TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 320.423 | Formula: C19H28O4
H donors: 2 H acceptors: 3 LogP: 4.21 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: C=CCc1cc(C(=O)C)c(cc1OCCCCCC(O)(C)C)O
InChi: 1S/C19H28O4/c1-5-9-15-12-16(14(2)20)17(21)13-18(15)23-11-8-6-7-10-19(3,4)22/h5,12-13,21-22H,1,6-11H2,2-4H3
InChiKey: GSZIAUDMKXYZBT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	G-protein coupled receptor	0.0036	0.0119	0.014
Plasmodium vivax	histone deacetylase 2, putative	0.0059	0.04	0.8031
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0535	0.5188
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0036	0.0119	0.0114
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0036	0.0119	0.0232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0103	0.0037
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0034	0.0103	0.0127
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Onchocerca volvulus		0.0145	0.1415	0.2886
Toxoplasma gondii	AGC kinase	0.01	0.0888	1
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0071	0.0535	0.0581
Schistosoma mansoni	opsin-like receptor	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	serotonin receptor	0.0158	0.1572	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0036	0.0119	0.0114
Brugia malayi	Dopamine receptor protein 2	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1572	0.1933
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0036	0.0119	0.0146
Echinococcus multilocularis	survival motor neuron protein 1	0.071	0.8133	0.8132
Schistosoma mansoni	hypothetical protein	0.0079	0.0635	0.0809
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0036	0.0119	0.0146
Brugia malayi	steroid hormone receptor	0.0045	0.0228	0.0273
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0228	0.0273
Echinococcus granulosus	serine:threonine protein kinase N2	0.0034	0.0103	0.0097
Onchocerca volvulus		0.0035	0.011	0.0214
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0119	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0045	0.0228	0.0273
Echinococcus multilocularis	allatostatin A receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	lozenge	0.0055	0.0346	0.0437
Brugia malayi	G-protein coupled receptor	0.0036	0.0119	0.014
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	protein kinase c epsilon type	0.0034	0.0103	0.0097
Leishmania major	squalene synthase, putative	0.0254	0.2715	1
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0119	0.0146
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0045	0.0228	0.0222
Echinococcus multilocularis	neuropeptide s receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0228	0.0222
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0119	0.0147
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0103	0.0037
Loa Loa (eye worm)	melatonin receptor type 1A	0.0036	0.0119	0.0147
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0067	0.0487	0.0482
Echinococcus multilocularis	histone deacetylase	0.0059	0.04	0.0395
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	microtubule associated protein 2	0.0681	0.7788	0.7787
Echinococcus multilocularis	geminin	0.0165	0.1654	0.1649
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Loa Loa (eye worm)	TYRA-2 protein	0.0036	0.0119	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Schistosoma mansoni	survival motor neuron protein	0.0145	0.1415	0.1811
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0188	0.0231
Brugia malayi	Melatonin receptor type 1A	0.0036	0.0119	0.014
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0034	0.0103	0.0127
Echinococcus multilocularis	Protein lozenge	0.0055	0.0346	0.034
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0228	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Onchocerca volvulus		0.0036	0.0119	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0228	0.0273
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0158	0.1572	0.1933
Echinococcus granulosus	orexin receptor type 2	0.0036	0.0119	0.0114
Echinococcus granulosus	Glutaredoxin protein 5	0.0066	0.0479	0.0473
Echinococcus granulosus	histone deacetylase 7	0.0059	0.04	0.0395
Onchocerca volvulus		0.0036	0.0119	0.0232
Echinococcus multilocularis	orexin receptor type 2	0.0036	0.0119	0.0114
Onchocerca volvulus		0.0036	0.0119	0.0232
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0071	0.0535	0.5188
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0036	0.0119	0.0146
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0036	0.0119	0.0147
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0036	0.0119	0.014
Loa Loa (eye worm)	G-protein coupled receptor	0.0036	0.0119	0.0147
Schistosoma mansoni	amine GPCR	0.0036	0.0119	0.0146
Brugia malayi	Histone deacetylase family protein	0.0059	0.04	0.0485
Echinococcus granulosus	neuropeptide FF receptor 2	0.0036	0.0119	0.0114
Toxoplasma gondii	histone deacetylase HDAC1	0.0059	0.04	0.4221
Loa Loa (eye worm)	hypothetical protein	0.0159	0.1582	0.1945
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0045	0.0228	0.0273
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Echinococcus granulosus	hypothetical protein	0.0728	0.8353	0.8352
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0045	0.0228	0.0273
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1111	0.1366
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0036	0.0119	0.0114
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0034	0.0103	0.0097
Echinococcus multilocularis	histone deacetylase 7	0.0059	0.04	0.0395
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0146
Schistosoma mansoni	hypothetical protein	0.0145	0.1415	0.1811
Onchocerca volvulus		0.0036	0.0119	0.0232
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0119	0.0114
Trypanosoma cruzi	squalene synthase, putative	0.0254	0.2715	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Entamoeba histolytica	protein kinase 2, putative	0.0067	0.0487	0.4621
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0045	0.0228	0.028
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0146	0.1435	0.1765
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0045	0.0228	0.0273
Schistosoma mansoni	myosin xvIII	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	FTZ F1 alpha	0.0045	0.0228	0.0222
Echinococcus multilocularis	g-protein coupled receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0045	0.0228	0.0286
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0045	0.0228	0.028
Echinococcus multilocularis	protein phosphatase 1b	0.0171	0.1732	0.1727
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0228	0.0222
Loa Loa (eye worm)	runx1	0.0055	0.0346	0.0425
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0034	0.0103	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0045	0.0228	0.0273
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0036	0.0119	0.014
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0034	0.0103	0.0127
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0045	0.0228	0.028
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0119	0.0114
Echinococcus granulosus	single minded 2	0.0035	0.011	0.0105
Echinococcus granulosus	geminin	0.0165	0.1654	0.1649
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Plasmodium vivax	histone deacetylase, putative	0.0059	0.04	0.8031
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Loa Loa (eye worm)	protein phosphatase 2C containing protein	0.0171	0.1732	0.213
Echinococcus granulosus	tm gpcr rhodopsin	0.0036	0.0119	0.0114
Schistosoma mansoni	jun-related protein	0.0068	0.0508	0.0646
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0034	0.0103	0.0097
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0036	0.0119	0.0232
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0119	0.0114
Brugia malayi	protein kinase C II.	0.0034	0.0103	0.012
Schistosoma mansoni	serine/threonine kinase	0.0034	0.0103	0.0125
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0797	0.9167	1
Brugia malayi	neuropeptide F receptor	0.0036	0.0119	0.014
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0006	0.0007
Brugia malayi	Pre-SET motif family protein	0.0205	0.2135	0.262
Schistosoma mansoni	amine GPCR	0.0036	0.0119	0.0146
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	protein phosphatase 2C	0.015	0.1474	0.1887
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0044	0.0054
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0045	0.0228	0.0273
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0044	0.0049
Onchocerca volvulus		0.0029	0.0044	0.0078
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0146
Echinococcus multilocularis	somatostatin receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	protein phosphatase 1b	0.015	0.1474	0.1469
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0036	0.0119	0.0146
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0036	0.0119	0.014
Echinococcus multilocularis	serine threonine protein kinase	0.0034	0.0103	0.0097
Brugia malayi	hypothetical protein	0.0119	0.1111	0.136
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.071	0.8133	1
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0034	0.0103	0.0127
Echinococcus multilocularis	protein kinase c iota type	0.0034	0.0103	0.0097
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0145	0.1415	0.1734
Echinococcus granulosus	protein kinase c epsilon type	0.0034	0.0103	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3648	0.4486
Brugia malayi	neuropeptide F receptor	0.0036	0.0119	0.014
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0119	0.0146
Brugia malayi	PAS domain containing protein	0.0047	0.0256	0.0309
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	sulfakinin receptor protein	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Schistosoma mansoni	coup transcription factor	0.0045	0.0228	0.0286
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Echinococcus granulosus	protein kinase C gamma type	0.0034	0.0103	0.0097
Echinococcus multilocularis	histone deacetylase 6	0.0059	0.04	0.0395
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0119	0.0114
Brugia malayi	bHLH-PAS transcription factor	0.0035	0.011	0.0129
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Echinococcus granulosus	7TM GPCR rhodopsin	0.0036	0.0119	0.0114
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0333	0.3648	0.4482
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0045	0.0228	0.0286
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0036	0.0119	0.0114
Echinococcus granulosus	serine threonine protein kinase nrc	0.0067	0.0487	0.0482
Echinococcus granulosus	histone deacetylase	0.0059	0.04	0.0395
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0034	0.0103	0.0127
Schistosoma mansoni	amine GPCR	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0036	0.0119	0.0232
Brugia malayi	follicle stimulating hormone receptor	0.0036	0.0119	0.014
Schistosoma mansoni	amine GPCR	0.0368	0.4072	0.5224
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0034	0.0103	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	photoreceptor-specific nuclear receptor	0.0045	0.0228	0.0273
Echinococcus granulosus	neuropeptide s receptor	0.0036	0.0119	0.0114
Onchocerca volvulus		0.0036	0.0119	0.0232
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0044	0.0049
Onchocerca volvulus		0.0045	0.0228	0.0455
Schistosoma mansoni	atypical protein kinase C	0.0034	0.0103	0.0125
Entamoeba histolytica	protein kinase, putative	0.0104	0.0935	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	Protein phosphatase 2C containing protein	0.0171	0.1732	0.2124
Loa Loa (eye worm)	histone deacetylase 7A	0.0059	0.04	0.0492
Schistosoma mansoni	protein phosphatase 2C	0.0171	0.1732	0.2218
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0067	0.0487	0.0377
Echinococcus granulosus	jun protein	0.0084	0.0696	0.069
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0119	0.0146
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0119	0.0114
Trichomonas vaginalis	set domain proteins, putative	0.0234	0.2472	1
Onchocerca volvulus		0.0036	0.0119	0.0232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0066	0.0481	0.0972
Schistosoma mansoni	histone deacetylase hda2	0.0059	0.04	0.0507
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0045	0.0228	0.0222
Brugia malayi	Steroid receptor seven-up type 2	0.0045	0.0228	0.0273
Brugia malayi	nuclear receptor NHR-88	0.0045	0.0228	0.0273
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	putative neuropeptide receptor	0.0036	0.0119	0.014
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0045	0.0228	0.0222
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Echinococcus granulosus	histone deacetylase 6	0.0059	0.04	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	neuropeptide F receptor	0.0036	0.0119	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0045	0.0228	0.028
Onchocerca volvulus		0.0234	0.2472	0.5051
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0036	0.0119	0.0114
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Schistosoma mansoni	opsin-like receptor	0.0036	0.0119	0.0146
Schistosoma mansoni	histone deacetylase 4 5	0.0059	0.04	0.0507
Onchocerca volvulus		0.0036	0.0119	0.0232
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0045	0.0228	0.0286
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0079	0.0635	0.058
Plasmodium vivax	rac-beta serine/threonine protein kinase, putative	0.0067	0.0487	1
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	G protein coupled receptor 139	0.0036	0.0119	0.0114
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0119	0.0114
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0045	0.0228	0.0273
Echinococcus granulosus	histone deacetylase 6	0.0059	0.04	0.0395
Schistosoma mansoni	hypothetical protein	0.0068	0.0508	0.0646
Schistosoma mansoni	RAR-like nuclear receptor	0.0045	0.0228	0.0286
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0045	0.0228	0.0286
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0066	0.0479	0.0473
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0036	0.0119	0.0114
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Echinococcus granulosus	Squalene phytoene synthase	0.0079	0.0635	0.063
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0044	0.0049
Echinococcus granulosus	histone deacetylase 6	0.0059	0.04	0.0395
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	dro:myosuppressin receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Entamoeba histolytica	protein kinase, putative	0.01	0.0888	0.9433
Brugia malayi	hypoxia-induced factor 1	0.0146	0.1435	0.1759
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0045	0.0228	0.0273
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0119	0.0146
Echinococcus multilocularis	conserved hypothetical protein	0.0692	0.7928	0.7927
Echinococcus granulosus	ecdysone induced protein 78C	0.0045	0.0228	0.0222
Echinococcus granulosus	g protein coupled receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	neuropeptide Y receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0045	0.0228	0.0286
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0036	0.0119	0.0114
Schistosoma mansoni	histamine h1 receptor	0.0036	0.0119	0.0146
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0044	0.0038
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0119	0.0146
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0036	0.0119	0.0232
Brugia malayi	AKH receptor	0.0036	0.0119	0.014
Brugia malayi	GnHR receptor homolog	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0006	0.0007
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	Glutaredoxin protein 5	0.0066	0.0479	0.0473
Loa Loa (eye worm)	hypothetical protein	0.0333	0.3648	0.4486
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0044	0.0049
Echinococcus multilocularis	ecdysone induced protein 78C	0.0045	0.0228	0.0222
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus granulosus	biogenic amine 5HT receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0006	0.0007
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0036	0.0119	0.0114
Echinococcus granulosus	g-protein coupled receptor	0.0036	0.0119	0.0114
Brugia malayi	putative neuropeptide receptor NPR1	0.0036	0.0119	0.014
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	allatostatin A receptor	0.0036	0.0119	0.0114
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0797	0.9167	0.5
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0034	0.0103	0.0127
Onchocerca volvulus	Bile acid receptor homolog	0.0045	0.0228	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0635	0.0781
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Echinococcus multilocularis	serotonin receptor	0.0158	0.1572	0.1567
Loa Loa (eye worm)	hypothetical protein	0.0437	0.4889	0.6012
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0119	0.0146
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.01	0.0888	0.1092
Schistosoma mansoni	opsin-like receptor	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0036	0.0119	0.0232
Brugia malayi	Nuclear hormone receptor-like 1	0.0045	0.0228	0.0273
Schistosoma mansoni	hypothetical protein	0.0165	0.1654	0.2118
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0034	0.0103	0.0097
Echinococcus granulosus	nervana 2	0.0066	0.0479	0.0473
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0119	0.0146
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0036	0.0119	0.014
Echinococcus multilocularis	neuropeptide receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0036	0.0119	0.0146
Schistosoma mansoni	neuropeptide receptor	0.0036	0.0119	0.0146
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Schistosoma mansoni	hypothetical protein	0.0165	0.1654	0.2118
Schistosoma mansoni	amine GPCR	0.0036	0.0119	0.0146
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0079	0.0635	0.129
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0044	0.0038
Echinococcus granulosus	protein kinase c iota type	0.0034	0.0103	0.0097
Onchocerca volvulus		0.0036	0.0119	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0119	0.0146
Brugia malayi	Pre-SET motif family protein	0.0029	0.0044	0.0047
Brugia malayi	ecdysteroid receptor	0.0045	0.0228	0.0273
Schistosoma mansoni	single-minded	0.0047	0.0256	0.0322
Echinococcus multilocularis	nervana 2	0.0066	0.0479	0.0473
Onchocerca volvulus		0.0036	0.0119	0.0232
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Echinococcus granulosus	sex peptide receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0045	0.0228	0.0286
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1111	0.2263
Echinococcus multilocularis	microtubule associated protein 2	0.0681	0.7788	0.7787
Onchocerca volvulus		0.0437	0.4889	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Schistosoma mansoni	adenoreceptor	0.0036	0.0119	0.0146
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	hypothetical protein	0.005	0.0292	0.0368
Brugia malayi	Dopamine receptor	0.0036	0.0119	0.014
Brugia malayi	hypothetical protein	0.0159	0.1582	0.1939
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0045	0.0228	0.0222
Brugia malayi	hypothetical protein	0.0437	0.4889	0.6009
Schistosoma mansoni	serine/threonine protein kinase	0.0034	0.0103	0.0125
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0036	0.0119	0.0147
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0067	0.0487	0.0482
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Onchocerca volvulus	Protein ultraspiracle homolog	0.0045	0.0228	0.0455
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Schistosoma mansoni	neuropeptide F-like receptor	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0036	0.0119	0.0232
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0036	0.0119	0.0146
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0036	0.0119	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	Squalene phytoene synthase	0.0079	0.0635	0.063
Brugia malayi	Dopamine receptor protein 1	0.0036	0.0119	0.014
Onchocerca volvulus		0.0036	0.0119	0.0232
Echinococcus multilocularis	fmrfamide receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0036	0.0119	0.0146
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0031	0.0025
Brugia malayi	ORL1-like opioid receptor	0.0036	0.0119	0.014
Brugia malayi	p70 ribosomal S6 kinase beta	0.01	0.0888	0.1085
Echinococcus multilocularis	g protein coupled receptor	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0119	0.1111	0.1366
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus granulosus	Protein kinase C brain isozyme	0.0034	0.0103	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0103	0.0127
Onchocerca volvulus		0.0036	0.0119	0.0232
Schistosoma mansoni	serine/threonine-protein kinase	0.0071	0.0535	0.068
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0188	0.0231
Echinococcus granulosus	dro:myosuppressin receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0034	0.0103	0.0097
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.0228	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0668	0.0822
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0045	0.0228	0.028
Brugia malayi	bZIP transcription factor family protein	0.0084	0.0696	0.0849
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0119	0.0114
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0119	0.0114
Echinococcus multilocularis	rac serine:threonine kinase	0.0071	0.0535	0.0529
Trichomonas vaginalis	AGC family protein kinase	0.0104	0.0935	0.3536
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0158	0.1572	0.2013
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0036	0.0119	0.014
Echinococcus granulosus	serotonin receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	neuropeptide receptor A26	0.0036	0.0119	0.0114
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0045	0.0228	0.0222
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Leishmania major	hypothetical protein, conserved	0.0079	0.0635	0.1017
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Schistosoma mansoni	biogenic amine receptor	0.0036	0.0119	0.0146
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0036	0.0119	0.0146
Echinococcus multilocularis	histone deacetylase 6	0.0059	0.04	0.0395
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0044	0.0038
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Echinococcus granulosus	somatostatin receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	neuropeptide f receptor 76f	0.0036	0.0119	0.0146
Trypanosoma brucei	squalene synthase, putative	0.0254	0.2715	1
Schistosoma mansoni	retinoic acid receptor RXR	0.0045	0.0228	0.0286
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0066	0.0479	0.0473
Echinococcus granulosus	biogenic amine 5HT receptor	0.0158	0.1572	0.1567
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0036	0.0119	0.0114
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0036	0.0119	0.0147
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0045	0.0228	0.0222
Echinococcus multilocularis	jun protein	0.0084	0.0696	0.069
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0036	0.0119	0.0146
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.0228	0.0222
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Schistosoma mansoni	thyroid hormone receptor	0.0045	0.0228	0.0286
Echinococcus granulosus	FTZ F1 alpha	0.0045	0.0228	0.0222
Entamoeba histolytica	protein kinase, putative	0.0104	0.0935	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Echinococcus granulosus	neuropeptides capa receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	survival motor neuron protein 1	0.071	0.8133	0.8132
Loa Loa (eye worm)	steroid hormone receptor	0.0045	0.0228	0.028
Schistosoma mansoni	aryl hydrocarbon receptor	0.0047	0.0256	0.0322
Schistosoma mansoni	protein phosphatase 2C	0.015	0.1474	0.1887
Echinococcus multilocularis	neuropeptides capa receptor	0.0036	0.0119	0.0114
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0228	0.0273
Brugia malayi	G protein-coupled receptor F59B2.13	0.0036	0.0119	0.014
Trichomonas vaginalis	AGC family protein kinase	0.0034	0.0103	0.0037
Echinococcus granulosus	serine/threonine protein kinase	0.0071	0.0535	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0437	0.4889	0.6012
Echinococcus granulosus	fmrfamide receptor	0.0036	0.0119	0.0114
Brugia malayi	Histone deacetylase family protein	0.0059	0.04	0.0485
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.0228	0.0286
Echinococcus multilocularis	G protein coupled receptor 139	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Trypanosoma cruzi	phytoene synthase, putative	0.0079	0.0635	0.1017
Giardia lamblia	Kinase, AGC PKA	0.0067	0.0487	0.5
Echinococcus multilocularis	nervana 2	0.0066	0.0479	0.0473
Echinococcus granulosus	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0034	0.0103	0.0097
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0205	0.2135	0.2625
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0036	0.0119	0.0147
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0036	0.0119	0.0146
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0045	0.0228	0.0455
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0119	0.0114
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0036	0.0119	0.0114
Echinococcus multilocularis	histone deacetylase 6	0.0059	0.04	0.0395
Onchocerca volvulus		0.0036	0.0119	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0867	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0045	0.0228	0.028
Echinococcus granulosus	nervana 2	0.0066	0.0479	0.0473
Schistosoma mansoni	hypothetical protein	0.0036	0.0119	0.0146
Onchocerca volvulus		0.0036	0.0119	0.0232
Brugia malayi	G protein-coupled receptor	0.0036	0.0119	0.014
Echinococcus multilocularis	neuropeptide receptor A26	0.0036	0.0119	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0036	0.0119	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0038	0.015	0.0235
Brugia malayi	nuclear hormone receptor	0.0045	0.0228	0.0273
Trypanosoma cruzi	squalene synthase, putative	0.0254	0.2715	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0036	0.0119	0.0114
Brugia malayi	larval opioid receptor	0.0036	0.0119	0.014
Echinococcus granulosus	NDR protein kinase	0.0034	0.0103	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0103	0.012
Brugia malayi	hypothetical protein	0.0066	0.0481	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Echinococcus granulosus	protein phosphatase 1b	0.0171	0.1732	0.1727
Echinococcus multilocularis	transfer RNA-Lys	0.0035	0.011	0.0105
Plasmodium falciparum	RAC-beta serine/threonine protein kinase	0.0067	0.0487	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0036	0.0119	0.0114
Schistosoma mansoni	histone deacetylase 4 5	0.0059	0.04	0.0507
Brugia malayi	RE15519p	0.0036	0.0119	0.014
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0104	0.0935	0.115
Brugia malayi	Serotonin receptor	0.0036	0.0119	0.014
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0228	0.028
Loa Loa (eye worm)	histone deacetylase	0.0059	0.04	0.0492
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.0084	0.0696	0.069
Echinococcus multilocularis	sex peptide receptor	0.0036	0.0119	0.0114
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.0084	0.0696	0.069
Onchocerca volvulus	Huntingtin homolog	0.0119	0.1111	0.2263
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0045	0.0228	0.0222
Echinococcus multilocularis	neuropeptide Y receptor	0.0036	0.0119	0.0114
Schistosoma mansoni	growth hormone secretagogue receptor	0.0036	0.0119	0.0146
Brugia malayi	hypothetical protein	0.0036	0.0119	0.014
Trypanosoma cruzi	Protein kinase B	0.0071	0.0535	0.0581
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0045	0.0228	0.0273
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0034	0.0103	0.0097
Brugia malayi	Protein kinase domain containing protein	0.0034	0.0103	0.012
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0045	0.0228	0.0273
Mycobacterium ulcerans	proteasome PrcA	0.0797	0.9167	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0036	0.0119	0.0146
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0034	0.0103	0.0097
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0333	0.3648	0.468
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0034	0.0103	0.0097
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0045	0.0228	0.0222
Brugia malayi	Hr1 repeat family protein	0.0034	0.0103	0.012
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0104	0.0935	0.231
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0045	0.0228	0.0222
Schistosoma mansoni	microtubule-associated protein tau	0.0681	0.7788	1
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0119	0.0147
Brugia malayi	Serotonin receptor	0.0497	0.5609	0.6894
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0045	0.0228	0.028
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0045	0.0228	0.0286
Brugia malayi	hypothetical protein	0.071	0.8133	1
Brugia malayi	Protein kinase domain containing protein	0.0104	0.0935	0.1143
Echinococcus granulosus	protein phosphatase 1b	0.015	0.1474	0.1469
Schistosoma mansoni	serine/threonine-protein kinase	0.0071	0.0535	0.068
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0036	0.0119	0.0114
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0045	0.0228	0.0222
Echinococcus granulosus	neuropeptide receptor	0.0036	0.0119	0.0114

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 60 %	Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM	ChEMBL.	1316967
Inhibition (binding)	= 60 %	Inhibition of [3H]-LTB4 binding to leukotriene B4 receptor from human peripheral neutrophils (PMN), at a concentration of 1 microM	ChEMBL.	1316967
Inhibition (binding)	= 98 %	Inhibition of binding of [3H]-LTB4 to the leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 10 uM.	ChEMBL.	1316967
Inhibition (binding)	= 98 %	Inhibition of binding of [3H]-LTB4 to the leukotriene B4 receptor of human peripheral neutrophils(PMN) at a concentration of 10 uM.	ChEMBL.	1316967

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL54623

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 79665