Detailed information for compound 798361

Basic information

Technical information
  • TDR Targets ID: 798361
  • Name: 7-methoxy-N-(2-methoxy-5-methylphenyl)furo[5, 4-b]quinoline-2-carboxamide
  • MW: 362.379 | Formula: C21H18N2O4
  • H donors: 1 H acceptors: 2 LogP: 4.4 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)nc1c(c2)cc(o1)C(=O)Nc1cc(C)ccc1OC
  • InChi: 1S/C21H18N2O4/c1-12-4-7-18(26-3)17(8-12)22-20(24)19-10-14-9-13-5-6-15(25-2)11-16(13)23-21(14)27-19/h4-11H,1-3H3,(H,22,24)
  • InChiKey: MTKVGKFBICLWIB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-methoxy-N-(2-methoxy-5-methyl-phenyl)furo[5,4-b]quinoline-2-carboxamide
  • 7-methoxy-N-(2-methoxy-5-methylphenyl)-2-furo[5,4-b]quinolinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0 0.5
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1465 1
Brugia malayi TAR-binding protein 0.0066 0.1118 0.1665
Trypanosoma brucei aminopeptidase, putative 0.0024 0.018 0.1225
Loa Loa (eye worm) RNA binding protein 0.0066 0.1118 0.1118
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.018 0.1225
Entamoeba histolytica Rab geranylgeranyltransferase alpha subunit, putative 0.0081 0.1465 0.1968
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.018 0.1225
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0313 0.6714 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Brugia malayi Peptidase family M1 containing protein 0.0024 0.018 0.0267
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Echinococcus multilocularis geranylgeranyl transferase type 2 subunit alpha 0.0081 0.1465 0.1465
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.018 0.018
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.018 0.0368
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0081 0.1465 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.018 0.0267
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.018 0.1225
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1118 0.1118
Brugia malayi hypothetical protein 0.021 0.4397 0.6549
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.018 0.1225
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.018 0.1225
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1118 0.1665
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0457 1 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.018 0.018
Toxoplasma gondii aminopeptidase N protein 0.0024 0.018 0.0368
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.018 0.018
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0313 0.6714 1
Trypanosoma brucei protein farnesyltransferase alpha subunit, putative 0.0081 0.1465 1
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0313 0.6714 1
Loa Loa (eye worm) hypothetical protein 0.0313 0.6714 0.6714
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.018 0.0368
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.018 0.0267
Brugia malayi hypothetical protein 0.0024 0.018 0.0267
Onchocerca volvulus 0.0081 0.1465 1
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.018 0.5
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.1465 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.018 0.1225
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.1465 1
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0081 0.1465 0.2183
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.018 0.5
Brugia malayi Peptidase family M1 containing protein 0.0024 0.018 0.0267
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0313 0.6714 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1118 0.1118
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0313 0.6714 0.6714
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1118 0.1118
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1118 0.1118
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Brugia malayi hypothetical protein 0.0024 0.018 0.0267
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.018 0.1225
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0457 1 1
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0313 0.6714 0.6714
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.018 0.018
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.018 0.1225
Echinococcus granulosus tar DNA binding protein 0.0066 0.1118 0.1118
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.018 0.018
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.018 0.1225
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1118 0.1118
Plasmodium falciparum geranylgeranyl transferase type-2 subunit alpha, putative 0.0081 0.1465 0.2183
Plasmodium vivax protein prenyltransferase alpha subunit, putative 0.0081 0.1465 0.2183
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.018 0.1225
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.018 0.1225
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0081 0.1465 0.1465
Echinococcus multilocularis protein prenyltransferase alpha subunit 0.0081 0.1465 0.1465
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.018 0.1225
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.018
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0232 0.4877 0.7189
Brugia malayi RNA binding protein 0.0066 0.1118 0.1665
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.018 0.1225
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1118 0.1118
Echinococcus granulosus geranylgeranyl transferase type 2 subunit alpha 0.0081 0.1465 0.1465
Toxoplasma gondii hypothetical protein 0.0232 0.4877 1
Giardia lamblia Rab geranylgeranyltransferase 0.0313 0.6714 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.018 0.018
Trypanosoma brucei Protein prenyltransferase alpha subunit repeat, putative 0.0081 0.1465 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.018 0.018
Toxoplasma gondii hypothetical protein 0.0081 0.1465 0.3005
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1118 0.1118
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.018 0.0267
Brugia malayi Protein prenyltransferase alpha subunit repeat containing protein 0.0313 0.6714 1
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1118 0.1118
Loa Loa (eye worm) aminopeptidase N 0.0024 0.018 0.018
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0313 0.6714 0.6714
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0081 0.1465 1
Trypanosoma cruzi protein farnesyltransferase alpha subunit, putative 0.0081 0.1465 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.018
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.018 0.1225
Brugia malayi TATA binding protein associated factor 0.0024 0.018 0.0267
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.018 0.018
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.018 0.1225
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0081 0.1465 0.1968
Echinococcus multilocularis aminopeptidase N 0.0024 0.018 0.018
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0457 1 1
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0313 0.6714 1
Trypanosoma cruzi Protein prenyltransferase alpha subunit repeat, putative 0.0081 0.1465 1
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.018 0.0267
Brugia malayi Peptidase family M1 containing protein 0.0024 0.018 0.0267
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0081 0.1465 0.1465
Echinococcus granulosus aminopeptidase N 0.0024 0.018 0.018
Echinococcus granulosus protein prenyltransferase alpha subunit 0.0081 0.1465 0.1465
Loa Loa (eye worm) hypothetical protein 0.0024 0.018 0.018
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0313 0.6714 0.6714
Leishmania major protein farnesyltransferase alpha subunit, putative 0.0081 0.1465 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0313 0.6714 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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