Detailed information for compound 79722

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 830.879 | Formula: C42H50N6O12
  • H donors: 7 H acceptors: 9 LogP: 1.21 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 3
  • SMILES: OCC1O[C@@H](OCc2ccccc2)[C@H]([C@@H](C1O)OC(C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N)CCC(=O)OCCNC(=O)c1cccc2c1nc1ccccc1c2)C)C)NC(=O)C
  • InChi: 1S/C42H50N6O12/c1-23(45-40(55)24(2)59-37-35(46-25(3)50)42(60-32(21-49)36(37)52)58-22-26-10-5-4-6-11-26)39(54)48-31(38(43)53)16-17-33(51)57-19-18-44-41(56)29-14-9-13-28-20-27-12-7-8-15-30(27)47-34(28)29/h4-15,20,23-24,31-32,35-37,42,49,52H,16-19,21-22H2,1-3H3,(H2,43,53)(H,44,56)(H,45,55)(H,46,50)(H,48,54)/t23-,24?,31-,32?,35+,36?,37+,42-/m1/s1
  • InChiKey: SEWAWDFUQGLQFA-IAXIIOBISA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0151 0.14 0.1652
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.7231 0.862
Echinococcus multilocularis carboxylesterase 5A 0.0066 0.0529 0.0612
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0202 0.1928 0.2283
Brugia malayi Pre-SET motif family protein 0.0445 0.4429 0.9975
Loa Loa (eye worm) carboxylesterase 0.0066 0.0529 0.1188
Schistosoma mansoni ATP-binding cassette transporter 0.0073 0.0606 0.0816
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.1356 0.1856
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0068 0.007
Loa Loa (eye worm) hypothetical protein 0.0446 0.4439 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0022 0.0072
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 1
Trypanosoma brucei hypothetical protein, conserved 0.0221 0.2125 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.005 0.0109
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0068 0.0046
Echinococcus multilocularis glutamate receptor 2 0.0073 0.0606 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.112 0.221
Onchocerca volvulus 0.0097 0.0845 0.1668
Toxoplasma gondii aldehyde dehydrogenase 0.0129 0.1175 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0178 0.1682 0.1989
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0258 0.1208
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0129 0.1175 0.1605
Echinococcus multilocularis glutamate receptor 2 0.006 0.047 0.0541
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0025 0.0112 0.009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0022 0.0072
Loa Loa (eye worm) glutamate receptor 2 0.0073 0.0606 0.1362
Schistosoma mansoni hypothetical protein 0.0036 0.022 0.0282
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Schistosoma mansoni glutamate receptor AMPA 0.0073 0.0606 0.0816
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0829 0.8386 1
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0115 0.1489
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.1112 0.1009
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0556 0.2232
Echinococcus granulosus transcription factor Dp 1 0.004 0.0258 0.0334
Brugia malayi hypothetical protein 0.0026 0.0115 0.0255
Schistosoma mansoni lamin 0.002 0.0054 0.0051
Trichomonas vaginalis chromobox protein, putative 0.022 0.2116 0.4179
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0556 0.2609
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0985 0.0965
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0556 0.1248
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0022 0.0041
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.002 0.0054 0.0117
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0115 0.1489
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0305 0.2489
Trichomonas vaginalis chromobox protein, putative 0.022 0.2116 0.4179
Schistosoma mansoni lozenge 0.0056 0.0425 0.0566
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0267 0.1071
Toxoplasma gondii hypothetical protein 0.0028 0.0133 0.1001
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0114 0.0528
Brugia malayi acetyltransferase, GNAT family protein 0.0151 0.14 0.3151
Schistosoma mansoni glutamate receptor NMDA 0.0087 0.075 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Loa Loa (eye worm) hypothetical protein 0.0116 0.1041 0.2342
Plasmodium vivax hypothetical protein, conserved 0.0036 0.022 0.3099
Plasmodium vivax glutathione reductase, putative 0.0048 0.0347 0.5035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0985 0.0965
Schistosoma mansoni calcium-activated potassium channel 0.0116 0.1041 0.1419
Echinococcus granulosus chromobox protein 1 0.022 0.2116 0.2909
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Echinococcus granulosus lamin 0.002 0.0054 0.0051
Loa Loa (eye worm) glutathione reductase 0.0048 0.0347 0.0779
Schistosoma mansoni chromobox protein 0.0036 0.022 0.0282
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0339 0.0446
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0036 0.022 0.3099
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0985 0.0881
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0506 0.0584
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0986 1 1
Entamoeba histolytica hypothetical protein 0.0026 0.0114 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0749 0.1477
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Toxoplasma gondii thioredoxin reductase 0.0048 0.0347 0.285
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.022 0.0282
Brugia malayi Carboxylesterase family protein 0.0066 0.0529 0.1188
Schistosoma mansoni alpha glucosidase 0.004 0.0258 0.0334
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1928 0.9071
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0673 0.0909
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0073 0.0606 0.0704
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0258 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0506 0.0678
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Onchocerca volvulus 0.0506 0.5061 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0258 0.0288
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0025 0.0112 0.0217
Echinococcus granulosus geminin 0.0125 0.1133 0.1547
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0319
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0258 0.0507
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0479 0.064
Loa Loa (eye worm) hypothetical protein 0.0123 0.112 0.252
Leishmania major DNA polymerase kappa, putative 0.0021 0.0068 0.0311
Loa Loa (eye worm) glutaminase 0.0284 0.2774 0.6246
Echinococcus granulosus glutamate receptor 2 0.0087 0.075 0.1015
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0133 0.1768
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0022 0.0095
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0305 0.06
Entamoeba histolytica serine/threonine protein kinase, putative 0.0202 0.1928 0.7762
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0985 0.0965
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0479 0.1075
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0479 0.064
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.2125 1
Trichomonas vaginalis chromobox protein, putative 0.0036 0.022 0.0432
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0556 0.2609
Loa Loa (eye worm) acetyltransferase 0.0151 0.14 0.3151
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0115 0.0541
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0479 0.064
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 1
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1175 0.1605
Echinococcus multilocularis Chromo domain 0.0036 0.022 0.0243
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0479 0.064
Plasmodium falciparum thioredoxin reductase 0.0048 0.0347 0.5035
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Schistosoma mansoni hypothetical protein 0.0125 0.1133 0.1547
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0046
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0112 0.009
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.1112 0.1092
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0267 0.3817
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Echinococcus granulosus glutamate receptor subunit protein glur 0.0027 0.013 0.0156
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0178 0.1682 0.2307
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0305 0.0399
Schistosoma mansoni aldehyde dehydrogenase 0.0129 0.1175 0.1605
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0035
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0068 0.006
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0305 0.4396
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0025 0.0112 0.009
Loa Loa (eye worm) CHromoDomain protein family member 0.0036 0.022 0.0493
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Onchocerca volvulus 0.01 0.0877 0.173
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0178 0.1682 0.2307
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0006
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0258 0.1208
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.013 0.0156
Trichomonas vaginalis chromobox protein, putative 0.0133 0.1216 0.2401
Brugia malayi Pre-SET motif family protein 0.0064 0.0506 0.1137
Loa Loa (eye worm) hypothetical protein 0.008 0.0673 0.1512
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0129 0.1175 0.1384
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0123 0.112 0.221
Plasmodium falciparum glutathione reductase 0.0017 0.0022 0.0072
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0112 0.0517
Loa Loa (eye worm) runx1 0.0056 0.0425 0.0954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1175 0.1156
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0339 0.0446
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0114 0.1412
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0036 0.022 0.0243
Brugia malayi hypothetical protein 0.0036 0.022 0.0493
Brugia malayi glutathione reductase 0.0048 0.0347 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.022 0.1755
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0035
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0305 0.2489
Plasmodium falciparum glutathione reductase 0.0048 0.0347 0.5035
Trypanosoma brucei unspecified product 0.0021 0.0068 0.0319
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0673 0.0783
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.0881
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Loa Loa (eye worm) glutaminase 2 0.0284 0.2774 0.6246
Loa Loa (eye worm) hypothetical protein 0.0446 0.4439 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0506 0.0678
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0673 0.0565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0339 0.0446
Schistosoma mansoni alpha-glucosidase 0.0154 0.1435 0.1965
Plasmodium falciparum thioredoxin reductase 0.0017 0.0022 0.0072
Echinococcus multilocularis NMDA receptor 0.0118 0.1062 0.1248
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0319
Mycobacterium ulcerans glutaminase 0.0284 0.2774 0.2758
Entamoeba histolytica hypothetical protein 0.0073 0.0599 0.2406
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0115 0.1489
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Plasmodium falciparum heterochromatin protein 1 0.0036 0.022 0.3099
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0036 0.022 0.1755
Schistosoma mansoni lamin 0.002 0.0054 0.0051
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0104
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0432
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0073
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0151 0.14 0.1917
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0129 0.1175 0.5526
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0479 0.0551
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0178 0.1682 0.2307
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0027 0.013 0.0134
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0347 0.0457
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0068 0.013
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0066 0.0529 0.0709
Mycobacterium tuberculosis Probable reductase 0.011 0.0985 0.0965
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 0.0652
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0035
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0022 0.0095
Loa Loa (eye worm) intermediate filament protein 0.002 0.0054 0.0117
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Loa Loa (eye worm) hypothetical protein 0.0052 0.0386 0.0865
Giardia lamblia Kinase, PLK 0.0202 0.1928 0.7744
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0556 0.1248
Trichomonas vaginalis hypothetical protein 0.0036 0.022 0.0432
Brugia malayi hypothetical protein 0.0017 0.0021 0.0043
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0036 0.022 0.1755
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Echinococcus granulosus chromobox protein 2 0.0036 0.022 0.0282
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0114 0.0092
Schistosoma mansoni calcium-activated potassium channel 0.011 0.0983 0.1339
Echinococcus multilocularis geminin 0.0125 0.1133 0.1333
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0506 0.0678
Brugia malayi Intermediate filament tail domain containing protein 0.002 0.0054 0.0117
Mycobacterium ulcerans proteasome PrcA 0.0986 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0068 0.0046
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0068 0.007
Loa Loa (eye worm) hypothetical protein 0.0021 0.0068 0.0149
Brugia malayi Protein cec-1. 0.0036 0.022 0.0493
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0035
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0114 0.1412
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.0881
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0129 0.1175 0.1156
Echinococcus multilocularis Chromobox protein 3 0.0036 0.022 0.0243
Schistosoma mansoni glutaminase 0.0284 0.2774 0.3821
Brugia malayi serine/threonine-protein kinase plk-2 0.0202 0.1928 0.434
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0178 0.1682 0.1989
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0027 0.013 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0432
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0112 0.0517
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0389 0.0444
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0035
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0114 0.0834
Echinococcus multilocularis chromobox protein 2 0.0036 0.022 0.0243
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0114 0.1412
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0035
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0025 0.0112 0.0517
Brugia malayi Valyl-tRNA synthetase 0.0036 0.022 0.0493
Schistosoma mansoni alpha-glucosidase 0.0154 0.1435 0.1965
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0506 0.4223
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0256 0.2483 1
Schistosoma mansoni kinase 0.0103 0.0906 0.1232
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0035
Brugia malayi hypothetical protein 0.0446 0.4439 1
Mycobacterium tuberculosis Conserved protein 0.0025 0.0112 0.009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0255
Schistosoma mansoni glutamate receptor kainate 0.0164 0.1538 0.2108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Brugia malayi Carboxylesterase family protein 0.0066 0.0529 0.1188
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0258 0.0507
Echinococcus multilocularis dna polymerase eta 0.0021 0.0068 0.006
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0036 0.022 0.0493
Loa Loa (eye worm) hypothetical protein 0.0064 0.0506 0.1137
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0311
Giardia lamblia DINP protein human, muc B family 0.0021 0.0068 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0258 0.0507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1175 0.1156
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0985 0.0965
Echinococcus granulosus glutamate receptor 2 0.006 0.047 0.0627
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0878 0.1733
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0479 0.0551
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0118 0.1062 0.1248
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0202 0.1928 0.2648
Brugia malayi Glutamate receptor 1 precursor 0.0073 0.0606 0.1362
Leishmania major hypothetical protein, conserved 0.0016 0.0017 0.0073
Loa Loa (eye worm) hypothetical protein 0.0097 0.0845 0.1901
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0258 0.2081
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0022 0.0104
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0133 0.1216 0.2401
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0068 0.0266
Echinococcus multilocularis Protein lozenge 0.0056 0.0425 0.0488
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.0749 0.1477
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0506 0.0584
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.022 0.0282
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0115 0.0843
Loa Loa (eye worm) helicase 0.0036 0.022 0.0493
Loa Loa (eye worm) hypothetical protein 0.0066 0.0529 0.1188
Echinococcus granulosus chromobox protein 1 0.022 0.2116 0.2909
Loa Loa (eye worm) cytochrome P450 family protein 0.0054 0.0401 0.09
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0068 0.0149
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0114 0.0834
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0673 0.5661
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0305 0.06
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0068 0.0319
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0258 0.1034
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Schistosoma mansoni hypothetical protein 0.0116 0.1041 0.1419
Schistosoma mansoni hypothetical protein 0.0125 0.1133 0.1547
Echinococcus granulosus Chromo domain 0.0036 0.022 0.0282
Plasmodium vivax hypothetical protein, conserved 0.0036 0.022 0.3099
Echinococcus multilocularis chromobox protein 1 0.022 0.2116 0.2508
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Echinococcus multilocularis L aminoadipate semialdehyde 0.0091 0.0789 0.0923
Onchocerca volvulus 0.0103 0.0915 0.1805
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0258 0.0507
Mycobacterium ulcerans aldehyde dehydrogenase 0.0129 0.1175 0.1156
Echinococcus granulosus Chromobox protein 3 0.0036 0.022 0.0282
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0258 0.0507
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0881
Loa Loa (eye worm) heterochromatin protein 1 0.022 0.2116 0.4764
Schistosoma mansoni chromobox protein 0.022 0.2116 0.2909
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.01 0.0877 0.1192
Echinococcus multilocularis small conductance calcium activated potassium 0.0116 0.1041 0.1224
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0339 0.0384
Schistosoma mansoni glutamate receptor kainate 0.0164 0.1538 0.2108
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0556 0.0643
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0036 0.022 0.0243
Echinococcus granulosus L aminoadipate semialdehyde 0.0091 0.0789 0.107
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0068 0.0046
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0068 0.0149
Brugia malayi Glutamate receptor 2 precursor 0.0073 0.0606 0.1362
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0556 0.2609
Loa Loa (eye worm) hypothetical protein 0.0066 0.0529 0.1188
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.007
Loa Loa (eye worm) acetylcholinesterase 1 0.0066 0.0529 0.1188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0022 0.0046
Trichomonas vaginalis chromobox protein, putative 0.0036 0.022 0.0432
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0178 0.1682 0.1989
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0022 0.004
Echinococcus granulosus dna polymerase kappa 0.0021 0.0068 0.007
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0073 0.0599 0.2406
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0339 0.076
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0311
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0258 0.0578
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0061 0.0482 0.0644
Mycobacterium ulcerans hypothetical protein 0.0025 0.0112 0.009
Leishmania major hypothetical protein, conserved 0.0026 0.0115 0.0533
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0068 0.0311
Echinococcus granulosus lamin dm0 0.002 0.0054 0.0051
Trichomonas vaginalis glutaminase, putative 0.0284 0.2774 0.5479
Echinococcus granulosus carboxylesterase 5A 0.0066 0.0529 0.0709
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0022 0.0095
Onchocerca volvulus 0.0091 0.0789 0.1557
Brugia malayi glutaminase DH11.1 0.0284 0.2774 0.6246
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0339 0.0446
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0133 0.1708
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0022 0.0072
Echinococcus granulosus dna polymerase eta 0.0021 0.0068 0.007
Echinococcus granulosus small conductance calcium activated potassium 0.0116 0.1041 0.1419
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0091 0.0789 0.107
Schistosoma mansoni DNA polymerase eta 0.0021 0.0068 0.007
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0881
Giardia lamblia DNA repair protein RAD52 0.0256 0.2483 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0022 0.0072
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0114 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0202 0.1928 0.2648
Echinococcus multilocularis lamin 0.002 0.0054 0.0044
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0022 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0017 0.0035
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0115 0.0533
Schistosoma mansoni glutamate receptor AMPA 0.0073 0.0606 0.0816
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0556 0.2615
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 0.0652
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0133 0.002
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0347 0.0394
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0036 0.022 0.0282
Trypanosoma brucei polo-like protein kinase 0.0202 0.1928 0.9071
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0432
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0258 0.0578
Entamoeba histolytica hypothetical protein 0.0036 0.022 0.0881
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0073
Brugia malayi jmjC domain containing protein 0.0016 0.0017 0.0035
Schistosoma mansoni glutamate receptor kainate 0.0073 0.0606 0.0816
Onchocerca volvulus 0.0446 0.4439 0.8771
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1691 0.2
Mycobacterium ulcerans hypothetical protein 0.0025 0.0112 0.009
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0114 0.1473
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0339 0.076
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.7231 1
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0002 0.0008
Schistosoma mansoni hypothetical protein 0.0027 0.013 0.0156
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0022 0.0095
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0017 0.0081
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0258 0.0507
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0114 0.0092
Schistosoma mansoni chromobox protein 0.022 0.2116 0.2909
Echinococcus granulosus intermediate filament protein 0.002 0.0054 0.0051
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0068 0.0311
Schistosoma mansoni glutamate receptor NMDA 0.0073 0.0606 0.0816
Loa Loa (eye worm) glutamate receptor 1 0.0073 0.0606 0.1362
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0114 0.1473
Brugia malayi intermediate filament protein 0.002 0.0054 0.0117
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0339 0.0446
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0673 0.0909
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0104
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0556 0.0746
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0068 0.0319
Trypanosoma brucei trypanothione reductase 0.0048 0.0347 0.1634
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0022 0.0104
Echinococcus granulosus citrate lyase subunit beta protein 0.0025 0.0112 0.0131
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0118 0.1062 0.1447
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Echinococcus multilocularis chromobox protein 1 0.022 0.2116 0.2508
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0733 0.2947
Brugia malayi Thioredoxin reductase 0.0048 0.0347 0.0779
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0133 0.1768
Schistosoma mansoni chromobox protein 0.0036 0.022 0.0282
Brugia malayi jmjC domain containing protein 0.0061 0.0479 0.1075
Onchocerca volvulus Serine\/threonine kinase homolog 0.0202 0.1928 0.3807
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0673 0.5661
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0118 0.1062 0.1248
Brugia malayi Associated with TFs and helicases family protein 0.0036 0.022 0.0493
Trypanosoma cruzi hypothetical protein, conserved 0.0221 0.2125 1
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0529 0.0612
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Brugia malayi Heterochromatin protein 1 0.022 0.2116 0.4764
Echinococcus granulosus acetylcholinesterase 0.0066 0.0529 0.0709
Echinococcus multilocularis acetylcholinesterase 0.0066 0.0529 0.0612
Echinococcus granulosus glutamate NMDA receptor subunit 0.0073 0.0606 0.0816
Onchocerca volvulus 0.002 0.0054 0.0103
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0258 0.1034
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0432
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0091 0.0789 0.1775
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.1691 0.3807
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0267 0.0997
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0432
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0114 0.0536
Brugia malayi jmjC domain containing protein 0.0061 0.0479 0.1075
Echinococcus granulosus microtubule associated protein 2 0.0717 0.7231 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 1
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0506 0.0678
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0022 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Brugia malayi CHD4 protein 0.0036 0.022 0.0493
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.1691 0.2321
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0258 0.0288
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0258 0.0507
Plasmodium vivax heterochromatin protein 1, putative 0.0036 0.022 0.3099
Brugia malayi chromobox protein homolog 3 0.0123 0.112 0.252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0339 0.0384
Brugia malayi SET domain containing protein 0.0038 0.0245 0.0547
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0087 0.075 0.1015
Loa Loa (eye worm) hypothetical protein 0.0091 0.0789 0.1775
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0036 0.022 0.0282
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0347 0.0326
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0027 0.013 0.0156
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0258 0.1208
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0673 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0389 0.0278
Trichomonas vaginalis CAMK family protein kinase 0.01 0.0878 0.1733
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0025 0.0112 0.009
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0985 0.0965
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0202 0.1928 0.434
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0389 0.0368
Loa Loa (eye worm) hypothetical protein 0.0058 0.0447 0.1003
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.1691 0.2
Onchocerca volvulus 0.002 0.0054 0.0103
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.022 0.0432
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0036 0.022 0.0282
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0347 0.5035
Echinococcus multilocularis citrate lyase subunit beta protein 0.0025 0.0112 0.0113
Echinococcus granulosus acetylcholinesterase 0.0066 0.0529 0.0709
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0086 0.0733 0.2947
Plasmodium vivax SET domain protein, putative 0.0064 0.0506 0.7461
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0022 0.0007
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0479 0.064
Brugia malayi Probable ClpP-like protease 0.008 0.0673 0.1512
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0258 0.0507
Leishmania major trypanothione reductase 0.0048 0.0347 0.1627
Loa Loa (eye worm) hypothetical protein 0.0036 0.022 0.0493
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0389 0.0515
Leishmania major hypothetical protein, conserved 0.0221 0.2125 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0022 0.0041
Trichomonas vaginalis Heterochromatin protein, putative 0.0036 0.022 0.0432
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0115 0.0533
Trichomonas vaginalis chromobox protein, putative 0.0036 0.022 0.0432
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0202 0.1928 0.9071
Echinococcus multilocularis musashi 0.002 0.0054 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0445 0.4429 0.9975
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0068 0.013
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0087 0.075 0.0875
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0068 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.0054 0.0117
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0118 0.1062 0.1447
Trypanosoma cruzi polo-like protein kinase, putative 0.0202 0.1928 0.9071
Trypanosoma brucei glucosidase, putative 0.004 0.0258 0.1215
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0258 0.0507
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0347 0.0779
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0389 0.0368
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.112 0.221
Trichomonas vaginalis chromobox protein, putative 0.0133 0.1216 0.2401
Brugia malayi Cytochrome P450 family protein 0.0054 0.0401 0.09
Trichomonas vaginalis CAMK family protein kinase 0.0202 0.1928 0.3807
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.022 0.0432
Loa Loa (eye worm) hypothetical protein 0.0086 0.0733 0.1648
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0556 0.0746
Onchocerca volvulus 0.0036 0.022 0.0432
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0068 0.0319
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0036 0.022 0.0282
Schistosoma mansoni intermediate filament proteins 0.002 0.0054 0.0051
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.1112 0.1092
Trichomonas vaginalis set domain proteins, putative 0.0506 0.5061 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0036 0.022 0.0881
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0673 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0036 0.022 0.3099
Brugia malayi M-phase phosphoprotein, mpp8 0.0036 0.022 0.0493
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0347 0.1627
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0068 0.0311
Echinococcus multilocularis glutamate receptor 2 0.0087 0.075 0.0875
Onchocerca volvulus 0.0036 0.022 0.0432
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.1112 0.1092
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.013 0.0134
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.1691 0.3807
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0068 0.006
Echinococcus multilocularis lamin dm0 0.002 0.0054 0.0044
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0022 0.0095
Leishmania major DNA polymerase eta, putative 0.0021 0.0068 0.0311

Activities

Activity type Activity value Assay description Source Reference
IA (functional) 0 Tested for cytotoxicity of compound against MCF-7 (breast) cell line; IA means inactive. ChEMBL. 12502372
IA (functional) 0 Tested for cytotoxicity of compound against NCI-H460 (lung)cell line; IA means inactive. ChEMBL. 12502372
IA (functional) 0 Tested for cytotoxicity of compound against SF-268(CNS) cell line; IA means inactive. ChEMBL. 12502372

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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