Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.6768 | 0.8625 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.1779 | 0.1779 |
Plasmodium vivax | endoplasmin, putative | 0.0033 | 0.1779 | 0.4029 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0038 | 0.232 | 0.3275 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.2511 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.7085 | 1 |
Echinococcus granulosus | dual specificity | 0.009 | 0.7085 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.009 | 0.7085 | 1 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0096 | 0.7661 | 1 |
Echinococcus granulosus | heat shock protein | 0.0033 | 0.1779 | 0.2511 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0317 | 0.0448 |
Echinococcus granulosus | heat shock protein 90 | 0.0033 | 0.1779 | 0.2511 |
Trichomonas vaginalis | endoplasmin, putative | 0.002 | 0.0614 | 0.139 |
Toxoplasma gondii | thioredoxin reductase | 0.0038 | 0.2273 | 0.5148 |
Schistosoma mansoni | serine/threonine protein kinase | 0.009 | 0.7085 | 0.7085 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.2119 | 0.2119 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0038 | 0.2273 | 0.3208 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0038 | 0.2273 | 0.1706 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0019 | 0.0544 | 0.0768 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0026 | 0.1165 | 0.1645 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.6768 | 0.8625 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.2511 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.6768 | 0.8625 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0061 | 0.4416 | 1 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.1779 | 0.1779 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.6768 | 0.8625 |
Echinococcus multilocularis | endoplasmin | 0.0026 | 0.1165 | 0.1645 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0017 | 0.0317 | 0.0448 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5643 | 0.7964 |
Leishmania major | trypanothione reductase | 0.0038 | 0.2273 | 0.3208 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0317 | 0.0448 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Brugia malayi | Protein kinase domain containing protein | 0.0061 | 0.4416 | 0.6233 |
Leishmania major | protein kinase, putative | 0.0061 | 0.4416 | 0.6233 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | serine/threonine-protein kinase, putative,protein kinase, putative | 0.009 | 0.7085 | 1 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0061 | 0.4416 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0017 | 0.0317 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.433 | 0.6112 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0.4416 | 0.6233 |
Plasmodium falciparum | heat shock protein 90 | 0.0033 | 0.1779 | 0.4029 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0033 | 0.1779 | 0.4029 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.7085 | 1 |
Echinococcus multilocularis | dual specificity | 0.009 | 0.7085 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0026 | 0.1165 | 0.1645 |
Trypanosoma brucei | CMGC/DYRK protein kinase, putative | 0.009 | 0.7085 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0038 | 0.232 | 0.3275 |
Schistosoma mansoni | heat shock protein | 0.0033 | 0.1779 | 0.1779 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.3672 | 0.5182 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.5643 | 0.5643 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5643 | 0.7964 |
Echinococcus multilocularis | heat shock protein 90 | 0.0033 | 0.1779 | 0.2511 |
Trichomonas vaginalis | heat shock protein, putative | 0.002 | 0.0614 | 0.139 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0096 | 0.7661 | 1 |
Entamoeba histolytica | hypothetical protein | 0.009 | 0.7085 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0038 | 0.2273 | 0.3208 |
Echinococcus multilocularis | heat shock protein | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0061 | 0.4416 | 0.6233 |
Brugia malayi | glutathione reductase | 0.0038 | 0.2273 | 0.3208 |
Echinococcus granulosus | hypothetical protein | 0.006 | 0.433 | 0.6112 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.2119 | 0.2991 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.6999 | 0.9879 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0074 | 0.5643 | 0.5643 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0.4416 | 0.6233 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0074 | 0.5643 | 0.7964 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0017 | 0.0317 | 0.0448 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0.2273 | 0.5148 |
Loa Loa (eye worm) | CMGC/DYRK/DYRK1 protein kinase | 0.009 | 0.7085 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0317 | 0.0317 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0317 | 0.0448 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0033 | 0.1779 | 0.1889 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0061 | 0.4416 | 0.6233 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0317 | 0.0317 |
Plasmodium falciparum | endoplasmin, putative | 0.002 | 0.0614 | 0.139 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Loa Loa (eye worm) | glutathione reductase | 0.0038 | 0.2273 | 0.3208 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0061 | 0.4416 | 0.6233 |
Echinococcus multilocularis | GPCR, family 2 | 0.0017 | 0.0317 | 0.0448 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.4416 | 0.4416 |
Echinococcus multilocularis | 0.006 | 0.433 | 0.6112 | |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Entamoeba histolytica | protein kinase domain containing protein | 0.009 | 0.7085 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0017 | 0.0317 | 0.0448 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.2511 |
Echinococcus granulosus | heat shock protein 90 | 0.0026 | 0.1165 | 0.1645 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0074 | 0.5643 | 0.7964 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0026 | 0.1165 | 0.1645 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.1165 | 0.2639 |
Leishmania major | protein kinase, putative | 0.0061 | 0.4416 | 0.6233 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0061 | 0.4416 | 0.6233 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.2511 |
Entamoeba histolytica | protein kinase, putative | 0.009 | 0.7085 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0038 | 0.2273 | 0.3208 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0017 | 0.0317 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0089 | 0.6999 | 0.9879 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0.2273 | 0.5148 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0026 | 0.1165 | 0.1645 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0061 | 0.4416 | 0.6233 |
Giardia lamblia | Kinase, CMGC CLK | 0.0061 | 0.4416 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0033 | 0.1779 | 0.4029 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0096 | 0.7661 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0038 | 0.2273 | 0.3208 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.1165 | 0.2639 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0317 | 0.0317 |
Brugia malayi | Endoplasmin precursor | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0033 | 0.1779 | 0.2511 |
Loa Loa (eye worm) | endoplasmin | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0.2273 | 0.5148 |
Brugia malayi | heat shock protein 90 | 0.0033 | 0.1779 | 0.2511 |
Trypanosoma brucei | heat shock protein, putative | 0.0033 | 0.1779 | 0.2511 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0061 | 0.4416 | 0.6233 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.3672 | 0.5182 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0096 | 0.7661 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0.2273 | 0.5148 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0026 | 0.1165 | 0.5 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0086 | 0.6768 | 0.8625 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.2119 | 0.2991 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0061 | 0.4416 | 0.4416 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0033 | 0.1779 | 0.2511 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0061 | 0.4416 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.6768 | 0.8625 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0033 | 0.1779 | 0.2511 |
Brugia malayi | hypothetical protein | 0.0074 | 0.5643 | 0.7964 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0061 | 0.4416 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.3672 | 0.5182 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.3672 | 0.5182 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0026 | 0.1165 | 0.5 |
Trichomonas vaginalis | heat shock protein, putative | 0.0033 | 0.1779 | 0.4029 |
Leishmania major | heat shock protein 83-1 | 0.0033 | 0.1779 | 0.2511 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0033 | 0.1779 | 0.4029 |
Treponema pallidum | heat shock protein 90 | 0.0026 | 0.1165 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0017 | 0.0317 | 0.0317 |
Trypanosoma cruzi | CMGC/DYRK protein kinase, putative | 0.009 | 0.7085 | 1 |
Echinococcus granulosus | endoplasmin | 0.0026 | 0.1165 | 0.1645 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5643 | 0.7964 |
Entamoeba histolytica | hypothetical protein | 0.0074 | 0.5643 | 0.7964 |
Trichomonas vaginalis | heat shock protein, putative | 0.0026 | 0.1165 | 0.2639 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0061 | 0.4416 | 0.6233 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.6768 | 0.8625 |
Echinococcus multilocularis | heat shock protein 90 | 0.0026 | 0.1165 | 0.1645 |
Schistosoma mansoni | endoplasmin | 0.0033 | 0.1779 | 0.1779 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0017 | 0.0317 | 0.0448 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.