Detailed information for compound 79691

Basic information

Technical information
  • TDR Targets ID: 79691
  • Name: 4-phenyl-2-(3-pyridin-3-ylpropyl)-1,3,4,5-tet rahydropyrido[4,3-b]indole
  • MW: 367.486 | Formula: C25H25N3
  • H donors: 1 H acceptors: 1 LogP: 4.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)C1CN(CCCc2cccnc2)Cc2c1[nH]c1c2cccc1
  • InChi: 1S/C25H25N3/c1-2-10-20(11-3-1)22-17-28(15-7-9-19-8-6-14-26-16-19)18-23-21-12-4-5-13-24(21)27-25(22)23/h1-6,8,10-14,16,22,27H,7,9,15,17-18H2
  • InChiKey: JULFDEFXVAZHOF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-phenyl-2-[3-(3-pyridyl)propyl]-1,3,4,5-tetrahydropyrido[4,3-b]indole
  • 4-phenyl-2-(3-pyridin-3-ylpropyl)-1,3,4,5-tetrahydropyrido[4,5-b]indole
  • 4-phenyl-2-[3-(3-pyridyl)propyl]-1,3,4,5-tetrahydropyrido[4,5-b]indole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) serotonin transporter b 0.0192 0.1945 0.3885
Trypanosoma cruzi DNA topoisomerase II, putative 0.0163 0.1627 0.6415
Schistosoma mansoni hypothetical protein 0.0054 0.0438 0.0474
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0153
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0221 0.227 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Schistosoma mansoni hypothetical protein 0.0016 0.0026 0.0028
Brugia malayi steroid hormone receptor 0.0102 0.0966 0.1806
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0032 0.0034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0966 0.1806
Schistosoma mansoni glucose transport protein 0.0101 0.0961 0.104
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0018 0.0046 0.005
Plasmodium falciparum DNA gyrase subunit B 0.0221 0.227 1
Brugia malayi Protein kinase domain containing protein 0.0029 0.0174 0.0299
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0018 0.0046 0.0098
Brugia malayi follicle stimulating hormone receptor 0.0472 0.5007 0.9492
Echinococcus multilocularis cpg binding protein 0.0034 0.0228 0.0246
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0474 0.1806
Onchocerca volvulus 0.0168 0.169 0.6325
Echinococcus granulosus Ankyrin 0.003 0.0176 0.0191
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Mycobacterium tuberculosis Probable hydrolase 0.0146 0.1442 0.1423
Echinococcus granulosus tyrosine kinase 0.0036 0.0246 0.0266
Echinococcus multilocularis tyrosine protein kinase Fgr 0.004 0.0288 0.0311
Brugia malayi PXA domain containing protein 0.002 0.007 0.0103
Brugia malayi Ets-domain containing protein 0.0075 0.0672 0.1247
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Echinococcus granulosus transcription factor Dp 1 0.008 0.0727 0.0787
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.1205 0.1304
Echinococcus multilocularis axis inhibition protein axin 0.002 0.007 0.0076
Brugia malayi PXA domain containing protein 0.002 0.007 0.0103
Mycobacterium tuberculosis Conserved protein 0.0146 0.1442 0.1423
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0213 0.023
Entamoeba histolytica hypothetical protein 0.002 0.007 0.027
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0146 0.1442 0.1423
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0201 0.0179
Loa Loa (eye worm) hypothetical protein 0.0159 0.1591 0.3178
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0066 0.0574 0.0621
Brugia malayi orphan nuclear receptor NR2E1 0.0048 0.0378 0.0689
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0102 0.0966 0.1929
Trypanosoma cruzi ISWI complex protein 0.0016 0.0026 0.0017
Echinococcus granulosus cathepsin l1 0.0016 0.0032 0.0034
Schistosoma mansoni sodium/chloride dependent transporter 0.0033 0.0209 0.0226
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0054 0.0441 0.0477
Brugia malayi nuclear receptor NHR-88 0.0048 0.0378 0.0689
Schistosoma mansoni DNA polymerase eta 0.0015 0.0022 0.0024
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0157 0.0268
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0032 0.0064
Entamoeba histolytica hypothetical protein 0.0035 0.0237 0.1195
Echinococcus multilocularis tyrosine protein kinase Blk 0.0036 0.0246 0.0266
Loa Loa (eye worm) hypothetical protein 0.004 0.0286 0.0571
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0153
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0378 0.1321
Echinococcus granulosus neuroglian 0.0014 0.0009 0.001
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.022 0.2259 0.2445
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.004 0.0288 0.0311
Loa Loa (eye worm) hypothetical protein 0.0053 0.0432 0.0863
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0102 0.0966 0.3563
Echinococcus multilocularis nervana 2 0.022 0.2259 0.2445
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0099
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0032 0.0041
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0989
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0048 0.0378 0.0409
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0273 0.1018
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0102 0.0966 0.1046
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Entamoeba histolytica hypothetical protein 0.0025 0.0125 0.0575
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1205 0.1305
Entamoeba histolytica DNA topoisomerase III, putative 0.0018 0.0046 0.0137
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0018 0.0046 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0102 0.0966 0.1806
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.007 0.0076
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.007 0.0076
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0046 0.0049
Giardia lamblia Histone acetyltransferase GCN5 0.008 0.0724 0.4126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0048 0.0378 0.0409
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0533 0.2042
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0966 0.1806
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0273 0.0919
Brugia malayi acetyltransferase, GNAT family protein 0.0298 0.3109 0.5883
Leishmania major cathepsin L-like protease 0.0062 0.0533 0.2042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0102 0.0966 0.1929
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0146 0.1442 0.288
Schistosoma mansoni hypothetical protein 0.0101 0.0961 0.104
Entamoeba histolytica hypothetical protein 0.002 0.007 0.027
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0102 0.0966 0.1046
Trypanosoma brucei DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0213 0.023
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0088 0.0819 0.1527
Toxoplasma gondii hypothetical protein 0.0033 0.0209 0.0989
Echinococcus granulosus dna polymerase kappa 0.0044 0.033 0.0358
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Loa Loa (eye worm) hypoxia-induced factor 1 0.0147 0.1456 0.2909
Mycobacterium leprae conserved hypothetical protein 0.0146 0.1442 1
Brugia malayi conserved hypotetical protein 0.0048 0.0378 0.0689
Echinococcus granulosus expressed protein 0.0386 0.407 0.4407
Schistosoma mansoni zinc finger protein 0.0029 0.0172 0.0186
Echinococcus granulosus lamin 0.0028 0.0157 0.017
Brugia malayi Fli-1 protein 0.0228 0.2337 0.4415
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Brugia malayi hypothetical protein 0.0064 0.0556 0.1026
Echinococcus multilocularis zinc finger protein 0.0029 0.0172 0.0186
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0018 0.0046 0.005
Loa Loa (eye worm) hypothetical protein 0.0082 0.0752 0.1502
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0086 0.0172
Echinococcus multilocularis sodium and chloride dependent glycine 0.0033 0.0209 0.0226
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0075 0.0672 0.1342
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0046 0.0049
Brugia malayi nuclear receptor NHR-88 0.0102 0.0966 0.1806
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0163 0.1627 0.6415
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0201 0.0217
Echinococcus multilocularis 0.0022 0.0095 0.0102
Onchocerca volvulus 0.0088 0.0819 0.3002
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0533 0.2042
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0032 0.0064
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0018 0.0046 0.0055
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Echinococcus multilocularis axis inhibition protein axin 0.002 0.007 0.0076
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0624 0.0675
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0018 0.0046 0.0098
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.0881
Loa Loa (eye worm) cysteine protease 0.0016 0.0032 0.0064
Echinococcus granulosus zinc finger protein 0.0029 0.0172 0.0186
Mycobacterium leprae Probable lipase LipE 0.0146 0.1442 1
Brugia malayi Bromodomain containing protein 0.0047 0.0364 0.0661
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0146 0.1442 0.1423
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0201 0.0217
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0624 0.0675
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0024 0.0119 0.0326
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0022 0.0095 0.0102
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0138 0.1363 0.536
Toxoplasma gondii hypothetical protein 0.0033 0.0209 0.0989
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0033 0.0209 0.0226
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0098
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Brugia malayi photoreceptor-specific nuclear receptor 0.0102 0.0966 0.1806
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0221 0.227 1
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Schistosoma mansoni nuclear receptor 0.0048 0.0378 0.041
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0015 0.0022 0.0043
Brugia malayi beta-lactamase 0.0146 0.1442 0.2711
Mycobacterium ulcerans beta-lactamase 0.0146 0.1442 0.4318
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Echinococcus multilocularis roundabout 2 0.0018 0.005 0.0053
Onchocerca volvulus Bile acid receptor homolog 0.0102 0.0966 0.3563
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.007 0.0103
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.007 0.0103
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0018 0.0046 0.0055
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0378 0.0689
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0102 0.0966 0.1046
Loa Loa (eye worm) acetyltransferase 0.0298 0.3109 0.6211
Echinococcus multilocularis nuclear factor of activated T cells 5 0.015 0.1493 0.1616
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0366
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0054 0.0441 0.0477
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.1442 0.1561
Loa Loa (eye worm) hypothetical protein 0.003 0.0176 0.0352
Brugia malayi nuclear receptor RXR 0.0054 0.0441 0.0808
Onchocerca volvulus 0.0028 0.0157 0.0478
Echinococcus granulosus nervana 2 0.022 0.2259 0.2445
Schistosoma mansoni cpg binding protein 0.0034 0.0228 0.0246
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0102 0.0966 0.1806
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0533 0.2042
Onchocerca volvulus 0.0135 0.1332 0.4959
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Plasmodium vivax hexose transporter 0.0101 0.0961 0.415
Chlamydia trachomatis DNA gyrase subunit A 0.0032 0.0203 0.0703
Echinococcus granulosus FTZ F1 alpha 0.0102 0.0966 0.1046
Echinococcus multilocularis neuroglian 0.0014 0.0009 0.001
Schistosoma mansoni coup transcription factor 0.0102 0.0966 0.1046
Schistosoma mansoni regulator of G protein signaling 0.002 0.007 0.0076
Echinococcus granulosus axis inhibition protein axin 0.002 0.007 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0098
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0033 0.0209 0.0226
Trichomonas vaginalis set domain proteins, putative 0.0256 0.2651 1
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.007 0.014
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0201 0.0351
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0221 0.227 0.2253
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0102 0.0966 0.1046
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0138 0.1363 0.2562
Echinococcus granulosus hypothetical protein 0.074 0.7926 0.8581
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0258 0.0279
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Entamoeba histolytica acetyltransferase, GNAT family 0.008 0.0724 0.3906
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0966 0.1046
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Onchocerca volvulus 0.0018 0.0046 0.0055
Loa Loa (eye worm) hypothetical protein 0.0101 0.0952 0.1901
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.022 0.2259 0.2445
Leishmania major hypothetical protein, conserved 0.0016 0.0026 0.0017
Mycobacterium ulcerans oxidoreductase 0.0022 0.0095 0.015
Toxoplasma gondii exonuclease III APE 0.0038 0.0273 0.1346
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0033 0.0209 0.0226
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1442 0.5384
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0041
Echinococcus granulosus sodium and chloride dependent glycine 0.0033 0.0209 0.0226
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.0125 0.0522
Echinococcus granulosus cpg binding protein 0.0034 0.0228 0.0246
Echinococcus granulosus General substrate transporter 0.0091 0.0852 0.0922
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0033 0.0209 0.0226
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0201 0.0944
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0101 0.0961 0.104
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0417
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.0132 0.0263
Loa Loa (eye worm) hypothetical protein 0.022 0.2259 0.4512
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0054 0.0441 0.0478
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0748 0.0809
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0095 0.0281
Onchocerca volvulus 0.0031 0.0187 0.0592
Brugia malayi protein-tyrosine kinase 0.0036 0.0246 0.0436
Schistosoma mansoni sodium-dependent amino acid transporter 0.0033 0.0209 0.0226
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0022 0.0095 0.015
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0201 0.0217
Echinococcus granulosus geminin 0.086 0.9237 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Brugia malayi hypothetical protein 0.0035 0.0237 0.0419
Onchocerca volvulus 0.0257 0.2653 1
Giardia lamblia DINP protein human, muc B family 0.0022 0.0098 0.0317
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Echinococcus granulosus histone acetyltransferase KAT2B 0.0089 0.083 0.0898
Mycobacterium ulcerans monoamine oxidase 0.0022 0.0095 0.015
Echinococcus multilocularis nervana 2 0.022 0.2259 0.2445
Brugia malayi SRC-1 0.004 0.0288 0.0516
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0127 0.0137
Echinococcus multilocularis lamin dm0 0.0028 0.0157 0.017
Mycobacterium ulcerans DNA gyrase subunit A 0.0032 0.0203 0.0484
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0237 0.0256
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0132 0.1294 0.4814
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Brugia malayi amine oxidase, flavin-containing family protein 0.0022 0.0095 0.0149
Brugia malayi CXXC zinc finger family protein 0.0031 0.0187 0.0325
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0032 0.0057
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0273 0.1076
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.004 0.0288 0.0311
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0157 0.0314
Loa Loa (eye worm) hypothetical protein 0.0048 0.038 0.0759
Schistosoma mansoni intermediate filament proteins 0.0028 0.0157 0.017
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0138 0.1363 0.2723
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0102 0.0966 0.1806
Loa Loa (eye worm) hypothetical protein 0.0018 0.005 0.0099
Echinococcus granulosus nervana 2 0.0135 0.1332 0.1442
Schistosoma mansoni amine oxidase 0.0022 0.0095 0.0103
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Brugia malayi Nuclear hormone receptor-like 1 0.0102 0.0966 0.1806
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0225 0.2312 0.4618
Mycobacterium tuberculosis Probable esterase LipL 0.0146 0.1442 0.1423
Echinococcus granulosus histone lysine methyltransferase setb 0.005 0.0405 0.0438
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0245 0.2525 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0378 0.0409
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0015 0.0022 0.0024
Onchocerca volvulus 0.0028 0.0157 0.0478
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0273 0.0488
Brugia malayi hypothetical protein 0.0159 0.1591 0.2995
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Schistosoma mansoni serine/threonine protein kinase 0.002 0.007 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0102 0.0966 0.1806
Onchocerca volvulus 0.0048 0.038 0.1328
Leishmania major DNA topoisomerase 1A 0.0018 0.0046 0.0098
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0273 0.07
Echinococcus granulosus tyrosine protein kinase Lyn 0.004 0.0288 0.0311
Trypanosoma brucei DNA polymerase IV, putative 0.0037 0.0254 0.0927
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0273 0.1076
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.022 0.2259 0.2445
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Echinococcus granulosus roundabout 2 0.0018 0.005 0.0053
Echinococcus multilocularis tyrosine protein kinase Src64B 0.004 0.0288 0.0311
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0314 0.3278 1
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0237 0.059
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0378 0.0409
Leishmania major cathepsin L-like protease 0.0062 0.0533 0.2042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0146 0.1442 0.1561
Echinococcus multilocularis cysteine protease 0.0016 0.0032 0.0034
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Loa Loa (eye worm) hypothetical protein 0.0049 0.0391 0.0782
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0989
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0022 0.0095 0.0281
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1205 0.3585
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0201 0.0715
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0029 0.0174 0.0188
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0157 0.0314
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.007 0.014
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0135 0.1332 0.1442
Echinococcus multilocularis nuclear receptor nhr 48 0.0048 0.0378 0.0409
Echinococcus granulosus dna polymerase eta 0.0015 0.0022 0.0023
Loa Loa (eye worm) TK protein kinase 0.0036 0.0246 0.049
Schistosoma mansoni cpg binding protein 0.0034 0.0228 0.0246
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0138 0.1363 0.1476
Entamoeba histolytica hypothetical protein 0.0035 0.0237 0.1195
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0237 0.0256
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0441 0.0808
Toxoplasma gondii facilitative glucose transporter GT1 0.0101 0.0961 0.5194
Echinococcus multilocularis lamin 0.0028 0.0157 0.017
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.022 0.2259 0.2445
Brugia malayi hypothetical protein 0.0022 0.0095 0.0149
Brugia malayi Nuclear hormone receptor-like 1 0.0054 0.0441 0.0808
Echinococcus granulosus sodium and chloride dependent glycine 0.0033 0.0209 0.0226
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0032 0.0034
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0032 0.0041
Leishmania major cathepsin L-like protease 0.0062 0.0533 0.2042
Echinococcus multilocularis sodium and chloride dependent glycine 0.0033 0.0209 0.0226
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0116 0.0232
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0125 0.0244
Brugia malayi ecdysteroid receptor 0.0102 0.0966 0.1806
Mycobacterium tuberculosis Possible oxidoreductase 0.0022 0.0095 0.0073
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0273 0.1396
Echinococcus granulosus nervana 2 0.022 0.2259 0.2445
Brugia malayi nuclear receptor RXR 0.0048 0.0378 0.0689
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0125 0.0417
Echinococcus multilocularis cysteine protease 0.0016 0.0032 0.0034
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0472 0.5007 1
Brugia malayi Ets-domain containing protein 0.0075 0.0672 0.1247
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0273 0.1003
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.1205 0.6561
Schistosoma mansoni serine/threonine protein kinase 0.002 0.007 0.0076
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0022 0.0095 0.0103
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Loa Loa (eye worm) DNA topoisomerase III 0.0018 0.0046 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.033 0.1233
Schistosoma mansoni regulator of G protein signaling 0.002 0.007 0.0076
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.033 0.114
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0748 0.0809
Echinococcus multilocularis nervana 2 0.0135 0.1332 0.1442
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0036 0.0246 0.0266
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.0125 0.0413
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0233 0.0252
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0258 0.0279
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0018 0.0046 0.005
Schistosoma mansoni transmemberane protein 0.022 0.2259 0.2445
Brugia malayi Bromodomain containing protein 0.0086 0.0796 0.1483
Brugia malayi intermediate filament protein 0.0028 0.0157 0.0268
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.007 0.0076
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0024 0.0115 0.0466
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0273 0.0251
Chlamydia trachomatis protoporphyrinogen oxidase 0.0022 0.0095 0.0218
Onchocerca volvulus 0.0033 0.0213 0.0689
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0033 0.0209 0.073
Mycobacterium ulcerans lipase LipD 0.0146 0.1442 0.4318
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Echinococcus multilocularis netrin receptor unc 5 0.0033 0.0214 0.0231
Brugia malayi ecdysone receptor 0.0048 0.0378 0.0689
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0314 0.3278 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0102 0.0966 0.1046
Echinococcus granulosus lamin dm0 0.0028 0.0157 0.017
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0032 0.0203 0.0703
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0041
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0022 0.0095 0.0348
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0966 0.1046
Schistosoma mansoni regulator of G protein signaling 0.002 0.007 0.0076
Trichomonas vaginalis bromodomain-containing protein, putative 0.0089 0.083 0.3047
Brugia malayi hypoxia-induced factor 1 0.0147 0.1456 0.2739
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Mycobacterium tuberculosis Conserved protein 0.0146 0.1442 0.1423
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0273 0.1378
Brugia malayi GRF zinc finger family protein 0.0018 0.0046 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.007 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0102 0.0966 0.1806
Brugia malayi Pre-SET motif family protein 0.0033 0.0213 0.0373
Schistosoma mansoni regulator of G protein signaling 0.002 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.005 0.0405 0.0808
Echinococcus granulosus tumor protein p63 0.033 0.345 0.3736
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0125 0.0565
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0032 0.0203 0.0181
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0048 0.0378 0.0409
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.007 0.0076
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0015 0.0022 0.0023
Loa Loa (eye worm) hypothetical protein 0.0015 0.0018 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0102 0.0966 0.1929
Echinococcus granulosus Nuclear hormone receptor HR96 0.0048 0.0378 0.0409
Plasmodium falciparum protoporphyrinogen oxidase 0.0022 0.0095 0.0281
Schistosoma mansoni retinoic acid receptor RXR 0.0102 0.0966 0.1046
Schistosoma mansoni netrin receptor unc5 0.0033 0.0214 0.0232
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0201 0.0715
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0257 0.2655 0.2875
Echinococcus granulosus netrin receptor unc 5 0.0033 0.0214 0.0231
Schistosoma mansoni bromodomain containing protein 0.0074 0.0664 0.0719
Trypanosoma cruzi ISWI complex protein 0.0016 0.0026 0.0017
Echinococcus multilocularis GA binding protein alpha chain 0.0075 0.0672 0.0727
Echinococcus granulosus thyroid hormone receptor alpha 0.0048 0.0378 0.0409
Mycobacterium tuberculosis Probable lipase LipD 0.0146 0.1442 0.1423
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0966 0.1806
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.007 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0102 0.0966 0.1046
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Onchocerca volvulus Tyrosine kinase homolog 0.0172 0.1734 0.6492
Trypanosoma brucei hypothetical protein, conserved 0.0146 0.1442 0.5674
Schistosoma mansoni jun-related protein 0.0067 0.058 0.0628
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.007 0.0076
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Loa Loa (eye worm) TK protein kinase 0.0032 0.0202 0.0404
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0378 0.041
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0089 0.083 0.4463
Schistosoma mansoni glucose transport protein 0.0101 0.0961 0.104
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Leishmania major DNA polymerase kappa, putative 0.0022 0.0098 0.0306
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.007 0.0076
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0032 0.0034
Loa Loa (eye worm) fibroinase 0.0016 0.0032 0.0064
Trypanosoma brucei DNA topoisomerase ii 0.0245 0.2525 1
Mycobacterium ulcerans hypothetical protein 0.0146 0.1442 0.4318
Leishmania major mitochondrial DNA topoisomerase II 0.0245 0.2525 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0102 0.0966 0.3563
Onchocerca volvulus 0.0146 0.1442 0.5378
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.018 0.182 0.3431
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Loa Loa (eye worm) hypothetical protein 0.0056 0.0464 0.0926
Plasmodium falciparum hexose transporter 0.0101 0.0961 0.415
Loa Loa (eye worm) hypothetical protein 0.0101 0.0952 0.1901
Schistosoma mansoni hypothetical protein 0.0257 0.2655 0.2875
Echinococcus multilocularis jun protein 0.0082 0.0748 0.0809
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0022 0.001
Schistosoma mansoni hypothetical protein 0.0021 0.0086 0.0093
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0146 0.1442 0.4318
Schistosoma mansoni ankyrin 23/unc44 0.0029 0.0174 0.0188
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.1205 0.1305
Schistosoma mansoni terminal deoxycytidyl transferase 0.0015 0.0022 0.0024
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0138 0.1363 0.1476
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0132 0.1294 0.4814
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.0125 0.0355
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Echinococcus multilocularis dna polymerase kappa 0.0044 0.033 0.0358
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0405 0.0438
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0022 0.0095 0.0103
Loa Loa (eye worm) norepinephrine transporter 0.0192 0.1945 0.3885
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0132 0.1294 0.4814
Mycobacterium tuberculosis Probable lipase LipE 0.0146 0.1442 0.1423
Brugia malayi hypothetical protein 0.0033 0.0209 0.0366
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0046 0.0049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0054 0.0441 0.0478
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0192 0.1945 0.3668
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.007 0.0076
Schistosoma mansoni z-protein (S1r protein) 0.002 0.007 0.0076
Echinococcus granulosus nuclear receptor nhr 48 0.0048 0.0378 0.0409
Schistosoma mansoni zinc finger protein 0.0016 0.0026 0.0028
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.038 0.0412
Echinococcus multilocularis regulator of G protein signaling 0.002 0.007 0.0076
Schistosoma mansoni hypothetical protein 0.0435 0.4603 0.4983
Loa Loa (eye worm) hypothetical protein 0.0033 0.0215 0.0429
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0187 0.0374
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0102 0.0966 0.1046
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.033 0.1233
Brugia malayi PAS domain containing protein 0.0047 0.0372 0.0676
Echinococcus multilocularis protoporphyrinogen oxidase 0.0022 0.0095 0.0102
Echinococcus granulosus death domain containing protein 0.0029 0.0174 0.0188
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0032 0.0035
Echinococcus granulosus L aminoadipate semialdehyde 0.0088 0.0819 0.0886
Trypanosoma brucei DNA topoisomerase IA, putative 0.0018 0.0046 0.0098
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0089 0.083 0.3047
Loa Loa (eye worm) hypothetical protein 0.0119 0.1153 0.2303
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0095 0.0281
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0032 0.0203 0.0703
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0146 0.1442 0.2711
Plasmodium vivax SET domain protein, putative 0.0033 0.0213 0.0807
Chlamydia trachomatis DNA gyrase subunit B 0.0157 0.1565 0.6831
Schistosoma mansoni steroid hormone receptor ad4bp 0.0102 0.0966 0.1046
Schistosoma mansoni sodium/chloride dependent transporter 0.0033 0.0209 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0102 0.0966 0.1806
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0015 0.0022 0.0023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0032 0.0034
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0125 0.0244
Toxoplasma gondii ABC1 family protein 0.0146 0.1442 0.7885
Trichomonas vaginalis conserved hypothetical protein 0.0101 0.0961 0.3546
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0048 0.0378 0.041
Echinococcus granulosus intermediate filament protein 0.0028 0.0157 0.017
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0098 0.0077
Schistosoma mansoni DNA topoisomerase II 0.018 0.182 0.197
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0237 0.042
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1442 0.5384
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.033 0.1233
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.1866 0.3519
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0089 0.083 0.3566
Echinococcus granulosus tyrosine protein kinase Blk 0.0036 0.0246 0.0266
Schistosoma mansoni axis inhibition protein axin 0.002 0.007 0.0076
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.022 0.2259 0.2445
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.003 0.0176 0.0191
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0135 0.1332 0.1442
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0233 0.0252
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.033 0.0879
Brugia malayi hypothetical protein 0.0054 0.0441 0.0808
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0366
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0048 0.0378 0.0756
Brugia malayi PHD-finger family protein 0.0035 0.0232 0.0411
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0022 0.0095 0.0281
Schistosoma mansoni nuclear receptor nhr-48 0.0048 0.0378 0.041
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0048 0.0378 0.1321
Echinococcus multilocularis geminin 0.086 0.9237 1
Schistosoma mansoni tyrosine kinase 0.004 0.0288 0.0312
Echinococcus multilocularis dna polymerase eta 0.0015 0.0022 0.0023
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0102 0.0966 0.1046
Loa Loa (eye worm) TOPoisomerase family member 0.018 0.182 0.3635
Onchocerca volvulus 0.0192 0.1945 0.7297
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Plasmodium vivax DNA gyrase subunit B, putative 0.0221 0.227 1
Plasmodium vivax DNA topoisomerase 3, putative 0.0018 0.0046 0.0064
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.007 0.0076
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0029 0.0174 0.0347
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0213 0.101
Plasmodium falciparum DNA topoisomerase 3, putative 0.0018 0.0046 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0359 0.3768 0.4079
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0054 0.0441 0.0881
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.1866 0.3728
Brugia malayi Fibroblast growth factor family protein 0.0056 0.0464 0.0851
Echinococcus multilocularis Ankyrin 0.003 0.0176 0.0191
Brugia malayi polk-prov protein 0.0033 0.0215 0.0377
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.007 0.0076
Leishmania major DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Schistosoma mansoni amine oxidase 0.0022 0.0095 0.0103
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.0881
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0237 0.0256
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0033 0.0209 0.0366
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0098 0.0306
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Entamoeba histolytica hypothetical protein 0.002 0.007 0.027
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0153
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0048 0.0378 0.0689
Loa Loa (eye worm) nuclear hormone receptor 0.0048 0.0378 0.0756
Loa Loa (eye worm) hypothetical protein 0.0028 0.0157 0.0314
Echinococcus granulosus single minded 2 0.0035 0.0237 0.0256
Brugia malayi Cytochrome P450 family protein 0.0024 0.0116 0.019
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0033 0.0209 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Toxoplasma gondii DNA topoisomerase family protein 0.0018 0.0046 0.0081
Echinococcus multilocularis transcription factor Dp 1 0.008 0.0727 0.0787
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0146 0.1442 0.1423
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.0125 0.0522
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0298 0.3109 0.3366
Schistosoma mansoni lamin 0.0028 0.0157 0.017
Schistosoma mansoni hypothetical protein 0.0035 0.0237 0.0256
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0102 0.0966 0.1046
Schistosoma mansoni axis inhibition protein axin 0.002 0.007 0.0076
Treponema pallidum sodium- and chloride- dependent transporter 0.0192 0.1945 0.8539
Loa Loa (eye worm) hypothetical protein 0.0082 0.0752 0.1502
Brugia malayi nuclear hormone receptor 0.0048 0.0378 0.0689
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.018 0.182 0.197
Entamoeba histolytica hypothetical protein 0.0035 0.0237 0.1195
Echinococcus granulosus serotonin transporter 0.0192 0.1945 0.2106
Trypanosoma brucei unspecified product 0.0037 0.0254 0.0927
Echinococcus granulosus jun protein 0.0082 0.0748 0.0809
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.0881
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.0125 0.0417
Echinococcus granulosus tyrosine protein kinase Src64B 0.004 0.0288 0.0311
Echinococcus multilocularis tyrosine protein kinase Srms 0.0036 0.0246 0.0266
Echinococcus granulosus ecdysone induced protein 78C 0.0102 0.0966 0.1046
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.1442 0.5674
Leishmania major UDP-galactopyranose mutase 0.0022 0.0095 0.0292
Mycobacterium ulcerans esterase/lipase LipP 0.0146 0.1442 0.4318
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Loa Loa (eye worm) steroid hormone receptor 0.0102 0.0966 0.1929
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Schistosoma mansoni regulator of G protein signaling 0.002 0.007 0.0076
Brugia malayi Death domain containing protein 0.0029 0.0174 0.0299
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0989
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0102 0.0966 0.1046
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.022 0.2259 0.2445
Onchocerca volvulus 0.0033 0.0209 0.0674
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0209 0.079
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0032 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0102 0.0966 0.1806
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.1205 0.4728
Schistosoma mansoni ets-related 0.0228 0.2337 0.253
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0041
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0073 0.065 0.1298
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.007 0.0103
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0273 0.0545
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.004 0.0288 0.0311
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0202 0.0219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0215 0.077
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0032 0.0034
Echinococcus granulosus beta LACTamase domain containing family member 0.0146 0.1442 0.1561
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.007 0.0076
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0048 0.0378 0.0409
Plasmodium falciparum histone acetyltransferase GCN5 0.008 0.0724 0.3093
Brugia malayi hypothetical protein 0.0054 0.0441 0.0808
Loa Loa (eye worm) hypothetical protein 0.0056 0.0464 0.0926
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0273 0.1018
Loa Loa (eye worm) fli-1 protein 0.0228 0.2337 0.4668
Echinococcus multilocularis rho GTPase activating protein 20 0.0018 0.0046 0.005
Onchocerca volvulus 0.0064 0.0556 0.1998
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0102 0.0966 0.1806
Echinococcus multilocularis musashi 0.0028 0.0157 0.017
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.007 0.0076
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0022 0.0095 0.0281
Giardia lamblia Hypothetical protein 0.0056 0.0464 0.2541
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0127 0.0137
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0098 0.0306
Loa Loa (eye worm) hypothetical protein 0.008 0.0723 0.1444
Leishmania major DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0201 0.0754
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0048 0.0378 0.041
Brugia malayi DNA topoisomerase II, alpha isozyme 0.018 0.182 0.3431
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0102 0.0966 0.1806
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0192 0.0208
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0125 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0215 0.077
Schistosoma mansoni cell adhesion molecule 0.0015 0.0018 0.0019
Loa Loa (eye worm) sugar transporter 0.0101 0.0961 0.1919
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.0881
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0417
Onchocerca volvulus 0.0035 0.0237 0.0782
Echinococcus multilocularis dnaJ subfamily B 0.0435 0.4603 0.4983
Plasmodium falciparum transporter, putative 0.0033 0.0209 0.079
Echinococcus multilocularis tumor protein p63 0.033 0.345 0.3736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0102 0.0966 0.1046
Brugia malayi Fibroblast growth factor family protein 0.0056 0.0464 0.0851
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0018 0.0046 0.005
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0372 0.0402
Toxoplasma gondii histone lysine-specific demethylase 0.0022 0.0095 0.0352
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.033 0.1233
Onchocerca volvulus 0.0146 0.1442 0.5378
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0202 0.0219
Onchocerca volvulus 0.0048 0.0378 0.1321
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0033 0.0209 0.0226
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0043
Brugia malayi Pre-SET motif family protein 0.0225 0.2312 0.4367
Brugia malayi isocitrate dehydrogenase 0.0032 0.0201 0.0351
Echinococcus granulosus nervana 2 0.0135 0.1332 0.1442
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0359 0.3768 0.4079
Loa Loa (eye worm) hypothetical protein 0.0029 0.0174 0.0347
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0273 0.0295
Plasmodium vivax amine transporter, putative 0.0033 0.0209 0.079
Brugia malayi Nuclear hormone receptor E75 0.0048 0.0378 0.0689
Echinococcus granulosus nuclear factor of activated T cells 5 0.015 0.1493 0.1616
Brugia malayi Cathepsin L-like precursor 0.0016 0.0032 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0102 0.0966 0.1929
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0016 0.0033
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0201 0.0715
Schistosoma mansoni nephrin 0.0014 0.0009 0.001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.1363 0.536
Echinococcus multilocularis serotonin transporter 0.0192 0.1945 0.2106
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0022 0.0095 0.0281
Toxoplasma gondii DNA topoisomerase 2, putative 0.018 0.182 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Brugia malayi DNA topoisomerase III 0.0018 0.0046 0.0057
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.0125 0.0355
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0018 0.0019
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0163 0.1627 0.6415
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0032 0.0034
Loa Loa (eye worm) solute carrier family 6 member 4 0.0192 0.1945 0.3885
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0387 0.1461
Chlamydia trachomatis DNA gyrase subunit B 0.0221 0.227 1
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.007 0.0076
Brugia malayi nuclear hormone receptor family member odr-7 0.0048 0.0378 0.0689
Brugia malayi nuclear hormone receptor family member nhr-6 0.0048 0.0378 0.0689
Brugia malayi hypothetical protein 0.002 0.007 0.0103
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0102 0.0966 0.1046
Schistosoma mansoni gabp alpha 0.0075 0.0672 0.0727
Echinococcus granulosus DNA topoisomerase 2 alpha 0.018 0.182 0.197
Brugia malayi nuclear hormone receptor 0.0102 0.0966 0.1806
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0201 0.0715
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Loa Loa (eye worm) hypothetical protein 0.0054 0.0441 0.0881
Trichomonas vaginalis esterase, putative 0.0146 0.1442 0.5384
Onchocerca volvulus Netrin receptor homolog 0.0032 0.0205 0.0661
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0201 0.0217
Onchocerca volvulus 0.0048 0.0378 0.1321
Schistosoma mansoni hypothetical protein 0.0067 0.058 0.0628
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0036 0.0246 0.0266
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0102 0.0966 0.1929
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Schistosoma mansoni single-minded 0.0047 0.0372 0.0402
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.007 0.014
Schistosoma mansoni lamin 0.0028 0.0157 0.017
Loa Loa (eye worm) DR-78 0.0048 0.0378 0.0756
Plasmodium falciparum amino acid transporter, putative 0.0033 0.0209 0.079
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0032 0.0035
Loa Loa (eye worm) hypothetical protein 0.0192 0.1945 0.3885
Echinococcus multilocularis General substrate transporter 0.0091 0.0852 0.0922
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.022 0.2259 0.2445
Loa Loa (eye worm) hypothetical protein 0.0064 0.0553 0.1105
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0273 0.0919
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0041
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0201 0.0715
Loa Loa (eye worm) hypothetical protein 0.0016 0.0032 0.0064
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0165 0.165 0.9046
Schistosoma mansoni ap endonuclease 0.0038 0.0273 0.0295
Brugia malayi bZIP transcription factor family protein 0.0082 0.0748 0.1391
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Brugia malayi hypothetical protein 0.0048 0.0378 0.0689
Brugia malayi SWIRM domain containing protein 0.0022 0.0095 0.0149
Schistosoma mansoni ap endonuclease 0.0038 0.0273 0.0295
Leishmania major hypothetical protein, conserved 0.0146 0.1442 0.5674
Trichomonas vaginalis DNA topoisomerase II, putative 0.018 0.182 0.6828
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0102 0.0966 0.1046
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Plasmodium falciparum DNA gyrase subunit A 0.0032 0.0203 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.002 0.007 0.0076
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0201 0.0944
Brugia malayi Serotonin receptor 0.0497 0.5274 1
Schistosoma mansoni zinc finger protein 0.0048 0.0378 0.041
Schistosoma mansoni cpg binding protein 0.0031 0.0187 0.0203
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0102 0.0966 0.1046
Onchocerca volvulus 0.0146 0.1442 0.5378
Onchocerca volvulus 0.022 0.2259 0.8494
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0089 0.083 0.4463
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0138 0.1363 0.1476
Schistosoma mansoni tyrosine kinase 0.004 0.0288 0.0312
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.005 0.0405 0.0438
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.033 0.1233
Leishmania major DNA topoisomerase ii 0.0163 0.1627 0.6415
Schistosoma mansoni thyroid hormone receptor 0.0359 0.3768 0.4079
Brugia malayi beta-lactamase family protein 0.0146 0.1442 0.2711
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0201 0.0217
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0032 0.0203 0.0955
Trypanosoma cruzi DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0102 0.0966 0.1046
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.033 0.0879
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Brugia malayi nuclear receptor NHR-67 0.0048 0.0378 0.0689
Plasmodium falciparum DNA topoisomerase 2 0.018 0.182 0.799
Echinococcus granulosus twitchin 0.0014 0.0009 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0125 0.0104
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0292 0.3037 0.3022
Brugia malayi Uncoordinated protein 44 0.0029 0.0174 0.0299
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.0125 0.0355
Entamoeba histolytica cysteine protease, putative 0.0016 0.0032 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Echinococcus multilocularis ecdysone induced protein 78C 0.0102 0.0966 0.1046
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0033 0.0209 0.0226
Mycobacterium ulcerans DNA gyrase subunit B 0.0221 0.227 0.688
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0146 0.1442 0.63
Brugia malayi Sugar transporter family protein 0.0101 0.0961 0.1796
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.004 0.0288 0.0311
Echinococcus multilocularis FTZ F1 alpha 0.0102 0.0966 0.1046
Chlamydia trachomatis DNA gyrase subunit A 0.0032 0.0203 0.0703
Entamoeba histolytica DNA topoisomerase II, putative 0.018 0.182 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0046 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0533 0.2042
Trypanosoma brucei ISWI complex protein 0.0016 0.0026 0.0017
Trypanosoma cruzi hypothetical protein, conserved 0.0146 0.1442 0.5674
Onchocerca volvulus 0.0033 0.0209 0.0674
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0213 0.023
Loa Loa (eye worm) hypothetical protein 0.002 0.007 0.014
Schistosoma mansoni nuclear hormone receptor 0.0102 0.0966 0.1046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1205 0.3585
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0192 0.1945 0.2106
Entamoeba histolytica hypothetical protein 0.0035 0.0237 0.1195
Schistosoma mansoni glucose transport protein 0.0101 0.0961 0.104
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0102 0.0966 0.1806
Loa Loa (eye worm) ctsf protein 0.0016 0.0032 0.0064
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.1205 0.1186
Echinococcus granulosus histone acetyltransferase KAT2B 0.0288 0.2992 0.3239
Loa Loa (eye worm) nuclear receptor NHR-67 0.0048 0.0378 0.0756
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0102 0.0966 0.1929
Echinococcus granulosus tyrosine protein kinase Src42A 0.004 0.0288 0.0311
Loa Loa (eye worm) SRC-1 0.004 0.0288 0.0575
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0033 0.0209 0.0366
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0029 0.0174 0.0188
Brugia malayi beta-lactamase family protein 0.0146 0.1442 0.2711
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0095 0.0292
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0135 0.1332 0.1442
Echinococcus multilocularis tyrosine protein kinase Src42A 0.004 0.0288 0.0311
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0245 0.2525 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1442 0.288
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.033 0.1233
Schistosoma mansoni hypothetical protein 0.0029 0.0174 0.0188
Echinococcus multilocularis beta LACTamase domain containing family member 0.0146 0.1442 0.1561
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.005 0.0405 0.0438
Loa Loa (eye worm) hypothetical protein 0.0192 0.1945 0.3885
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0048 0.0378 0.0409
Entamoeba histolytica protein kinase, putative 0.0032 0.0202 0.1003
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.007 0.0076
Loa Loa (eye worm) beta-lactamase 0.0146 0.1442 0.288
Mycobacterium tuberculosis Conserved protein 0.0146 0.1442 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Brugia malayi hypothetical protein 0.0048 0.0378 0.0689
Echinococcus granulosus tyrosine protein kinase Fyn 0.004 0.0288 0.0311
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0257 0.2655 0.2875
Mycobacterium leprae Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) 0.0085 0.0781 0.5267
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0201 0.0754
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0201 0.0401
Trichomonas vaginalis conserved hypothetical protein 0.002 0.007 0.0146
Leishmania major cathepsin L-like protease 0.0016 0.0032 0.0041
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0102 0.0966 0.1929
Brugia malayi DNA topoisomerase III beta-1 0.0018 0.0046 0.0057
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Trypanosoma cruzi UDP-galactopyranose mutase 0.0022 0.0095 0.0292
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.1205 0.3585
Echinococcus granulosus GA binding protein alpha chain 0.0075 0.0672 0.0727
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0088 0.0819 0.0887
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0095 0.0073
Trichomonas vaginalis D-aminoacylase, putative 0.0146 0.1442 0.5384
Onchocerca volvulus 0.0022 0.0095 0.024
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0102 0.0966 0.1046
Loa Loa (eye worm) hypothetical protein 0.0088 0.0819 0.1636
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.1442 0.5384
Schistosoma mansoni hypothetical protein 0.086 0.9237 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0102 0.0966 0.1046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Onchocerca volvulus 0.0102 0.0966 0.3563
Onchocerca volvulus 0.0033 0.0209 0.0674
Schistosoma mansoni nuclear receptor 0.0048 0.0378 0.041
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0033 0.0209 0.0226
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0604 0.32
Loa Loa (eye worm) hypothetical protein 0.0102 0.0966 0.1929
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.007 0.0146
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0273 0.1003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0138 0.1363 0.746
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0298 0.3109 0.3366
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.004 0.0288 0.0311
Loa Loa (eye worm) hypothetical protein 0.0192 0.1945 0.3885
Loa Loa (eye worm) hypothetical protein 0.0022 0.0095 0.0189
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.1363 0.536
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0303
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.033 0.1233
Echinococcus granulosus dnaJ subfamily B 0.0435 0.4603 0.4983
Loa Loa (eye worm) RGS-3 protein 0.002 0.007 0.014
Trypanosoma brucei DNA topoisomerase III, putative 0.0018 0.0046 0.0098
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0095 0.0102
Echinococcus multilocularis expressed protein 0.0386 0.407 0.4407
Brugia malayi Protein kinase domain containing protein 0.0119 0.1153 0.2162
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.007 0.0103
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.007 0.0076
Schistosoma mansoni RAR-like nuclear receptor 0.0102 0.0966 0.1046
Echinococcus multilocularis conserved hypothetical protein 0.0729 0.7811 0.8457
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.007 0.014
Schistosoma mansoni sodium/chloride dependent transporter 0.0192 0.1945 0.2106
Loa Loa (eye worm) hypothetical protein 0.022 0.2259 0.4512
Trypanosoma cruzi DNA topoisomerase II, putative 0.0163 0.1627 0.6415
Echinococcus granulosus axis inhibition protein axin 0.002 0.007 0.0076
Brugia malayi ImpB/MucB/SamB family protein 0.0015 0.0022 0.001
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0201 0.0217
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.007 0.0103
Brugia malayi tailless protein 0.0048 0.0378 0.0689
Mycobacterium ulcerans dehydrogenase 0.0022 0.0095 0.015
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.033 0.114
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.1363 0.536
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0201 0.0217
Echinococcus granulosus lysine specific histone demethylase 1A 0.0022 0.0095 0.0102
Loa Loa (eye worm) hypothetical protein 0.0033 0.0209 0.0417
Schistosoma mansoni nuclear hormone receptor 0.0048 0.0378 0.041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0102 0.0966 0.1806
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0032 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0033 0.0214 0.0376
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0127 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0146 0.1442 0.5384
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0018 0.0046 0.005
Brugia malayi Probable DNA topoisomerase II 0.018 0.182 0.3431
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0101 0.0961 0.104
Plasmodium vivax DNA topoisomerase II, putative 0.018 0.182 0.799
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.022 0.2259 0.2445
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0018 0.0046 0.0081
Entamoeba histolytica DNA topoisomerase III, putative 0.0018 0.0046 0.0137
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0237 0.0256
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.1205 0.1304
Echinococcus multilocularis L aminoadipate semialdehyde 0.0088 0.0819 0.0886
Loa Loa (eye worm) hypothetical protein 0.0048 0.0378 0.0756
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0048 0.0378 0.0409
Plasmodium vivax DNA gyrase subunit A, putative 0.0032 0.0203 0.0763
Giardia lamblia DNA topoisomerase II 0.0168 0.1689 1
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0135 0.1332 0.1442
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0273 0.0295
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0273 0.1003
Brugia malayi hypothetical protein 0.002 0.007 0.0103
Echinococcus multilocularis nervana 2 0.0135 0.1332 0.1442
Schistosoma mansoni hypothetical protein 0.086 0.9237 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0533 0.2042
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0273 0.1003

Activities

Activity type Activity value Assay description Source Reference
AB50 (functional) 0 mg kg-1 Potential antipsychotic activity was assessed by measuring the ability to block the conditioned avoidance response(CAR) in rats on oral administration ; NT means not tested ChEMBL. 2888898
Ki (binding) 0 nM In vitro binding affinity at 5-hydroxytryptamine 2 receptor in rat cortical tissue by [3H]-Spiperone displacement; No data. ChEMBL. 2888898
Ki (binding) = 140 nM In vitro Dopamine receptor D2 affinity by using [3H]-Spiperone as the radioligand in rat limbic system at 1 microM concentration of compound ; value may range from 70 to 270 ChEMBL. 2888898

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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