Detailed information for compound 798779

Basic information

Technical information
  • TDR Targets ID: 798779
  • Name: N-(4-diethylamino-3-methylphenyl)-2-(1-phenyl tetrazol-5-yl)sulfanylacetamide
  • MW: 396.509 | Formula: C20H24N6OS
  • H donors: 1 H acceptors: 4 LogP: 4.19 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1C)NC(=O)CSc1nnnn1c1ccccc1)CC
  • InChi: 1S/C20H24N6OS/c1-4-25(5-2)18-12-11-16(13-15(18)3)21-19(27)14-28-20-22-23-24-26(20)17-9-7-6-8-10-17/h6-13H,4-5,14H2,1-3H3,(H,21,27)
  • InChiKey: YMQIWWMZJGYIQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-diethylamino-3-methyl-phenyl)-2-(1-phenyltetrazol-5-yl)sulfanyl-acetamide
  • N-(4-diethylamino-3-methylphenyl)-2-[(1-phenyl-5-tetrazolyl)thio]acetamide
  • N-(4-diethylamino-3-methyl-phenyl)-2-[(1-phenyltetrazol-5-yl)thio]acetamide
  • N-(4-diethylamino-3-methyl-phenyl)-2-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanamide
  • ZINC02841952

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.3209 0.4464
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0977 0.3992
Schistosoma mansoni cpg binding protein 0.003 0.0496 0.0458
Echinococcus granulosus tar DNA binding protein 0.0135 0.3042 0.3042
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.013 0.0139
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1596 0.1563
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0229 0.0144
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1596 0.1596
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0229 0.0289
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.4515 0.6792
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Toxoplasma gondii exonuclease III APE 0.0019 0.0229 0.1732
Echinococcus granulosus geminin 0.0354 0.8341 0.8341
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0674 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.6629 0.69
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0977 0.2638
Brugia malayi RNA binding protein 0.0135 0.3042 0.3144
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0674 0.1687
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0039 0.0039
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.013 0.1433
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0977 0.3992
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.013 0.0256
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0229 0.0289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0229 0.0272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0977 0.255
Onchocerca volvulus Huntingtin homolog 0.0122 0.2719 0.6328
Onchocerca volvulus 0.0015 0.013 0.0215
Brugia malayi CHE-14 protein 0.0046 0.0899 0.09
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.4273 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.13 0.1266
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.239 0.2461
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0682 0.0673
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.3511 0.3511
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.013 0.0095
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.3209 0.4536
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.013 0.0136
Echinococcus granulosus nibrin 0.0011 0.0039 0.0039
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.013 0.0138
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Schistosoma mansoni hypothetical protein 0.0354 0.8341 0.8334
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0797 0.1085
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.013 0.097
Toxoplasma gondii propionate-CoA ligase 0.0015 0.013 0.0828
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.243 0.24
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.102 0.1404
Echinococcus multilocularis geminin 0.0354 0.8341 0.8341
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.013 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Leishmania major malonyl-coa decarboxylase-like protein 0.0159 0.3633 0.5079
Onchocerca volvulus 0.0015 0.013 0.0215
Loa Loa (eye worm) hypothetical protein 0.0057 0.1151 0.12
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0229 0.0239
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0229 0.2995
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Loa Loa (eye worm) oxidoreductase 0.0015 0.013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0015 0.013 0.0136
Echinococcus multilocularis nibrin 0.0011 0.0039 0.0039
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.239 0.239
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.239 0.239
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.3042 0.3144
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1596 0.1596
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Schistosoma mansoni hypothetical protein 0.0075 0.1596 0.1563
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0229 0.2995
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0196 0.0165
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0229 1
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Loa Loa (eye worm) hypothetical protein 0.0122 0.2719 0.2835
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Schistosoma mansoni ap endonuclease 0.0019 0.0229 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.7027 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0921 0.0921
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0921 0.0921
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.013 0.0256
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.013 0.1433
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0674 1
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0899 0.0899
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.013 0.0095
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.6629 0.6913
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.3511 0.3511
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.11 0.1148
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.013 0.0139
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0196 0.0196
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0921 0.096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.013 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Schistosoma mansoni hypothetical protein 0.0422 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.013 0.0828
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0499
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0229 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.013 0.0136
Brugia malayi hypothetical protein 0.0122 0.2719 0.2805
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0196 0.0196
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.11 0.1111
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0977 1
Brugia malayi hypothetical protein 0.015 0.3405 0.3524
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Schistosoma mansoni ap endonuclease 0.0019 0.0229 0.0191
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0229 0.0272
Loa Loa (eye worm) RNA binding protein 0.0135 0.3042 0.3172
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.013 0.0139
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Echinococcus granulosus GPCR family 2 0.0017 0.0196 0.0196
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.239 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0496 0.0517
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0899 0.0937
Mycobacterium ulcerans hypothetical protein 0.0158 0.3596 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.7027 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Loa Loa (eye worm) hypothetical protein 0.0108 0.239 0.2492
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.3596 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0405 0.959 1
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0229 0.0422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0196 0.0205
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.013 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.013 0.0138
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.3042 0.3172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1138 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Loa Loa (eye worm) TAR-binding protein 0.0135 0.3042 0.3172
Onchocerca volvulus 0.015 0.3405 0.7949
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0921 0.0923
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0229 0.0229
Onchocerca volvulus 0.003 0.0496 0.1078
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.013 0.0387
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.3209 0.4536
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0977 0.2638
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.013 0.0828
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Echinococcus multilocularis protein patched 0.0046 0.0899 0.0899
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Loa Loa (eye worm) hypothetical protein 0.0055 0.11 0.1148
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Onchocerca volvulus 0.0015 0.013 0.0215
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.013 0.0256
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.013 0.0091
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0229 0.0199
Echinococcus granulosus expressed conserved protein 0.0101 0.2231 0.2231
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Echinococcus multilocularis tar DNA binding protein 0.0135 0.3042 0.3042
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.015 0.3405 0.3551
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0196 0.0196
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0921 0.0921
Brugia malayi CXXC zinc finger family protein 0.003 0.0496 0.0478
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.013 0.0256
Loa Loa (eye worm) hypothetical protein 0.0037 0.0682 0.0711
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0977 0.3992
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Brugia malayi hypothetical protein 0.0075 0.1596 0.163
Leishmania major mitochondrial DNA polymerase beta 0.03 0.7027 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.013 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0229 0.0535
Echinococcus multilocularis expressed conserved protein 0.0101 0.2231 0.2231
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.013 0.097
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0977 1
Echinococcus multilocularis GPCR, family 2 0.0017 0.0196 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0899 0.1304
Echinococcus granulosus cpg binding protein 0.0031 0.0537 0.0537
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Toxoplasma gondii hypothetical protein 0.0048 0.0947 0.8265
Onchocerca volvulus Huntingtin homolog 0.0122 0.2719 0.6328
Echinococcus multilocularis cpg binding protein 0.0031 0.0537 0.0537
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0674 0.1785
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.013 0.0256
Onchocerca volvulus 0.005 0.0977 0.2216
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0196 0.0165
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.013 0.0136
Schistosoma mansoni hypothetical protein 0.0037 0.0682 0.0645
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.013 0.0256
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0229 0.0809
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.013 0.0256
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.013 0.0139
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.013 0.0139
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.11 0.1111
Brugia malayi TAR-binding protein 0.0135 0.3042 0.3144
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0039 0.0039
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.0405 0.959 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0229 0.0229
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0229 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Schistosoma mansoni hypothetical protein 0.0354 0.8341 0.8334
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Echinococcus multilocularis protein dispatched 1 0.0053 0.1057 0.1057
Loa Loa (eye worm) hypothetical protein 0.0122 0.2719 0.2835
Loa Loa (eye worm) hypothetical protein 0.0046 0.0899 0.0937
Schistosoma mansoni patched 1 0.0046 0.0899 0.0863
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0196 0.0196
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Brugia malayi putative malonyl-CoA decarboxylase 0.0405 0.959 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0921 0.0921
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0977 0.255
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0229 0.0272
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.013 0.0139
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.013 0.097
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0977 0.2638
Echinococcus multilocularis dnaJ subfamily B 0.0422 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0977 0.2638
Mycobacterium ulcerans hypothetical protein 0.005 0.0977 0.2638
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.4515 0.6792
Onchocerca volvulus 0.0019 0.0227 0.0443
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0196 0.0205
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.7027 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0674 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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