Detailed information for compound 798989

Basic information

Technical information
  • TDR Targets ID: 798989
  • Name: N-(2-diethylaminoethyl)-6,7-dimethoxy-3-(4-me thoxyphenyl)-2-methyl-1-oxo-3,4-dihydroisoqui noline-4-carboxamide
  • MW: 469.573 | Formula: C26H35N3O5
  • H donors: 1 H acceptors: 2 LogP: 2.62 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)C1C(c2ccc(cc2)OC)N(C)C(=O)c2c1cc(OC)c(c2)OC)CC
  • InChi: 1S/C26H35N3O5/c1-7-29(8-2)14-13-27-25(30)23-19-15-21(33-5)22(34-6)16-20(19)26(31)28(3)24(23)17-9-11-18(32-4)12-10-17/h9-12,15-16,23-24H,7-8,13-14H2,1-6H3,(H,27,30)
  • InChiKey: YHGXJEDBWKISBP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-diethylaminoethyl)-1-keto-6,7-dimethoxy-3-(4-methoxyphenyl)-2-methyl-3,4-dihydroisoquinoline-4-carboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0857 0.4109
Schistosoma mansoni hypothetical protein 0.0015 0.019 0.019
Leishmania major inositol phosphosphingolipid phospholipase C-Like 0.0015 0.019 0.0913
Mycobacterium ulcerans lipase LipD 0.004 0.0939 0.4501
Onchocerca volvulus 0.0153 0.4461 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0433 0.0461
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0433 0.0466
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0857 0.4109
Schistosoma mansoni survival motor neuron protein 0.0052 0.1325 0.1325
Toxoplasma gondii ABC1 family protein 0.004 0.0939 0.4501
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.2086 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1743 0.8355
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0433 0.2074
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Trypanosoma cruzi Inositol phosphosphingolipids phospholipase C 0.0015 0.019 0.0913
Trichomonas vaginalis chaperonin, putative 0.0026 0.0521 0.2496
Onchocerca volvulus 0.0052 0.133 0.2948
Loa Loa (eye worm) hypothetical protein 0.0029 0.0607 0.0646
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.4198 0.4198
Loa Loa (eye worm) hypothetical protein 0.0148 0.4304 0.4585
Echinococcus multilocularis para nitrobenzyl esterase 0.0052 0.133 0.133
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1743 0.8355
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0037 0.0857 0.0857
Leishmania major GTP-binding protein, putative 0.0021 0.0378 0.1812
Brugia malayi RNA, U transporter 1 0.0083 0.2288 0.2463
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0607 0.2908
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.025 0.5
Schistosoma mansoni hypothetical protein 0.0029 0.0607 0.0607
Entamoeba histolytica Ran family GTPase 0.0021 0.0378 0.0616
Onchocerca volvulus Huntingtin homolog 0.0148 0.4304 0.9647
Entamoeba histolytica hypothetical protein 0.0024 0.0446 0.0839
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.004 0.0939 0.1242
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.103 0.494
Mycobacterium tuberculosis Probable lipase LipD 0.004 0.0939 0.1242
Echinococcus granulosus neutral sphingomyelinase 0.0015 0.019 0.019
Trichomonas vaginalis skeletal muscle/kidney enriched inositol 5-phosphatase, putative 0.0015 0.019 0.0912
Mycobacterium tuberculosis Probable hydrolase 0.004 0.0939 0.1242
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2643 0.2643
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.019 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0433 0.0795
Echinococcus granulosus FTZ F1 alpha 0.001 0.0021 0.0021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.004 0.0939 0.1242
Brugia malayi Bromodomain containing protein 0.0032 0.0717 0.0771
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.019 0.0912
Trichomonas vaginalis type II inositol 5-phosphatase, putative 0.0015 0.019 0.0912
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0021 0.0022
Mycobacterium ulcerans beta-lactamase 0.004 0.0939 0.4501
Leishmania major importin beta-1 subunit, putative 0.0024 0.0446 0.2137
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0021
Schistosoma mansoni nuclear hormone receptor 0.001 0.0021 0.0021
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0521 0.056
Brugia malayi jmjC domain containing protein 0.0095 0.2645 0.2847
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0021 0.0021
Echinococcus granulosus para nitrobenzyl esterase 0.0052 0.133 0.133
Schistosoma mansoni ferritin 0.0009 0.0000031895 0.0000031895
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0022
Echinococcus granulosus traf and tnf receptor associated protein 0.0015 0.019 0.019
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.019 0.0913
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0939 0.4501
Echinococcus multilocularis carboxylesterase 5A 0.0309 0.9291 0.9291
Plasmodium vivax hypothetical protein, conserved 0.004 0.0939 0.4501
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0026 0.0521 0.2496
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1743 0.8355
Trypanosoma brucei DNA-(apurinic or apyrimidinic site) lyase, putative 0.0015 0.019 0.0913
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.133 0.133
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0022
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.019 0.0913
Schistosoma mansoni ferritin 0.0009 0.0000031895 0.0000031895
Echinococcus multilocularis peregrin 0.0032 0.0717 0.0717
Onchocerca volvulus 0.0015 0.019 0.0382
Brugia malayi Carboxylesterase family protein 0.0309 0.9291 1
Brugia malayi hypothetical protein 0.0114 0.3237 0.3484
Echinococcus multilocularis expressed protein 0.0009 0.0000031895 0.0000031895
Brugia malayi steroid hormone receptor 0.001 0.0021 0.0022
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Echinococcus multilocularis survival motor neuron protein 1 0.0255 0.7624 0.7624
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0022
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0021
Onchocerca volvulus Putative neutral sphingomyelinase 0.0015 0.019 0.0382
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0378 0.0403
Onchocerca volvulus 0.0052 0.133 0.2948
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.019 0.0203
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0857 0.0913
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0939 0.0939
Schistosoma mansoni synaptojanin 0.0015 0.019 0.019
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.103 0.494
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0021 0.0021
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.103 0.494
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0617 0.0617
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.025 0.1199
Loa Loa (eye worm) RNA binding protein 0.0129 0.371 0.3952
Leishmania major pantothenate kinase subunit, putative 0.0016 0.022 0.1054
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0378 0.1812
Schistosoma mansoni cpg binding protein 0.0034 0.0776 0.0776
Trypanosoma brucei inositol/phosphatidylinositol phosphatase, putative 0.0015 0.019 0.0913
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0021 0.0022
Entamoeba histolytica hypothetical protein 0.0114 0.3237 1
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Echinococcus granulosus acetylcholinesterase 0.0309 0.9291 0.9291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0022
Echinococcus granulosus snurportin 1 0.0312 0.9387 0.9387
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0021 0.0021
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.019 0.0913
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Brugia malayi hypothetical protein 0.0148 0.4304 0.4632
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0026 0.0521 0.1084
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0015 0.019 0.019
Brugia malayi MH2 domain containing protein 0.0129 0.3706 0.3989
Loa Loa (eye worm) histone methyltransferase 0.001 0.0022 0.0024
Onchocerca volvulus 0.004 0.0939 0.2068
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Echinococcus multilocularis traf and tnf receptor associated protein 0.0015 0.019 0.019
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.103 0.103
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0021 0.0021
Onchocerca volvulus Alhambra homolog 0.0029 0.0607 0.132
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0065 0.0312
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0939 0.4501
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0718 0.0765
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Brugia malayi TAR-binding protein 0.0129 0.371 0.3993
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.019 0.0203
Loa Loa (eye worm) acetyltransferase 0.0145 0.4198 0.4472
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0378 0.099
Schistosoma mansoni jumonji domain containing protein 0.0075 0.2042 0.2042
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0021 0.0021
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.019 0.0912
Schistosoma mansoni cpg binding protein 0.0032 0.0718 0.0718
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.7557 1
Treponema pallidum hypothetical protein 0.0015 0.019 0.0912
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0017 0.025 0.0267
Schistosoma mansoni apoferritin-2 0.0009 0.0000031895 0.0000031895
Loa Loa (eye worm) carboxylesterase 0.0052 0.133 0.1416
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.025 0.1199
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0021 0.0021
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0958 0.0958
Schistosoma mansoni apoferritin-2 0.0009 0.0000031895 0.0000031895
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.371 0.3993
Schistosoma mansoni ran 0.0021 0.0378 0.0378
Mycobacterium tuberculosis Conserved protein 0.004 0.0939 0.1242
Trypanosoma cruzi endonuclease/exonuclease/phosphatase, putative 0.0015 0.019 0.0913
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0607 0.0607
Brugia malayi beta-lactamase 0.004 0.0939 0.1011
Mycobacterium ulcerans esterase/lipase LipP 0.004 0.0939 0.4501
Onchocerca volvulus Huntingtin homolog 0.0148 0.4304 0.9647
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.9387 1
Mycobacterium ulcerans hypothetical protein 0.004 0.0939 0.4501
Onchocerca volvulus 0.0052 0.133 0.2948
Schistosoma mansoni tar DNA-binding protein 0.0129 0.371 0.371
Schistosoma mansoni coup transcription factor 0.001 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0433 0.2074
Echinococcus granulosus expressed protein 0.0009 0.0000031895 0.0000031895
Plasmodium falciparum DNase I-like protein, putative 0.0015 0.019 0.0913
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0939 0.0939
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.3237 0.3237
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0607 0.2908
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0021
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0052 0.133 0.133
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0021
Giardia lamblia TCP-1 chaperonin subunit beta 0.0026 0.0521 0.1743
Schistosoma mansoni ferritin light chain 0.0009 0.0000031895 0.0000031895
Brugia malayi Importin beta-1 subunit 0.0029 0.0617 0.0664
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0221 0.0292
Entamoeba histolytica hypothetical protein 0.0114 0.3237 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0446 0.2137
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0433 0.4608
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.2086 0.276
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0037 0.0857 0.0923
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0026 0.0521 0.2496
Trichomonas vaginalis ran, putative 0.0021 0.0378 0.1812
Loa Loa (eye worm) hypothetical protein 0.0023 0.0433 0.0461
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0016 0.022 0.1054
Loa Loa (eye worm) hypothetical protein 0.0015 0.019 0.0203
Loa Loa (eye worm) jmjC domain-containing protein 0.0037 0.0853 0.0908
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Echinococcus granulosus neuroligin 0.0052 0.133 0.133
Trichomonas vaginalis carbon catabolite repressor protein, putative 0.0015 0.019 0.0912
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0433 0.0572
Echinococcus multilocularis neuroligin 0.0052 0.133 0.133
Plasmodium vivax importin-beta 2, putative 0.0029 0.0617 0.2959
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Loa Loa (eye worm) TAR-binding protein 0.0129 0.371 0.3952
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0853 0.0853
Plasmodium vivax exodeoxyribonuclease III, putative 0.0015 0.019 0.0913
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1743 0.2306
Schistosoma mansoni hypothetical protein 0.0052 0.1325 0.1325
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0037 0.0857 0.0923
Loa Loa (eye worm) hypothetical protein 0.0011 0.0061 0.0065
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0015 0.019 0.0203
Schistosoma mansoni hypothetical protein 0.0114 0.3237 0.3237
Echinococcus granulosus lysine specific demethylase 5A 0.0037 0.0853 0.0853
Leishmania major inositol/phosphatidylinositol phosphatase, putative 0.0015 0.019 0.0913
Toxoplasma gondii PHD-finger domain-containing protein 0.0009 0.0004 0.0017
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0021 0.0022
Onchocerca volvulus 0.0052 0.133 0.2948
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0939 0.4501
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0037 0.0857 0.0857
Mycobacterium ulcerans hypothetical protein 0.0023 0.0433 0.2074
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0378 0.1812
Echinococcus multilocularis neutral sphingomyelinase 0.0015 0.019 0.019
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0037 0.0857 0.4109
Loa Loa (eye worm) hypothetical protein 0.0255 0.7624 0.8122
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0022 0.0022
Brugia malayi Carboxylesterase family protein 0.0052 0.133 0.1431
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0607 0.0646
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0617 0.2959
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0021 0.0022
Toxoplasma gondii t-complex protein beta subunit 0.0026 0.0521 0.2496
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1743 0.1743
Loa Loa (eye worm) acetylcholinesterase 1 0.0309 0.9291 0.9898
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0015 0.019 0.019
Schistosoma mansoni neuroligin 3 (S09 family) 0.0052 0.133 0.133
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.4072 0.4072
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0011 0.0057 0.0057
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0433 0.2074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0446 0.2137
Schistosoma mansoni ap endonuclease 0.0077 0.2086 0.2086
Schistosoma mansoni eyes absent homolog 0.0088 0.2439 0.2439
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0037 0.0857 0.4109
Loa Loa (eye worm) transcription factor SMAD2 0.0129 0.3706 0.3948
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0221 0.0292
Schistosoma mansoni cpg binding protein 0.0034 0.0776 0.0776
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0037 0.0857 0.0913
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0607 0.0607
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0617 0.2959
Loa Loa (eye worm) MH2 domain-containing protein 0.0129 0.3706 0.3948
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.2086 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0311 0.0335
Brugia malayi Carboxylesterase family protein 0.0309 0.9291 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0022
Brugia malayi Carboxylesterase family protein 0.0052 0.133 0.1431
Brugia malayi Carboxylesterase family protein 0.0052 0.133 0.1431
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0378 0.1812
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0021
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0433 0.2074
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0011 0.0065 0.0312
Echinococcus granulosus jumonji domain containing protein 0.004 0.0958 0.0958
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0433 0.0466
Schistosoma mansoni cript-related 0.0015 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0052 0.133 0.1416
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0015 0.019 0.019
Schistosoma mansoni gliotactin 0.0052 0.133 0.133
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0433 0.2074
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.2086 1
Onchocerca volvulus 0.0032 0.0718 0.1571
Brugia malayi CCR4 0.0015 0.019 0.0205
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0221 0.0292
Schistosoma mansoni carbon catabolite repressor protein 0.0015 0.019 0.019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0021 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0021 0.0022
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0021 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.3237 0.3237
Schistosoma mansoni synaptojanin 0.0015 0.019 0.019
Brugia malayi hypothetical protein 0.0255 0.7624 0.8206
Brugia malayi ecdysteroid receptor 0.001 0.0021 0.0022
Mycobacterium tuberculosis Carboxylesterase LipT 0.0052 0.133 0.1759
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0049 0.1247 0.1328
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.2643 0.2845
Loa Loa (eye worm) hypothetical protein 0.0309 0.9291 0.9898
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Echinococcus granulosus carboxylesterase 5A 0.0309 0.9291 0.9291
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2643 0.2643
Schistosoma mansoni hypothetical protein 0.0312 0.9387 0.9387
Onchocerca volvulus 0.004 0.0939 0.2068
Schistosoma mansoni tar DNA-binding protein 0.0129 0.371 0.371
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.2086 1
Trypanosoma cruzi inositol 5-phosphatase 1, putative 0.0015 0.019 0.0913
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.103 0.494
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Schistosoma mansoni ferritin 0.0009 0.0000031895 0.0000031895
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0921 0.3852
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.133 0.1759
Entamoeba histolytica hypothetical protein 0.0114 0.3237 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.2086 0.6222
Echinococcus granulosus importin subunit beta 1 0.0029 0.0617 0.0617
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.2086 0.2222
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0521 0.0521
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0939 0.4501
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0021 0.0021
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.2086 1
Brugia malayi nuclear hormone receptor 0.001 0.0021 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.004 0.0939 0.1242
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0021 0.0021
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0378 0.1812
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0021 0.0021
Schistosoma mansoni hypothetical protein 0.0331 1 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0939 0.1
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0037 0.0857 0.4109
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0617 0.2959
Mycobacterium tuberculosis Conserved protein 0.004 0.0939 0.1242
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0021 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0153 0.4461 0.4752
Echinococcus multilocularis synaptojanin 1 0.0015 0.019 0.019
Brugia malayi PHD-finger family protein 0.0029 0.0607 0.0653
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1743 0.8355
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0009 0.0004 0.0017
Brugia malayi PHD-finger family protein 0.0011 0.0061 0.0066
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.4198 0.4518
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1743 0.1743
Trichomonas vaginalis type IV inositol 5-phosphatase, putative 0.0015 0.019 0.0912
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.133 0.133
Onchocerca volvulus 0.0015 0.019 0.0382
Trypanosoma brucei inositol-1,4,5-trisphosphate (IP3) 5-phosphatase, putative 0.0015 0.019 0.0913
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2643 0.2643
Echinococcus granulosus BC026374 protein S09 family 0.0052 0.133 0.133
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1743 0.1743
Loa Loa (eye worm) hypothetical protein 0.0148 0.4304 0.4585
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0021 0.0021
Trypanosoma brucei Inositol phosphosphingolipids phospholipase C 0.0015 0.019 0.0913
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0521 0.0521
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0857 0.4109
Schistosoma mansoni ran 0.0021 0.0378 0.0378
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0433 0.4608
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0939 0.0939
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0026 0.0521 0.0521
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.133 0.133
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0026 0.0521 0.0521
Echinococcus multilocularis cpg binding protein 0.0034 0.0776 0.0776
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0433 0.0795
Brugia malayi jmjC domain containing protein 0.0037 0.0853 0.0918
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0004 0.0017
Echinococcus multilocularis geminin 0.0331 1 1
Mycobacterium tuberculosis Probable lipase LipE 0.004 0.0939 0.1242
Schistosoma mansoni BC026374 protein (S09 family) 0.0052 0.133 0.133
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0433 0.2074
Echinococcus granulosus cpg binding protein 0.0034 0.0776 0.0776
Schistosoma mansoni importin beta-1 0.0029 0.0617 0.0617
Echinococcus multilocularis snurportin 1 0.0312 0.9387 0.9387
Leishmania major RNA-editing complex protein MP100, putative 0.0015 0.019 0.0913
Loa Loa (eye worm) hypothetical protein 0.004 0.0939 0.1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.371 0.3952
Onchocerca volvulus 0.0052 0.133 0.2948
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.103 0.494
Brugia malayi T-complex protein 1, beta subunit 0.0026 0.0521 0.056
Loa Loa (eye worm) hypothetical protein 0.0015 0.019 0.0203
Brugia malayi nuclear receptor NHR-88 0.001 0.0021 0.0022
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0309 0.9291 0.9291
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.2086 0.2086
Trypanosoma cruzi RNA-editing complex protein MP100, putative 0.0015 0.019 0.0913
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.133 0.1759
Mycobacterium leprae conserved hypothetical protein 0.004 0.0939 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.2086 1
Schistosoma mansoni nocturnin 0.0015 0.019 0.019
Plasmodium falciparum phd finger protein, putative 0.0029 0.0607 0.2908
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0378 0.0407
Brugia malayi hypothetical protein 0.0153 0.4461 0.4801
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0921 0.4413
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0607 0.0607
Brugia malayi RNA binding protein 0.0129 0.371 0.3993
Loa Loa (eye worm) carboxylesterase 0.0052 0.133 0.1416
Mycobacterium tuberculosis Probable conserved lipoprotein 0.004 0.0939 0.1242
Trichomonas vaginalis sphingomyelinase C 2 precursor, putative 0.0015 0.019 0.0912
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.2086 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0378 0.0378
Trichomonas vaginalis spcc417.12 protein, putative 0.0052 0.133 0.6374
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0939 0.4501
Echinococcus multilocularis ferritin 0.0009 0.0000031895 0.0000031895
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0939 0.1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0021 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2643 0.2643
Plasmodium falciparum importin beta, putative 0.0029 0.0617 0.2959
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.2086 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.2086 1
Giardia lamblia PHD finger protein 15 0.0029 0.0607 0.2196
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0015 0.019 0.019
Schistosoma mansoni tar DNA-binding protein 0.0129 0.371 0.371
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.2645 0.2645
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Plasmodium vivax endonuclease/exonuclease/phosphatase domain containing protein 0.0015 0.019 0.0913
Mycobacterium tuberculosis Conserved protein 0.004 0.0939 0.1242
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0037 0.0857 0.4109
Schistosoma mansoni ap endonuclease 0.0077 0.2086 0.2086
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0433 0.2074
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.019 0.0203
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0433 0.0466
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0052 0.133 0.6374
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0015 0.019 0.0913
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0433 0.2074
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Trypanosoma brucei RNA editing exonuclease 2 0.0015 0.019 0.0913
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0607 0.2908
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.019 0.019
Brugia malayi AF-10 protein 0.0009 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0088 0.2439 0.2598
Loa Loa (eye worm) T-complex protein 1 0.0026 0.0521 0.0555
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0433 0.0572
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.3237 0.3237
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0021 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0021 0.0021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.2086 1
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0026 0.0521 0.2496
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0021 0.0021
Toxoplasma gondii endonuclease/exonuclease/phosphatase family protein 0.0015 0.019 0.0913
Schistosoma mansoni jumonji/arid domain-containing protein 0.0037 0.0853 0.0853
Onchocerca volvulus 0.0052 0.1325 0.2937
Toxoplasma gondii exonuclease III APE 0.0077 0.2086 1
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0939 0.0939
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0037 0.0857 0.0857
Loa Loa (eye worm) hypothetical protein 0.0023 0.0433 0.0461
Loa Loa (eye worm) hypothetical protein 0.0017 0.025 0.0267
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0433 0.2074
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.2086 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0718 0.0773
Echinococcus granulosus peregrin 0.0032 0.0717 0.0717
Loa Loa (eye worm) hypothetical protein 0.0029 0.0617 0.0658
Schistosoma mansoni ferritin 0.0009 0.0000031895 0.0000031895
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.025 0.0331
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Loa Loa (eye worm) hypothetical protein 0.0309 0.9291 0.9898
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0021 0.0021
Loa Loa (eye worm) carboxylesterase 0.0309 0.9291 0.9898
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0939 0.1011
Loa Loa (eye worm) hypothetical protein 0.0017 0.025 0.0267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.019 0.0913
Trichomonas vaginalis ocrl type II inositol 5-phosphatase, putative 0.0015 0.019 0.0912
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.1325 0.1426
Echinococcus granulosus synaptojanin 1 0.0015 0.019 0.019
Schistosoma mansoni tar DNA-binding protein 0.0129 0.371 0.371
Echinococcus multilocularis acetylcholinesterase 0.0309 0.9291 0.9291
Leishmania major hypothetical protein, conserved 0.004 0.0939 0.4501
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0021
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.1729 0.8289
Leishmania major hypothetical protein, conserved 0.0015 0.019 0.0913
Brugia malayi hypothetical protein 0.0052 0.133 0.1431
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0795 0.0795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.2643 0.2643
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0378 0.1812
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0021 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.2643 0.2643
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.2086 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0021 0.0021
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0446 0.2137
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.025 0.1199
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0011 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0022
Brugia malayi beta-lactamase family protein 0.004 0.0939 0.1011
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.1561 0.1662
Brugia malayi Carboxylesterase family protein 0.0052 0.133 0.1431
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.019 0.0913
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0037 0.0857 0.4109
Loa Loa (eye worm) hypothetical protein 0.0015 0.019 0.0203
Brugia malayi beta-lactamase family protein 0.004 0.0939 0.1011
Entamoeba histolytica hypothetical protein 0.0114 0.3237 1
Schistosoma mansoni ferritin light chain 0.0009 0.0000031895 0.0000031895
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0037 0.0857 0.4109
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.004 0.0939 0.4501
Schistosoma mansoni tar DNA-binding protein 0.0129 0.371 0.371
Onchocerca volvulus 0.0023 0.0433 0.0928
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0021 0.0022
Echinococcus granulosus ferritin 0.0009 0.0000031895 0.0000031895
Schistosoma mansoni acetylcholinesterase 0.0052 0.133 0.133
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0378 0.1812
Mycobacterium tuberculosis Probable exported protein 0.0015 0.019 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0433 0.0795
Loa Loa (eye worm) hypothetical protein 0.0017 0.025 0.0267
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0221 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0021 0.0022
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.4198 0.4198
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0015 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0015 0.019 0.0203
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0021 0.0021
Schistosoma mansoni neutral sphingomyelinase 0.0015 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Leishmania major hypothetical protein, conserved 0.0015 0.019 0.0913
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Schistosoma mansoni hypothetical protein 0.0331 1 1
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0939 0.4501
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.2086 0.2245
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0021 0.0022
Echinococcus granulosus tar DNA binding protein 0.0129 0.371 0.371
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0015 0.019 0.0913
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.2645 0.2645
Echinococcus multilocularis acetylcholinesterase 0.0309 0.9291 0.9291
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0015 0.019 0.0203
Loa Loa (eye worm) hypothetical protein 0.0017 0.025 0.0267
Brugia malayi hypothetical protein 0.0088 0.2439 0.2625
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0009 0.0004 0.0017
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0017 0.0254 0.0254
Brugia malayi Endonuclease/Exonuclease/phosphatase family protein 0.0015 0.019 0.0205
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0021 0.0022
Trypanosoma brucei Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0037 0.0857 0.2188
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0021 0.0021
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0015 0.019 0.019
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0433 0.2074
Echinococcus granulosus survival motor neuron protein 1 0.0255 0.7624 0.7624
Mycobacterium ulcerans carboxylesterase, LipT 0.0052 0.133 0.6374
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0021 0.0021
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0939 0.4501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.2643 0.2643
Plasmodium vivax hypothetical protein, conserved 0.0015 0.019 0.0913
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0446 0.2137
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.2643 0.2816
Echinococcus multilocularis deoxyribonuclease 1 2 0.0015 0.019 0.019
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0015 0.019 0.0913
Leishmania major hypothetical protein, conserved 0.0015 0.019 0.0913
Schistosoma mansoni hypothetical protein 0.0009 0.0004 0.0004
Echinococcus granulosus acetylcholinesterase 0.0309 0.9291 0.9291
Mycobacterium leprae Probable lipase LipE 0.004 0.0939 1
Trypanosoma cruzi Endonuclease/Exonuclease/phosphatase family, putative 0.0015 0.019 0.0913
Trypanosoma cruzi mitochondrial protein 99, putative 0.0015 0.019 0.0913
Plasmodium falciparum T-complex protein 1 subunit beta 0.0026 0.0521 0.2496
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0026 0.0521 0.2496
Onchocerca volvulus 0.004 0.0939 0.2068
Echinococcus multilocularis BC026374 protein (S09 family) 0.0052 0.133 0.133
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0939 0.4501
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1847 0.1847
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0921 0.2396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1743 0.8355
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0026 0.0521 0.0521
Leishmania major endonuclease/exonuclease protein-like protein 0.0015 0.019 0.0913
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.2086 0.2086
Loa Loa (eye worm) hypothetical protein 0.001 0.0021 0.0022
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0052 0.133 0.133
Loa Loa (eye worm) hypothetical protein 0.0088 0.2439 0.2598
Leishmania major T-complex protein 1, beta subunit, putative 0.0026 0.0521 0.2496
Schistosoma mansoni thyroid hormone receptor 0.001 0.0021 0.0021
Trichomonas vaginalis Phospholipase C precursor, putative 0.0015 0.019 0.0912
Echinococcus multilocularis tar DNA binding protein 0.0129 0.371 0.371
Trichomonas vaginalis esterase, putative 0.004 0.0939 0.4501

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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