Detailed information for compound 79719

Basic information

Technical information
  • TDR Targets ID: 79719
  • Name: 2-amino-6-(4-chlorophenyl)-5-iodo-1H-pyrimidi n-4-one
  • MW: 347.54 | Formula: C10H7ClIN3O
  • H donors: 2 H acceptors: 3 LogP: 2.77 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nc(N)nc(c1I)O
  • InChi: 1S/C10H7ClIN3O/c11-6-3-1-5(2-4-6)8-7(12)9(16)15-10(13)14-8/h1-4H,(H3,13,14,15,16)
  • InChiKey: LAQVGSHDIFLIFU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-azanyl-6-(4-chlorophenyl)-5-iodo-1H-pyrimidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0045 0.0485 0.0813
Schistosoma mansoni jumonji domain containing protein 0.0017 0.0128 0.0151
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0045 0.0485 0.1011
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0823 0.0968
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0234
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0028 0.0276 0.2672
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0485 0.5414
Schistosoma mansoni BC026374 protein (S09 family) 0.0011 0.0054 0.0063
Brugia malayi hypothetical protein 0.0024 0.0225 0.0445
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0225 0.1557
Toxoplasma gondii type I fatty acid synthase, putative 0.0045 0.0485 0.0823
Schistosoma mansoni phosphatidylserine receptor 0.0017 0.0128 0.0151
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0999
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0231
Schistosoma mansoni cpg binding protein 0.0028 0.0269 0.0316
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0745 0.0876
Onchocerca volvulus 0.0071 0.0823 0.1685
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0397 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0045 0.0485 0.0813
Loa Loa (eye worm) hypoxia-induced factor 1 0.0162 0.1993 0.429
Schistosoma mansoni ap endonuclease 0.0018 0.0145 0.0171
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0337 0.0554
Giardia lamblia Kinase, CMGC MAPK 0.0055 0.0616 1
Echinococcus granulosus jumonji domain containing 1A 0.0017 0.0128 0.0151
Brugia malayi beta-lactamase family protein 0.0071 0.0823 0.1746
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0231
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0086 0.0818
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0632 0.115
Onchocerca volvulus 0.0028 0.0276 0.0487
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0151 0.0178
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0045 0.0485 0.1011
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0823 0.0968
Onchocerca volvulus 0.0014 0.0086 0.0071
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0823 0.0968
Trypanosoma brucei unspecified product 0.0019 0.0151 0.0999
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0485 0.5414
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0151 0.1633
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0365 0.4615 1
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0823 0.1404
Leishmania major hypothetical protein, conserved 0.0024 0.0225 0.1885
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0063
Loa Loa (eye worm) hypothetical protein 0.0045 0.0485 0.1008
Brugia malayi PAS domain containing protein 0.0052 0.0584 0.1226
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Mycobacterium tuberculosis Possible dehydrogenase 0.0045 0.0485 0.0813
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0365 0.4615 1
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0045 0.0485 0.0813
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0365 0.4615 1
Echinococcus multilocularis geminin 0.0346 0.4362 0.4362
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0442 0.525
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0054 0.0058
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0397 0.7425
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0011 0.0054 0.0058
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0269 0.0537
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0135
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0045 0.0485 1
Mycobacterium ulcerans quinone oxidoreductase 0.0045 0.0485 0.1011
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0011 0.0054 0.0054
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0442 0.4618
Mycobacterium ulcerans lipase LipD 0.0071 0.0823 0.1746
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0145 0.1084
Brugia malayi hypothetical protein 0.0016 0.0114 0.0203
Schistosoma mansoni inositol monophosphatase 0.0037 0.0387 0.0455
Plasmodium vivax JmjC domain containing protein 0.0017 0.0128 0.019
Mycobacterium ulcerans oxidoreductase 0.0045 0.0485 0.1011
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0485 0.5789
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0055 0.0616 0.1113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.0887
Loa Loa (eye worm) hypothetical protein 0.0017 0.0128 0.0231
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0022
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0017 0.0128 0.003
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0017 0.0128 0.0151
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0745 0.1574
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0823 0.1404
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.0887
Brugia malayi Inositol-1 0.0037 0.0387 0.0797
Echinococcus multilocularis lysine specific demethylase 5A 0.0063 0.0724 0.0724
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Trypanosoma brucei protein kinase, putative 0.0055 0.0616 0.7225
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0234
Echinococcus multilocularis lysine specific demethylase 6a 0.0017 0.0128 0.0128
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0387 0.0387
Toxoplasma gondii ABC1 family protein 0.0071 0.0823 0.1573
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0387 0.7109
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0823 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0055 0.0616 0.1293
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0145 0.0219
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0014 0.0086 0.0818
Leishmania major hypothetical protein, conserved 0.0016 0.012 0.0461
Echinococcus granulosus mitogen activated protein kinase 3 0.0055 0.0616 0.0725
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0151 0.0151
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0145 0.0145
Schistosoma mansoni ferritin 0.0008 0.002 0.0024
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0145 0.0171
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0387 0.4081
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0045 0.0485 0.0813
Leishmania major hypothetical protein, conserved 0.0071 0.0823 1
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0045 0.0485 0.0813
Schistosoma mansoni cpg binding protein 0.0029 0.0289 0.034
Schistosoma mansoni hypothetical protein 0.0346 0.4362 0.5134
Trypanosoma cruzi quinone oxidoreductase, putative 0.0016 0.012 0.0461
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0178
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0823 1
Schistosoma mansoni protein phosphatase 2C 0.0017 0.0128 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0823 1
Trypanosoma cruzi quinone oxidoreductase, putative 0.0016 0.012 0.0461
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0092 0.0087
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0045 0.0485 0.0571
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0442 0.052
Onchocerca volvulus 0.0045 0.0485 0.0945
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0387 0.4566
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0823 0.1404
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8497 1
Schistosoma mansoni ferritin light chain 0.0008 0.002 0.0024
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0442 0.525
Echinococcus granulosus carboxylesterase 5A 0.0065 0.0755 0.0888
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0022 0.0026
Schistosoma mansoni hypothetical protein 0.0011 0.0052 0.0061
Brugia malayi isocitrate dehydrogenase 0.0016 0.0115 0.0205
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0388
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium leprae Possible regulatory protein 0.0014 0.0086 0.0143
Schistosoma mansoni gliotactin 0.0011 0.0054 0.0063
Mycobacterium ulcerans hypothetical protein 0.0071 0.0823 0.1746
Toxoplasma gondii exonuclease III APE 0.0018 0.0145 0.0068
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0823 0.1404
Loa Loa (eye worm) hypothetical protein 0.0014 0.0086 0.014
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.0887
Leishmania major DNA polymerase eta, putative 0.0019 0.0151 0.0887
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Echinococcus multilocularis mitogen activated protein kinase 3 0.0055 0.0616 0.0616
Echinococcus multilocularis expressed protein 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase (E subunit) AdhE1 0.0321 0.4042 0.7039
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0055 0.0616 0.719
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0086 0.0818
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0485 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0485 0.0813
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0365 0.4615 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0145 0.1557
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0037 0.0387 0.7886
Leishmania major protein kinase, putative 0.0014 0.0092 0.0087
Trypanosoma brucei oxidoreductase, putative 0.0045 0.0485 0.547
Loa Loa (eye worm) acyl carrier protein 0.0028 0.0276 0.0554
Echinococcus multilocularis dna polymerase eta 0.0019 0.0151 0.0151
Leishmania major protein kinase, putative 0.0014 0.0092 0.0087
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0409 0.0409
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0999
Trypanosoma cruzi oxidoreductase, putative 0.0016 0.012 0.0461
Leishmania major hypothetical protein, conserved 0.0017 0.0128 0.0571
Schistosoma mansoni inositol monophosphatase 0.0037 0.0387 0.0455
Echinococcus granulosus phd:f box containing protein 0.0017 0.0128 0.0151
Brugia malayi hypothetical protein 0.0175 0.2167 0.4672
Echinococcus granulosus synaptic vesicle membrane protein VAT 1 0.0016 0.012 0.0141
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0014 0.0086 0.5
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0011 0.0054 0.0063
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0151 0.0229
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0485 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0045 0.0485 0.0813
Leishmania major DNA polymerase kappa, putative 0.0019 0.0151 0.0887
Toxoplasma gondii quinone oxidoreductase, putative 0.0045 0.0485 0.0823
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0231
Schistosoma mansoni alcohol dehydrogenase 0.0365 0.4615 0.5432
Echinococcus granulosus acetylcholinesterase 0.0065 0.0755 0.0888
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0145 0.0917
Trypanosoma brucei oxidoreductase, putative 0.0045 0.0485 0.547
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0045 0.0485 0.0813
Brugia malayi Cytochrome P450 family protein 0.0044 0.0474 0.0987
Echinococcus multilocularis para nitrobenzyl esterase 0.0011 0.0054 0.0054
Echinococcus granulosus ferritin 0.0008 0.002 0.0024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0145 0.0804
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0151 0.0151
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0092 0.0087
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0151 0.0229
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0365 0.4615 1
Onchocerca volvulus 0.0071 0.0823 0.1685
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0063 0.0724 0.0852
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0017 0.0128 0.003
Echinococcus multilocularis jumonji domain containing 1A 0.0017 0.0128 0.0128
Trichomonas vaginalis esterase, putative 0.0071 0.0823 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0387 0.4154
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0276 0.0556
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0115 0.0205
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0387 0.4081
Schistosoma mansoni ferritin 0.0008 0.002 0.0024
Mycobacterium tuberculosis Conserved protein 0.0071 0.0823 0.1404
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0045 0.0485 0.5414
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0086 0.0101
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0823 0.1404
Schistosoma mansoni single-minded 0.0052 0.0584 0.0687
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0014 0.0086 0.0818
Mycobacterium tuberculosis Carboxylesterase LipT 0.0011 0.0054 0.0058
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0285
Mycobacterium leprae Probable lipase LipE 0.0071 0.0823 0.1746
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0616 0.742
Echinococcus granulosus neuroligin 0.0011 0.0054 0.0063
Onchocerca volvulus Fatty acid synthase homolog 0.0028 0.0276 0.0487
Echinococcus granulosus para nitrobenzyl esterase 0.0011 0.0054 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Echinococcus granulosus JmjC domain containing protein 4 0.0017 0.0128 0.0151
Echinococcus granulosus lysine specific demethylase 5A 0.0065 0.0745 0.0876
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0616 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0669 0.0788
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.012 0.0461
Onchocerca volvulus 0.0039 0.0409 0.0779
Mycobacterium leprae Probable polyketide synthase Pks1 0.0045 0.0485 0.1011
Brugia malayi jmjC domain containing protein 0.0063 0.0724 0.1532
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0387 0.0797
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0018 0.0148 0.0148
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0225 0.1985
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0485 0.5414
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0045 0.0485 0.1011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0052 0.0052
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0055 0.0616 0.7225
Loa Loa (eye worm) carboxylesterase 0.0065 0.0755 0.1595
Echinococcus multilocularis carboxylesterase 5A 0.0065 0.0755 0.0755
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0145 0.0269
Loa Loa (eye worm) carboxylesterase 0.0011 0.0054 0.007
Brugia malayi hypothetical protein 0.0011 0.0054 0.0073
Echinococcus granulosus dna polymerase eta 0.0019 0.0151 0.0178
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0365 0.4615 0.8043
Schistosoma mansoni ap endonuclease 0.0018 0.0145 0.0171
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0145 0.0804
Leishmania major quinone oxidoreductase-like protein,alcohol dehydrogenase, zinc-containing-like protein 0.0016 0.012 0.0461
Mycobacterium ulcerans short-chain dehydrogenase 0.0045 0.0485 0.1011
Mycobacterium leprae Probable oxidireductase 0.0045 0.0485 0.1011
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0045 0.0485 0.0813
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0387 0.0455
Brugia malayi Alcohol dehydrogenase class III 0.0365 0.4615 1
Mycobacterium tuberculosis Conserved protein 0.0071 0.0823 0.1404
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0045 0.0485 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0823 0.1404
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0086 0.0818
Loa Loa (eye worm) hypothetical protein 0.0175 0.2167 0.4671
Loa Loa (eye worm) inositol-1 0.0037 0.0387 0.0794
Mycobacterium tuberculosis Possible dehydrogenase 0.0045 0.0485 0.0813
Mycobacterium ulcerans oxidoreductase 0.0016 0.012 0.0217
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0045 0.0485 0.0813
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0823 0.1746
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0045 0.0485 0.0813
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0365 0.4615 1
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.1714 0.3687
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0506
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0073
Trichomonas vaginalis spcc417.12 protein, putative 0.0011 0.0054 0.0416
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0755 0.0755
Leishmania major oxidoreductase-like protein 0.0045 0.0485 0.5414
Trypanosoma brucei Trans-2-enoyl-ACP reductase 1, putative 0.0016 0.012 0.0578
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0823 1
Trypanosoma cruzi oxidoreductase, putative 0.0045 0.0485 0.5414
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8497 1
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0045 0.0485 0.0485
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0485 0.5789
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0145 0.1557
Mycobacterium ulcerans dehydrogenase 0.0045 0.0485 0.1011
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0045 0.0485 0.1011
Mycobacterium tuberculosis Probable oxidoreductase 0.0045 0.0485 0.0813
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0151 0.0999
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0115 0.0388
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0045 0.0485 0.5414
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0151 0.0999
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.0584 0.0687
Loa Loa (eye worm) hypothetical protein 0.0065 0.0755 0.1595
Onchocerca volvulus 0.0071 0.0823 0.1685
Giardia lamblia DINP protein human, muc B family 0.0019 0.0151 0.013
Brugia malayi jmjC domain containing protein 0.0065 0.0745 0.1576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0151 0.0887
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.1714 0.1714
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0234
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0055 0.0616 0.719
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0045 0.0485 0.1011
Echinococcus granulosus mitogen activated protein kinase 0.0055 0.0616 0.0725
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0823 0.1404
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0086 0.0818
Echinococcus multilocularis cpg binding protein 0.0029 0.0289 0.0289
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0616 0.742
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0387 0.0604
Brugia malayi jmjC domain containing protein 0.0017 0.0128 0.0234
Brugia malayi Carboxylesterase family protein 0.0065 0.0755 0.1598
Loa Loa (eye worm) jmjC domain-containing protein 0.0017 0.0128 0.0231
Loa Loa (eye worm) hypothetical protein 0.0019 0.0151 0.0282
Mycobacterium ulcerans polyketide synthase 0.0045 0.0485 0.1011
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0115 0.0506
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0823 0.1746
Schistosoma mansoni DNA polymerase eta 0.0019 0.0151 0.0178
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0823 0.1746
Loa Loa (eye worm) oxidoreductase 0.0016 0.012 0.0214
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0616 0.719
Leishmania major zinc-binding dehydrogenase-like protein 0.0028 0.0276 0.258
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0063
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0011 0.0054 0.0416
Schistosoma mansoni neuroligin 3 (S09 family) 0.0011 0.0054 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0045 0.0485 0.5414
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0616 0.742
Leishmania major quinone oxidoreductase, putative 0.0045 0.0485 0.5414
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0823 0.1743
Schistosoma mansoni apoferritin-2 0.0008 0.002 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0225 0.3899
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0387 0.4566
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0045 0.0485 0.1011
Mycobacterium ulcerans carboxylesterase, LipT 0.0011 0.0054 0.0073
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0115 0.0115
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.1714 0.2018
Loa Loa (eye worm) hypothetical protein 0.0024 0.0225 0.0442
Mycobacterium ulcerans oxidoreductase FadB5 0.0045 0.0485 0.1011
Schistosoma mansoni apoferritin-2 0.0008 0.002 0.0024
Leishmania major nuclear receptor binding factor-like protein 0.0028 0.0276 0.258
Loa Loa (eye worm) cytochrome P450 family protein 0.0044 0.0474 0.0985
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8497 0.8497
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0055 0.0616 0.719
Brugia malayi CXXC zinc finger family protein 0.0028 0.0269 0.054
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0145 0.0272
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0115 0.0388
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0092 0.0087
Echinococcus granulosus geminin 0.0346 0.4362 0.5134
Onchocerca volvulus 0.0028 0.0269 0.0471
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0145 0.0272
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0045 0.0485 0.0813
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0055 0.0616 0.719
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0145 0.2689
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Loa Loa (eye worm) hypothetical protein 0.0045 0.0485 0.1008
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0073
Schistosoma mansoni zinc binding dehydrogenase 0.0045 0.0485 0.0571
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0028 0.0276 0.0556
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0151 0.0887
Echinococcus granulosus single minded 2 0.0039 0.0409 0.0481
Schistosoma mansoni cpg binding protein 0.0029 0.0289 0.034
Echinococcus multilocularis phd:f box containing protein 0.0017 0.0128 0.0128
Echinococcus granulosus dna polymerase kappa 0.0019 0.0151 0.0178
Brugia malayi MAP kinase sur-1 0.0055 0.0616 0.1295
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0055 0.0616 0.719
Echinococcus granulosus expressed protein 0.0008 0.002 0.0024
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0052 0.0061
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0045 0.0485 0.5789
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.1664 0.1958
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0151 0.0178
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0011 0.0054 0.0063
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0086 0.014
Schistosoma mansoni ferritin light chain 0.0008 0.002 0.0024
Leishmania major hypothetical protein, conserved 0.0016 0.012 0.0461
Schistosoma mansoni hypothetical protein 0.0346 0.4362 0.5134
Trypanosoma cruzi oxidoreductase, putative 0.0045 0.0485 0.5414
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0409 0.0846
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0045 0.0485 0.5414
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0115 0.0202
Loa Loa (eye worm) carboxylesterase 0.0011 0.0054 0.007
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0285
Trichomonas vaginalis guanylate cyclase, putative 0.0014 0.0086 0.0818
Loa Loa (eye worm) hypothetical protein 0.0065 0.0755 0.1595
Toxoplasma gondii type I fatty acid synthase 0.0016 0.012 0.0012
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0045 0.0485 0.1011
Schistosoma mansoni quinone oxidoreductase 0.0016 0.012 0.0141
Echinococcus granulosus cpg binding protein 0.0029 0.0289 0.034
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0365 0.4615 1
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0045 0.0485 0.1011
Schistosoma mansoni jumonji domain containing protein 0.0063 0.0724 0.0852
Schistosoma mansoni acetylcholinesterase 0.0011 0.0054 0.0063
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0045 0.0485 0.1011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0017 0.0128 0.0476
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0442 0.0726
Loa Loa (eye worm) hypothetical protein 0.0045 0.0485 0.1008
Loa Loa (eye worm) beta-lactamase 0.0071 0.0823 0.1743
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0151 0.0999
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0045 0.0485 0.0813
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0151 0.0282
Echinococcus multilocularis ferritin 0.0008 0.002 0.002
Brugia malayi beta-lactamase 0.0071 0.0823 0.1746
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0365 0.4615 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.007
Mycobacterium tuberculosis Possible zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0321 0.4042 0.7039
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0115 0.0115
Echinococcus multilocularis synaptic vesicle membrane protein VAT 1 0.0016 0.012 0.012
Brugia malayi beta-lactamase family protein 0.0071 0.0823 0.1746
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0086 0.0818
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0409 0.0846
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0045 0.0485 0.1011
Onchocerca volvulus Putative alcohol dehydrogenase 0.0365 0.4615 1
Mycobacterium ulcerans beta-lactamase 0.0071 0.0823 0.1746
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0065 0.0755 0.0888
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0028 0.0276 0.0556
Echinococcus multilocularis JmjC domain containing protein 4 0.0017 0.0128 0.0128
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0092 0.0087
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0045 0.0485 0.1011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0387 0.4081
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0823 1
Echinococcus granulosus lysine specific demethylase 6a 0.0017 0.0128 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0823 1
Echinococcus multilocularis mitogen activated protein kinase 0.0055 0.0616 0.0616
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0225 0.1885
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0128 0.0571
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0073
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0442 0.0726
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0017 0.0128 0.0571
Leishmania major zinc binding dehydrogenase-like protein 0.0045 0.0485 0.5414
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0017 0.0128 0.0687
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0151 0.0285
Brugia malayi hypoxia-induced factor 1 0.0162 0.1993 0.4292
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0225 0.1885
Echinococcus granulosus BC026374 protein S09 family 0.0011 0.0054 0.0063
Schistosoma mansoni phd/f-box containing protein 0.0017 0.0128 0.0151
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0145 0.0804
Loa Loa (eye worm) acetyltransferase 0.014 0.1714 0.3685
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0115 0.0135
Trichomonas vaginalis CMGC family protein kinase 0.0055 0.0616 0.742
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0151 0.0285
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0086 0.0086
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0145 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0823 1
Echinococcus multilocularis neuroligin 0.0011 0.0054 0.0054
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0086 0.0818
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0086 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0452 0.5734 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0397 0.536
Schistosoma mansoni jumonji/arid domain-containing protein 0.0065 0.0745 0.0876
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0016 0.012 0.0174
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0151 0.018
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0033 0.0337 0.0689
Brugia malayi Carboxylesterase family protein 0.0065 0.0755 0.1598
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0225 0.3899
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0225 0.0245
Echinococcus granulosus acetylcholinesterase 0.0065 0.0755 0.0888
Mycobacterium tuberculosis Conserved protein 0.0071 0.0823 0.1404
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0115 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0823 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0014 0.0086 0.0818
Leishmania major d-xylulose reductase, putative 0.0045 0.0485 0.5414
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0063 0.0724 0.0724
Loa Loa (eye worm) acetylcholinesterase 1 0.0065 0.0755 0.1595
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0018 0.0148 0.0175
Mycobacterium ulcerans oxidoreductase 0.0028 0.0276 0.0556
Mycobacterium ulcerans quinone oxidoreductase 0.0045 0.0485 0.1011
Echinococcus multilocularis BC026374 protein (S09 family) 0.0011 0.0054 0.0054
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0045 0.0485 0.1011
Loa Loa (eye worm) hypothetical protein 0.0028 0.0276 0.0554
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0823 0.0823
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0115 0.0115
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0151 0.0887
Echinococcus multilocularis acetylcholinesterase 0.0065 0.0755 0.0755
Trichomonas vaginalis adenylate cyclase, putative 0.0014 0.0086 0.0818
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0387 0.4566
Loa Loa (eye worm) hypothetical protein 0.0071 0.0823 0.1743
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0016 0.012 0.0217
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0151 0.1633
Schistosoma mansoni ferritin 0.0008 0.002 0.0024
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0045 0.0485 0.0813
Trypanosoma cruzi oxidoreductase, putative 0.0028 0.0276 0.258
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0823 0.1746
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0145 0.0433
Leishmania major oxidoreductase, putative 0.0045 0.0485 0.5414
Brugia malayi Carboxylesterase family protein 0.0011 0.0054 0.0073
Schistosoma mansoni ferritin 0.0008 0.002 0.0024
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0045 0.0485 0.0813
Mycobacterium ulcerans quinone reductase Qor 0.0045 0.0485 0.1011
Mycobacterium ulcerans alcohol dehydrogenase AdhA 0.0016 0.012 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0823 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 110 mg kg-1 Antiviral activity against Forest virus (SFV) ChEMBL. 2999405
ED50 (functional) > 400 mg kg-1 Effective dose administered perorally againist Forest virus infected mice ChEMBL. 2999405
ED50 (functional) > 400 mg kg-1 Effective dose administered subcutaneously againist Forest virus infected mice ChEMBL. 2999405
IFN (functional) = 10 ml Evaluation for serum interferon response from a single 800 mg/kg intraperitoneal administration in vesicular stomatitis virus on L292 cells; Range 10-50 units/mL ChEMBL. 2999405
IFN (functional) = 10 ml Evaluation for serum interferon response from a single 800 mg/kg intraperitoneal administration in vesicular stomatitis virus on L292 cells; Range 10-50 units/mL ChEMBL. 2999405
Protection index (functional) = 0.27 Intraperitoneal administration against herpes simplex virus type-1 (HSV-1) infected mice ChEMBL. 2999405

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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