Detailed information for compound 796871

Basic information

Technical information
  • TDR Targets ID: 796871
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-5-methyl -2-(4-methylsulfanylphenyl)imidazo[3,2-a]pyri din-3-amine
  • MW: 403.497 | Formula: C23H21N3O2S
  • H donors: 1 H acceptors: 1 LogP: 5.93 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CSc1ccc(cc1)c1nc2n(c1Nc1ccc3c(c1)OCCO3)c(C)ccc2
  • InChi: 1S/C23H21N3O2S/c1-15-4-3-5-21-25-22(16-6-9-18(29-2)10-7-16)23(26(15)21)24-17-8-11-19-20(14-17)28-13-12-27-19/h3-11,14,24H,12-13H2,1-2H3
  • InChiKey: LACDNOLTCAAUQK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-5-methyl-2-[4-(methylthio)phenyl]-3-imidazo[3,2-a]pyridinamine
  • 2,3-dihydro-1,4-benzodioxin-7-yl-[5-methyl-2-[4-(methylthio)phenyl]imidazo[3,2-a]pyridin-3-yl]amine
  • STK228219
  • ZINC04733669

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0418 0.04
Brugia malayi hypothetical protein 0.0015 0.03 0.0263
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0065 0.257 0.2803
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Leishmania major hypothetical protein, conserved 0.0017 0.0418 0.0153
Echinococcus multilocularis glutamate receptor 2 0.0015 0.03 0.037
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0015 0.03 0.037
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0418 1
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0065 0.257 0.8554
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0418 0.0517
Echinococcus granulosus thioredoxin glutathione reductase 0.0188 0.8095 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.097 0.1199
Echinococcus granulosus nmda type glutamate receptor 0.0015 0.03 0.037
Echinococcus granulosus atrial natriuretic peptide receptor 0.0015 0.03 0.037
Echinococcus granulosus nmda type glutamate receptor 0.0102 0.4219 0.5212
Chlamydia trachomatis glutamine binding protein 0.0073 0.2934 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0048 0.1793 0.1984
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0418 0.0517
Onchocerca volvulus 0.003 0.097 0.0691
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Brugia malayi Pre-SET motif family protein 0.0203 0.8746 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2404 0.297
Brugia malayi CXXC zinc finger family protein 0.0028 0.0894 0.0948
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0418 0.0153
Schistosoma mansoni hypothetical protein 0.0181 0.7763 0.9591
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0926 0.1144
Echinococcus multilocularis geminin 0.0181 0.7763 0.9591
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0926 0.1144
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0043 0.1584 0.1957
Schistosoma mansoni tyrosine kinase 0.0015 0.03 0.037
Echinococcus multilocularis nmda type glutamate receptor 0.0015 0.03 0.037
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0418 0.0153
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0043 0.1584 0.1957
Brugia malayi glutamate synthase 0.0017 0.0418 0.04
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0015 0.03 0.0257
Echinococcus granulosus glutamate receptor 2 0.0043 0.1584 0.1957
Schistosoma mansoni protein kinase 0.0015 0.03 0.037
Echinococcus granulosus glutamate receptor subunit protein glur 0.0029 0.0926 0.1144
Trichomonas vaginalis set domain proteins, putative 0.0231 1 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0418 0.0517
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0926 0.1144
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0926 0.1144
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0065 0.257 0.3175
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.8746 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0029 0.0926 0.1144
Schistosoma mansoni glutamate receptor NMDA 0.0043 0.1584 0.1957
Echinococcus multilocularis receptor type guanylyl cyclase 0.0015 0.03 0.037
Brugia malayi RNA binding protein 0.0062 0.2404 0.2689
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0065 0.257 0.3175
Loa Loa (eye worm) glutathione reductase 0.0188 0.8095 0.9249
Brugia malayi Thioredoxin reductase 0.0188 0.8095 0.9249
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0418 0.0517
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.03 0.0257
Loa Loa (eye worm) glutamate receptor 2 0.0029 0.0926 0.098
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2404 0.2689
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Onchocerca volvulus 0.0017 0.0418 0.0123
Echinococcus granulosus metabotropic glutamate receptor 2 0.0015 0.03 0.037
Schistosoma mansoni cpg binding protein 0.0029 0.0965 0.1192
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0418 0.0517
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0076 0.0094
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0894 0.0943
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.257 0.2803
Loa Loa (eye worm) hypothetical protein 0.003 0.097 0.1031
Schistosoma mansoni hypothetical protein 0.0181 0.7763 0.9591
Echinococcus multilocularis glutamate synthase 0.0017 0.0418 0.0517
Plasmodium vivax glutathione reductase, putative 0.0188 0.8095 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0015 0.03 0.0263
Echinococcus granulosus tyrosine kinase 0.0015 0.03 0.037
Brugia malayi Guanylyl cyclase protein 23 0.0015 0.03 0.0263
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0418 0.0153
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.097 0.1199
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2404 0.297
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0065 0.257 0.2913
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.03 0.0263
Echinococcus multilocularis thioredoxin glutathione reductase 0.0188 0.8095 1
Brugia malayi metabotropic glutamate receptor type 2 0.0015 0.03 0.0263
Echinococcus granulosus cpg binding protein 0.0029 0.0965 0.1192
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0029 0.0926 0.1144
Plasmodium falciparum glutathione reductase 0.0065 0.257 0.2803
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0418 0.0517
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0418 0.0517
Loa Loa (eye worm) RNA binding protein 0.0062 0.2404 0.2685
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0017 0.0418 0.0153
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0926 0.1144
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.03 0.0257
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0065 0.257 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0065 0.257 0.3175
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0418 0.0153
Trypanosoma cruzi NADH dehydrogenase, putative 0.0017 0.0418 0.0153
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.1584 0.1957
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0073 0.2934 1
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.03 0.037
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0015 0.03 0.037
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0926 0.1144
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0418 0.0517
Loa Loa (eye worm) hypothetical protein 0.0017 0.0418 0.0395
Plasmodium falciparum glutathione reductase 0.0188 0.8095 1
Schistosoma mansoni glutamate synthase 0.0017 0.0418 0.0517
Mycobacterium tuberculosis Probable oxidoreductase 0.0065 0.257 0.2803
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2404 0.297
Schistosoma mansoni glutamate synthase 0.0017 0.0418 0.0517
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.097 0.1199
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2404 0.2685
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2404 0.297
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.097 0.1199
Plasmodium falciparum thioredoxin reductase 0.0065 0.257 0.2803
Brugia malayi Pre-SET motif family protein 0.003 0.097 0.1036
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.1584 0.1957
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0065 0.257 0.8554
Schistosoma mansoni glutamate synthase 0.0017 0.0418 0.0517
Loa Loa (eye worm) glutamate receptor 1 0.0029 0.0926 0.098
Entamoeba histolytica thioredoxin reductase, putative 0.0017 0.0418 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Schistosoma mansoni metabotropic glutamate receptor 0.0015 0.03 0.037
Echinococcus granulosus metabotropic glutamate receptor 5 0.0015 0.03 0.037
Toxoplasma gondii thioredoxin reductase 0.0188 0.8095 1
Plasmodium falciparum thioredoxin reductase 0.0188 0.8095 1
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0017 0.0418 1
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.257 0.2913
Echinococcus granulosus receptor type guanylyl cyclase 0.0015 0.03 0.037
Loa Loa (eye worm) RGC/RGC protein kinase 0.0015 0.03 0.0257
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0043 0.1584 0.1957
Echinococcus granulosus geminin 0.0181 0.7763 0.9591
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2404 0.297
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0065 0.257 0.2803
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0418 0.0517
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0418 0.0517
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0029 0.0926 0.1144
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2404 0.2685
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0418 0.0517
Schistosoma mansoni cpg binding protein 0.0028 0.0894 0.1104
Leishmania major NADH dehydrogenase, putative 0.0017 0.0418 0.0153
Trichomonas vaginalis glutathione reductase, putative 0.0065 0.257 0.2246
Echinococcus multilocularis NMDA receptor 0.0029 0.0926 0.1144
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0188 0.8095 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0073 0.2934 1
Echinococcus multilocularis tyrosine kinase 0.0015 0.03 0.037
Leishmania major hypothetical protein, conserved 0.0017 0.0418 0.0153
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.257 0.2913
Echinococcus granulosus glutamate NMDA receptor subunit 0.0029 0.0926 0.1144
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0073 0.2934 1
Brugia malayi Receptor family ligand binding region containing protein 0.0015 0.03 0.0263
Trypanosoma cruzi trypanothione reductase, putative 0.0188 0.8095 1
Schistosoma mansoni ATP-binding cassette transporter 0.0029 0.0926 0.1144
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.2346 0.2898
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0065 0.257 0.8554
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0065 0.257 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0073 0.2934 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.097 0.1199
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.257 1
Brugia malayi glutathione reductase 0.0188 0.8095 0.9249
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0015 0.03 0.0257
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0029 0.0926 0.1144
Echinococcus granulosus tar DNA binding protein 0.0062 0.2404 0.297
Schistosoma mansoni hypothetical protein 0.0017 0.0418 0.0517
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0065 0.257 0.2881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.097 0.1199
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0048 0.1793 0.1984
Brugia malayi Glutamate receptor 2 precursor 0.0029 0.0926 0.0985
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.097 0.1199
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0926 0.1144
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0065 0.257 0.2803
Echinococcus multilocularis cpg binding protein 0.0029 0.0965 0.1192
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.257 0.2913
Leishmania major hypothetical protein, conserved 0.0017 0.0418 0.0153
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0017 0.0418 1
Schistosoma mansoni tyrosine kinase 0.0015 0.03 0.037
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0015 0.03 0.0263
Echinococcus granulosus glutamate receptor 2 0.0015 0.03 0.037
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.1584 0.1957
Schistosoma mansoni cpg binding protein 0.0029 0.0965 0.1192
Brugia malayi TAR-binding protein 0.0062 0.2404 0.2689
Treponema pallidum NADH oxidase 0.0065 0.257 0.8554
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0065 0.257 0.2803
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0015 0.03 0.0257
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0029 0.0926 0.1144
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2404 0.297
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0418 0.0153
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.097 0.0719
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0029 0.0926 0.1144
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0073 0.2934 0.3277
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.2062 0.2141
Entamoeba histolytica disulphide oxidoreductase, putative 0.0017 0.0418 1
Echinococcus multilocularis nmda type glutamate receptor 0.0102 0.4219 0.5212
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.1584 0.1957
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0065 0.257 0.2803
Echinococcus multilocularis glutamate receptor 2 0.0043 0.1584 0.1957
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0065 0.257 0.2803
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0017 0.0418 0.0153
Onchocerca volvulus 0.0028 0.0894 0.0612
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0065 0.257 0.2913
Plasmodium vivax SET domain protein, putative 0.003 0.097 0.0719
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0418 0.0517
Loa Loa (eye worm) hypothetical protein 0.0015 0.03 0.0257
Brugia malayi Glutamate receptor 1 precursor 0.0029 0.0926 0.0985
Trypanosoma brucei trypanothione reductase 0.0188 0.8095 1
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0418 0.0395
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Giardia lamblia NADH oxidase lateral transfer candidate 0.0065 0.257 1
Loa Loa (eye worm) thioredoxin reductase 0.0188 0.8095 0.9249
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0418 0.04
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0418 0.0517
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0015 0.03 0.037
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0418 0.04
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0017 0.0418 1
Leishmania major trypanothione reductase 0.0188 0.8095 1
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0418 0.0517
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0017 0.0418 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0065 0.257 0.2803
Toxoplasma gondii NADPH-glutathione reductase 0.0065 0.257 0.2803
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0029 0.0926 0.1144
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0102 0.4219 0.5212
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0065 0.257 0.2803
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0017 0.0418 0.0153
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0065 0.257 0.2803
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0418 0.0517
Echinococcus granulosus glutamate synthase 0.0017 0.0418 0.0517
Plasmodium vivax thioredoxin reductase, putative 0.0188 0.8095 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0065 0.257 0.8554
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0017 0.0418 0.0153
Schistosoma mansoni hypothetical protein 0.0029 0.0926 0.1144
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0043 0.1584 0.1957
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.257 0.2803
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.257 1
Loa Loa (eye worm) glutamate receptor 0.0015 0.03 0.0257
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0895 0.1106
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0076 0.0094
Trichomonas vaginalis mercuric reductase, putative 0.0065 0.257 0.2246
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0017 0.0418 0.0153
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.257 0.2913
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0418 0.0395

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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