0.0195
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0031 0.0195 0.0587
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0232 0.034
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0279 0.0279
Brugia malayi Pax transcription factor protein 2 0.0485 0.441 0.6723
Schistosoma mansoni hypothetical protein 0.0079 0.0635 0.0635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.0518
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0232 0.0297
Trichomonas vaginalis glutathione reductase, putative 0.0118 0.0999 0.2316
Trypanosoma brucei polo-like protein kinase 0.0094 0.0782 0.2526
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0081 0.0112
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0195 0.0587
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0279 0.036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0118 0.0999 0.3237
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0016 0.0017
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0081 0.0118
Brugia malayi Pre-SET motif family protein 0.0414 0.3749 0.5713
Mycobacterium ulcerans monoxygenase 0.0031 0.0195 0.1595
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0195 0.0603
Brugia malayi ecdysteroid receptor 0.004 0.0279 0.0414
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0081 0.011
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0265 0.2215
Loa Loa (eye worm) hypothetical protein 0.0022 0.0105 0.0146
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0516
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0863 0.7916 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0031 0.0195 0.0284
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0102 0.0142
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0265 0.0594
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0265 0.0418
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Schistosoma mansoni smad1 5 8 and 0.0049 0.0358 0.0358
Schistosoma mansoni thyroid hormone receptor 0.004 0.0279 0.0279
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0014 0.0034 0.0023
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0079 0.0635 0.0835
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0279 0.0441
Toxoplasma gondii propionate-CoA ligase 0.0014 0.0034 0.0077
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0279 0.036
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0023
Brugia malayi MH2 domain containing protein 0.0716 0.6556 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0049 0.0358 0.0532
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0776 0.7112 0.8982
Echinococcus multilocularis Smad4 0.0049 0.0358 0.0465
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0016 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0248 0.2212 0.3364
Onchocerca volvulus 0.006 0.0461 0.0774
Schistosoma mansoni hypothetical protein 0.0508 0.4618 0.4618
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0031 0.0195 0.0226
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0195 0.0587
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0014 0.0034 0.0023
Brugia malayi Pre-SET motif family protein 0.006 0.0461 0.0692
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Schistosoma mansoni cpg binding protein 0.0031 0.0193 0.0193
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0776 0.7112 0.8982
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni glutamate synthase 0.0031 0.0195 0.0195
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0461 0.0739
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0074 0.0189
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0118 0.0999 0.3226
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0012 0.0016 0.0017
Trypanosoma brucei hypothetical protein, conserved 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0782 0.2513
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0074 0.0099
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0279 0.0444
Entamoeba histolytica hypothetical protein 0.0145 0.125 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0118 0.0999 0.3226
Echinococcus granulosus mothers against decapentaplegic 2 0.0022 0.0107 0.016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0347 0.2573
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0031 0.0195 0.1595
Brugia malayi conserved hypotetical protein 0.0019 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0217 0.0254
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Loa Loa (eye worm) hypothetical protein 0.0011 0.0011 0.0003
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0031 0.0195 0.0587
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0442 0.1413
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0195 0.0603
Leishmania major DNA polymerase kappa, putative 0.0039 0.0265 0.0815
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0031 0.0195 0.0603
Onchocerca volvulus 0.005 0.0371 0.061
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0863 0.7916 1
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0279 0.0444
Echinococcus granulosus mothers against decapentaplegic 5 0.0049 0.0358 0.057
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0217 0.0254
Loa Loa (eye worm) hypothetical protein 0.0031 0.0195 0.0284
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0031 0.0195 0.1595
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0009
Schistosoma mansoni kinase 0.0048 0.035 0.035
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0081 0.0118
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0279 0.0279
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0118 0.0999 0.8769
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Brugia malayi nuclear receptor NHR-88 0.004 0.0279 0.0414
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0118 0.0999 0.3226
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trypanosoma cruzi trypanothione reductase, putative 0.0118 0.0999 0.3226
Onchocerca volvulus 0.004 0.0279 0.0444
Loa Loa (eye worm) glutathione reductase 0.034 0.3064 0.4666
Onchocerca volvulus 0.0035 0.0232 0.0358
Entamoeba histolytica hypothetical protein 0.0145 0.125 1
Onchocerca volvulus 0.0029 0.0178 0.026
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0031 0.0195 0.0431
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0081 0.0096
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0279 0.0441
Onchocerca volvulus 0.0035 0.0232 0.0358
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0265 0.0392
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0081 0.0081
Onchocerca volvulus 0.0019 0.0081 0.0085
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0782 0.118
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0031 0.0195 0.1595
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0279 0.0414
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0265 0.0815
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0145 0.125 0.203
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0031 0.0195 0.0587
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0137 0.0197
Toxoplasma gondii ABC1 family protein 0.0035 0.0232 0.0724
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0118 0.0999 0.8769
Loa Loa (eye worm) hypothetical protein 0.0064 0.0503 0.0754
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0118 0.0999 0.1514
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0347 0.0419
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0081 0.0081
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0195 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0279 0.0441
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0195 0.0304
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.006
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0347 0.0397
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0031 0.0195 0.0248
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0347 0.2954
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Plasmodium falciparum thioredoxin reductase 0.034 0.3064 1
Schistosoma mansoni DNA polymerase eta 0.0064 0.0503 0.0503
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Schistosoma mansoni nuclear receptor 0.0019 0.0081 0.0081
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0031 0.0195 0.0248
Mycobacterium tuberculosis Probable dehydrogenase 0.0776 0.7112 0.8982
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0347 0.0518
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0118 0.0999 1
Mycobacterium ulcerans glutamate synthase subunit beta 0.0031 0.0195 0.1595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0279 0.0414
Leishmania major hypothetical protein, conserved 0.0031 0.0195 0.0587
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0195 0.0285
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0273
Loa Loa (eye worm) MH2 domain-containing protein 0.0716 0.6556 1
Schistosoma mansoni disulfide oxidoreductase 0.0031 0.0195 0.0195
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0118 0.0999 0.0999
Brugia malayi hypothetical protein 0.0019 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0079 0.0635 0.1023
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0516
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0102 0.0102
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0279 0.0441
Trypanosoma cruzi trypanothione reductase, putative 0.034 0.3064 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0782 0.1032
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0347 0.0397
Schistosoma mansoni cpg binding protein 0.0031 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0345
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Onchocerca volvulus 0.0485 0.441 0.7939
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0074 0.0189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium ulcerans hypothetical protein 0.0035 0.0232 0.1925
Brugia malayi ecdysone receptor 0.0019 0.0081 0.0112
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0347 0.2954
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0049 0.0358 0.0358
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0137 0.0209
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0118 0.0999 0.3237
Entamoeba histolytica hypothetical protein 0.0025 0.0137 0.0844
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Treponema pallidum NADH oxidase 0.0118 0.0999 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0255 0.0783
Schistosoma mansoni smad 0.0022 0.0107 0.0107
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.0503 0.0756
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0265 0.0314
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0074 0.01
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0031 0.0195 0.0603
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0273
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0345
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0153 0.0465
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0118 0.0999 0.3226
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0118 0.0999 0.3226
Echinococcus granulosus cpg binding protein 0.0031 0.0193 0.0301
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Trypanosoma cruzi NADH dehydrogenase, putative 0.0031 0.0195 0.0587
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0016 0.0017
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0347 0.1086
Brugia malayi hypothetical protein 0.0021 0.0102 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni transcription factor LCR-F1 0.0145 0.125 0.125
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0139 0.0418
Schistosoma mansoni cpg binding protein 0.0029 0.0178 0.0178
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0049 0.0358 0.0465
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0782 0.1356
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0034 0.0163
Mycobacterium leprae PROBABLE CONSERVED LIPOPROTEIN LPQF 0.0064 0.0496 0.0586
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0265 0.0594
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0195 0.0195
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0031 0.0195 0.0226
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0081 0.0118
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0279 0.036
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0081 0.0096
Leishmania major trypanothione reductase 0.034 0.3064 1
Brugia malayi MH1 domain containing protein 0.0049 0.0358 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Brugia malayi beta-lactamase family protein 0.0035 0.0232 0.0342
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0031 0.0195 0.0226
Brugia malayi beta-lactamase family protein 0.0035 0.0232 0.0342
Plasmodium vivax thioredoxin reductase, putative 0.034 0.3064 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0014 0.0034 0.0077
Brugia malayi mothers against decapentaplegic homolog 3 0.0022 0.0107 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0265 0.0341
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0232 0.0232
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0012 0.0016 0.0017
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0232 0.0251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni acetyl-CoA synthetase 0.0014 0.0034 0.0034
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0265 0.1892
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0189
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Plasmodium falciparum glutathione reductase 0.0118 0.0999 0.3226
Brugia malayi tailless protein 0.0019 0.0081 0.0112
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0279 0.0412
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0265 0.0815
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0142
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0232 0.0364
Trypanosoma brucei unspecified product 0.0027 0.0153 0.0465
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0279 0.0412
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0074 0.0074
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.004 0.0279 0.0444
Loa Loa (eye worm) hypothetical protein 0.0022 0.0107 0.0149
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0014 0.0034 0.0023
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0195 0.0587
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0074 0.0086
Trypanosoma brucei beta lactamase 0.0064 0.0496 0.159
Loa Loa (eye worm) hypothetical protein 0.0025 0.0139 0.0198
Echinococcus granulosus microtubule associated protein 2 0.067 0.6123 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0776 0.7112 0.898
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0347 0.0518
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0232 0.0342
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0195 0.0248
Trypanosoma brucei hypothetical protein, conserved 0.0031 0.0195 0.0603
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0074 0.0189
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0118 0.0999 0.3237
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0081 0.0112
Leishmania major DNA polymerase eta, putative 0.0064 0.0503 0.1598
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0279 0.0412
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0081 0.0118
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0102 0.0124
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0031 0.0195 0.1595
Loa Loa (eye worm) thioredoxin reductase 0.034 0.3064 0.4666
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni microtubule-associated protein tau 0.067 0.6123 0.6123
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.006 0.0461 0.069
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0031 0.0195 0.1819
Brugia malayi polk-prov protein 0.0012 0.0016 0.0012
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0776 0.7112 0.8982
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0137 0.0413
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0102 0.0144
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0133 0.1137 0.1419
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0232 0.0518
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0016 0.0017
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0034 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Echinococcus multilocularis cpg binding protein 0.0031 0.0193 0.0246
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0279 0.0441
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0279 0.0414
Schistosoma mansoni smad 0.0049 0.0358 0.0358
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0347 0.0419
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0195 0.0587
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Mycobacterium ulcerans NADH dehydrogenase 0.0031 0.0195 0.1595
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Giardia lamblia NADH oxidase lateral transfer candidate 0.0118 0.0999 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0034 0.0055
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0081 0.0081
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0347 0.1086
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0118 0.0999 0.3226
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0142
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0019 0.0081 0.011
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0347 0.2954
Giardia lamblia GTOR 0.0018 0.0074 0.0586
Brugia malayi Calcitonin receptor-like protein seb-1 0.0248 0.2212 0.3365
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0371 0.0371
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0782 0.1264
Brugia malayi CXXC zinc finger family protein 0.0029 0.0178 0.0259
Toxoplasma gondii NADPH-glutathione reductase 0.0118 0.0999 0.3237
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Leishmania major NADH dehydrogenase, putative 0.0031 0.0195 0.0587
Mycobacterium ulcerans dehydrogenase 0.0031 0.0195 0.1595
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0863 0.7916 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0347 0.0516
Plasmodium falciparum thioredoxin reductase 0.0118 0.0999 0.3226
Plasmodium falciparum ferrodoxin reductase-like protein 0.0031 0.0195 0.0587
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0195 0.0587
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0232 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0153 0.0465
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0139 0.0402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0217 0.0254
Trichomonas vaginalis glutamate synthase, putative 0.0031 0.0195 0.0431
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0023
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0031 0.0195 0.0431
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0232 0.0273
Echinococcus multilocularis microtubule associated protein 2 0.067 0.6123 0.816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0232 0.0273
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0118 0.0999 0.1322
Trypanosoma brucei trypanothione reductase 0.034 0.3064 1
Entamoeba histolytica hypothetical protein 0.0145 0.125 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0232 0.0232
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0102 0.0144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0279 0.0441
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0014 0.0034 0.0023
Brugia malayi MH1 domain containing protein 0.0027 0.0155 0.0224
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0206
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Brugia malayi hypothetical protein 0.0019 0.0081 0.0112
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0265 0.0265
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Echinococcus multilocularis mothers against decapentaplegic 2 0.0022 0.0107 0.013
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0232 0.0724
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0014 0.0034 0.0023
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0034 0.0163
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Loa Loa (eye worm) MH2 domain-containing protein 0.0022 0.0107 0.0149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0155 0.0223
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0118 0.0999 0.3226
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0031 0.0195 0.1595
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0074 0.0206
Echinococcus granulosus geminin 0.0508 0.4618 0.7539
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0074 0.0106
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0782 0.2513
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0153 0.0465
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0347 0.0518
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0031 0.0195 0.0587
Leishmania major hypothetical protein, conserved 0.0031 0.0195 0.0587
Echinococcus granulosus TGF beta signal transducer SmadC 0.0049 0.0358 0.057
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0031 0.0195 0.1321
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0074 0.0074
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0139 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0279 0.0414
Brugia malayi hypothetical protein 0.0145 0.125 0.1897
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0014 0.0034 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0279 0.0412
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0031 0.0195 0.0587
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0195 0.0587
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0435 0.0696
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0178 0.0257
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0265 0.0831
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.004
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0347 0.2573
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0279 0.0414
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0014 0.0034 0.0039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0137 0.0296
Echinococcus granulosus glutamate synthase 0.0031 0.0195 0.0304
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0014 0.0034 0.0023
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0079 0.0635 0.0957
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0105 0.029
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0081 0.0085
Mycobacterium leprae Probable NADPH:adrenodoxin oxidoreductase FprA (NADPH-FERREDOXIN REDUCTASE) 0.0031 0.0195 0.0204
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.0518
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0195 0.0587
Giardia lamblia Glutamate synthase 0.0031 0.0195 0.1819
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni nuclear receptor 0.0019 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0607 0.5546 0.8457
Brugia malayi Smad1 0.0049 0.0358 0.0534
Trypanosoma brucei DNA polymerase kappa, putative 0.0012 0.0016 0.0017
Loa Loa (eye worm) MH1 domain-containing protein 0.0022 0.0107 0.0149
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0279 0.036
Mycobacterium ulcerans beta-lactamase 0.0035 0.0232 0.1925
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Brugia malayi hypothetical protein 0.0607 0.5546 0.8458
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0081 0.0081
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0118 0.0999 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0031 0.0195 0.0304
Brugia malayi Latrophilin receptor protein 2 0.0079 0.0635 0.0957
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0031 0.0195 0.0304
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0031 0.0195 0.0587
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0081 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0232 0.0708
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0339 0.0768
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0079 0.0635 0.1023
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0034 0.0163
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0347 0.2954
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0279 0.0412
Trypanosoma brucei chrX additional, unordered contigs 0.0012 0.0016 0.0017
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0031 0.0195 0.1595
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0217 0.0254
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0039
Echinococcus multilocularis smad 0.0049 0.0358 0.0465
Loa Loa (eye worm) pax transcription factor protein 2 0.0485 0.441 0.6722
Brugia malayi nuclear hormone receptor 0.0019 0.0081 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Mycobacterium ulcerans lipoprotein LpqF 0.0064 0.0496 0.4282
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0279 0.0414
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0014 0.0034 0.0034
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0118 0.0999 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0265 0.0265
Schistosoma mansoni zinc finger protein 0.0019 0.0081 0.0081
Leishmania major hypothetical protein, conserved 0.0031 0.0195 0.0587
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0031 0.0195 0.1595
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0279 0.0414
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0279 0.0414
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0235 0.0501
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0034 0.0163
Onchocerca volvulus 0.0471 0.4279 0.7701
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0087 0.0709 0.107
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0142
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0074 0.019
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0782 0.0782
Echinococcus multilocularis thioredoxin glutathione reductase 0.0342 0.3083 0.4103
Echinococcus granulosus tumor protein p63 0.0343 0.3091 0.504
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0782 0.1807
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0782 0.2513
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0279 0.036
Leishmania major DNA polymerase eta, putative 0.0038 0.0255 0.0783
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0118 0.0999 0.162
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0279 0.0414
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0235 0.1955
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0074 0.0324
Mycobacterium ulcerans ferredoxin reductase 0.0031 0.0195 0.1595
Schistosoma mansoni sulfide quinone reductase 0.0031 0.0195 0.0195
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.004
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0133 0.1137 1
Echinococcus granulosus Smad4 0.0049 0.0358 0.057
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0232 0.1925
Loa Loa (eye worm) hypothetical protein 0.0079 0.0635 0.0955
Brugia malayi MH2 domain containing protein 0.0049 0.0358 0.0534
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0461 0.0603
Schistosoma mansoni smad1 5 8 and 0.0049 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0034 0.0163
Mycobacterium tuberculosis Probable oxidoreductase 0.0863 0.7916 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0139 0.0418
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0232 0.0708
Trypanosoma brucei NADH dehydrogenase 0.0031 0.0195 0.0603
Brugia malayi nuclear receptor NHR-67 0.0019 0.0081 0.0112
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0074 0.0206
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0081 0.011
Loa Loa (eye worm) nuclear factor I 0.0027 0.0155 0.0223
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0039
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Trichomonas vaginalis set domain proteins, putative 0.0471 0.4279 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0279 0.0414
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0014 0.0034 0.0023
Brugia malayi glutamate synthase 0.0031 0.0195 0.0285
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0074 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0248 0.2212 0.3365
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0074 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0461 0.0461
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0031 0.0195 0.0603
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Schistosoma mansoni nuclear hormone receptor 0.004 0.0279 0.0279
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0031 0.0195 0.0587
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0014 0.0034 0.004
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0031 0.0195 0.0204
Loa Loa (eye worm) hypothetical protein 0.005 0.0371 0.0552
Schistosoma mansoni smad1 5 8 and 0.0049 0.0358 0.0358
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0504 0.0504
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0031 0.0195 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0014 0.0034 0.004
Giardia lamblia Thioredoxin reductase 0.0031 0.0195 0.1819
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0265 0.039
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trichomonas vaginalis mercuric reductase, putative 0.0118 0.0999 0.2316
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0031 0.0195 0.0226
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0031 0.0195 0.0431
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0034 0.0055
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0279 0.036
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0195 0.0226
Echinococcus multilocularis GPCR, family 2 0.0079 0.0635 0.0835
Toxoplasma gondii thioredoxin reductase 0.034 0.3064 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0279 0.036
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0232 0.0273
Echinococcus granulosus thioredoxin glutathione reductase 0.0342 0.3083 0.5028
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0255 0.0799
Brugia malayi latrophilin 2 splice variant baaae 0.017 0.1482 0.2251
Echinococcus granulosus mothers against decapentaplegic 6 0.0022 0.0107 0.016
Entamoeba histolytica thioredoxin reductase, putative 0.0031 0.0195 0.1321
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0195 0.0603
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0031 0.0195 0.1321
Onchocerca volvulus 0.0607 0.5546 1
Plasmodium vivax ferrodoxin reductase, putative 0.0031 0.0195 0.0587
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0232 0.0273
Brugia malayi hypothetical protein 0.0025 0.0139 0.0199
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0035 0.0232 0.034
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0461 0.1474
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0137 0.0137
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0031 0.0195 0.0304
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.0503 0.1598
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0279 0.0279
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0232 0.0518
Leishmania major acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Echinococcus granulosus smad 0.0049 0.0358 0.057
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0081 0.0112
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0074 0.0206
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0189
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0081 0.0118
Loa Loa (eye worm) hypothetical protein 0.0248 0.2212 0.3364
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0232 0.0273
Loa Loa (eye worm) DR-78 0.0019 0.0081 0.011
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0014 0.0034 0.0077
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0235 0.0719
Onchocerca volvulus 0.0019 0.0081 0.0085
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0014 0.0034 0.0023
Brugia malayi MH1 domain containing protein 0.0027 0.0155 0.0224
Trypanosoma brucei unspecified product 0.0027 0.0153 0.0465
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0461 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0279 0.0414
Brugia malayi beta-lactamase 0.0035 0.0232 0.0342
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0074 0.019
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0145 0.125 0.1657
Trichomonas vaginalis glutamate synthase, putative 0.0031 0.0195 0.0431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0074 0.01
Mycobacterium tuberculosis Probable reductase 0.0776 0.7112 0.8982
Brugia malayi hypothetical protein 0.0016 0.0056 0.0072
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0034 0.0163
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0279 0.036
Onchocerca volvulus 0.0031 0.0195 0.0291
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0031 0.0195 0.0304
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0235 0.0277
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0265 0.0831
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0118 0.0999 0.3237
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0279 0.0412
Echinococcus granulosus FTZ F1 alpha 0.004 0.0279 0.0441
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0014 0.0034 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0079 0.0635 0.0835
Schistosoma mansoni hypothetical protein 0.0079 0.0635 0.0635
Trichomonas vaginalis apoptosis inducing factor, putative 0.0031 0.0195 0.0431
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0081 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0081 0.0096
Mycobacterium tuberculosis Conserved protein 0.0035 0.0232 0.0273
Schistosoma mansoni coup transcription factor 0.004 0.0279 0.0279
Loa Loa (eye worm) beta-lactamase 0.0035 0.0232 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0137 0.0397
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0279 0.0414
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0265 0.0815
Brugia malayi nuclear receptor RXR 0.0019 0.0081 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0461 0.0461
Plasmodium vivax acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0034 0.0163
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0014 0.0034 0.0077
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0081 0.0096
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0081 0.0096
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0782 0.1182
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0279 0.0279
Trypanosoma brucei DNA damage repair protein, putative 0.0012 0.0016 0.0017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0011
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.034 0.3064 0.3858
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0279 0.0412
Brugia malayi nuclear receptor NHR-88 0.0019 0.0081 0.0112
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0031 0.0195 0.0248
Giardia lamblia Kinase, PLK 0.0094 0.0782 0.7789
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0064 0.0496 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0232 0.0273
Schistosoma mansoni Smad4 0.0022 0.0107 0.0107
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0402
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0347 0.2954
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0074 0.0189
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.1997 0.2508
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0347 0.2573
Schistosoma mansoni hypothetical protein 0.0508 0.4618 0.4618
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0031 0.0195 0.0248
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0118 0.0999 0.3237
Mycobacterium leprae Probable lipase LipE 0.0035 0.0232 0.0251
Echinococcus multilocularis mothers against decapentaplegic 6 0.0022 0.0107 0.013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Echinococcus multilocularis mothers against decapentaplegic 5 0.0049 0.0358 0.0465
Loa Loa (eye worm) Smad1 0.0049 0.0358 0.0532
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0081 0.0112
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0414 0.3749 0.5712
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0345
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0031 0.0195 0.0603
Plasmodium vivax SET domain protein, putative 0.006 0.0461 0.1459
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0279 0.0414
Brugia malayi steroid hormone receptor 0.004 0.0279 0.0414
Entamoeba histolytica hypothetical protein 0.0145 0.125 1
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0034 0.0163
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0031 0.0195 0.1321
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0081 0.0112
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0087 0.0709 0.107
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0818 0.7501 1
Onchocerca volvulus 0.0048 0.0347 0.0568
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0081 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0461 0.0461
Brugia malayi glutathione reductase 0.034 0.3064 0.4667
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0031 0.0195 0.1321
Giardia lamblia DINP protein human, muc B family 0.0039 0.0265 0.2526
Schistosoma mansoni Smad4 0.0022 0.0107 0.0107
Leishmania major hypothetical protein, conserved 0.0035 0.0232 0.0708
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0347 0.1086
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0074 0.0099
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0014 0.0034 0.006
Schistosoma mansoni hypothetical protein 0.017 0.1482 0.1482
Onchocerca volvulus 0.0035 0.0232 0.0358
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0265 0.0831
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0074 0.0106
Loa Loa (eye worm) oxidoreductase 0.0014 0.0034 0.0039
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0102 0.0152
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0074 0.0189
Brugia malayi nuclear receptor RXR 0.0021 0.0102 0.0144
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0137 0.0171
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0279 0.0414
Brugia malayi MH2 domain containing protein 0.0022 0.0107 0.0151
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Brugia malayi nuclear hormone receptor 0.004 0.0279 0.0414
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0279 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0279 0.0414
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0074 0.0086
Plasmodium vivax glutathione reductase, putative 0.034 0.3064 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0118 0.0999 0.8769
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0118 0.0999 0.3226
Plasmodium falciparum glutathione reductase 0.034 0.3064 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0279 0.0279
Mycobacterium ulcerans lipase LipD 0.0035 0.0232 0.1925
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0279 0.0279
Schistosoma mansoni thyroid hormone receptor 0.004 0.0279 0.0279
Schistosoma mansoni Smad4 0.0049 0.0358 0.0358
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0265 0.0314
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0031 0.0195 0.0431
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Echinococcus granulosus GPCR family 2 0.0079 0.0635 0.1023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0776 0.7112 0.8982
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0139 0.0402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0235 0.0345
Echinococcus granulosus dna polymerase eta 0.0064 0.0503 0.0808
Echinococcus multilocularis dna polymerase eta 0.0064 0.0503 0.0659
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0265 0.0341
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0031 0.0195 0.0603
Trypanosoma brucei unspecified product 0.0039 0.0265 0.0831
Mycobacterium leprae Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0031 0.0195 0.0204
Loa Loa (eye worm) hypothetical protein 0.004 0.0279 0.0412
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0031 0.0195 0.0431
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0232 0.1925
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0019 0.0081 0.0085
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0142
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0232 0.0708
Schistosoma mansoni hypothetical protein 0.0079 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0265 0.0815
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0118 0.0999 0.3226
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0137 0.0413
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0031 0.0195 0.0304
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0031 0.0195 0.0285
Loa Loa (eye worm) hypothetical protein 0.017 0.1482 0.2249
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0031 0.0195 0.0248
Loa Loa (eye worm) programmed cell death 8 0.0031 0.0195 0.0284
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0074 0.0189
Schistosoma mansoni hypothetical protein 0.0145 0.125 0.125
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0347 0.2954
Brugia malayi hypothetical protein 0.0021 0.0102 0.0144
Toxoplasma gondii selenide, water dikinase 0.0031 0.0195 0.0603
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0232 0.0518
Brugia malayi AMP-binding enzyme family protein 0.0014 0.0034 0.004
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0279 0.0279
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Echinococcus granulosus dna polymerase kappa 0.0039 0.0265 0.0418
Echinococcus multilocularis glutamate synthase 0.0031 0.0195 0.0248
Brugia malayi MH1 domain containing protein 0.0049 0.0358 0.0534
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0074 0.0189
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0022 0.0107 0.0132
Entamoeba histolytica disulphide oxidoreductase, putative 0.0031 0.0195 0.1321
Mycobacterium ulcerans hypothetical protein 0.0048 0.0347 0.2954
Schistosoma mansoni hypothetical protein 0.0079 0.0635 0.0635
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0279 0.036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0279 0.0414
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.0503 0.1612
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0265 0.0815
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0347 0.2954
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0235 0.0719
Trichomonas vaginalis esterase, putative 0.0035 0.0232 0.0518
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0279 0.0279
Echinococcus multilocularis geminin 0.0508 0.4618 0.6152
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0031 0.0195 0.1321
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0031 0.0195 0.0285
Brugia malayi Thioredoxin reductase 0.034 0.3064 0.4667
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0074 0.0324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0265 0.2215
Loa Loa (eye worm) hypothetical protein 0.0019 0.0081 0.011
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0034 0.0163
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0265 0.0831
Schistosoma mansoni hypothetical protein 0.0031 0.0195 0.0195
Schistosoma mansoni glutamate synthase 0.0031 0.0195 0.0195
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0279 0.0441
Loa Loa (eye worm) hypothetical protein 0.0021 0.0102 0.0142
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0081 0.0112
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0118 0.0999 0.1244
Loa Loa (eye worm) transcription factor SMAD2 0.0716 0.6556 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0079 0.0635 0.0955
Mycobacterium ulcerans hypothetical protein 0.0031 0.0195 0.1595
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0074 0.0147

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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