Detailed information for compound 797385

Basic information

Technical information
  • TDR Targets ID: 797385
  • Name: BAS 00935764
  • MW: 287.309 | Formula: C13H21NO6
  • H donors: 1 H acceptors: 1 LogP: -0.02 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=O)C1OC2OC(OC2C2C1OC(O2)(C)C)(C)C
  • InChi: 1S/C13H21NO6/c1-12(2)17-6-7(18-12)9-11(20-13(3,4)19-9)16-8(6)10(15)14-5/h6-9,11H,1-5H3,(H,14,15)
  • InChiKey: NPNBRDAWKZSZPO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • A2223/0093605
  • ChemDiv1_019555
  • Hexopyranuronamide, N-methyl-1,2:3,4-bis-O-(1-methylethylidene)-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.1848 0.1848
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0508 0.5136
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.059 0.1778
Brugia malayi Receptor family ligand binding region containing protein 0.0021 0.0135 0.0408
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0989 0.1969
Echinococcus multilocularis ferritin 0.0018 0.0089 0.0089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0539 0.0539
Echinococcus granulosus geminin 0.0168 0.251 0.251
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0576 0.0576
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0072 0.0268
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0989 0.1342
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0989 0.1969
Brugia malayi nuclear hormone receptor family member nhr-6 0.0022 0.0151 0.0456
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0508 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0046 0.0539 0.0539
Plasmodium falciparum glutathione reductase 0.0048 0.0575 0.2144
Schistosoma mansoni tyrosine kinase 0.0021 0.0135 0.0135
Leishmania major hypothetical protein, conserved 0.0074 0.0989 1
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0193 0.0581
Brugia malayi glutathione reductase 0.0048 0.0575 0.1733
Echinococcus granulosus tyrosine kinase 0.0021 0.0135 0.0135
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0508 0.0508
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.156 0.2117
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0151 0.1528
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0576 0.0576
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0053 0.0161
Echinococcus multilocularis tyrosine kinase 0.0021 0.0135 0.0135
Brugia malayi ecdysone receptor 0.0022 0.0151 0.0456
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2581 0.2581
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.077 0.077
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0193
Mycobacterium ulcerans bacterioferritin BfrB 0.0018 0.0089 0.0176
Schistosoma mansoni hypothetical protein 0.0127 0.1848 0.1848
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0151 0.0456
Echinococcus multilocularis GPCR, family 2 0.0015 0.0053 0.0053
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0508 0.1896
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0035 0.0375 0.0375
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0035 0.0375 0.1131
Mycobacterium ulcerans lipase LipD 0.0074 0.0989 0.1969
Brugia malayi metabotropic glutamate receptor type 2 0.0106 0.1517 0.4573
Brugia malayi RNA binding protein 0.0127 0.1854 0.5591
Echinococcus granulosus atrial natriuretic peptide receptor 0.0021 0.0135 0.0135
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0072 0.0268
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0018 0.0089 0.0331
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.737 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0046 0.0539 0.0539
Echinococcus granulosus nmda type glutamate receptor 0.0021 0.0135 0.0135
Brugia malayi beta-lactamase family protein 0.0074 0.0989 0.2983
Onchocerca volvulus 0.0022 0.0151 0.1528
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0046 0.0539 0.0539
Mycobacterium tuberculosis Conserved protein 0.0074 0.0989 0.1342
Entamoeba histolytica Ran family GTPase 0.0044 0.0508 0.5194
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0022 0.0151 0.0151
Schistosoma mansoni ferritin light chain 0.0018 0.0089 0.0089
Loa Loa (eye worm) glutathione reductase 0.0048 0.0575 0.0575
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.156 0.2117
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0135 0.0135
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Brugia malayi ecdysteroid receptor 0.0046 0.0539 0.1624
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0046 0.0539 0.0539
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0324 0.5024 0.6817
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0989 0.3517
Echinococcus granulosus thyroid hormone receptor alpha 0.0022 0.0151 0.0151
Plasmodium vivax glutathione reductase, putative 0.0048 0.0575 0.2144
Echinococcus multilocularis receptor type guanylyl cyclase 0.0021 0.0135 0.0135
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0179 0.268 1
Echinococcus granulosus cpg binding protein 0.003 0.0286 0.0286
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0046 0.0539 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1854 0.1854
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0021 0.0135 0.1369
Loa Loa (eye worm) RNA binding protein 0.0127 0.1854 0.1854
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Onchocerca volvulus Poor gastrulation protein homolog 0.0035 0.0375 0.3792
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0053
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0046 0.0539 0.0539
Leishmania major importin beta-1 subunit, putative 0.0048 0.058 0.5859
Trypanosoma cruzi extracellular receptor, putative 0.0021 0.0135 0.1369
Echinococcus granulosus receptor type guanylyl cyclase 0.0021 0.0135 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0046 0.0539 0.1624
Brugia malayi Metabotropic glutamate receptor precursor. 0.0218 0.3316 1
Brugia malayi nuclear receptor NHR-88 0.0046 0.0539 0.1624
Brugia malayi beta-lactamase 0.0074 0.0989 0.2983
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0053
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0056 0.0705 0.0705
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0575 0.078
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0021 0.0135 0.0135
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0072
Onchocerca volvulus 0.0028 0.026 0.2631
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0989 0.0989
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0018 0.0089 0.012
Echinococcus multilocularis cpg binding protein 0.003 0.0286 0.0286
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.1756 0.2383
Echinococcus granulosus dnaJ subfamily B 0.0403 0.6286 0.6286
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0072 0.0727
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0179 0.268 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0022 0.0151 0.0151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0046 0.0539 0.0539
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0576 0.0576
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1854 0.1854
Brugia malayi hypothetical protein 0.0024 0.0193 0.0581
Plasmodium falciparum thioredoxin reductase 0.0048 0.0575 0.2144
Brugia malayi photoreceptor-specific nuclear receptor 0.0046 0.0539 0.1624
Brugia malayi tailless protein 0.0022 0.0151 0.0456
Loa Loa (eye worm) beta-lactamase 0.0074 0.0989 0.0989
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0024 0.0193 0.0193
Plasmodium vivax importin-beta 2, putative 0.0059 0.076 0.2836
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0053 0.0053
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.0667 0.249
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0072 0.0268
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0508 0.0508
Loa Loa (eye worm) DR-78 0.0022 0.0151 0.0151
Echinococcus multilocularis snurportin 1 0.0634 1 1
Entamoeba histolytica hypothetical protein 0.0073 0.0978 1
Onchocerca volvulus 0.0046 0.0539 0.5444
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0508 0.0508
Brugia malayi conserved hypotetical protein 0.0022 0.0151 0.0456
Brugia malayi Steroid receptor seven-up type 2 0.0046 0.0539 0.1624
Leishmania major extracellular receptor, putative 0.0021 0.0135 0.1369
Schistosoma mansoni ferritin 0.0018 0.0089 0.0089
Echinococcus granulosus metabotropic glutamate receptor 2 0.0183 0.2746 0.2746
Leishmania major GTP-binding protein, putative 0.0044 0.0508 0.5136
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0022 0.0151 0.0456
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0989 0.1342
Schistosoma mansoni hypothetical protein 0.0073 0.0978 0.0978
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Schistosoma mansoni thyroid hormone receptor 0.0173 0.2581 0.2581
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.076 0.7685
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0072 0.0268
Schistosoma mansoni apoferritin-2 0.0018 0.0089 0.0089
Brugia malayi Guanylyl cyclase protein 23 0.0021 0.0135 0.0408
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0046 0.0539 0.5444
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0179 0.268 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0046 0.0539 0.0539
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0046 0.0539 0.0539
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0022 0.0151 0.0151
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0024 0.0193 0.0193
Onchocerca volvulus 0.0074 0.0989 1
Schistosoma mansoni ran 0.0044 0.0508 0.0508
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0072
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0072 0.0143
Plasmodium falciparum glutathione reductase 0.0017 0.0072 0.0268
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0576 0.1737
Brugia malayi Importin beta-1 subunit 0.0059 0.076 0.2292
Schistosoma mansoni metabotropic glutamate receptor 0.0106 0.1517 0.1517
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0135 0.0135
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0022 0.0151 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0989 0.3517
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0135 0.0135
Brugia malayi orphan nuclear receptor NR2E1 0.0022 0.0151 0.0456
Schistosoma mansoni hypothetical protein 0.0035 0.0375 0.0375
Schistosoma mansoni nuclear hormone receptor 0.0046 0.0539 0.0539
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0015 0.0053 0.0053
Plasmodium falciparum enoyl-acyl carrier reductase 0.0179 0.268 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0508 0.5136
Brugia malayi beta-lactamase family protein 0.0074 0.0989 0.2983
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0539 0.1624
Echinococcus multilocularis geminin 0.0168 0.251 0.251
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0001 0.0003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0046 0.0539 0.0539
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0575 0.0575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0539 0.0539
Schistosoma mansoni ferritin 0.0018 0.0089 0.0089
Schistosoma mansoni ferritin light chain 0.0018 0.0089 0.0089
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0053 0.0053
Mycobacterium leprae Probable lipase LipE 0.0074 0.0989 0.3691
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0072 0.0143
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0021 0.0135 0.0408
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.058 0.1946
Onchocerca volvulus 0.0074 0.0989 1
Echinococcus granulosus FTZ F1 alpha 0.0046 0.0539 0.0539
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0634 1 1
Echinococcus granulosus importin subunit beta 1 0.0059 0.076 0.076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0576 0.0576
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0022 0.0151 0.0151
Schistosoma mansoni hypothetical protein 0.0168 0.251 0.251
Toxoplasma gondii HEAT repeat-containing protein 0.0059 0.076 0.2836
Schistosoma mansoni hypothetical protein 0.0168 0.251 0.251
Trichomonas vaginalis ferritin, putative 0.0018 0.0089 0.0064
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0989 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0539 0.1624
Mycobacterium tuberculosis Conserved protein 0.0074 0.0989 0.1342
Echinococcus multilocularis nuclear receptor nhr 48 0.0022 0.0151 0.0151
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0151 0.0151
Brugia malayi CXXC zinc finger family protein 0.0028 0.026 0.0785
Trypanosoma brucei importin beta-1 subunit, putative 0.0059 0.076 0.7685
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.026 0.026
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0989 0.1342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0989 0.2983
Schistosoma mansoni cpg binding protein 0.003 0.0286 0.0286
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.156 0.2117
Onchocerca volvulus 0.0022 0.0151 0.1528
Echinococcus multilocularis thyroid hormone receptor alpha 0.0173 0.2581 0.2581
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0059 0.076 0.076
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0989 1
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0989 0.3691
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0989 0.0989
Brugia malayi nuclear hormone receptor 0.0022 0.0151 0.0456
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0072 0.0268
Echinococcus granulosus GPCR family 2 0.0015 0.0053 0.0053
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0193 0.0581
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.0035 0.0375 0.3792
Plasmodium falciparum thioredoxin reductase 0.0017 0.0072 0.0268
Brugia malayi Thioredoxin reductase 0.0048 0.0575 0.1733
Toxoplasma gondii thioredoxin reductase 0.0048 0.0575 0.2144
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0072 0.0727
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0576 0.0576
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0046 0.0539 0.0539
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0179 0.268 1
Schistosoma mansoni ferritin 0.0018 0.0089 0.0089
Onchocerca volvulus Protein ultraspiracle homolog 0.0046 0.0539 0.5444
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Trichomonas vaginalis importin beta-1, putative 0.0048 0.058 0.1946
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0072 0.0268
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0269 0.4128 0.4128
Trichomonas vaginalis hypothetical protein 0.0179 0.268 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0151 0.0151
Loa Loa (eye worm) glutamate receptor 0.0218 0.3316 0.3316
Brugia malayi hypothetical protein 0.0022 0.0151 0.0456
Entamoeba histolytica hypothetical protein 0.0021 0.0135 0.1384
Schistosoma mansoni coup transcription factor 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0049 0.059 0.059
Echinococcus granulosus ecdysone induced protein 78C 0.0046 0.0539 0.0539
Brugia malayi steroid hormone receptor 0.0046 0.0539 0.1624
Echinococcus multilocularis dnaJ subfamily B 0.0403 0.6286 0.6286
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0989 0.0989
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1854 0.1854
Plasmodium falciparum importin beta, putative 0.0059 0.076 0.2836
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0727
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Brugia malayi hypothetical protein 0.0024 0.0193 0.0581
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0989 0.3517
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.1756 0.6552
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0072 0.0727
Trypanosoma brucei trypanothione reductase 0.0048 0.0575 0.5809
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.156 0.2117
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0978 0.0978
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Echinococcus granulosus glutamate receptor 2 0.0021 0.0135 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0056 0.0705 0.0705
Schistosoma mansoni RAR-like nuclear receptor 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0022 0.0151 0.1528
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0072 0.0727
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0508 0.1896
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0024 0.0193 0.0193
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0072 0.0727
Echinococcus multilocularis nmda type glutamate receptor 0.0021 0.0135 0.0135
Trichomonas vaginalis esterase, putative 0.0074 0.0989 0.3517
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0151 0.0151
Mycobacterium ulcerans epoxide hydrolase EphA 0.0324 0.5024 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0989 0.1342
Brugia malayi nuclear receptor RXR 0.0022 0.0151 0.0456
Entamoeba histolytica hypothetical protein 0.0048 0.058 0.5925
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0576 0.0576
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0046 0.0539 0.0539
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0072 0.0268
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0001 0.0003
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0151 0.0151
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0072 0.0268
Loa Loa (eye worm) nuclear hormone receptor 0.0022 0.0151 0.0151
Brugia malayi nuclear hormone receptor 0.0046 0.0539 0.1624
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0024 0.0193 0.0193
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0046 0.0539 0.1624
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0193
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.059 0.1778
Onchocerca volvulus 0.0074 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0989 0.0989
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0135 0.0135
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0135 0.0135
Brugia malayi Nuclear hormone receptor-like 1 0.0046 0.0539 0.1624
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1854 0.1854
Mycobacterium tuberculosis Conserved protein 0.0074 0.0989 0.1342
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0508 0.1532
Brugia malayi hypothetical protein 0.0021 0.0135 0.0408
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0046 0.0539 0.0539
Schistosoma mansoni hypothetical protein 0.0033 0.0341 0.0341
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0018 0.0089 0.0331
Schistosoma mansoni cpg binding protein 0.0028 0.026 0.026
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1854 0.5591
Loa Loa (eye worm) hypothetical protein 0.0269 0.4128 0.4128
Entamoeba histolytica hypothetical protein 0.0073 0.0978 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0193
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0179 0.268 0.5336
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0072 0.0268
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0989 0.1342
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0072 0.0217
Brugia malayi Receptor family ligand binding region containing protein 0.0056 0.0705 0.2127
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0248 0.3797 0.3797
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0046 0.0539 0.0539
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1854 0.1854
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0053 0.0053
Brugia malayi Nuclear hormone receptor E75 0.0022 0.0151 0.0456
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0989 0.3517
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0018 0.0089 0.012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Schistosoma mansoni glutamate receptor NMDA 0.0021 0.0135 0.0135
Brugia malayi nuclear hormone receptor family member odr-7 0.0022 0.0151 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0539 0.1624
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Echinococcus granulosus glutamate receptor 2 0.0021 0.0135 0.0135
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0179 0.268 1
Schistosoma mansoni nuclear receptor 0.0022 0.0151 0.0151
Schistosoma mansoni steroid hormone receptor ad4bp 0.0046 0.0539 0.0539
Trichomonas vaginalis ran, putative 0.0044 0.0508 0.1672
Schistosoma mansoni cpg binding protein 0.003 0.0286 0.0286
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0575 0.0575
Mycobacterium ulcerans bacterioferritin BfrA 0.0018 0.0089 0.0176
Schistosoma mansoni apoferritin-2 0.0018 0.0089 0.0089
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0046 0.0539 0.0539
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0135 0.0135
Loa Loa (eye worm) glutamate receptor 0.0086 0.1186 0.1186
Treponema pallidum bacterioferrin (TpF1) 0.0018 0.0089 1
Echinococcus granulosus tar DNA binding protein 0.0127 0.1854 0.1854
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.059 0.059
Echinococcus multilocularis ecdysone induced protein 78C 0.0046 0.0539 0.0539
Schistosoma mansoni retinoic acid receptor RXR 0.0046 0.0539 0.0539
Schistosoma mansoni tyrosine kinase 0.0021 0.0135 0.0135
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0183 0.2746 0.2746
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0989 0.0989
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0135 0.0135
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0053 0.0161
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0053
Echinococcus multilocularis expressed protein 0.0018 0.0089 0.0089
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0021 0.0135 0.0135
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0727
Schistosoma mansoni hypothetical protein 0.0634 1 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.156 0.2117
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0046 0.0539 0.1624
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0046 0.0539 0.1624
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0989 0.3691
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0046 0.0539 0.0539
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1854 0.1854
Entamoeba histolytica hypothetical protein 0.0073 0.0978 1
Echinococcus granulosus ferritin 0.0018 0.0089 0.0089
Schistosoma mansoni nuclear receptor 0.0022 0.0151 0.0151
Loa Loa (eye worm) RGC/RGC protein kinase 0.0021 0.0135 0.0135
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0989 0.0989
Entamoeba histolytica hypothetical protein 0.0073 0.0978 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0022 0.0151 0.0151
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0022 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Echinococcus multilocularis FTZ F1 alpha 0.0046 0.0539 0.0539
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.1848 0.1848
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0022 0.0151 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0046 0.0539 0.0539
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0046 0.0539 0.0539
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1854 0.1854
Trypanosoma cruzi importin beta-1 subunit, putative 0.0048 0.058 0.5859
Schistosoma mansoni nuclear receptor nhr-48 0.0022 0.0151 0.0151
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0341 0.103
Brugia malayi nuclear receptor NHR-67 0.0022 0.0151 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0046 0.0539 0.1624
Schistosoma mansoni protein kinase 0.0021 0.0135 0.0135
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0021 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0575 0.0575
Brugia malayi hypothetical protein 0.0073 0.0978 0.295
Schistosoma mansoni importin beta-1 0.0059 0.076 0.076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0046 0.0539 0.1624
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0072 0.0098
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0021 0.0135 0.0135
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0056 0.0705 0.0705
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0053 0.0053
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0046 0.0539 0.0539
Mycobacterium tuberculosis Probable reductase 0.0109 0.156 0.2117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0151 0.0151
Toxoplasma gondii ABC1 family protein 0.0074 0.0989 0.3691
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0989 0.3517
Brugia malayi hypothetical protein 0.0022 0.0151 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0046 0.0539 0.1624
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0989 0.1342
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Onchocerca volvulus 0.0021 0.0135 0.1369
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0053 0.0053
Echinococcus granulosus nuclear receptor nhr 48 0.0022 0.0151 0.0151
Schistosoma mansoni ferritin 0.0018 0.0089 0.0089
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1854 0.1854
Brugia malayi nuclear receptor RXR 0.0024 0.0193 0.0581
Loa Loa (eye worm) hypothetical protein 0.0024 0.0193 0.0193
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0048 0.058 0.1946
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0198 0.2986 0.9005
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0072 0.0727
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.1756 0.2383
Echinococcus multilocularis glutamate receptor 2 0.0021 0.0135 0.0135
Mycobacterium ulcerans beta-lactamase 0.0074 0.0989 0.1969
Schistosoma mansoni ran 0.0044 0.0508 0.0508
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0575 0.5809
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0989 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0539 0.0539
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0576 0.0576
Echinococcus granulosus metabotropic glutamate receptor 5 0.0269 0.4128 0.4128
Brugia malayi TAR-binding protein 0.0127 0.1854 0.5591
Schistosoma mansoni hypothetical protein 0.0403 0.6286 0.6286
Schistosoma mansoni metabotropic glutamate receptor 0.0183 0.2746 0.2746
Loa Loa (eye worm) steroid hormone receptor 0.0046 0.0539 0.0539
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0072 0.0727
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0046 0.0539 0.1624
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0021 0.0135 0.0135
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.156 0.5821
Echinococcus multilocularis GPCR, family 3, C terminal 0.0035 0.0375 0.0375
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0072 0.0143
Leishmania major trypanothione reductase 0.0048 0.0575 0.5809
Echinococcus multilocularis importin subunit beta 1 0.0059 0.076 0.076
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0508 0.1896
Echinococcus granulosus Nuclear hormone receptor HR96 0.0022 0.0151 0.0151
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0575 0.2144
Schistosoma mansoni hypothetical protein 0.0015 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0033 0.0341 0.0341
Echinococcus granulosus GPCR family 3 C terminal 0.0035 0.0375 0.0375
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0021 0.0135 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0046 0.0539 0.0539
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0046 0.0539 0.0539
Brugia malayi RNA, U transporter 1 0.0169 0.2521 0.7602
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0072 0.0727
Onchocerca volvulus Bile acid receptor homolog 0.0046 0.0539 0.5444
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0179 0.268 0.3637
Brugia malayi nuclear receptor NHR-88 0.0022 0.0151 0.0456
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0046 0.0539 0.1624
Mycobacterium ulcerans hypothetical protein 0.0074 0.0989 0.1969
Loa Loa (eye worm) hypothetical protein 0.0021 0.0135 0.0135
Schistosoma mansoni zinc finger protein 0.0022 0.0151 0.0151
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0022 0.0151 0.0151
Onchocerca volvulus 0.0021 0.0135 0.1369
Echinococcus granulosus expressed protein 0.0018 0.0089 0.0089
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0508 0.5136
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0989 0.1342
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.1756 0.2383
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0046 0.0539 0.1624

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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