Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | APEX nuclease (multifunctional DNA repair enzyme) 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.4534 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0.4534 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0025 | 0.4534 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0023 | 0.3407 | 0.3407 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0023 | 0.3407 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0025 | 0.4534 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0025 | 0.4534 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0023 | 0.3407 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0025 | 0.4534 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0023 | 0.3407 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0023 | 0.3407 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.3407 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0023 | 0.3407 | 0.5 |
Brugia malayi | hypothetical protein | 0.0025 | 0.4534 | 0.4534 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0036 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 1 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 1 | 1 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0.4534 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0036 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 1 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0023 | 0.3407 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.5221 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.