Detailed information for compound 798719

Basic information

Technical information
  • TDR Targets ID: 798719
  • Name: 2-[(4-tert-butylphenyl)sulfonylamino]-3-(1H-i ndol-3-yl)propanoic acid
  • MW: 400.491 | Formula: C21H24N2O4S
  • H donors: 3 H acceptors: 4 LogP: 4.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C21H24N2O4S/c1-21(2,3)15-8-10-16(11-9-15)28(26,27)23-19(20(24)25)12-14-13-22-18-7-5-4-6-17(14)18/h4-11,13,19,22-23H,12H2,1-3H3,(H,24,25)
  • InChiKey: OFXQTTQOWIQPTN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-tert-butylphenyl)sulfonylamino]-3-(1H-indol-3-yl)propionic acid
  • ZERO/006033

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.3165 0.384
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0407 0.0329
Plasmodium vivax hypothetical protein, conserved 0.003 0.062 0.262
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0103
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0413 0.1451
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.1373 0.1303
Brugia malayi hypothetical protein 0.0147 0.5084 0.5044
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0038 0.0956 0.2382
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0413 0.1451
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.0081 0.0048
Schistosoma mansoni transcription factor LCR-F1 0.0181 0.6362 0.6333
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0145 0.0282
Brugia malayi Niemann-Pick C1 protein precursor 0.0095 0.3113 0.3057
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0413 0.0266
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.2368 1
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0038 0.0956 0.1394
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0081 0.034
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1416 0.1347
Loa Loa (eye worm) TAR-binding protein 0.0196 0.6938 0.6913
Schistosoma mansoni hypothetical protein 0.0035 0.0811 0.0736
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0103
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.062 0.0544
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.1178 0.2985
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0174 0.0094
Trichomonas vaginalis ferritin, putative 0.0017 0.0151 0.0071
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0108 0.0081
Loa Loa (eye worm) glutaminase 2 0.0277 1 1
Schistosoma mansoni hypothetical protein 0.0039 0.0996 0.0923
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0182 0.0032
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0097 0.3169 0.3113
Echinococcus multilocularis synaptojanin 1 0.0015 0.0081 0.0048
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0081 0.0048
Loa Loa (eye worm) acetyltransferase 0.015 0.5201 0.5162
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0811 0.0736
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.2368 0.2306
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0103
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0413 0.0266
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0038 0.0956 0.3829
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.0081 0.0048
Schistosoma mansoni ferritin light chain 0.0017 0.0151 0.0071
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0413 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.1052 0.0979
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0403 0.0513
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.6938 0.6913
Schistosoma mansoni ferritin 0.0017 0.0151 0.0071
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0103
Echinococcus granulosus expressed protein 0.0017 0.0151 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0196 0.6938 0.6913
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.4109 0.4062
Brugia malayi CHE-14 protein 0.0041 0.1052 0.0979
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0413 0.0335
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.1178 0.2985
Echinococcus granulosus geminin 0.0172 0.6002 0.7329
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0015 0.0081 0.034
Echinococcus multilocularis Niemann Pick C1 protein 0.0095 0.3113 0.3776
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.098 0.1153
Schistosoma mansoni ap endonuclease 0.0076 0.2368 0.2306
Plasmodium falciparum phd finger protein, putative 0.003 0.062 0.262
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0531 0.0454
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0081 0.034
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0182 0.0445
Schistosoma mansoni ap endonuclease 0.0076 0.2368 0.2306
Schistosoma mansoni tar DNA-binding protein 0.0196 0.6938 0.6913
Mycobacterium ulcerans hypothetical protein 0.0024 0.0413 0.0266
Schistosoma mansoni hypothetical protein 0.0039 0.0996 0.0923
Plasmodium vivax exodeoxyribonuclease III, putative 0.0015 0.0081 0.034
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0403 0.0325
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.2368 0.286
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0108 0.0027
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.2368 0.3641
Echinococcus multilocularis geminin 0.0172 0.6002 0.7329
Schistosoma mansoni cpg binding protein 0.0061 0.1798 0.1731
Schistosoma mansoni jumonji domain containing protein 0.0077 0.2412 0.235
Echinococcus multilocularis expressed conserved protein 0.009 0.2894 0.3507
Echinococcus multilocularis muscleblind protein 0.0146 0.502 0.6121
Schistosoma mansoni ferritin 0.0017 0.0151 0.0071
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0108 0.0081
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0182 0.5
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.0081 0.034
Giardia lamblia PHD finger protein 15 0.003 0.062 0.236
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.2368 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.3165 0.384
Plasmodium vivax hypothetical protein, conserved 0.0015 0.0081 0.034
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.062 0.0712
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0017 0.0151 0.0307
Brugia malayi TAR-binding protein 0.0196 0.6938 0.6913
Schistosoma mansoni hypothetical protein 0.0172 0.6002 0.597
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0181 0.6362 0.7772
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0403 0.0877
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.2368 1
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.8175 1
Echinococcus multilocularis ferritin 0.0017 0.0151 0.0134
Schistosoma mansoni eyes absent homolog 0.0091 0.2967 0.2909
Loa Loa (eye worm) hypothetical protein 0.005 0.14 0.133
Brugia malayi hypothetical protein 0.0229 0.8175 0.816
Treponema pallidum bacterioferrin (TpF1) 0.0017 0.0151 0.0307
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0413 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.098 0.0906
Echinococcus multilocularis GPCR, family 2 0.0016 0.0108 0.0081
Schistosoma mansoni ferritin 0.0017 0.0151 0.0071
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.0081 0.0048
Schistosoma mansoni hypothetical protein 0.0016 0.0108 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0145 0.0282
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0038 0.0956 0.1125
Brugia malayi jmjC domain containing protein 0.0039 0.098 0.0906
Schistosoma mansoni cpg binding protein 0.0061 0.1798 0.1731
Echinococcus granulosus synaptojanin 1 0.0015 0.0081 0.0048
Loa Loa (eye worm) hypothetical protein 0.0146 0.502 0.4979
Echinococcus granulosus Protein patched homolog 1 0.0041 0.1052 0.1242
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.5201 0.5162
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0413 0.0335
Trichomonas vaginalis chaperonin, putative 0.0024 0.0403 0.0325
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.098 0.0906
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.2368 1
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.0081 0.0048
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0181 0.6362 0.7772
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0038 0.0956 0.0883
Schistosoma mansoni hypothetical protein 0.0016 0.0108 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.2368 0.2306
Brugia malayi hypothetical protein 0.0091 0.2967 0.2909
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1416 0.1347
Echinococcus granulosus GPCR family 2 0.0016 0.0108 0.0081
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.0403 0.1702
Plasmodium falciparum DNase I-like protein, putative 0.0015 0.0081 0.034
Onchocerca volvulus Alhambra homolog 0.003 0.062 0.1079
Brugia malayi CXXC zinc finger family protein 0.0057 0.1674 0.1607
Loa Loa (eye worm) hypothetical protein 0.0091 0.2967 0.2909
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.1178 0.4974
Leishmania major pantothenate kinase subunit, putative 0.0016 0.0118 0.0162
Echinococcus granulosus Niemann Pick C1 protein 0.0136 0.4662 0.5681
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0038 0.0956 0.3829
Schistosoma mansoni hypothetical protein 0.0016 0.0108 0.0027
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.0403 0.1409
Schistosoma mansoni tar DNA-binding protein 0.0196 0.6938 0.6913
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.2368 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0413 0.1451
Loa Loa (eye worm) hypothetical protein 0.0229 0.8175 0.816
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0038 0.0956 0.0883
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.2368 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0413 0.0266
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.2368 1
Schistosoma mansoni hypothetical protein 0.0172 0.6002 0.597
Loa Loa (eye worm) hypothetical protein 0.003 0.062 0.0544
Brugia malayi hypothetical protein 0.0181 0.6362 0.6333
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1416 0.1347
Brugia malayi Bromodomain containing protein 0.0033 0.076 0.0685
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.0081 0.0048
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0182 0.077
Brugia malayi jmjC domain containing protein 0.0097 0.3165 0.3109
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.0081 0.0048
Echinococcus granulosus muscleblind protein 0.0146 0.502 0.6121
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0017 0.0151 0.0307
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0956 0.4039
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0413 0.0528
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0403 0.0325
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0403 0.0325
Loa Loa (eye worm) RNA binding protein 0.0196 0.6938 0.6913
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.0403 0.0444
Entamoeba histolytica hypothetical protein 0.0181 0.6362 1
Schistosoma mansoni glutaminase 0.0277 1 1
Brugia malayi Cytochrome P450 family protein 0.0049 0.1373 0.1303
Echinococcus granulosus cpg binding protein 0.0061 0.1798 0.216
Echinococcus granulosus tar DNA binding protein 0.0196 0.6938 0.8479
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.0118 0.0162
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.062 0.1468
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.0403 0.0444
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0038 0.0956 0.4039
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0174 0.0163
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.098 0.0906
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0413 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.1674 0.1607
Onchocerca volvulus 0.0057 0.1674 0.3185
Schistosoma mansoni hypothetical protein 0.003 0.062 0.0544
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.1052 0.0979
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0403 0.0325
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.1811 0.1745
Loa Loa (eye worm) hypothetical protein 0.0041 0.1052 0.0979
Loa Loa (eye worm) glutaminase 0.0277 1 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.6938 0.6913
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.8175 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0108 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.2368 0.286
Echinococcus granulosus Niemann Pick C1 protein 0.0095 0.3113 0.3776
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.1052 0.1242
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0095 0.3113 0.4827
Schistosoma mansoni hypothetical protein 0.0047 0.1271 0.12
Trichomonas vaginalis glutaminase, putative 0.0277 1 1
Brugia malayi PHD-finger family protein 0.003 0.062 0.0544
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.1178 0.1106
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.062 0.1468
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.0403 0.0325
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0174 0.0163
Loa Loa (eye worm) hypothetical protein 0.0018 0.0182 0.0103
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.2368 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0146 0.5041 0.6147
Schistosoma mansoni hypothetical protein 0.0016 0.0108 0.0027
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0038 0.0956 0.0883
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0108 0.0027
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0413 0.0266
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0145 0.0282
Schistosoma mansoni cpg binding protein 0.0057 0.1674 0.1607
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0956 0.0883
Entamoeba histolytica hypothetical protein 0.0181 0.6362 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0413 0.1451
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.0081 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0145 0.0282
Loa Loa (eye worm) hypothetical protein 0.0095 0.3113 0.3057
Loa Loa (eye worm) hypothetical protein 0.0035 0.0811 0.0736
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.0081 0.0048
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0038 0.0956 0.1125
Schistosoma mansoni ferritin light chain 0.0017 0.0151 0.0071
Schistosoma mansoni survival motor neuron protein 0.0047 0.1271 0.12
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.1178 0.1106
Onchocerca volvulus 0.0047 0.1271 0.2379
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.0403 0.1409
Echinococcus granulosus jumonji domain containing protein 0.0041 0.1058 0.125
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0856 0.1001
Echinococcus multilocularis tar DNA binding protein 0.0196 0.6938 0.8479
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.0403 0.1702
Echinococcus granulosus ferritin 0.0017 0.0151 0.0134
Loa Loa (eye worm) hypothetical protein 0.0024 0.0413 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.2368 0.2306
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0413 0.0335
Loa Loa (eye worm) hypothetical protein 0.0024 0.0413 0.0335
Schistosoma mansoni tar DNA-binding protein 0.0196 0.6938 0.6913
Loa Loa (eye worm) hypothetical protein 0.0051 0.1419 0.135
Brugia malayi RNA binding protein 0.0196 0.6938 0.6913
Schistosoma mansoni hypothetical protein 0.0039 0.0996 0.0923
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.2368 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0413 0.0266
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.1178 0.1397
Echinococcus multilocularis peregrin 0.0033 0.076 0.0883
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0108 0.0027
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0038 0.0956 0.0883
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.1038 0.4385
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.2368 0.2251
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.062 0.0712
Entamoeba histolytica hypothetical protein 0.0181 0.6362 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0136 0.4662 0.5681
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.1058 0.125
Onchocerca volvulus 0.0147 0.5084 1
Schistosoma mansoni apoferritin-2 0.0017 0.0151 0.0071
Schistosoma mansoni apoferritin-2 0.0017 0.0151 0.0071
Schistosoma mansoni hypothetical protein 0.0181 0.6362 0.6333
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.0403 0.0325
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0413 0.0528
Toxoplasma gondii exonuclease III APE 0.0076 0.2368 0.6222
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.1271 0.12
Schistosoma mansoni patched 1 0.0041 0.1052 0.0979
Echinococcus multilocularis protein dispatched 1 0.0047 0.1271 0.1511
Loa Loa (eye worm) hypothetical protein 0.0024 0.0413 0.0335
Loa Loa (eye worm) PHD-finger family protein 0.003 0.062 0.0544
Echinococcus multilocularis expressed protein 0.0017 0.0151 0.0134
Echinococcus multilocularis muscleblind protein 1 0.0146 0.502 0.6121
Echinococcus multilocularis cpg binding protein 0.0061 0.1798 0.216
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0403 0.0325
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0413 0.0528
Brugia malayi Muscleblind-like protein 0.0146 0.502 0.4979
Loa Loa (eye worm) hypothetical protein 0.0147 0.5084 0.5044
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.2368 0.2306
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.1038 0.1524
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.1038 0.4187
Loa Loa (eye worm) hypothetical protein 0.0051 0.1416 0.1347
Entamoeba histolytica hypothetical protein 0.0181 0.6362 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.3757 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.0081 0.0048
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.0081 0.0048
Schistosoma mansoni hypothetical protein 0.0039 0.0996 0.0923
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.0403 0.1409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0108 0.0027
Schistosoma mansoni ferritin 0.0017 0.0151 0.0071
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0108 0.0081
Mycobacterium ulcerans glutaminase 0.0277 1 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.2368 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0956 0.0883
Onchocerca volvulus 0.0024 0.0413 0.0663
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0413 0.1451
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0956 0.3829
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0182 0.077
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.5201 0.6343
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0015 0.0081 0.034
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.1052 0.1242
Echinococcus multilocularis protein patched 0.0041 0.1052 0.1242
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.5201 0.5162
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0038 0.0956 0.3829
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0403 0.1409
Schistosoma mansoni tar DNA-binding protein 0.0196 0.6938 0.6913
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0038 0.0956 0.0883
Loa Loa (eye worm) hypothetical protein 0.0091 0.2967 0.2909
Loa Loa (eye worm) hypothetical protein 0.0146 0.502 0.4979
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0413 0.0266
Echinococcus granulosus expressed conserved protein 0.009 0.2894 0.3507
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.0081 0.034
Echinococcus granulosus peregrin 0.0033 0.076 0.0883

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.