Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0847 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0011 | 0.0215 | 0.016 |
Echinococcus multilocularis | cpg binding protein | 0.0031 | 0.1107 | 0.1633 |
Mycobacterium tuberculosis | Probable cytochrome P450 136 Cyp136 | 0.0011 | 0.0215 | 0.0138 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1107 | 0.3554 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0035 | 0.1311 | 0.1842 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0023 | 0.0775 | 0.1131 |
Mycobacterium tuberculosis | Probable cytochrome P450 123 Cyp123 | 0.0011 | 0.0215 | 0.0138 |
Mycobacterium ulcerans | cytochrome P450 124A1, Cyp124A1 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1311 | 0.1242 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3061 | 1 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0035 | 0.1311 | 0.1242 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0023 | 0.0775 | 0.1027 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0775 | 0.5113 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0078 | 0.0161 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0023 | 0.0775 | 0.7397 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1747 | 0.5666 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0571 | 0.4355 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium ulcerans | cytochrome P450 144A4 Cyp144A4 | 0.0011 | 0.0215 | 0.1112 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3061 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0151 | 0.6627 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3061 | 1 |
Echinococcus multilocularis | muscleblind protein | 0.0151 | 0.6627 | 1 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0078 | 0.0161 |
Trichomonas vaginalis | ferritin, putative | 0.0008 | 0.0078 | 0.0594 |
Echinococcus multilocularis | ferritin | 0.0008 | 0.0078 | 0.0074 |
Brugia malayi | beta-lactamase | 0.0035 | 0.1311 | 0.1848 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0215 | 0.016 |
Mycobacterium ulcerans | cytochrome P450 188A3 Cyp188A3 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium tuberculosis | Cytochrome P450 121 Cyp121 | 0.0011 | 0.0215 | 0.0138 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1747 | 0.2603 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0035 | 0.1311 | 0.1942 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.1031 | 0.1419 |
Mycobacterium ulcerans | cytochrome P450 187A5 Cyp187A5 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium tuberculosis | Probable cytochrome P450 132 Cyp132 | 0.0011 | 0.0215 | 0.0138 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0775 | 0.2461 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1747 | 0.2511 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0571 | 0.4355 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0035 | 0.1311 | 0.1242 |
Mycobacterium tuberculosis | Possible cytochrome P450 126 Cyp126 | 0.0011 | 0.0215 | 0.0138 |
Mycobacterium tuberculosis | Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) | 0.0011 | 0.0215 | 0.0138 |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0078 | 0.0161 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1311 | 0.4227 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1747 | 0.2603 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0571 | 0.0497 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0571 | 0.3247 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.2525 | 0.8231 |
Mycobacterium tuberculosis | Probable cytochrome P450 124 Cyp124 | 0.0011 | 0.0215 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0571 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0.0571 | 0.3247 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0.0571 | 0.1772 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.3061 | 0.4595 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.3061 | 0.4595 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1747 | 0.5666 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.0847 | 0.3148 |
Mycobacterium tuberculosis | Probable cytochrome P450 141 Cyp141 | 0.0011 | 0.0215 | 0.0138 |
Brugia malayi | Muscleblind-like protein | 0.0151 | 0.6627 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.3061 | 1 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0035 | 0.1311 | 0.1242 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1311 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.0847 | 0.5769 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6627 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0.1311 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0571 | 0.1786 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0035 | 0.1311 | 0.4227 |
Mycobacterium tuberculosis | Possible cytochrome P450 135B1 Cyp135B1 | 0.0011 | 0.0215 | 0.0138 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0.1311 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0215 | 0.0168 |
Brugia malayi | hypothetical protein | 0.0025 | 0.0847 | 0.1138 |
Mycobacterium tuberculosis | Probable cytochrome P450 137 Cyp137 | 0.0011 | 0.0215 | 0.0138 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1311 | 1 |
Mycobacterium tuberculosis | Probable cytochrome P450 144 Cyp144 | 0.0011 | 0.0215 | 0.0138 |
Mycobacterium ulcerans | cytochrome P450 143A3 Cyp143A3 | 0.0011 | 0.0215 | 0.1112 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1311 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0073 | 0.3061 | 1 |
Echinococcus multilocularis | Ataxin 2, N terminal,domain containing protein | 0.0011 | 0.0213 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0078 | 0.0161 |
Mycobacterium leprae | putative cytochrome p450 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0571 | 0.1786 |
Mycobacterium ulcerans | cytochrome P450 140A5 Cyp140A5 | 0.0011 | 0.0215 | 0.1112 |
Schistosoma mansoni | cpg binding protein | 0.0031 | 0.1107 | 0.3554 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.2073 | 0.3011 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0.1311 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1311 | 0.1242 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.0847 | 1 |
Mycobacterium ulcerans | cytochrome P450 189A7 Cyp189A7 | 0.0011 | 0.0215 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0035 | 0.1311 | 0.1242 |
Schistosoma mansoni | cytochrome P450 | 0.0011 | 0.0215 | 0.0613 |
Echinococcus multilocularis | 0.0011 | 0.0215 | 0.0282 | |
Schistosoma mansoni | apoferritin-2 | 0.0008 | 0.0078 | 0.0161 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.1311 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1747 | 0.5666 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.0847 | 0.113 |
Mycobacterium ulcerans | cytochrome P450 150A6 Cyp150A6 | 0.0011 | 0.0215 | 0.1112 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0.0571 | 0.3247 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Toxoplasma gondii | t-complex protein beta subunit | 0.0023 | 0.0775 | 0.279 |
Echinococcus granulosus | Ataxin 2 N terminaldomain containing protein | 0.0011 | 0.0213 | 0.0279 |
Mycobacterium ulcerans | cytochrome P450 143A4 Cyp143A4 | 0.0011 | 0.0215 | 0.1112 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.0847 | 0.3735 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0023 | 0.0775 | 0.0821 |
Schistosoma mansoni | ferritin | 0.0008 | 0.0078 | 0.0161 |
Mycobacterium tuberculosis | Probable cytochrome P450 monooxygenase 142 Cyp142 | 0.0011 | 0.0215 | 0.0138 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0035 | 0.1311 | 0.1942 |
Loa Loa (eye worm) | beta-lactamase | 0.0035 | 0.1311 | 0.1842 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.011 | 0.0123 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0213 | 0.0608 |
Echinococcus multilocularis | expressed protein | 0.0008 | 0.0078 | 0.0074 |
Mycobacterium tuberculosis | Probable cytochrome P450 140 Cyp140 | 0.0011 | 0.0215 | 0.0138 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0011 | 0.0215 | 0.0282 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.3061 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0215 | 0.0168 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0571 | 0.3998 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0571 | 0.0821 |
Onchocerca volvulus | 0.0035 | 0.1311 | 1 | |
Mycobacterium leprae | Conserved hypothetical protein | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium tuberculosis | Probable cytochrome P450 125 Cyp125 | 0.0011 | 0.0215 | 0.0138 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0775 | 0.2461 |
Mycobacterium ulcerans | cytochrome p450 150 cyp150 | 0.0011 | 0.0215 | 0.1112 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0775 | 0.5113 |
Brugia malayi | Cytochrome P450 family protein | 0.0011 | 0.0215 | 0.0168 |
Trichomonas vaginalis | chaperonin, putative | 0.0023 | 0.0775 | 0.5914 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0023 | 0.0775 | 0.5113 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0847 | 0.5769 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.0847 | 0.5769 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0023 | 0.0775 | 0.102 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0571 | 0.0821 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.2073 | 0.3017 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0035 | 0.1311 | 0.1242 |
Mycobacterium ulcerans | cytochrome P450 51B1 Cyp51B1 | 0.0011 | 0.0215 | 0.1112 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.2223 | 1 |
Onchocerca volvulus | 0.0035 | 0.1311 | 1 | |
Mycobacterium ulcerans | cytochrome P450 126A3 Cyp126A3 | 0.0011 | 0.0215 | 0.1112 |
Echinococcus granulosus | muscleblind protein | 0.0151 | 0.6627 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0035 | 0.1311 | 0.1242 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.011 | 0.0123 |
Brugia malayi | hypothetical protein | 0.0016 | 0.044 | 0.0513 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.1031 | 0.1412 |
Mycobacterium tuberculosis | Probable cytochrome P450 128 Cyp128 | 0.0011 | 0.0215 | 0.0138 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0.1311 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0.1311 | 0.5457 |
Mycobacterium tuberculosis | Probable cytochrome P450 143 Cyp143 | 0.0011 | 0.0215 | 0.0138 |
Brugia malayi | cytochrome P450 | 0.0011 | 0.0215 | 0.0168 |
Echinococcus granulosus | cpg binding protein | 0.0031 | 0.1107 | 0.1633 |
Onchocerca volvulus | 0.0035 | 0.1311 | 1 | |
Mycobacterium ulcerans | cytochrome P450 187A4 Cyp187A4 | 0.0011 | 0.0215 | 0.1112 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1747 | 0.2517 |
Giardia lamblia | TCP-1 chaperonin subunit beta | 0.0023 | 0.0775 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0.1311 | 1 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0023 | 0.0775 | 0.2763 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0.1311 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0011 | 0.0215 | 0.016 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1031 | 0.3303 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0023 | 0.0775 | 0.1027 |
Mycobacterium ulcerans | cytochrome P450 108B4 Cyp108B4 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium ulcerans | cytochrome P450 191A3 Cyp191A3 | 0.0011 | 0.0215 | 0.1112 |
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.0215 | 0.0613 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0571 | 0.0714 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0023 | 0.0775 | 0.2461 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0035 | 0.1311 | 0.1242 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0.1311 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.6627 | 1 |
Mycobacterium ulcerans | cytochrome P450 125A7 Cyp125A7 | 0.0011 | 0.0215 | 0.1112 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0023 | 0.0775 | 0.5914 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1311 | 0.1848 |
Loa Loa (eye worm) | cytochrome P450 | 0.0011 | 0.0215 | 0.016 |
Mycobacterium tuberculosis | Probable cytochrome P450 130 Cyp130 | 0.0011 | 0.0215 | 0.0138 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0035 | 0.1311 | 0.1848 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0078 | 0.0161 |
Brugia malayi | beta-lactamase family protein | 0.0035 | 0.1311 | 0.1848 |
Mycobacterium ulcerans | cytochrome P450 105Q4 Cyp105Q4 | 0.0011 | 0.0215 | 0.1112 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0571 | 0.0706 |
Mycobacterium tuberculosis | Possible cytochrome P450 135A1 Cyp135A1 | 0.0011 | 0.0215 | 0.0138 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1747 | 0.2603 |
Mycobacterium tuberculosis | Probable cytochrome P450 139 Cyp139 | 0.0011 | 0.0215 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1311 | 0.1842 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0035 | 0.1311 | 0.1242 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.1311 | 1 |
Schistosoma mansoni | ferritin light chain | 0.0008 | 0.0078 | 0.0161 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0023 | 0.0775 | 0.1131 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0.0571 | 0.3247 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1747 | 0.2603 |
Brugia malayi | hypothetical protein | 0.0073 | 0.3061 | 0.4532 |
Echinococcus granulosus | expressed protein | 0.0008 | 0.0078 | 0.0074 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0.1311 | 1 |
Mycobacterium ulcerans | cytochrome P450 136A2 Cyp136A2 | 0.0011 | 0.0215 | 0.1112 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.0847 | 0.5769 |
Echinococcus granulosus | ferritin | 0.0008 | 0.0078 | 0.0074 |
Mycobacterium ulcerans | cytochrome P450 142A3 Cyp142A3 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium ulcerans | cytochrome P450 123A3 Cyp123A3 | 0.0011 | 0.0215 | 0.1112 |
Mycobacterium tuberculosis | Probable cytochrome P450 138 Cyp138 | 0.0011 | 0.0215 | 0.0138 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0.0571 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.