Detailed information for compound 799005

Basic information

Technical information
  • TDR Targets ID: 799005
  • Name: 2-[(2-fluorophenyl)methylsulfanyl]-7-(4-hydro xyphenyl)-5-methyl-1,7-dihydro-[1,2,4]triazol o[1,5-a]pyrimidine-6-carboxamide
  • MW: 411.453 | Formula: C20H18FN5O2S
  • H donors: 3 H acceptors: 4 LogP: 3.17 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc(cc1)C1C(=C(C)Nc2n1nc(n2)SCc1ccccc1F)C(=O)N
  • InChi: 1S/C20H18FN5O2S/c1-11-16(18(22)28)17(12-6-8-14(27)9-7-12)26-19(23-11)24-20(25-26)29-10-13-4-2-3-5-15(13)21/h2-9,17,27H,10H2,1H3,(H2,22,28)(H,23,24,25)
  • InChiKey: UTNFNAFFLNCLCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(2-fluorophenyl)methylthio]-7-(4-hydroxyphenyl)-5-methyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • 2-[(2-fluorobenzyl)thio]-7-(4-hydroxyphenyl)-5-methyl-1,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxamide
  • Oprea1_000418
  • ST5204425

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0016 0.0021
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0049 0.0097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0093 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0093 0.068
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0184 0.0528
Loa Loa (eye worm) latrophilin receptor protein 2 0.0084 0.0801 0.2335
Onchocerca volvulus 0.01 0.0978 0.2827
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.1397 0.4302
Loa Loa (eye worm) hypothetical protein 0.0014 0.0049 0.0132
Loa Loa (eye worm) hypothetical protein 0.0169 0.173 0.5056
Trichomonas vaginalis maltase-glucoamylase, putative 0.0038 0.031 0.0398
Echinococcus granulosus lamin 0.0027 0.0184 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0693 1
Mycobacterium ulcerans lipase LipD 0.0074 0.0693 0.2038
Onchocerca volvulus 0.0074 0.0693 0.199
Loa Loa (eye worm) beta-lactamase 0.0074 0.0693 0.2018
Plasmodium falciparum glutathione reductase 0.0044 0.037 0.961
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0184 0.0528
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0016 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0021
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.0059 0.0043
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.094
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0059 0.0798
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0382 0.5517
Echinococcus multilocularis tar DNA binding protein 0.0263 0.2749 0.2737
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0693 0.1284
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.0059 0.0798
Brugia malayi Glycosyl hydrolases family 31 protein 0.0038 0.031 0.0866
Schistosoma mansoni tar DNA-binding protein 0.0263 0.2749 0.3593
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0073
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Schistosoma mansoni intermediate filament proteins 0.0027 0.0184 0.0241
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0693 0.0983
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0983
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.0059 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0693 0.0906
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0184 0.0496
Loa Loa (eye worm) hypothetical protein 0.0181 0.1854 0.5419
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1768 0.1754
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.031 0.0398
Entamoeba histolytica recQ family DNA helicase 0.001 0.0004 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0179 0.0512
Mycobacterium tuberculosis Probable reductase 0.01 0.0979 0.1862
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0018 0.0093 0.1341
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0016 0.0035
Brugia malayi steroid hormone receptor 0.0011 0.0016 0.0002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.0059 0.0154
Schistosoma mansoni hypothetical protein 0.0084 0.0801 0.1047
Echinococcus multilocularis lamin 0.0027 0.0184 0.0168
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.037 0.1071
Loa Loa (eye worm) hypothetical protein 0.0325 0.3418 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0264 0.2761 0.8069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0388 0.0372
Brugia malayi Thioredoxin reductase 0.0044 0.037 0.1042
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0016 0.0002
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.011 0.0094
Loa Loa (eye worm) RecQ helicase 0.002 0.011 0.0309
Brugia malayi hypothetical protein 0.0073 0.0687 0.1974
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0049 0.0654
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0179 0.1278
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.1284
Echinococcus multilocularis muscleblind protein 0.0169 0.173 0.1717
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0277
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.031 0.0398
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0016 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0029 0.0073
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0093 0.0665
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.037 0.5307
Giardia lamblia Fructose-bisphosphate aldolase 0.0618 0.6599 1
Brugia malayi glutathione reductase 0.0044 0.037 0.1042
Schistosoma mansoni tar DNA-binding protein 0.0263 0.2749 0.3593
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0687 0.0878
Echinococcus multilocularis neuropeptide s receptor 0.0513 0.5463 0.5455
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Toxoplasma gondii aldehyde dehydrogenase 0.0139 0.1397 1
Onchocerca volvulus 0.0027 0.0184 0.0494
Brugia malayi Isocitrate dehydrogenase 0.0018 0.0093 0.0228
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.1284
Brugia malayi Glycosyl hydrolases family 31 protein 0.0173 0.1768 0.515
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0016 0.0002
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0084 0.0801 0.0787
Loa Loa (eye worm) hypothetical protein 0.0057 0.0511 0.1484
Entamoeba histolytica recQ family helicase, putative 0.002 0.011 0.0166
Treponema pallidum fructose-bisphosphate aldolase 0.0618 0.6599 1
Echinococcus granulosus bloom syndrome protein 0.002 0.011 0.0123
Loa Loa (eye worm) TAR-binding protein 0.0263 0.2749 0.8041
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0.0004 0.0005
Echinococcus granulosus tar DNA binding protein 0.0263 0.2749 0.3579
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.011 0.1565
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.0449
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.031 0.4439
Echinococcus granulosus lamin dm0 0.0027 0.0184 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0035
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0139 0.1397 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0038 0.031 0.0385
Brugia malayi RNA recognition motif domain containing protein 0.0263 0.2749 0.8034
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1267 0.3699
Echinococcus granulosus GPCR family 2 0.0084 0.0801 0.1028
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.011 0.0092
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0382 0.1079
Mycobacterium tuberculosis Conserved protein 0.0074 0.0693 0.1284
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0093 0.0325
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0507
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.0059 0.0798
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.037 0.5335
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.0059 0.0853
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0693 0.1284
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0693 0.1284
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0018
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0905 0.1164
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.01 0.0979 0.1862
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.011 0.0123
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0179 0.096
Mycobacterium leprae Probable lipase LipE 0.0074 0.0693 0.172
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.031 0.0398
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0084 0.0801 0.1028
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.0059 0.0853
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0693 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0002
Brugia malayi Latrophilin receptor protein 2 0.0084 0.0801 0.231
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0038 0.031 0.0896
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0693 0.0906
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0382 0.0367
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0173 0.1768 0.5166
Echinococcus multilocularis lysosomal alpha glucosidase 0.0173 0.1768 0.1754
Brugia malayi MH2 domain containing protein 0.0126 0.1267 0.3678
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0093 0.0077
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0693 0.2038
Plasmodium vivax glutathione reductase, putative 0.0044 0.037 0.5335
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.01 0.0979 0.1862
Echinococcus multilocularis geminin 0.0715 0.7653 0.7649
Echinococcus granulosus muscleblind protein 0.0169 0.173 0.2245
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0038 0.031 0.2219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0035
Brugia malayi nuclear receptor NHR-88 0.0011 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0111 0.11 0.2107
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0016 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0018 0.0093 0.0101
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0016 0.0035
Echinococcus granulosus neuropeptide s receptor 0.0513 0.5463 0.7132
Schistosoma mansoni lamin 0.0027 0.0184 0.0241
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Plasmodium falciparum thioredoxin reductase 0.0044 0.037 0.961
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0382 0.1079
Brugia malayi ecdysteroid receptor 0.0011 0.0016 0.0002
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.1397 0.1826
Schistosoma mansoni hypothetical protein 0.0181 0.1854 0.2423
Toxoplasma gondii isocitrate dehydrogenase 0.0018 0.0093 0.0665
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.031 0.0398
Loa Loa (eye worm) hypothetical protein 0.001 0.0004 0.00000000026013
Schistosoma mansoni alpha glucosidase 0.0038 0.031 0.0405
Treponema pallidum NADH oxidase 0.0015 0.0059 0.0083
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0179 0.0242
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.011 0.1565
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0035
Brugia malayi hypothetical protein 0.0325 0.3418 1
Echinococcus multilocularis lamin dm0 0.0027 0.0184 0.0168
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0016 0.0021
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0049 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0018 0.0093 0.0077
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0018 0.0093 0.0122
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0059 0.0154
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.1397 0.4302
Schistosoma mansoni tar DNA-binding protein 0.0263 0.2749 0.3593
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0693 0.2038
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0376 0.0361
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0801 0.2335
Trichomonas vaginalis esterase, putative 0.0074 0.0693 0.0983
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0018 0.0093 0.1289
Echinococcus multilocularis tumor protein p63 0.0388 0.4105 0.4096
Loa Loa (eye worm) hypothetical protein 0.0045 0.0382 0.1108
Schistosoma mansoni tar DNA-binding protein 0.0263 0.2749 0.3593
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0179 0.2577
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0388 0.0372
Brugia malayi nuclear hormone receptor 0.0011 0.0016 0.0002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0302 0.317 1
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0045 0.0382 0.2737
Echinococcus multilocularis bloom syndrome protein 0.002 0.011 0.0094
Trypanosoma brucei glucosidase, putative 0.0038 0.031 0.405
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Mycobacterium ulcerans aldehyde dehydrogenase 0.0139 0.1397 0.4302
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0002
Schistosoma mansoni coup transcription factor 0.0011 0.0016 0.0021
Schistosoma mansoni alpha-glucosidase 0.0149 0.1507 0.1969
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0018 0.0093 0.0077
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0693 0.2018
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0018 0.0093 0.1046
Onchocerca volvulus 0.0057 0.0511 0.1454
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0179 0.0384
Schistosoma mansoni hypothetical protein 0.0084 0.0801 0.1047
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0049 0.0654
Schistosoma mansoni DNA helicase recq1 0.002 0.011 0.0143
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0038 0.031 0.0398
Loa Loa (eye worm) hypothetical protein 0.0027 0.0184 0.0528
Echinococcus multilocularis neuropeptide receptor A26 0.0513 0.5463 0.5455
Toxoplasma gondii thioredoxin reductase 0.0044 0.037 0.2647
Brugia malayi isocitrate dehydrogenase 0.0018 0.0093 0.0228
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0016 0.0002
Loa Loa (eye worm) hypothetical protein 0.0264 0.2761 0.8076
Leishmania major hypothetical protein, conserved 0.0074 0.0693 0.4777
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0084 0.0801 0.1028
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0693 0.0887
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0074
Onchocerca volvulus 0.0027 0.0184 0.0494
Echinococcus granulosus neuropeptide receptor A26 0.0513 0.5463 0.7132
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0016 0.0002
Leishmania major trypanothione reductase 0.0044 0.037 0.2378
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0983
Schistosoma mansoni hypothetical protein 0.0715 0.7653 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0179 0.0265
Echinococcus granulosus intermediate filament protein 0.0027 0.0184 0.022
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.0059 0.0423
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0179 0.201
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0018 0.0093 0.1289
Brugia malayi beta-lactamase 0.0074 0.0693 0.1992
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0693 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0018 0.0093 0.068
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0388 0.1124
Schistosoma mansoni hypothetical protein 0.0084 0.0801 0.1047
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.0059 0.0015
Trypanosoma brucei trypanothione reductase 0.0044 0.037 0.4979
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.1835 0.5347
Mycobacterium ulcerans hypothetical protein 0.0074 0.0693 0.2038
Loa Loa (eye worm) glutathione reductase 0.0044 0.037 0.1071
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0139 0.1397 0.1384
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.031 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0016 0.0002
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.0059 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0507
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.6599 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0302 0.317 0.6298
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0376 0.0472
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0139 0.1397 0.271
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.1041
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0002
Echinococcus granulosus tumor protein p63 0.0388 0.4105 0.5355
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.031 0.4439
Loa Loa (eye worm) hypothetical protein 0.0074 0.0693 0.2018
Brugia malayi Bloom's syndrome protein homolog 0.002 0.011 0.0277
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.1041
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0693 0.1992
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.011 0.0092
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.0059 0.0423
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0693 0.0983
Onchocerca volvulus 0.0093 0.0905 0.2613
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0084 0.0801 0.231
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0693 1
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0693 0.1284
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0302 0.317 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0018 0.0093 0.0068
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.005 0.0133
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0111 0.11 0.2107
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.011 0.1532
Echinococcus multilocularis muscleblind protein 1 0.0169 0.173 0.1717
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0111 0.11 0.308
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0693 1
Schistosoma mansoni DNA helicase recq5 0.002 0.011 0.0143
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0088
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0786
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0111 0.11 0.2107
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.0059 0.0015
Brugia malayi intermediate filament protein 0.0027 0.0184 0.0496
Trichomonas vaginalis sucrase-isomaltase, putative 0.0038 0.031 0.0398
Echinococcus multilocularis GPCR, family 2 0.0084 0.0801 0.0787
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0264 0.2761 0.8076
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0693 0.172
Brugia malayi RNA binding protein 0.0263 0.2749 0.8034
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0693 0.1284
Brugia malayi Cytochrome P450 family protein 0.0052 0.0463 0.1315
Echinococcus granulosus geminin 0.0715 0.7653 1
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.0059 0.0056
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0511 0.0667
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0016 0.0002
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0388 0.1094
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0139 0.1397 0.1809
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0905 0.1183
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0004 0.003
Schistosoma mansoni hypothetical protein 0.0045 0.0382 0.05
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0016 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0388 0.0487
Loa Loa (eye worm) isocitrate dehydrogenase 0.0018 0.0093 0.026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0687 0.0672
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0045 0.0382 0.1079
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0798
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0016 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.01 0.0979 0.2676
Schistosoma mansoni lamin 0.0027 0.0184 0.0241
Schistosoma mansoni hypothetical protein 0.0715 0.7653 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0038 0.031 0.0398
Schistosoma mansoni alpha-glucosidase 0.0149 0.1507 0.1969
Loa Loa (eye worm) RNA binding protein 0.0263 0.2749 0.8041
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0016 0.0021
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0786
Loa Loa (eye worm) hypothetical protein 0.0093 0.0905 0.2639
Mycobacterium tuberculosis Putative ferredoxin reductase 0.01 0.0979 0.1862
Entamoeba histolytica hypothetical protein 0.0026 0.0179 0.0271
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0179 1
Loa Loa (eye worm) hypothetical protein 0.0179 0.1835 0.5363
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.0059 0.0129
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.011 0.0123
Brugia malayi Calcitonin receptor-like protein seb-1 0.0264 0.2761 0.8069
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0693 0.0983
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Loa Loa (eye worm) hypothetical protein 0.0011 0.0016 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.0059 0.0154
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0463 0.1344
Loa Loa (eye worm) hypothetical protein 0.0169 0.173 0.5056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.0059 0.0154
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0179 0.1278
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0016 0.0002
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.011 0.0077
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.1041
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1267 0.3699
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0693 0.1284
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0016 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0388 0.0487
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0179 0.0384
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.037 0.0629
Schistosoma mansoni hypothetical protein 0.0084 0.0801 0.1047
Mycobacterium tuberculosis Probable dehydrogenase 0.01 0.0979 0.1862
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.0059 0.0074
Brugia malayi beta-lactamase family protein 0.0074 0.0693 0.1992
Leishmania major alpha glucosidase II subunit, putative 0.0038 0.031 0.1935
Schistosoma mansoni tar DNA-binding protein 0.0263 0.2749 0.3593
Echinococcus multilocularis isocitrate dehydrogenase 0.0018 0.0093 0.0077
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0905 0.089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0016 0.0035
Mycobacterium ulcerans beta-lactamase 0.0074 0.0693 0.2038
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0179 0.3696
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0263 0.2749 0.8041
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.011 0.0092
Entamoeba histolytica hypothetical protein 0.0073 0.0687 0.1041
Onchocerca volvulus 0.0074 0.0693 0.199
Brugia malayi latrophilin 2 splice variant baaae 0.0181 0.1854 0.5404
Brugia malayi hypothetical protein 0.0041 0.0335 0.094
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.0059 0.0074
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0016 0.0021
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0618 0.6599 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.047 0.4998 1
Echinococcus granulosus lysosomal alpha glucosidase 0.0173 0.1768 0.2294
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.011 0.0094
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.011 0.0277
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0905 0.2614
Schistosoma mansoni hypothetical protein 0.0073 0.0687 0.0898
Echinococcus multilocularis neutral alpha glucosidase AB 0.0038 0.031 0.0294
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0016 0.0002
Brugia malayi beta-lactamase family protein 0.0074 0.0693 0.1992
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0388 0.0507
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0084 0.0801 0.0787
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0016 0.0002
Echinococcus multilocularis musashi 0.0027 0.0184 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0016 0.0002
Onchocerca volvulus 0.0074 0.0693 0.199
Brugia malayi hypothetical protein 0.0041 0.0335 0.094
Brugia malayi TAR-binding protein 0.0263 0.2749 0.8034
Toxoplasma gondii ABC1 family protein 0.0074 0.0693 0.4961
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.011 0.0309
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0016 0.0021
Brugia malayi N-terminal motif family protein 0.0179 0.1835 0.5348
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.031 0.047
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0016 0.0002
Onchocerca volvulus 0.0325 0.3418 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.011 0.0309
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0687 0.0898
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0049 0.0099
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0618 0.6599 1
Schistosoma mansoni aldehyde dehydrogenase 0.0139 0.1397 0.1826
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0045 0.0382 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0038 0.031 0.047
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0016 0.0021
Brugia malayi Muscleblind-like protein 0.0169 0.173 0.504
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0693 0.1284
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.001 0.0004 0.006
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0179 1
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.005 0.0101
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.01 0.0979 0.1862

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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