Detailed information for compound 798779

Basic information

Technical information
  • TDR Targets ID: 798779
  • Name: N-(4-diethylamino-3-methylphenyl)-2-(1-phenyl tetrazol-5-yl)sulfanylacetamide
  • MW: 396.509 | Formula: C20H24N6OS
  • H donors: 1 H acceptors: 4 LogP: 4.19 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1C)NC(=O)CSc1nnnn1c1ccccc1)CC
  • InChi: 1S/C20H24N6OS/c1-4-25(5-2)18-12-11-16(13-15(18)3)21-19(27)14-28-20-22-23-24-26(20)17-9-7-6-8-10-17/h6-13H,4-5,14H2,1-3H3,(H,21,27)
  • InChiKey: YMQIWWMZJGYIQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-diethylamino-3-methyl-phenyl)-2-(1-phenyltetrazol-5-yl)sulfanyl-acetamide
  • N-(4-diethylamino-3-methylphenyl)-2-[(1-phenyl-5-tetrazolyl)thio]acetamide
  • N-(4-diethylamino-3-methyl-phenyl)-2-[(1-phenyltetrazol-5-yl)thio]acetamide
  • N-(4-diethylamino-3-methyl-phenyl)-2-[(1-phenyl-1,2,3,4-tetrazol-5-yl)sulfanyl]ethanamide
  • ZINC02841952

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0899 0.0899
Echinococcus granulosus nibrin 0.0011 0.0039 0.0039
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Onchocerca volvulus 0.0015 0.013 0.0215
Brugia malayi hypothetical protein 0.015 0.3405 0.3524
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1596 0.1596
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.013 0.0136
Leishmania major malonyl-coa decarboxylase-like protein 0.0159 0.3633 0.5079
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.1138 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0229 0.0289
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0196 0.0196
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0674 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.005 0.0977 0.2638
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0899 0.1304
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.013 0.0138
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0015 0.013 0.013
Onchocerca volvulus 0.005 0.0977 0.2216
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.013 0.0136
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0039 0.0039
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0977 0.3992
Echinococcus multilocularis GPCR, family 2 0.0017 0.0196 0.0196
Brugia malayi RNA binding protein 0.0135 0.3042 0.3144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.11 0.1111
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Onchocerca volvulus 0.015 0.3405 0.7949
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0015 0.013 0.0256
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0015 0.013 0.0256
Toxoplasma gondii exonuclease III APE 0.0019 0.0229 0.1732
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0682 0.0673
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Toxoplasma gondii propionate-CoA ligase 0.0015 0.013 0.0828
Brugia malayi CHE-14 protein 0.0046 0.0899 0.09
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0674 0.1687
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0015 0.013 0.0828
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0229 0.0229
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0229 0.0144
Toxoplasma gondii hypothetical protein 0.0048 0.0947 0.8265
Echinococcus granulosus tar DNA binding protein 0.0135 0.3042 0.3042
Loa Loa (eye worm) oxidoreductase 0.0015 0.013 0.0136
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0674 1
Brugia malayi hypothetical protein 0.0122 0.2719 0.2805
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0015 0.013 0.1433
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.011 0.243 0.24
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Loa Loa (eye worm) hypothetical protein 0.0046 0.0899 0.0937
Schistosoma mansoni patched 1 0.0046 0.0899 0.0863
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.3209 0.4464
Echinococcus granulosus cpg binding protein 0.0031 0.0537 0.0537
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0229 0.0272
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0899 0.0937
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0015 0.013 0.097
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.13 0.1266
Schistosoma mansoni hypothetical protein 0.0422 1 1
Echinococcus multilocularis expressed conserved protein 0.0101 0.2231 0.2231
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0015 0.013 0.0256
Trypanosoma brucei malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0229 0.0809
Loa Loa (eye worm) TAR-binding protein 0.0135 0.3042 0.3172
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0015 0.013 0.013
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0015 0.013 0.0387
Schistosoma mansoni hypothetical protein 0.0037 0.0682 0.0645
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.005 0.0977 0.255
Brugia malayi hypothetical protein 0.0075 0.1596 0.163
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Schistosoma mansoni ap endonuclease 0.0019 0.0229 0.0191
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.7027 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.005 0.0977 0.2638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0921 0.0921
Echinococcus multilocularis protein patched 0.0046 0.0899 0.0899
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0921 0.0923
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0674 0.1785
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0499
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Trichomonas vaginalis antibiotic synthetase, putative 0.0015 0.013 0.0138
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0015 0.013 0.0256
Schistosoma mansoni cpg binding protein 0.003 0.0496 0.0458
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.3209 0.4536
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0015 0.013 0.0256
Entamoeba histolytica acyl-CoA synthetase, putative 0.005 0.0977 0.3992
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Mycobacterium ulcerans hypothetical protein 0.0158 0.3596 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0015 0.013 0.0256
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0797 0.1085
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0229 0.0272
Onchocerca volvulus 0.0019 0.0227 0.0443
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Echinococcus granulosus GPCR family 2 0.0017 0.0196 0.0196
Echinococcus multilocularis Niemann Pick C1 protein 0.0108 0.239 0.239
Onchocerca volvulus 0.0015 0.013 0.0215
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0229 0.2995
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.3209 0.4536
Echinococcus multilocularis Niemann Pick C1 protein 0.0154 0.3511 0.3511
Schistosoma mansoni ap endonuclease 0.0019 0.0229 0.0191
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0196 0.0196
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0229 1
Entamoeba histolytica acyl-coA synthetase, putative 0.005 0.0977 0.3992
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0108 0.239 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Loa Loa (eye worm) hypothetical protein 0.0405 0.959 1
Brugia malayi putative malonyl-CoA decarboxylase 0.0405 0.959 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0496 0.0517
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.3042 0.3172
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0015 0.013 0.0139
Mycobacterium ulcerans hypothetical protein 0.005 0.0977 0.2638
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0015 0.013 0.0256
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0015 0.013 0.0256
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0015 0.013 0.097
Onchocerca volvulus Huntingtin homolog 0.0122 0.2719 0.6328
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Echinococcus multilocularis nibrin 0.0011 0.0039 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.4515 0.6792
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Echinococcus granulosus expressed conserved protein 0.0101 0.2231 0.2231
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0196 0.0205
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.7027 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0229 0.0535
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0229 0.0199
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Loa Loa (eye worm) hypothetical protein 0.0037 0.0682 0.0711
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0977 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.005 0.0977 0.2638
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0921 0.0921
Onchocerca volvulus 0.0015 0.013 0.0215
Mycobacterium ulcerans acyl-CoA synthetase 0.005 0.0977 0.2638
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0015 0.013 0.097
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0229 0.0289
Loa Loa (eye worm) hypothetical protein 0.005 0.0977 0.1019
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0229 0.0272
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0899 0.0899
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Loa Loa (eye worm) hypothetical protein 0.015 0.3405 0.3551
Brugia malayi Niemann-Pick C1 protein precursor 0.0108 0.239 0.2461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0921 0.0885
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0921 0.096
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0354 0.8341 0.8334
Trichomonas vaginalis glucosylceramidase, putative 0.0283 0.6629 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Leishmania major mitochondrial DNA polymerase beta 0.03 0.7027 1
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0797 0.1085
Echinococcus multilocularis protein dispatched 1 0.0053 0.1057 0.1057
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0015 0.013 0.0256
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0015 0.013 0.0139
Echinococcus granulosus Niemann Pick C1 protein 0.0108 0.239 0.239
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0015 0.013 0.0139
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0229 0.2995
Onchocerca volvulus 0.003 0.0496 0.1078
Echinococcus multilocularis cpg binding protein 0.0031 0.0537 0.0537
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0196 0.0196
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0229 1
Onchocerca volvulus Huntingtin homolog 0.0122 0.2719 0.6328
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.3596 1
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0015 0.013 0.0139
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0015 0.013 0.0139
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0015 0.013 0.0139
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0015 0.013 0.0828
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Loa Loa (eye worm) hypothetical protein 0.0057 0.1151 0.12
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0921 0.0921
Echinococcus multilocularis tar DNA binding protein 0.0135 0.3042 0.3042
Schistosoma mansoni hypothetical protein 0.0017 0.0196 0.0158
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1596 0.1563
Loa Loa (eye worm) hypothetical protein 0.0122 0.2719 0.2835
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0015 0.013 0.0095
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.3042 0.3144
Echinococcus multilocularis geminin 0.0354 0.8341 0.8341
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0015 0.013 0.0139
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0196 0.0165
Schistosoma mansoni hypothetical protein 0.0045 0.0858 0.0822
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0196 0.0165
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Brugia malayi TAR-binding protein 0.0135 0.3042 0.3144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0196 0.0196
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.11 0.1148
Loa Loa (eye worm) hypothetical protein 0.0015 0.013 0.0136
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Plasmodium vivax acetyl-CoA synthetase, putative 0.0015 0.013 0.1433
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0921 0.0921
Loa Loa (eye worm) hypothetical protein 0.0122 0.2719 0.2835
Schistosoma mansoni tar DNA-binding protein 0.0135 0.3042 0.3014
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0625 0.1548
Schistosoma mansoni hypothetical protein 0.0075 0.1596 0.1563
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0229 0.0422
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0015 0.013 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.005 0.0977 0.255
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Loa Loa (eye worm) hypothetical protein 0.0011 0.0039 0.0041
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Schistosoma mansoni hypothetical protein 0.0354 0.8341 0.8334
Onchocerca volvulus Glucosylceramidase homolog 0.0186 0.4273 1
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0283 0.6629 0.6913
Brugia malayi AMP-binding enzyme family protein 0.0015 0.013 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0229 0.0239
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Echinococcus granulosus Niemann Pick C1 protein 0.0154 0.3511 0.3511
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0015 0.013 0.0136
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0015 0.013 0.013
Wolbachia endosymbiont of Brugia malayi malonyl-CoA decarboxylase 0.0405 0.959 1
Trypanosoma cruzi malonyl-CoA decarboxylase, mitochondrial precursor, putative 0.0159 0.3633 0.5143
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0015 0.013 0.0095
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703
Schistosoma mansoni cpg binding protein 0.0031 0.0537 0.0499
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.11 0.1111
Trichomonas vaginalis glucosylceramidase, putative 0.0186 0.4273 0.6425
Loa Loa (eye worm) RNA binding protein 0.0135 0.3042 0.3172
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.7027 1
Trichomonas vaginalis glucosylceramidase, putative 0.0196 0.4515 0.6792
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0015 0.013 0.013
Echinococcus multilocularis dnaJ subfamily B 0.0422 1 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.11 0.1148
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.005 0.0977 0.2638
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1596 0.1596
Entamoeba histolytica hypothetical protein 0.0075 0.1596 0.6623
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0039 0.0039
Brugia malayi AMP-binding enzyme family protein 0.005 0.0977 0.0982
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0229 0.0199
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0674 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.102 0.1404
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.005 0.0977 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0283 0.6629 0.69
Loa Loa (eye worm) hypothetical protein 0.0017 0.0196 0.0205
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0899 0.0899
Leishmania major 4-coumarate:coa ligase-like protein 0.005 0.0977 0.1229
Brugia malayi CXXC zinc finger family protein 0.003 0.0496 0.0478
Schistosoma mansoni acetyl-CoA synthetase 0.0015 0.013 0.0091
Echinococcus granulosus geminin 0.0354 0.8341 0.8341
Mycobacterium ulcerans acyl-CoA synthetase 0.0015 0.013 0.0256
Loa Loa (eye worm) hypothetical protein 0.0108 0.239 0.2492
Loa Loa (eye worm) hypothetical protein 0.0037 0.0674 0.0703

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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