Detailed information for compound 796272

Basic information

Technical information
  • TDR Targets ID: 796272
  • Name: EU-0086034
  • MW: 381.447 | Formula: C17H23N3O5S
  • H donors: 1 H acceptors: 4 LogP: 2.73 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCNC(=O)n1c(=O)oc2c1ccc(c2)S(=O)(=O)N1CCCCC1
  • InChi: 1S/C17H23N3O5S/c1-2-3-9-18-16(21)20-14-8-7-13(12-15(14)25-17(20)22)26(23,24)19-10-5-4-6-11-19/h7-8,12H,2-6,9-11H2,1H3,(H,18,21)
  • InChiKey: VTDYHBBXTZNEAJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ST051076
  • ZINC04558068

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis muscleblind protein 0.0165 0.0896 0.0896
Schistosoma mansoni hypothetical protein 0.0172 0.0937 0.1923
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0751 0.0751
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Brugia malayi ecdysteroid receptor 0.0021 0.0043 0.0096
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0751 0.1541
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0015 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0837 0.4875 0.4875
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0043 0.0043
Toxoplasma gondii thioredoxin reductase 0.0039 0.0151 0.2301
Mycobacterium tuberculosis Conserved protein 0.0074 0.0361 0.081
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0107 0.0551 0.2645
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0045 0.0188 0.1119
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0145 0.3934
Brugia malayi nuclear receptor NHR-88 0.0021 0.0043 0.0096
Schistosoma mansoni patched 1 0.0046 0.0191 0.0392
Toxoplasma gondii histone lysine methyltransferase SET1 0.0114 0.0593 0.9056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0361 0.081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0519 0.1136
Echinococcus granulosus neutral amino acid transporter A 0.0766 0.4452 0.9133
Onchocerca volvulus 0.0074 0.0361 0.0721
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0446 0.1001
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0043 0.0088
Echinococcus multilocularis GPCR, family 2 0.0032 0.011 0.011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.0751 0.0751
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0015 0.0015
Echinococcus granulosus ubiquitin specific protease 41 0.0076 0.0368 0.0755
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.011 0.011
Brugia malayi steroid hormone receptor 0.0021 0.0043 0.0096
Echinococcus multilocularis survival motor neuron protein 1 0.0241 0.1344 0.1344
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.002 0.002
Echinococcus granulosus Excitatory amino acid transporter 0.0766 0.4452 0.9133
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0015 0.003
Brugia malayi CHE-14 protein 0.0046 0.0191 0.0429
Entamoeba histolytica hypothetical protein 0.005 0.0215 0.0459
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0225
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0043 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0043 0.0043
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.002 0.0041 0.0084
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0145 0.0297
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0015 0.003
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0145 0.0145
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0476 0.2735 0.6142
Loa Loa (eye worm) hypothetical protein 0.0026 0.0072 0.0129
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0072 0.11
Schistosoma mansoni microtubule-associated protein tau 0.07 0.4063 0.8334
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0043 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0361 0.1289
Echinococcus granulosus cpg binding protein 0.0062 0.0288 0.0591
Echinococcus granulosus excitatory amino acid transporter 2 0.0766 0.4452 0.9133
Loa Loa (eye worm) hypothetical protein 0.0062 0.0289 0.0619
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0191 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0043 0.0096
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0151 0.409
Echinococcus multilocularis microtubule associated protein 2 0.07 0.4063 0.4063
Echinococcus granulosus neutral amino acid transporter 0.0766 0.4452 0.9133
Giardia lamblia Fructose-bisphosphate aldolase 0.0297 0.168 1
Brugia malayi Latrophilin receptor protein 2 0.0032 0.011 0.0246
Echinococcus multilocularis muscleblind protein 1 0.0165 0.0896 0.0896
Echinococcus multilocularis neutral amino acid transporter A 0.0766 0.4452 0.4452
Schistosoma mansoni cpg binding protein 0.0059 0.0268 0.055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0751 0.1541
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0043 0.0088
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0043 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0043 0.0043
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0339 0.1929 0.1929
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Brugia malayi hypothetical protein 0.0026 0.0072 0.0162
Echinococcus granulosus GTP binding nuclear protein Ran 0.0045 0.0188 0.0386
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0654 0.0654
Mycobacterium tuberculosis Probable C4-dicarboxylate-transport transmembrane protein DctA 0.0766 0.4452 1
Mycobacterium ulcerans beta-lactamase 0.0074 0.0361 0.4624
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0822 0.0822
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0284 0.7716
Leishmania major trypanothione reductase 0.0039 0.0151 0.2301
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0361 0.081
Echinococcus multilocularis Excitatory amino acid transporter 0.0766 0.4452 0.4452
Echinococcus granulosus sodium:dicarboxylate symporter 0.0766 0.4452 0.9133
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0145 0.2213
Brugia malayi CXXC zinc finger family protein 0.0059 0.0268 0.0602
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0361 0.1289
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0289 0.0594
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0654 0.8389
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Echinococcus multilocularis Excitatory amino acid transporter 0.0766 0.4452 0.4452
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0289 0.0594
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0361 0.078
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0339 0.1929 0.3957
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0072 0.1955
Echinococcus granulosus geminin 0.0172 0.0937 0.1923
Brugia malayi nuclear hormone receptor 0.0021 0.0043 0.0096
Treponema pallidum glutamate transporter 0.0339 0.1929 1
Echinococcus granulosus expressed conserved protein 0.01 0.0513 0.1052
Schistosoma mansoni hypothetical protein 0.0069 0.0329 0.0676
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0368 0.0755
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0329 0.074
Schistosoma mansoni ran 0.0045 0.0188 0.0386
Schistosoma mansoni jumonji domain containing protein 0.006 0.0274 0.0563
Echinococcus granulosus lysine specific demethylase 5A 0.0063 0.0294 0.0603
Echinococcus multilocularis neutral amino acid transporter excitatory amino acid transporter 0.0766 0.4452 0.4452
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0015 0.003
Schistosoma mansoni hypothetical protein 0.0049 0.0211 0.0432
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0751 0.1541
Schistosoma mansoni coup transcription factor 0.0021 0.0043 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0069 0.0329 0.0709
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0151 0.0306
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0339 0.1929 0.1929
Echinococcus granulosus microtubule associated protein 2 0.07 0.4063 0.8334
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0072 0.2533
Echinococcus multilocularis expressed conserved protein 0.01 0.0513 0.0513
Leishmania major hypothetical protein, conserved 0.0016 0.0015 0.0223
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0015 0.003
Echinococcus granulosus neutral amino acid transporter A 0.0766 0.4452 0.9133
Leishmania major hypothetical protein, conserved 0.0026 0.0072 0.11
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0191 0.0682
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0045 0.0188 0.5212
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Echinococcus granulosus importin subunit beta 1 0.0061 0.0284 0.0583
Mycobacterium tuberculosis Conserved protein 0.0074 0.0361 0.081
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0043 0.0043
Echinococcus granulosus survival motor neuron protein 1 0.0241 0.1344 0.2758
Brugia malayi jmjC domain containing protein 0.006 0.0274 0.0616
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0043 0.0096
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0225
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0072 0.1955
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0274 0.0563
Onchocerca volvulus 0.0486 0.2797 0.6247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0361 0.074
Treponema pallidum fructose-bisphosphate aldolase 0.0297 0.168 0.8712
Mycobacterium ulcerans lipase LipD 0.0074 0.0361 0.4624
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0361 0.4624
Onchocerca volvulus 0.0059 0.0268 0.0511
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.002 0.0041 0.0041
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.011 0.0246
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0043 0.0043
Plasmodium vivax importin-beta 2, putative 0.0061 0.0284 0.7876
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0274 0.0274
Loa Loa (eye worm) glutathione reductase 0.0039 0.0151 0.0306
Echinococcus multilocularis neutral amino acid transporter A 0.0766 0.4452 0.4452
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0145 0.078 0.1752
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0043 0.0043
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0289 0.0594
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0043 0.0064
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0241 0.1344 0.2997
Echinococcus multilocularis neuropeptide receptor A26 0.0471 0.2705 0.2705
Echinococcus multilocularis excitatory amino acid transporter 3 0.0766 0.4452 0.4452
Entamoeba histolytica Ran family GTPase 0.0045 0.0188 0.0281
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0446 0.1001
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0361 0.081
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0072 0.2533
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.0504 0.3427
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0446 0.1001
Echinococcus multilocularis neutral amino acid transporter A 0.0766 0.4452 0.4452
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.168 1
Schistosoma mansoni hypothetical protein 0.0044 0.0181 0.0372
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0043 0.0088
Echinococcus granulosus Excitatory amino acid transporter 0.0766 0.4452 0.9133
Brugia malayi Pre-SET motif family protein 0.0062 0.0289 0.065
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0268 0.0551
Loa Loa (eye worm) hypothetical protein 0.0165 0.0896 0.1985
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0151 0.0338
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0368 0.1316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.0751 0.1541
Wolbachia endosymbiont of Brugia malayi Na+/H+-dicarboxylate symporter 0.0766 0.4452 1
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0361 0.081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0043 0.0096
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0289 0.0594
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0361 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0043 0.0064
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0519 0.1165
Echinococcus granulosus excitatory amino acid transporter 3 0.0766 0.4452 0.9133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0043 0.0064
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0294 0.0603
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.0504 0.1133
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.0751 0.166
Trypanosoma brucei trypanothione reductase 0.0039 0.0151 0.409
Echinococcus multilocularis Niemann Pick C1 protein 0.0107 0.0551 0.0551
Brugia malayi Niemann-Pick C1 protein precursor 0.0107 0.0551 0.1238
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0368 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0107 0.0551 0.1209
Trypanosoma brucei importin beta-1 subunit, putative 0.0061 0.0284 0.7716
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0145 0.5098
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0671 0.1377
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Schistosoma mansoni cpg binding protein 0.0062 0.0288 0.0591
Brugia malayi Thioredoxin reductase 0.0039 0.0151 0.0338
Toxoplasma gondii ABC1 family protein 0.0074 0.0361 0.5512
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0043 0.0096
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0033
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0225
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0076 0.0368 0.1316
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0145 0.3934
Brugia malayi Excitatory amino acid transporter 0.0766 0.4452 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0191 0.0191
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.011 0.0225
Plasmodium vivax SET domain protein, putative 0.0062 0.0289 0.8023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0076 0.0368 0.0827
Echinococcus multilocularis protein dispatched 1 0.0052 0.0229 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0015 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0043 0.0096
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0033
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0289 0.0289
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0072 0.1955
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0043 0.0064
Schistosoma mansoni solute carrier family 1 (glial high affinity glutamate transporter 0.0766 0.4452 0.9133
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0289 0.0289
Echinococcus multilocularis cpg binding protein 0.0062 0.0288 0.0288
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0145 0.4015
Echinococcus granulosus Niemann Pick C1 protein 0.0107 0.0551 0.113
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0654 0.1342
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0043 0.0088
Schistosoma mansoni hypothetical protein 0.0172 0.0937 0.1923
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0043 0.0088
Echinococcus multilocularis excitatory amino acid transporter 2 0.0766 0.4452 0.4452
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0188 0.5106
Echinococcus granulosus GPCR family 2 0.0032 0.011 0.0225
Chlamydia trachomatis glutamate symporter 0.0766 0.4452 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0145 0.0518
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0361 0.4624
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0076 0.0368 0.0755
Echinococcus granulosus neuropeptide s receptor 0.0471 0.2705 0.5549
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0015 0.003
Trichomonas vaginalis set domain proteins, putative 0.0486 0.2797 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0043 0.0088
Brugia malayi RNA, U transporter 1 0.0175 0.0955 0.2145
Brugia malayi Importin beta-1 subunit 0.0061 0.0284 0.0638
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0654 0.8389
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0043 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0043 0.0096
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0043 0.0088
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0361 0.081
Brugia malayi beta-lactamase family protein 0.0074 0.0361 0.081
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0361 0.1289
Toxoplasma gondii exonuclease III APE 0.0038 0.0145 0.2213
Loa Loa (eye worm) hypothetical protein 0.0061 0.0284 0.0607
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0368 0.0755
Brugia malayi hypothetical protein 0.0241 0.1344 0.302
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.002 0.0041
Schistosoma mansoni importin beta-1 0.0061 0.0284 0.0583
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0561 0.115
Schistosoma mansoni hypothetical protein 0.0837 0.4875 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Onchocerca volvulus 0.0074 0.0361 0.0721
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0043 0.0043
Loa Loa (eye worm) excitatory amino acid transporter 0.0766 0.4452 1
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0043 0.0088
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0046 0.0191 0.0397
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0043 0.0096
Echinococcus granulosus phd:f box containing protein 0.0016 0.0015 0.003
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0361 0.081
Schistosoma mansoni hypothetical protein 0.0656 0.3805 0.7805
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0045 0.0188 0.0188
Schistosoma mansoni ran 0.0045 0.0188 0.0386
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0654 0.8389
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0427 0.2449 0.5486
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0191 0.0392
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0076 0.0368 0.5626
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0361 0.1289
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0145 0.0325
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0151 0.4175
Schistosoma mansoni jumonji/arid domain-containing protein 0.0063 0.0294 0.0603
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0043 0.0096
Onchocerca volvulus 0.0062 0.0289 0.0559
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Brugia malayi jmjC domain containing protein 0.0016 0.0015 0.0033
Loa Loa (eye worm) hypothetical protein 0.0101 0.0519 0.1136
Onchocerca volvulus Excitatory amino acid transporter homolog 0.0766 0.4452 1
Schistosoma mansoni hypothetical protein 0.0044 0.0181 0.0372
Schistosoma mansoni hypothetical protein 0.0044 0.0181 0.0372
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0361 0.074
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0076 0.0368 0.0368
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0361 0.9797
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0446 0.1001
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0361 0.9797
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0043 0.0096
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.0504 0.1133
Schistosoma mansoni ap endonuclease 0.0038 0.0145 0.0297
Plasmodium falciparum thioredoxin reductase 0.0039 0.0151 0.5301
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0215 0.0769
Plasmodium falciparum importin beta, putative 0.0061 0.0284 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0361 0.081
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0015 0.0223
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0043 0.0064
Trichomonas vaginalis Importin beta-1 subunit, putative 0.005 0.0215 0.0769
Schistosoma mansoni ap endonuclease 0.0038 0.0145 0.0297
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0015 0.0015
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0015 0.0015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0154 0.0154
Brugia malayi beta-lactamase 0.0074 0.0361 0.081
Echinococcus multilocularis protein patched 0.0046 0.0191 0.0191
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0656 0.3805 0.8542
Echinococcus granulosus dnaJ subfamily B 0.0837 0.4875 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0145 0.0751
Echinococcus multilocularis geminin 0.0172 0.0937 0.0937
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0045 0.0188 0.2873
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0034 0.0071
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0822 0.1686
Mycobacterium tuberculosis Conserved protein 0.0074 0.0361 0.081
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0654 0.1342
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0072 0.1995
Trichomonas vaginalis importin beta-1, putative 0.005 0.0215 0.0769
Schistosoma mansoni sodium/dicarboxylate symporter-related 0.0339 0.1929 0.3957
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0289 0.4422
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Plasmodium falciparum glutathione reductase 0.0039 0.0151 0.5301
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0043 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0043 0.0064
Brugia malayi Muscleblind-like protein 0.0165 0.0896 0.2011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0015 0.0514
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0043 0.0088
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0145 0.0325
Leishmania major GTP-binding protein, putative 0.0045 0.0188 0.2873
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Echinococcus multilocularis importin subunit beta 1 0.0061 0.0284 0.0284
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0017 0.002 0.002
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0043 0.0088
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0074 0.0361 0.078
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0211 0.0473
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0519 0.1165
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0043 0.0088
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0043 0.0096
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.0504 0.1133
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0368 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Echinococcus multilocularis excitatory amino acid transporter 2 0.0766 0.4452 0.4452
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0361 0.081
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0043 0.0096
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0034 0.0034
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0154 0.0315
Echinococcus multilocularis sodium:dicarboxylate symporter 0.0766 0.4452 0.4452
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0043 0.0096
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0076 0.0368 0.2191
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0064
Brugia malayi glutathione reductase 0.0039 0.0151 0.0338
Loa Loa (eye worm) histone methyltransferase 0.002 0.0041 0.006
Leishmania major hypothetical protein, conserved 0.0074 0.0361 0.5512
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0145 0.0325
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0446 0.2029
Brugia malayi Pre-SET motif family protein 0.0427 0.2449 0.55
Trichomonas vaginalis esterase, putative 0.0074 0.0361 0.1289
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0043 0.0096
Brugia malayi hypothetical protein 0.0017 0.0018 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0043 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0289 0.0594
Echinococcus granulosus muscleblind protein 0.0165 0.0896 0.1837
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0015 0.0223
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0045 0.0188 0.6618
Loa Loa (eye worm) hypothetical protein 0.0056 0.0252 0.0534
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0361 0.9797
Echinococcus multilocularis neuropeptide s receptor 0.0471 0.2705 0.2705
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0045 0.0188 0.5106
Onchocerca volvulus 0.0074 0.0361 0.0721
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0043 0.0088
Loa Loa (eye worm) beta-lactamase 0.0074 0.0361 0.078
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0076 0.0368 0.1454
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.011 0.011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0043 0.0064
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0076 0.0368 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0045 0.0188 0.0391
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0191 0.0397
Mycobacterium ulcerans hypothetical protein 0.0074 0.0361 0.4624
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0654 1
Schistosoma mansoni cpg binding protein 0.0062 0.0288 0.0591
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0361 0.0361
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0043 0.0088
Echinococcus multilocularis ubiquitin specific protease 41 0.0076 0.0368 0.0368
Plasmodium vivax JmjC domain containing protein 0.0016 0.0015 0.0405
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0043 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0076 0.0368 0.0755
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0654 0.147
Leishmania major importin beta-1 subunit, putative 0.005 0.0215 0.3289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0145 0.3934
Trypanosoma cruzi importin beta-1 subunit, putative 0.005 0.0215 0.5847
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.002 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0145 0.1857
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0045 0.0188 0.0422
Schistosoma mansoni survival motor neuron protein 0.0049 0.0211 0.0432
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0015 0.003
Mycobacterium tuberculosis Probable reductase 0.0089 0.0446 0.1001
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.004 0.0089
Treponema pallidum glutamate/aspartate transporter 0.0339 0.1929 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0015 0.0015
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0294 0.063
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0654 1
Brugia malayi beta-lactamase family protein 0.0074 0.0361 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0368 0.1316
Plasmodium vivax glutathione reductase, putative 0.0039 0.0151 0.4175
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0274 0.0274
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0297 0.168 0.6007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.011 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0361 0.074
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0145 0.078 1
Echinococcus granulosus snurportin 1 0.0656 0.3805 0.7805
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0297 0.168 1
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0145 0.0518
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0043 0.0088
Chlamydia trachomatis neutral amino acid transporter 0.0339 0.1929 0.4333
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.011 0.0225
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0043 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0045 0.0188 0.5106
Schistosoma mansoni hypothetical protein 0.0044 0.0181 0.0372
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0076 0.0368 0.0368
Schistosoma mansoni hypothetical protein 0.0032 0.011 0.0225
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0145 0.0862
Echinococcus granulosus excitatory amino acid transporter 2 0.0766 0.4452 0.9133
Onchocerca volvulus 0.0049 0.0211 0.038
Trichomonas vaginalis ran, putative 0.0045 0.0188 0.0672
Echinococcus multilocularis snurportin 1 0.0656 0.3805 0.3805
Echinococcus granulosus mixed lineage leukemia protein mll 0.0017 0.002 0.0041
Loa Loa (eye worm) hypothetical protein 0.0165 0.0896 0.1985
Echinococcus granulosus neuropeptide receptor A26 0.0471 0.2705 0.5549
Toxoplasma gondii HEAT repeat-containing protein 0.0061 0.0284 0.4341
Loa Loa (eye worm) CXXC zinc finger family protein 0.0059 0.0268 0.0571
Brugia malayi jmjC domain containing protein 0.0063 0.0294 0.0661
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0361 0.1289
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0145 0.0293
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0145 0.078 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.0751 0.1687
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0015 0.0397
Loa Loa (eye worm) hypothetical protein 0.0032 0.011 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.0751 0.1541
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0043 0.0088
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0446 0.1001
Loa Loa (eye worm) hypothetical protein 0.0076 0.0368 0.0797
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0654 0.1342

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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