Detailed information for compound 79698

Basic information

Technical information
  • TDR Targets ID: 79698
  • Name: 2-(5-chloro-2-phenyl-1H-indol-3-yl)-2-oxo-N,N -dipropylacetamide
  • MW: 382.883 | Formula: C22H23ClN2O2
  • H donors: 1 H acceptors: 2 LogP: 5.47 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)C(=O)c1c([nH]c2c1cc(Cl)cc2)c1ccccc1)CCC
  • InChi: 1S/C22H23ClN2O2/c1-3-12-25(13-4-2)22(27)21(26)19-17-14-16(23)10-11-18(17)24-20(19)15-8-6-5-7-9-15/h5-11,14,24H,3-4,12-13H2,1-2H3
  • InChiKey: BTSIMBPOPMQFJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(5-chloro-2-phenyl-1H-indol-3-yl)-2-oxo-N,N-dipropyl-acetamide
  • 2-(5-chloro-2-phenyl-1H-indol-3-yl)-2-oxo-N,N-dipropyl-ethanamide
  • 2-(5-chloro-2-phenyl-1H-indol-3-yl)-2-keto-N,N-dipropyl-acetamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Peripheral-type benzodiazepine receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129542 All targets in OG5_129542
Onchocerca volvulus Get druggable targets OG5_129542 All targets in OG5_129542
Mycobacterium ulcerans tryptophan-rich sensory protein Get druggable targets OG5_129542 All targets in OG5_129542
Onchocerca volvulus Get druggable targets OG5_129542 All targets in OG5_129542
Schistosoma mansoni peripheral-type benzodiazepine receptor Get druggable targets OG5_129542 All targets in OG5_129542
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129542 All targets in OG5_129542
Brugia malayi TspO/MBR family protein Get druggable targets OG5_129542 All targets in OG5_129542
Echinococcus granulosus translocator protein Get druggable targets OG5_129542 All targets in OG5_129542
Echinococcus multilocularis translocator protein Get druggable targets OG5_129542 All targets in OG5_129542
Onchocerca volvulus Get druggable targets OG5_129542 All targets in OG5_129542
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129542 All targets in OG5_129542
Onchocerca volvulus Get druggable targets OG5_129542 All targets in OG5_129542
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129542 All targets in OG5_129542
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus vacuolar h atpase Peripheral-type benzodiazepine receptor   169 aa 137 aa 25.5 %
Onchocerca volvulus Peripheral-type benzodiazepine receptor   169 aa 156 aa 25.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis thymidine kinase 0.1328 1 1
Schistosoma mansoni hypothetical protein 0.0175 0.1145 0.1142
Schistosoma mansoni inositol monophosphatase 0.0037 0.0084 0.0081
Giardia lamblia Hypothetical protein 0.0071 0.0346 0.0134
Loa Loa (eye worm) hypothetical protein 0.0322 0.2274 0.983
Schistosoma mansoni thymidylate kinase 0.0143 0.0902 0.0899
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0084 0.0208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0233 0.061
Trypanosoma brucei RNA helicase, putative 0.0219 0.1486 0.401
Giardia lamblia Deoxynucleoside kinase 0.1219 0.9168 1
Echinococcus granulosus concentrative Na nucleoside cotransporter 0.0355 0.2526 0.2524
Trichomonas vaginalis thymidine kinase, putative 0.0507 0.3695 1
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0233 0.0991
Schistosoma mansoni inositol monophosphatase 0.0037 0.0084 0.0081
Trypanosoma cruzi thymidylate kinase, putative 0.0143 0.0902 0.2266
Trypanosoma cruzi thymidylate kinase, putative 0.0143 0.0902 0.2266
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0159 0.1021 1
Giardia lamblia Hypothetical protein 0.0071 0.0346 0.0134
Loa Loa (eye worm) hypothetical protein 0.0322 0.2274 0.983
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0084 0.0081
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0055 0.0227 0.178
Trypanosoma brucei thymidylate kinase, putative 0.0143 0.0902 0.2427
Trichomonas vaginalis thymidine kinase, putative 0.0507 0.3695 1
Brugia malayi cytidine deaminase, identical 0.0055 0.0227 0.0965
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Onchocerca volvulus 0.0322 0.2274 0.983
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0233 0.0678
Onchocerca volvulus 0.0322 0.2274 0.983
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0496 0.0492
Schistosoma mansoni hypothetical protein 0.0034 0.0061 0.0057
Brugia malayi Inositol-1 0.0037 0.0084 0.0349
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0233 0.0229
Brugia malayi carbohydrate phosphorylase 0.0327 0.2313 1
Echinococcus multilocularis Glycosyl transferase, family 35 0.0327 0.2313 0.231
Echinococcus granulosus thymidylate synthase 0.0159 0.1021 0.1017
Echinococcus granulosus glycogen phosphorylase 0.0327 0.2313 0.231
Loa Loa (eye worm) hypothetical protein 0.0034 0.0061 0.0264
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 1
Echinococcus granulosus cytidine deaminase 0.0055 0.0227 0.0223
Trypanosoma brucei thymidine kinase 0.0507 0.3695 1
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0159 0.1021 1
Mycobacterium leprae probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK) 0.0143 0.0902 0.8774
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0496 0.0492
Echinococcus granulosus Na+ dependent nucleoside transporter 0.0355 0.2526 0.2524
Schistosoma mansoni thyroid hormone receptor 0.014 0.0879 0.0876
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0346 0.0725
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0181 0.0784
Leishmania major thymidine kinase, putative 0.0507 0.3695 1
Schistosoma mansoni ap endonuclease 0.0056 0.0233 0.0229
Echinococcus granulosus thymidine kinase 0.1328 1 1
Onchocerca volvulus 0.0322 0.2274 0.983
Trypanosoma cruzi thymidine kinase, putative 0.0507 0.3695 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0004 0.0016
Brugia malayi thymidylate kinase 0.0143 0.0902 0.3891
Entamoeba histolytica Thymidylate kinase, putative 0.0143 0.0902 0.2266
Trichomonas vaginalis thymidylate kinase, putative 0.0143 0.0902 0.2266
Toxoplasma gondii thymidylate kinase 0.0143 0.0902 0.8735
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 0.2748
Onchocerca volvulus 0.0322 0.2274 0.983
Leishmania major thymidylate kinase-like protein 0.0143 0.0902 0.2266
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 0.2594
Brugia malayi TspO/MBR family protein 0.0322 0.2274 0.983
Leishmania major cytidine deaminase-like protein 0.0055 0.0227 0.0394
Trypanosoma brucei cytidine deaminase 0.0055 0.0227 0.0594
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.5899 0.5898
Schistosoma mansoni thymidylate kinase 0.0143 0.0902 0.0899
Giardia lamblia Glycogen phosphorylase 0.0327 0.2313 0.2333
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0233 0.1815
Schistosoma mansoni ap endonuclease 0.0056 0.0233 0.0229
Mycobacterium tuberculosis Hypothetical protein 0.0076 0.0381 0.3381
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0181 0.0769
Echinococcus multilocularis translocator protein 0.0322 0.2274 0.2271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0496 0.0492
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0233 0.1844
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 0.2594
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0233 0.0007
Treponema pallidum thymidylate kinase (tmk) 0.0143 0.0902 1
Brugia malayi hypothetical protein 0.0076 0.0381 0.1635
Onchocerca volvulus 0.0055 0.0227 0.0965
Entamoeba histolytica glycogen phosphorylase, putative 0.0141 0.0887 0.2224
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0061 0.0248
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0346 0.0725
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0346 0.0725
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0141 0.0887 0.3667
Giardia lamblia CDC8 0.0143 0.0902 0.0756
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Echinococcus multilocularis thymidylate kinase 0.0143 0.0902 0.0899
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0141 0.0887 0.8616
Echinococcus multilocularis sodium:nucleoside cotransporter 2 0.0231 0.1578 0.1575
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0183 0.0275
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0233 0.0411
Schistosoma mansoni hypothetical protein 0.0175 0.1145 0.1142
Schistosoma mansoni peripheral-type benzodiazepine receptor 0.0322 0.2274 0.2271
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0346 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0346 0.0725
Echinococcus granulosus thymidylate kinase 0.0143 0.0902 0.0899
Plasmodium falciparum thymidylate kinase 0.0143 0.0902 0.8585
Onchocerca volvulus Glycogen phosphorylase homolog 0.0327 0.2313 1
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Entamoeba histolytica thymidine kinase, putative 0.0507 0.3695 1
Mycobacterium ulcerans cytidine deaminase 0.0055 0.0227 0.065
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0183 0.0275
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Schistosoma mansoni thymidine kinase 0.1328 1 1
Brugia malayi thymidylate synthase 0.0159 0.1021 0.4404
Loa Loa (eye worm) thymidylate kinase 0.0143 0.0902 0.3901
Schistosoma mansoni hypothetical protein 0.0219 0.1486 0.1483
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0183 0.106
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0004 0.0016
Loa Loa (eye worm) hypothetical protein 0.0322 0.2274 0.983
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0233 0.0413
Entamoeba histolytica glycogen phosphorylase, putative 0.0327 0.2313 0.6173
Loa Loa (eye worm) hypothetical protein 0.005 0.0181 0.0784
Loa Loa (eye worm) glycogen phosphorylase 0.0327 0.2313 1
Mycobacterium ulcerans thymidylate kinase 0.0143 0.0902 0.3736
Brugia malayi hypothetical protein 0.005 0.0183 0.0778
Entamoeba histolytica glycogenphosphorylase, putative 0.0141 0.0887 0.2224
Leishmania major hypothetical protein, conserved 0.0056 0.0233 0.0413
Trypanosoma cruzi thymidine kinase, putative 0.0507 0.3695 1
Chlamydia trachomatis glycogen phosphorylase 0.0327 0.2313 1
Schistosoma mansoni hypothetical protein 0.0053 0.0211 0.0207
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0233 0.0229
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0055 0.0227 0.0394
Trichomonas vaginalis glycogen phosphorylase, putative 0.0327 0.2313 0.6173
Wolbachia endosymbiont of Brugia malayi thymidylate kinase 0.0143 0.0902 1
Brugia malayi hypothetical protein 0.013 0.0799 0.3445
Trypanosoma brucei thymidylate kinase, putative 0.0143 0.0902 0.2427
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0233 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0346 0.0725
Echinococcus multilocularis geminin 0.0175 0.1145 0.1142
Mycobacterium tuberculosis Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK) 0.0143 0.0902 0.8774
Trichomonas vaginalis thymidylate kinase, putative 0.0143 0.0902 0.2266
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0159 0.1021 1
Trichomonas vaginalis glycogen phosphorylase, putative 0.0327 0.2313 0.6173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0496 0.0492
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0346 0.0725
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0346 0.0725
Echinococcus granulosus glycogen phosphorylase 0.0327 0.2313 0.231
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0233 0.0411
Giardia lamblia Thymidine kinase 0.0507 0.3695 0.3879
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0076 0.0381 0.0823
Leishmania major hypothetical protein, conserved 0.005 0.0183 0.0275
Mycobacterium ulcerans tryptophan-rich sensory protein 0.0322 0.2274 1
Entamoeba histolytica glycogen phosphorylase, putative 0.0327 0.2313 0.6173
Echinococcus granulosus solute carrier family 28 0.0355 0.2526 0.2524
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1328 1 1
Loa Loa (eye worm) inositol-1 0.0037 0.0084 0.0364
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.0799 0.0796
Onchocerca volvulus Putative thymidylate kinase 0.0143 0.0902 0.3891
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0004 0.0016
Echinococcus granulosus geminin 0.0175 0.1145 0.1142
Schistosoma mansoni hypothetical protein 0.0143 0.0902 0.0899
Schistosoma mansoni glycogen phosphorylase 0.0141 0.0887 0.0884
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0233 0.1006
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0055 0.0227 0.178
Trypanosoma cruzi UMP-CMP kinase, mitochondrial, putative 0.0056 0.0233 0.0413
Onchocerca volvulus 0.0159 0.1021 0.4404
Echinococcus multilocularis thymidine kinase 0.1328 1 1
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0071 0.0346 0.0342
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0233 0.0411
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 1
Onchocerca volvulus 0.0055 0.0227 0.0965
Echinococcus granulosus translocator protein 0.0322 0.2274 0.2271
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0233 0.0411
Echinococcus multilocularis cytidine deaminase 0.0055 0.0227 0.0223
Trypanosoma cruzi cytidine deaminase-like protein 0.0055 0.0227 0.0394
Toxoplasma gondii exonuclease III APE 0.0056 0.0233 0.1585
Trichomonas vaginalis thymidine kinase, putative 0.0507 0.3695 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.0496 0.213
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0233 0.0588
Echinococcus multilocularis glycogen phosphorylase 0.0327 0.2313 0.231
Plasmodium vivax thymidylate kinase, putative 0.0143 0.0902 0.8585
Mycobacterium ulcerans thymidylate synthase 0.0159 0.1021 0.4277
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0227 0.0394
Entamoeba histolytica glycogen phosphorylase, putative 0.0141 0.0887 0.2224
Schistosoma mansoni glycogen phosphorylase 0.0327 0.2313 0.231
Entamoeba histolytica cytidine deaminase, putative 0.0055 0.0227 0.0394
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0071 0.0346 0.0725
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0071 0.0346 0.0134
Loa Loa (eye worm) deoxynucleoside kinase 0.0071 0.0346 0.1496
Echinococcus multilocularis thymidylate synthase 0.0159 0.1021 0.1017
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0084 0.0081
Loa Loa (eye worm) thymidylate synthase 0.0159 0.1021 0.4413
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0159 0.1021 0.1017
Schistosoma mansoni hypothetical protein 0.013 0.0799 0.0796
Loa Loa (eye worm) hypothetical protein 0.005 0.0183 0.0793
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0071 0.0346 0.0342
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.0496 0.2143
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0233 0.0588
Brugia malayi hypothetical protein 0.0032 0.0048 0.0191
Schistosoma mansoni thyroid hormone receptor 0.014 0.0879 0.0876
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.0496 0.0492
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0055 0.0227 0.152
Schistosoma mansoni glycogen phosphorylase 0.0327 0.2313 0.231
Echinococcus granulosus Glycosyl transferase family 35 0.0327 0.2313 0.231
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0233 0.0411
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0071 0.0346 0.0342
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0183 0.0477
Echinococcus multilocularis solute carrier family 28 0.0355 0.2526 0.2524
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0181 0.0769
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0381 0.0823
Echinococcus multilocularis transfer RNA-Ile 0.1328 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.0496 0.0492
Echinococcus multilocularis concentrative Na+ nucleoside cotransporter 0.0355 0.2526 0.2524
Echinococcus multilocularis glycogen phosphorylase 0.0327 0.2313 0.231
Trichomonas vaginalis cytidine deaminase, putative 0.0055 0.0227 0.0394
Loa Loa (eye worm) hypothetical protein 0.0322 0.2274 0.983
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.0879 0.0876
Brugia malayi Deoxynucleoside kinase family protein 0.0071 0.0346 0.1482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.0496 0.0492
Entamoeba histolytica hypothetical protein 0.0071 0.0346 0.0725
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.0799 0.0796

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 10 % Stimulation of pregnenolone formation from rat C6 glioma cells ChEMBL. 15027878
Activity (functional) = 10 % Stimulation of pregnenolone formation from rat C6 glioma cells ChEMBL. 15027878
Inhibition (binding) = 10 % Percent inhibition of rat benzodiazepine receptor assayed using [3H]-flumazenil radioligand at 10 um concentration ChEMBL. 15027878
Inhibition (binding) = 10 % Percent inhibition of rat benzodiazepine receptor assayed using [3H]-flumazenil radioligand at 10 um concentration ChEMBL. 15027878
Ki (binding) = 2.8 nM Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane ChEMBL. 15027878
Ki (binding) = 2.8 nM Binding affinity to peripheral benzodiazepine receptors using [3H]-PK11195 radioligand in rat kidney mitochondrial membrane ChEMBL. 15027878
Ki (binding) = 2.8 nM Displacement of [3H]PK11195 from translocator protein in rat kidney mitochondrial membrane ChEMBL. 18729350

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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